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Preprint ARTICLE | doi:10.20944/preprints202004.0374.v2

Global Comparison of Changes in the Number of Test-Positive Cases and Deaths by Coronavirus Infection (COVID-19) in the World

Akihiro Hisaka, Hideki Yoshioka, Hiroto Hatakeyama, Hiromi Sato, Yoshihiro Onouchi, Naohiko Anzai

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; coronavirus; infectious disease; infection management; PCR test; mortality; kinetic analysis

Online: 3 June 2020 (05:10:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0376.v1

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, Robert D. Finn, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, René Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, Maria J. Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric Nawrocki, Áine Niamh O'Toole, Nancy Palacios-Ontiveros, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David L. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz

Subject: Biology And Life Sciences, Virology Keywords: virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools

Online: 23 May 2020 (11:01:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0155.v1

COVID-19 Testing: Challenges, Limitations and Suggestions for Improvement

Emily Hu

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Coronavirus; False-negative; Nucleic Acid Test; Screening; Diagnostic Accuracy; Missed Diagnosis; Epidemic; Infectious Disease

Online: 9 April 2020 (14:37:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0071.v1

Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach

Suresh Kumar

Subject: Biology And Life Sciences, Virology Keywords: 2019-nCoV; novel corona virus; Wuhan virus; drug; vaccine; spike protein; epitope; vaccine design

Online: 5 February 2020 (15:34:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1541.v1

Factors Influencing Attitudes of University Students towards ChatGPT and its Usage: A Multi-National Study Validating the TAME-ChatGPT Survey Instrument

Maram Abdaljaleel, Muna Barakat, Mariam Alsanafi, Nesreen A. Salim, Husam Abazid, Diana Malaeb, Ali Haider Mohammed, Bassam Abdul Rasool Hassan, Abdulrasool M. Wayyes, Sinan Subhi Farhan, Sami El Khatib, Mohamad Rahal, Ali Sahban, Doaa H. Abdelaziz, Noha O. Mansour, Reem AlZayer, Roaa Khalil, Feten Fekih-Romdhane, Rabih Hallit, Souheil Hallit, Malik Sallam

Subject: Social Sciences, Education Keywords: higher education; technology acceptance; generative pre-trained transformer; curriculum design; academia

Online: 22 September 2023 (08:39:44 CEST)

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Artificial intelligence (AI)-based models hold the potential to transform higher education if adopted properly and ethically. A prime example is ChatGPT with earlier studies indicating its widespread adoption in academia and by university students. The current study aimed to identify the factors influencing the attitude towards ChatGPT and its usage among university students in Arab countries. A previous survey instrument termed Technology Acceptance Model Edited to Assess ChatGPT Adoption (TAME-ChatGPT) was administered online using a convenience-based approach among the contacts of the authors. Confirmatory factor analysis (CFA) for the survey constructs was done using root mean square error of approximation (RMSEA), standardized root mean square residual (SRMR), comparative fit index (CFI), and Tucker-Lewis index (TLI). The final study sample comprised a total of 2240 participant divided as follows: Iraq (n=736, 32.9%), Kuwait (n=582, 26.0%), Egypt (n=417, 18.6%), Lebanon (n=263, 11.7%), and Jordan (n=242, 10.8%). A total of 1048 respondents heard of ChatGPT before the study (46.8%), of which 551 used ChatGPT (52.6%). The mean scores of TAME-ChatGPT constructs showed that the ease of ChatGPT use, positive attitude towards technology and social influence, higher perceived usefulness, the influence of behavioral/cognitive factors, low perceived risks and low anxiety were the determinants of positive attitude to ChatGPT and its use. For both the attitude and usage scales of TAME-ChatGPT, CFA collectively yielded satisfactory fit indices as indicated by low RMSEA and SRMR together with high CFI and TLI. Multivariate analysis showed that attitude to ChatGPT use was significantly influenced by country of residence, age, university type, and the latest grade point average of the students. The current study confirmed the validity of TAME-ChatGPT as a survey instrument to assess the possible determinants of ChatGPT use among university students in Arab countries. The study findings highlighted that successful adoption of ChatGPT in higher education could be dependent on perceived ease of use, usefulness, positive attitudes to technology, social influence, behavioral/cognitive factors, lower anxiety, and minimal perceived risks. The utility of ChatGPT in higher education requires policies that should be tailored for various settings, considering the differences observed in attitude towards ChatGPT among participating students in this study.

Working Paper ARTICLE

Macromolecular Modeling and Design in Rosetta: New Methods and Frameworks

Julia Koehler Leman, Brian D Weitzner, Steven M Lewis, RosettaCommons Consortium, Richard Bonneau

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: structure prediction; Rosetta; computational modeling; protein design

Online: 16 October 2019 (05:40:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0789.v1

Catcalling As a Representation of the Strong Patriarchal Culture in the Perspective of Feminism

Meilisa Dwi Ervinda, Raselly Elfa Putri, Moses Pandin

Subject: Social Sciences, Gender And Sexuality Studies Keywords: catcalling, harassment; patriarchy; qualitative design; women

Online: 30 April 2021 (15:19:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0182.v1

Escape Education: A Systematic Review on Escape Rooms in Education

Alice Veldkamp, Liesbeth van de Grint, Marie-Christine Knippels, Wouter van Joolingen

Subject: Social Sciences, Education Keywords: escape room; escape game; game design; team work; collaborative learning; student engagement

Online: 11 March 2020 (10:25:22 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0323.v1

Biophilic Architecture for Restoration and Therapy within the Built Environment: A Review

Farhan Asim, Venu Shree

Subject: Social Sciences, Cognitive Science Keywords: biophilia; biophilic design; sustainability; sustainable architecture; built environment; well-being; restorative environment

Online: 28 July 2019 (17:24:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0003.v1

