Preprint Review Version 1 This version is not peer-reviewed

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Version 1 : Received: 2 October 2019 / Approved: 3 October 2019 / Online: 3 October 2019 (13:59:22 CEST)

How to cite: Seo, D.Y.; Ko, J.R.; Jang, J.E.; Kim, T.N.; Youm, J.B.; Kwak, H.; Bae, J.H.; Kim, A.H.; Ko, K.S.; Rhee, B.D.; Han, J. Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms. Preprints 2019, 2019100040 (doi: 10.20944/preprints201910.0040.v1). Seo, D.Y.; Ko, J.R.; Jang, J.E.; Kim, T.N.; Youm, J.B.; Kwak, H.; Bae, J.H.; Kim, A.H.; Ko, K.S.; Rhee, B.D.; Han, J. Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms. Preprints 2019, 2019100040 (doi: 10.20944/preprints201910.0040.v1).

Abstract

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising from diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include the prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function, and calcium regulation. The present review summarizes the recent findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

Subject Areas

diabetes; exercise; cardiomyopathy; heart failure

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