Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dental Implant Failure Rate and Marginal Bone Loss in Transplanted Patients: A Systematic Review and Meta-Analysis

Version 1 : Received: 24 August 2020 / Approved: 25 August 2020 / Online: 25 August 2020 (13:45:34 CEST)

How to cite: Paraizo, M.; Botelho, J.; Machado, V.; Mendes, J.J.; Alves, R.; Mascarenhas, P.; Cardoso, J.M. Dental Implant Failure Rate and Marginal Bone Loss in Transplanted Patients: A Systematic Review and Meta-Analysis. Preprints 2020, 2020080557 (doi: 10.20944/preprints202008.0557.v1). Paraizo, M.; Botelho, J.; Machado, V.; Mendes, J.J.; Alves, R.; Mascarenhas, P.; Cardoso, J.M. Dental Implant Failure Rate and Marginal Bone Loss in Transplanted Patients: A Systematic Review and Meta-Analysis. Preprints 2020, 2020080557 (doi: 10.20944/preprints202008.0557.v1).

Abstract

This systematic review investigates the failure rate and marginal bone loss (MBL) of dental implants placed in Solid-organ transplant (SOT) patients compared to healthy controls. Three databases (PubMed, Web of Sciences and the Cochrane Library) were searched up to June 2020 (PROSPERO CRD42019124896). Case-control and cohort studies reporting data failure rate and marginal bone loss (MBL) of dental implants placed in SOT patients were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Four case-control studies fulfilled the inclusion criteria, all of low risk of bias. Meta-analyses revealed consistently lower implant failure rate than control populations at patient and implant levels. SOT patients had a significant difference of -18% (p-value <0.001) of MLB towards healthy patients. SOT status poses no serious threat to implant survival. Overall, this group of patients presented lower levels of dental implant failure rate and marginal bone loss compared to otherwise healthy patients. Further intervention trials with wider sample size and longer follow-ups are necessary to confirm these summary results.

Subject Areas

transplantation; dental implant; marginal bone loss; implant failure rate; systematic review; periodontitis; periodontal diseases; oral health

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