Bio-Inspired Manufacturing Multi-Agent System for Control and Coordination of AGV Systems

Branislav Micieta, Lukas Durica, Vladimira Binasova

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: industrial automation; autonomous design; multi-agent systems; industry 4.0; biologically inspired techniques; AGV systems; energy efficiency

Online: 1 September 2016 (10:48:48 CEST)

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Preprint ARTICLE | doi:10.3390/sci2040074

Rainfall and Temperature Trend Analysis by Mann–Kendall Test and Significance for Rainfed Cereal Yields in Northern Togo

Agossou Gadedjisso-Tossou, Komlavi Adjegan, Armand Kablan

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: trend analysis; Mann–Kendall test; Sen’s slope estimator; linear regression; cereal yield; northern Togo

Online: 24 September 2020 (00:00:00 CEST)

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This study investigates the trend in monthly and annual rainfall, minimum and maximum temperature (T_min and T_max) using the Mann–Kendall (MK) test and Sen’s slope (SS) method and evaluates the significance of their variability for maize, sorghum and millet yields in northern Togo employing multiple regression analysis. The historical data of Kara, Niamtougou, Mango and Dapaong weather stations from 1977 to 2012 were used. Four non-parametric methods—Alexandersson’s Standard Normal Homogeneity Test (SNHT), Buishand’s Range Test (BRT), Pettitt’s Test (PT) and Von Neumann’s Ratio Test (VNRT)—were applied to detect homogeneity in the data. For the data which were serially correlated, a modified version of the MK test (pre-whitening) was utilised. Results showed an increasing trend in the annual rainfall in all four locations. However, this trend was only significant at Dapaong (p < 0.1). There was an increasing trend in T_max at Kara, Mango and Niamtougou, unlike Dapaong where T_max revealed a significant decreasing trend (p < 0.01). Similarly, there was an increasing trend in T_min at Kara, Mango and Dapaong, unlike Niamtougou where T_min showed a non-significant decreasing trend (p > 0.05). Rainfall in Dapaong was found to have increased (7.79 mm/year) more than the other locations such as Kara (2.20 mm/year), Niamtougou (4.57 mm/year) and Mango (0.67 mm). T_max increased by 0.13, 0.13 and 0.32 °C per decade at Kara, Niamtougou and Mango, respectively, and decreased by 0.20 per decade in Dapaong. Likewise, T_min increased by 0.07, 0.20 and 0.02 °C per decade at Kara, Mango and Dapaong, respectively, and decreased by 0.01 °C per decade at Niamtougou. Results of multiple regression analysis revealed nonlinear yield responses to changes in rainfall and temperature. Rainfall and temperature variability affects rainfed cereal crops production, but the effects vary across crops. The temperature has a positive effect on maize yield in Kara, Niamtougou and Mango but a negative effect on sorghum in Niamtougou and millet in Dapaong, while rainfall has a negative effect on maize yield in Niamtougou and Dapaong and millet yield in Mango. In all locations, rainfall and temperature variability has a significant effect on the cereal crop yields. There is, therefore, a need to adopt some adaptation strategies for sustainable agricultural production in northern Togo.

Preprint ARTICLE | doi:10.20944/preprints202002.0234.v1

Sequence Properties of the MAAP Protein and of the VP1 Capsid Protein of Adeno-Associated Viruses

David G. Karlin

Subject: Biology And Life Sciences, Virology Keywords: adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix

Online: 17 February 2020 (02:42:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0085.v1

Garments Texture Design Class Identification Using Deep Convolutional Neural Network

S.M. Sofiqul Islam, Emon Kumar Dey, Md. Nurul Ahad Tawhid, B. M. Mainul Hossain

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: CNN; Deep Learning; AlexNet; VGGNet; Texture Descriptor; Garment Categories; 13 Garment Trend Identification; Design Classification for Garments.

Online: 27 July 2016 (15:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0100.v1

Aluminum Wires have the Free Air Balls (FABs): Electronic Flame-Off, Fracture Strength, Electrical Properties and Bonding Characteristics of Nano Zn Film Al-Si Bonding Wires

Fei-Yi Hung, Truan-Sheng Lui, Kuan-Ming Chu, Yi-Wei Tseng

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Al wire, free air ball (FAB),electronic flame-off (EFO), coating, bias test

Online: 18 November 2016 (15:03:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0026.v1

Propose of Mix Design Method for CO₂ Reduction Concrete Using the Regression Analysis

Tae Hyoung Kim

Subject: Engineering, Civil Engineering Keywords: concrete; sustainability; regression analysis mix design; CO2 emission; cost

Online: 3 August 2016 (06:05:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0045.v1

Methodology for a Dump Design Optimization in Large-Scale Open Pit Mines

Jorge Puell Ortiz

Subject: Engineering, Control And Systems Engineering Keywords: mine planning; dump design; open pit; optimization

Online: 5 May 2017 (05:29:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0763.v1

Overview of Microbial Fuel Cell (MFC) Recent Advancement from Fundamentals to Applications: MFC Designs, Major Elements, and Scalability

Sami G. A. Flimban, Taeyoung Kim, Iqbal Mohammad Ibrahim Ismail, Sang-Eun Oh

Subject: Engineering, Energy And Fuel Technology Keywords: Microbial fuel cell (MFC); fuel cell elements; design; energy generation; Scaling up; configuration

Online: 2 November 2018 (10:04:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0252.v1

Prevalence and Associated Risk Factors of Typhoid Fever in Children Attending “Deo Gratias” Hospital in Douala, Littoral Region

Teh Exodus Akwa, Nguimbous Simone

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Salmonella typhi; control; Widal test; incidence

Online: 21 June 2020 (10:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0085.v2

Modeling and Simulation of Passenger Flow Distribution in Urban Rail Transit Hub Platform

Long Gao, Limin Jia

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: passenger flow distribution model; simulation design; performance evaluation; passenger flow volume; service level; urban rail transit hub platform

Online: 2 December 2016 (07:52:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0148.v1

Design and Optimization of an Efficient (96.1%) and Compact (2 kW/dm³) Bidirectional Isolated Single-Phase Dual Active Bridge Ac–Dc Converter

Jordi Everts

Subject: Engineering, Electrical And Electronic Engineering Keywords: ac–dc power converters; battery chargers; dual active bridge; DAB; optimal design; power MOSFETs; single-stage

Online: 15 August 2016 (11:06:09 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201608.0047.v1

Toughness of Railroad Concrete Crossties with Holes and Web Opening

Erosha K. Gamage, Sakdirat Kaewunruen, Alex M. Remennikov, Tetsuya Ishida

Subject: Engineering, Civil Engineering Keywords: Concrete sleeper; crosstie; design standard; holes; web opening; railway infrastructure; static performance

Online: 5 August 2016 (08:06:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0372.v1

Structural Genomics and Interactomics of 2019 Wuhan Novel Coronavirus, SARS-CoV-2, Indicate Evolutionary Conserved Functional Regions of Viral Proteins

Hongzhu Cui, Ziyang Gao, Ming Liu, Senbao Lu, Winnie Mkandawire, Oleksandr Narykov, Suhas Srinivasan, Mo Sun, Dmitry Korkin

Subject: Biology And Life Sciences, Virology Keywords: structural genomics; protein-protein interactions; structural bioinformaticscomparative modeling; functional annotation; antiviral design; SARS-CoV-2; 2019-nCoV

Online: 25 February 2020 (11:24:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0037.v1

THE AVERAGE LOWER 2-DOMINATION NUMBER OF WHEELS RELATED GRAPHS AND AN ALGORITHM

TUFAN TURACI

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: graph vulnerability; connectivity; network design and communication; domination number; average lower 2-domination number

Online: 15 July 2016 (09:50:33 CEST)

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The problem of quantifying the vulnerability of graphs has received much attention nowadays, especially in the field of computer or communication networks. In a communication network, the vulnerability measures the resistance of the network to disruption of operation after the failure of certain stations or communication links. If we think of a graph as modeling a network, the average lower 2-domination number of a graph is a measure of the graph vulnerability and it is defined by

γ_{2 a v} (G) = \frac{1}{| V (G) |} \sum_{v \in V (G)} γ_{2 v} (G)

, where the lower 2-domination number, denoted by

γ_{2 v} (G)

, of the graph G relative to v is the minimum cardinality of 2-domination set in G that contains the vertex v. In this paper, the average lower 2-domination number of wheels and some related networks namely gear graph, friendship graph, helm graph and sun flower graph are calculated. Then, we offer an algorithm for computing the 2-domination number and the average lower 2-domination number of any graph G.

Preprint ARTICLE | doi:10.20944/preprints201805.0178.v1

Graph Coloring: A Novel Heuristic Based on Trailing Path; Properties, Perspective and Applications in Structured Networks

Abhirup Bandyopadhyay, Amit Kumar Dhar, Sankar Basu

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: chromatic number; graph partitioning; NP to P; motif identifier; protein design

Online: 11 May 2018 (08:58:35 CEST)

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Graph coloring is a manifestation of graph partitioning, wherein, a graph is partitioned based on the adjacency of its elements. Partitioning serves potentially as a compartmentalization for any structural problem. Vertex coloring is the heart of the problem which is to find the chromatic number of a graph. The fact that there is no general efficient solution to this problem that may work unequivocally for all graphs opens up the realistic scope for combinatorial optimization algorithms to be invoked. The algorithmic complexity of graph coloring is non-deterministic in polynomial time (NP) and hard. To the best of our knowledge, there is no algorithm as yet that procures an exact solution of the chromatic number comprehensively for any and all graphs within the polynomial (P) time domain. However, several heuristics as well as some approximation algorithms have been attempted to obtain an approximate solution for the same. Here, we present a novel heuristic, namely, the 'trailing path', which returns an approximate solution of the chromatic number within polynomial time, and, with a better accuracy than most existing algorithms. The ‘trailing path’ algorithm is effectively a subtle combination of the search patterns of two existing heuristics (DSATUR and Largest First), and, operates along a trailing path of consecutively connected nodes (and thereby effectively maps to the problem of finding spanning tree(s) of the graph) during the entire course of coloring, where essentially lies both the novelty and the apt of the current approach. The study also suggests that the judicious implementation of randomness is one of the keys towards rendering an improved accuracy in such combinatorial optimization algorithms. Apart from the algorithmic attributes, essential properties of graph partitioning in random and different structured networks have also been surveyed, followed by a comparative study. The study reveals the remarkable stability and absorptive property of chromatic number across a wide array of graphs. Finally, a case study is presented to demonstrate the potential use of graph coloring in protein design – yet another hard problem in structural and evolutionary biology.

Preprint ARTICLE | doi:10.20944/preprints201701.0035.v1

Use of the QuantiFERON-TB Gold In-Tube Test in the Diagnosis and Monitoring of Treatment Efficacy in Active Pulmonary Tuberculosis

Ping-Chin Chang, Pin-Hui Wang, Kow-Tong Chen

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: QuantiFERON-TB Gold In-Tube test; pulmonary tuberculosis; sensitivity; specificity

Online: 9 January 2017 (03:58:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0147.v1

A MEMS Device for Quantitative in situ Mechanical Testing in Electron Microscope

Xiaodong Wang, Shengcheng Mao, Jianfei Zhang, Zhipeng Li, Qingsong Deng, Jin Ning, Xudong Yang, Li Wang, Yuan Ji, Xiaochen Li, Yinong Liu, Ze Zhang, Xiaodong Han

Subject: Chemistry And Materials Science, Nanotechnology Keywords: piezoresistive sensor; electron microscope; in situ mechanical test

Online: 30 December 2016 (04:16:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0183.v3

Creole Hens and Ranga-Ranga: Campesino Foodways and Biocultural Resource-Based Development in the Central Valley of Tarija, Bolivia

Katherine L. Turner, Iain J. Davidson-Hunt, Annette Aurélie Desmarais, Ian Hudson

Subject: Social Sciences, Geography, Planning And Development Keywords: biocultural resources; biocultural design; alternative food networks; sustainable rural development; local food systems; Bolivia

Online: 8 September 2016 (10:19:43 CEST)

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Working Paper REVIEW

Phage Assisted Continuous Evolution (PACE): A How-to Guide for Directed Evolution

Serban C. Popa, Ichiro Inamoto, Benjamin W. Thuronyi, Jumi A. Shin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: continuous evolution; protein design; protein engineering; phage; bacterial one-hybrid; plaque assay; mutational analysis; DNA sequencing

Online: 5 November 2019 (02:19:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0148.v1

Systemic Analysis of Certified Artisan Cheese Production for Improvement—The Case of the Serra da Estrela PDO Cheese

Denis A. Coelho, Tiago E. P. Carrola, Ana F. Couvinhas

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: process improvement; ewe’s cheese; systemic design

Online: 30 December 2016 (07:34:54 CET)

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The research reported on this paper was aimed at improving the overall efficiency of a PDO certified artisanal cheese production process. Being a PDO certified foodstuff by the EU, it is considered to have properties and qualities determined by the geographical environment in which is made, with its production taking place in a specific and determined geographical location, in this case the Serra da Estrela region. In that sense, the authors conducted a mapping according to a systemic perspective of the processes involved in the context of manufacturing and distribution of certified Serra da Estrela cheese. Numerous methods were used throughout the process, such as a systemic design analysis, and techniques derived from ethnographic methods, which led to the collection of data in the field and consequently provided the immersion of the researcher in genuine work situations. Critical points were identified and emphasized in the systemic map with the purpose of encouraging initiatives to address and overcome the gaps and inefficiencies detected. The systemic design analysis triggered the development of design work. Observations following an ethnographic approach identified ergonomic risks in cheese making during the process of cutting excess chips, fostering the emergence of musculoskeletal disorders at the wrist. A tool that fits best to the task at hand was developed. A prototype of the new tool enabled collecting feedback from use in the work context, in order to inform product development. The domains of agricultural production and microbiology, considering the specific microorganisms developed trough the ripening process of the cheese, turned out to be aspects of high importance for the issue under focus, contributing to a broader understanding of the ripening process and its risks, simultaneously improving the efficiency and success of cheese production. If it were not for the systemic analysis, which served as a link between the boundaries of distinct domains such as the risk of microorganism contamination, ergonomics, energy efficiency, legislation and regulation policies, transportation challenges and economic viability, approached throughout the research. Simultaneously creating bridges between them, the various problems might not have been detected in the first place, as they are usually addressed in specialized disciplines, predetermined by the restrictions of each specific area of knowledge. As a consequence of the development of this research, which was based on an analysis that sought to establish possible connections between various disciplines and tried to constantly maintain a holistic perspective, making new connections and observing the issues from a new angle, apart from the already established methodologies. All this allowed to lay out the seeds for the development of a plan to tackle the critical points identified by the systemic analysis reported in this paper.

Preprint ARTICLE | doi:10.20944/preprints201712.0076.v1

Design and Manufacturing of Conformal Cooling for Hot Stamping Dies Using Hybrid Process of Laser Metal Deposition (LMD) and Milling

Magdalena Cortina, Jon Iñaki Arrizubieta, Amaia Calleja, Eneko Ukar, Amaia Alberdi

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: additive manufacturing; laser metal deposition; hot stamping; die and mold; conformal cooling; design optimization.

Online: 12 December 2017 (15:24:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0121.v1

The Techno-Economic Potential of Offshore Wind Energy with Optimized Future Turbine Designs in Europe

Dilara Gulcin Caglayan, Severin Ryberg, Heidi Heinrichs, Jochen Linßen, Detlef Stolten, Martin Robinius

Subject: Engineering, Energy And Fuel Technology Keywords: Offshore wind energy, future turbine design, floating foundation, fixed-bottom foundation, levelized cost of electricity

Online: 13 February 2019 (15:43:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0056.v1

Power and Obstacle Aware 3D Clock Tree Synthesis

Leena Chandrakar, Ravi S., Harish M. Kittur

Subject: Engineering, Electrical And Electronic Engineering Keywords: Clock Tree Synthesis (CTS); Clock Network Design (CND); Integrated-Circuits (ICs); 3D ICs; Through-Silicon-Via (TSV); obstacles; mmm-algorithm; exact-zero skew algorithm; obstacle aware algorithm; power; wire-length; skew; slew; delay

Online: 8 May 2017 (09:36:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0017.v4

Propositions for Confidence Interval in Systematic Sampling on Real Line

Mehmet Niyazi Çankaya

Subject: Computer Science And Mathematics, Mathematics Keywords: biomedical imaging; covariogram; design-based stereology; estimation of volume; systematic sampling

Online: 15 September 2016 (05:18:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0044.v1

A Comprehensive Technological Survey on Dependable Self-Managing CPS: The Decade of Researches on Correctness and Dependability

Peng Zhou, Kunmean HOU, Zhan Zhang, Decheng Zuo, Jian Dong, Jianjin Li, Haiyin Zhou

Subject: Engineering, Control And Systems Engineering Keywords: cyber physical systems; industry 4.0; MDE; hardware and software co-design; lifetime verification & validation; dependability; correctness; flexibility; self-management; self-adapting; self-healing

Online: 17 July 2017 (10:27:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0050.v1

Performance Analysis of Data–Driven and Model–Based Control Strategies Applied to a Thermal Unit Model

Cihan Turhan, Silvio Simani, Ivan Zajic, Gulden Gokcen Akkurt

Subject: Engineering, Control And Systems Engineering Keywords: modelling and simulation for control; advanced control design; model–based and data-driven approaches; artificial intelligence; thermal unit nonlinear system

Online: 9 December 2016 (03:17:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0143.v1

None Operational Amplifier (OPA) Based: Design of Analogous Bandgap Reference Voltage

Hao-Ping Chan, Yu-Cherng Hung

Subject: Engineering, Electrical And Electronic Engineering Keywords: Band-gap voltage reference; voltage reference; circuit design

Online: 29 December 2016 (15:47:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0181.v1

An on-site, ultra-sensitive, quantitative sensing method for the determination of total aflatoxin in peanut and rice based on quantum dot nanobeads strip

Suiyan Ouyang, Zhaowei Zhang, Ting He, Peiwu Li, Qi Zhang, Xiaomei Chen, Du Wang, Hui Li, Xiaoqian Tang, Wen Zhang

Subject: Chemistry And Materials Science, Food Chemistry Keywords: total aflatoxin; quantum dot nanobead; test strip; on-site; peanut and rice; agro-food safety

Online: 24 March 2017 (03:59:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0148.v1

Multi-objective Optimization of Draft Tube in Francis Turbine Using DOE, RBF and NSGA-II

Chol Nam Mun, De Chun Ba, Xiang Ji Yue, Myong Il Kim

Subject: Engineering, Energy And Fuel Technology Keywords: francis turbine; draft tube; optimization design; experiment of design; non–dominated sorting genetic algorithm

Online: 24 April 2017 (10:52:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0091.v1

A Novel Methods for Fracture Toughness Evaluation of Tool Steels with Post-Tempering Cryogenic Treatment

Ramona Sola, Roberto Giovanardi, Paolo Veronesi, Giovanni Parigi

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: fracture toughness, scratch test, residual stress, tool steel, cryogenic treatment

Online: 24 February 2017 (14:46:47 CET)

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Preprint ESSAY | doi:10.20944/preprints201704.0120.v2

Synthesis and Anti-Tumor Activity of Oleanolic Acid Derivatives

Kuai ZhenYu, Lei Li, Shengwen Zhan, Chunlin Li, Yuwei Zhao, Hongrong Chen, Yanqiu Meng

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: oleanolic acid derivatives; synthesis; anti-tumor activity; molecular docking; computer-aided drug design

Online: 24 April 2017 (12:08:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0065.v1

Using the HEXACO Model of Personality to Test the Validity of the Durand Adaptive Psychopathic Traits Questionnaire

Guillaume Durand

Subject: Social Sciences, Psychology Keywords: DAPTQ; adaptive personality; psychometric properties; HEXACO; psychopathic personality traits; confirmatory factor analysis; test-retest validity

Online: 14 June 2017 (07:47:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0047.v1

The Influence of Tool Texture on Friction and Lubrication in Strip Reduction Testing

Mohd Hafis Sulaiman, Peter Christiansen, Niels Bay

Subject: Engineering, Mechanical Engineering Keywords: tool surface texture; lubricant entrapment; strip drawing test

Online: 8 December 2016 (10:09:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0114.v1

Optimal Design of Safety Instrumented Systems for Pressure Control of Methanol Separation Columns in the Bisphenol A Manufacturing Process

In-Bok Lee, Insung Woo

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: relief system; safety instrumented system; pressure relief valve; safety integrity level; minimize design capacity

Online: 23 December 2016 (10:12:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0087.v1

While We Wait for a Vaccine Against SARS-CoV-2, Why Not Think About Available Drugs?

Francisco J. Barrantes

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Coronavirus; COVID-19; SARS-CoV-2; design drugs; ACE2; prophylaxis

Online: 7 April 2020 (11:02:13 CEST)

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At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, but full validation of this and other current developments is likely to take many more months to reach completion. The ongoing pandemic constitutes a major health burden of world proportions that is also having a devastating impact on whole economies worldwide, the knock-on effects of which could be catastrophic especially in poorer countries. Alternative measures to ameliorate the impact and hamper or minimally slow down disease progression are urgently called for. This review discusses past and currently evolving data on the etiological agent of the current pandemic, SARS-CoV-2, and its host cell receptors with a view to disclosing alternative drugs for palliative or therapeutic approaches. Firstly, SARS-CoV-2 exhibits marked tropism for cells that harbor the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) at their plasmalemma, predominantly in cells lining the oral cavity, upper respiratory tract, and bronchoalveolar cells, making these epithelial mucosae the most likely viral receptor cell targets and entry routes. Secondly, the crystal structures of several coronavirus spike proteins in complex with their cell host target receptors, and of SARS-Cov-2 in complex with an inhibitor, are now available at atomic resolution through X-ray diffraction and cryo-electron microscopy studies. Thirdly, viral entry of other viruses has been successfully blocked by inhibiting viral endogenous proteases or clathrin/dynamin-dependent endocytosis, the same internalization pathway followed by ACE2 and some viruses. Fourthly, the target cell-surface receptor molecules and SARS-CoV-2 possess other putative sites for drugs potentially modulating receptor activity or virus processing. A multi-pronged pharmacological approach attacking more than one flank of the viral-receptor interactions is worth considering as a front-line strategy.

Preprint ARTICLE | doi:10.20944/preprints202004.0347.v1

Potential Chimeric Peptides to Block the SARS-CoV-2 Spike RBD

Debmalya Barh, Sandeep Tiwari, Bruno Silva Andrade, Marta Giovanetti, Ranjith Kumavath, Preetam Ghosh, Aristóteles Góes-Neto, Luiz Carlos Junior Alcantara, Vasco Azevedo

Subject: Biology And Life Sciences, Virology Keywords: antiviral peptides; COVID-19; SARS-CoV-2; nCoV-19; peptide design; ACE2; Spike protein

Online: 19 April 2020 (13:21:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0106.v1

Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone Grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans

Christine Knabe, Doaa Adel-Khattab, Esther Kluk, Rainer Struck, Michael Stiller

Subject: Chemistry And Materials Science, Biomaterials Keywords: Tricalcium phosphate putty scaffold; bioactive ceramics; bone formation, osteogenesis, osteogenic markers, hard tissue histology; immunohistochemical analysis; split-mouth design; sinus floor augmentation; bone grafting materials

Online: 22 June 2017 (18:33:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0082.v1

Two Common Mistakes in Applying ANOVA Test: Guide for Biological Researchers

Fateme Azizi, Rasoul Ghasemi, Maryam Ardalan

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: ANOVA; homogeneity of variance; Levene’s test; multiple comparison analysis; post hoc test

Online: 6 July 2022 (03:41:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0185.v1

Design, Fabrication and Analysis of Threshold-Value Judging Mechanism in MEMS Safety and Arming Device

Dakui Wang, Wenzhong Lou, Yue Feng, Fufu Wang

Subject: Engineering, Mechanical Engineering Keywords: MEMS S&A device; threshold-value judging mechanism; fabrication process; tensile test; theoretical, simulationand experimentalanalysis; parametric design method

Online: 24 March 2017 (10:12:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0163.v1

A New Health Assessment Index of Tunnel Lining Based on the Digital Inspection of Surface Cracks

Xuezhen Wu, Yujing Jiang, Jianhua Wang, Kusaba Masaya, Tetsuya Taniguchi, Takahide Yamato

Subject: Engineering, Civil Engineering Keywords: tunnel lining; health assessment; fractal dimension; tunnel-lining crack index; digital inspection test; field test

Online: 26 April 2017 (05:59:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0572.v1

From Conventional to Virtual Smile Design Systems: A Current Systematic Review

Mohamed Ahmed, Mohamed Tharwat, Abdelrahman Sanad, Karim Abdelhamid, Hager Ali, Raafat Tammam

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Digital Smile Design; digital dentistry; dentistry software; dentistry design software

Online: 21 April 2021 (11:46:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0580.v1

A Face Serum Containing Bakuchiol, Palmitoyl Tripeptide-38, Hydrolyzed Hyaluronic Acid and a Polyherbal and Vitamin Blend Improves Skin Quality in Human Volunteers and Protects Skin Structure In vitro

Brett J West, Ifedayo Alabi, Shixin Deng

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: face serum; bakuchiol; palmitoyl tripeptide-38; hyaluronic acid; repeat insult patch test; tyrosinase; collagenase; antioxidant; clinical trial

Online: 23 June 2021 (12:18:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0007.v1

Site-Specific Treatment Responses in On-Farm Precision Experimentation

Rodrigo Gonçalves Trevisan, David S. Bullock, Nicolas Federico Martin

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Zea mays L.; nitrogen; chessboard design; geographically weighted regression; yield response functions

Online: 1 February 2019 (09:22:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0153.v1

Surgical Mask Use in Physical Exercise in Young Healthy Subjects - SUME Trial

Hugo Mendonça Café, Marta Leitão, Anya Freitas, Ana Marreiros

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Surgical mask; exercise; treadmill test; stress test; Oxygen saturation; Covid19; ECG

Online: 5 February 2021 (10:03:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0194.v1

Aromatic Plants: Antioxidant Capacity and Polyphenol Characterisation

Charalampos Proestos, Theo Varzakas

Subject: Chemistry And Materials Science, Food Chemistry Keywords: aromatic plants; HPLC; antioxidant capacity; DPPH; Rancimat test

Online: 27 March 2017 (09:57:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0271.v1

Insights from Molecular Dynamics Simulations for GPCR Drug Discovery

Ye Zou, John Ewalt, Ho-Leung Ng

Subject: Biology And Life Sciences, Biophysics Keywords: GPCRs; membrane protein; molecular dynamics; protein structure; drug design; biased-signaling pathway; allosteric sites

Online: 26 August 2019 (15:34:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0072.v2

Gridded Population Survey Sampling: A Review of the Field and Strategic Research Agenda

Dana R. Thomson, Dale A. Rhoda, Andrew J. Tatem, Marcia C. Castro

Subject: Social Sciences, Geography, Planning And Development Keywords: census; survey design; household survey; LMIC; WorldPop; LandScan

Online: 19 April 2020 (08:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0011.v1

Restaurant Acoustics – the Science behind Verbal Communication in Eating Establishments

Jens Holger Rindel

Subject: Physical Sciences, Acoustics Keywords: Verbal communication; Lombard effect; Cocktail party effect; Noise; Acoustic capacity; Universal design

Online: 1 December 2017 (18:22:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0197.v1

Co-integration and Causality Analysis of Carbon Intensity and Coal Consumption of China

Xing Wang, Zhongqi Fan, Ying Zhang

Subject: Engineering, Energy And Fuel Technology Keywords: carbon intensity; coal consumption; co-integration test; Granger causality; error correction model

Online: 27 March 2017 (10:33:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0005.v2

An Application-Oriented Design Method for Networked Driving Simulation

Kareem Abdelgawad, Jürgen Gausemeier, Ansgar Trächtler, Sandra Gausemeier, Roman Dumitrescu, Jan Berssenbrügge, Jörg Stöcklein, Michael Grafe

Subject: Engineering, Automotive Engineering Keywords: autonomous and cooperative vehicle systems; connected driving simulators; systems engineering; system of systems; system-level design; application-oriented development

Online: 12 September 2017 (15:32:19 CEST)

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Working Paper REVIEW

Web-Based Tools for Computational Enzyme Design

Sérgio M. Marques, Joan Planas-Iglesias, Jiri Damborsky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: web server; rational design; functionalizing enzymes; enzyme discovery; user-friendly tools

Online: 28 January 2021 (07:51:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0004.v1

Implant Stability of Biological Hydroxyapatites Used in Dentistry

María Piedad Ramírez Fernández, Sergio Alexander Gehrke, Patricia Mazón, Jose Luis Calvo-Guirado, Piedad N. De Aza

Subject: Chemistry And Materials Science, Biomaterials Keywords: hydroxyapatite, xenografts; implant design; implant surface

Online: 1 June 2017 (06:19:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0094.v1

Barriers and Challenges Going From Conventional to Cryogenic Superconducting Propulsion for Hybrid and All-Electric Aircrafts

F. Ferreira da Silva, João F. P. Fernandes, P. J. da Costa Branco

Subject: Engineering, Electrical And Electronic Engineering Keywords: Review; Electrical Machines; Superconducting Machines; Hybrid-Electric Aircraft; Propulsion Design; All-Electric Aircraft; Specific Power

Online: 6 September 2021 (13:04:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0309.v1

Acoustic Design of a Classical Concert Hall and Evaluation of its Acoustic Performance – A Case Study

Kwangbok Jeong, Taehoon Hong, Sung Hoon Kim, Jimin Kim, Sangyoub Lee

Subject: Engineering, Architecture, Building And Construction Keywords: Acoustic design; Reverberation time; Clarity; Lateral fraction; Acoustic measurements; Classical concert hall

Online: 22 May 2018 (13:49:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0242.v1

A General Design Procedure for Symmetrical Windings of Electrical Machines

Massimo Caruso, Antonino Oscar Di Tommaso, Fabrizio Marignetti, Rosario Miceli, Giuseppe Ricco Galluzzo

Subject: Engineering, Electrical And Electronic Engineering Keywords: Rotating electrical machines; winding design; symmetrical winding; star of slots.

Online: 25 January 2018 (12:18:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0042.v1

Experimental and Analytical Characterization of Drop Impact Behavior for a Mobile Haptic Actuator

Byungjoo Choi, Jiwoon Kwon, Yongho Jeon, Moon Gu Lee

Subject: Engineering, Mechanical Engineering Keywords: drop test; impact analysis; reliability; haptic actuator; linear resonant actuator (LRA)

Online: 4 May 2017 (11:39:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0004.v1

An Evaluation-Driven Design Process for Exhibitions

Wolfgang Leister, Ingvar Tjøstheim, Göran Joryd, Michel de Brisis, Syver Lauritzsen, Sigrun Reisæter

Subject: Arts And Humanities, Other Keywords: design process; installations; science centres; museums; visitor engagement

Online: 1 September 2017 (18:01:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0155.v1

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms

Sofia Giorgetti, Claudio Greco, Paolo Tortora, Francesco Antonio Aprile

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: amyloid diseases; biocomputing; drug design; natural antiamyloids

Online: 8 August 2018 (04:27:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0225.v1

Selective Colorimetric Sensors for Cyanide and Acetate Ion in Partially Aqueous Medium

Divya Singhal, Neha Gupta, Ashok Kumar Singh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chemosensors; CN− selective sensor; test strip sensor

Online: 27 March 2018 (12:13:34 CEST)

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Working Paper BRIEF REPORT

Positive Rate Is Useful to Evaluate the Sufficiency of RT-PCR Test Availability for COVID-19

Sadao Suzuki

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; RT-PCR test; pre-test probability; positive rate

Online: 5 May 2020 (06:04:41 CEST)

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Working Paper ARTICLE

Mass Timber Solutions for Eight Story Mixed-Use Buildings: A Comparative Study of GHG emissions

Aurora Jensen, Zlatan Sehovic, Nicole St. Clair Knobloch, John Klein, Paul Richardson, Julie Janiski

Subject: Engineering, Architecture, Building And Construction Keywords: mass timber; life cycle assessment; embodied carbon; sustainable design; functional equivalence

Online: 20 August 2020 (03:59:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201710.0046.v1

Full-Scale/Model Test Comparisons to Validate the Traditional ABL Wind Tunnel Simulation Technique: A Literature Review

X.X. Cheng, J. Dong, Y. Peng, L. Zhao, Y.J. Ge

Subject: Engineering, Civil Engineering Keywords: comparative study; full-scale measurement; wind tunnel model test; multiple-fan actively controlled wind tunnel; research scheme

Online: 9 October 2017 (06:38:40 CEST)

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Preprint ARTICLE | doi:10.3390/sci2040061

A Hybrid Approach: Dynamic Diagnostic Rules for Sensor Systems in Industry 4.0 Generated by Online Hyperparameter Tuned Random Forest

Ahlam Mallak, Madjid Fathi

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: industry4.0; fault detection; fault diagnosis; random forest; diagnostic graph; distributed diagnosis; model-based; data-driven; hybrid approach; hydraulic test rig

Online: 24 September 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0278.v1

COVID-19 Serological Tests: How Well Do They Actually Perform?

Abdi Ghaffari, Robyn Meurant, Ali Ardakani

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; serological diagnostic test; performance evaluation

Online: 21 June 2020 (14:58:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0558.v1

Investigating the Gap between Research and Practice in Additive Manufacturing

Jennifer Bracken, Zachary Bentley, James Meye, Erik Miller, Jablokow Kathryn W., Simpson Timothy, Meisel Nicholas

Subject: Physical Sciences, Acoustics Keywords: Additive Manufacturing; Design

Online: 27 January 2021 (12:31:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0148.v2

Designing Strategic Games With Preestablished Nash Equilibrium Through Artificial Inference and Global Learning

Hime A. e Oliveira Jr.

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Nash equilibria; game and mechanism design; simulated annealing; fuzzy ASA; artificial inference; global machine learning

Online: 18 November 2019 (07:34:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0051.v1

Topology Optimization of Large-Scale 3D Morphing Wingstructures

Peter Dørffler Ladegaard Jensen, Fengwen Wang, Ignazio Dimino, Ole Sigmund

Subject: Engineering, Automotive Engineering Keywords: Topology Optimization; Morphing Wing; Aerospace Design Optimization; Smart and Adaptive Structures; Feature Mapping

Online: 2 July 2021 (12:28:24 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0325.v3

The adapted Autonomic Profile (aAP) Home-Based Test for the Evaluation of Neuro-Cardiovascular Autonomic Dysfunction

Manoj Sivan, Joanna Corrado, Christopher Mathias

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: autonomic failure; lean test; active stand; long covid; Post-COVID-19 condition

Online: 28 July 2022 (03:42:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0253.v1

Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design

Yuji Sumii, Kenta Sasaki, Seiji Tsuzuki, Norio Shibata

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: halogen bonding; fluorine; iodine; pentafluorosulfanyl; titration; ab initio calculation; NMR study; drug design

Online: 25 August 2019 (15:41:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1667.v2

Active Confinement of Masonry Walls with Stainless Steel Straps: The Effect of Strap Arrangement on the in-Plane Behavior of Strength, Poisson’s Ratio and Pseudo-Ductility

Elena Ferretti

Subject: Engineering, Civil Engineering Keywords: masonry walls; CAM®; System; shear behavior; reinforcement arrangement; diagonal compression test; pseudo-ductility; anisotropy; elastic moduli; Poisson’ s ratio.

Online: 29 November 2023 (16:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0178.v2

The Optimal Tuning, within Carbon Limits, of Thermal Mass in Naturally Ventilated Buildings

Salmaan Craig

Subject: Engineering, Architecture, Building And Construction Keywords: thermal mass; natural ventilation; thermal resilience; materials design; life cycle analysis; thermal optimization; low carbon

Online: 16 July 2019 (08:50:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0421.v1

CO₂ Pipeline Design: A Review

Suoton P. Peletiri, Nejat Rahmanian, Iqbal M. Mujtaba

Subject: Engineering, Energy And Fuel Technology Keywords: CCS; CO2 pipeline design; pressure drop; pipeline diameter models; CO2 transportation; diameter equation

Online: 26 June 2018 (13:00:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0119.v1

An Alternative for Indicators Which Characterize the Structure of Economic Systems

Irina-Maria Dragan, Alexandru Isaic-Maniu

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: subunit distribution; structural analysis; statistical hypothesis; parameter estimation; sequential test

Online: 16 May 2017 (07:41:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0006.v1

Applying Petroleum Pressure Buildup Well Test Procedure on Thermal Response Test—A Novel Method to Improve Accuracy of Thermal Conductivity Determination

Tomislav Kurevija, Kristina Strpić, Sonja Koščak-Kolin

Subject: Engineering, Energy And Fuel Technology Keywords: shallow geothermal resource; borehole heat exchanger; thermal response test; TRT

Online: 1 December 2017 (11:18:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0299.v1

Green Synthesis, Structural, In Vitro and Vivo Bioactivity Properties of ZnO Nanoparticles for Biomedical Applications

Essam H. Ibrahim, Obaid Albulym, Omer Kaygili, Mona Kilany, Mohd Shkir, Mai S.A. Hussien, Niyazi Bulut, I.S. Yahia

Subject: Chemistry And Materials Science, Biomaterials Keywords: X-ray diffraction; bioactivities; cytotoxicity test; Anti-cancer activities

Online: 26 April 2019 (11:00:21 CEST)

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Working Paper ARTICLE

Cyber Risk at the Edge: Current and future trends on Cyber Risk Analytics and Artificial Intelligence in the Industrial Internet of Things and Industry 4.0 Supply Chains

Petar Radanliev, David De Roure, Kevin Page, Jason R.C. Nurse, Rafael Mantilla Montalvo, Omar Santos, La'Treall Maddox, Peter Burnap

Subject: Engineering, Automotive Engineering Keywords: Industry 4.0; Supply Chain Design; Transformational Design Roadmap; IIoT Supply Chain Model; Decision Support for Information Management

Online: 24 December 2020 (13:37:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0091.v1

A Routine Thermal Response Test (TRT) for Estimating Soil Thermal Properties in Connection with Geotechnical Analysis

Alessandro Franco

Subject: Engineering, Mechanical Engineering Keywords: Ground coupled Heat Exchangers; Thermal Response Test; Thermal conductivity; Thermal diffusivity; Geotechnical properties; Borehole heat exchangers

Online: 11 February 2019 (16:13:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0237.v1

Development of Continuum Robot Arm and Gripper for Harvesting Cherry Tomatoes

Azamat Yeshmukhametov, Koichi Koganezawa, Zholdas Buribayev, Yedilkhan Amirgaliyev, Yoshio Yamamoto

Subject: Engineering, Mechanical Engineering Keywords: tomato harvesting; gripper; continuum robot; tomato detection; design; agricultural robot

Online: 18 December 2019 (04:34:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0547.v1

Design of Experiments for Light Speed Invariance to Moving Observers

Qian Chen

Subject: Physical Sciences, Acoustics Keywords: Design of experiments, Light velocity, observers, Special Relativity, Time dilation, Time synchronization, Sagnac effect, Mass-Energy relationship, Particle acceleration, Michelson-Morley experiment, Asymmetry Theory

Online: 24 February 2021 (11:41:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0483.v1

Design and Analysis of a Helium-Assisted Hybrid Drone for Flight Time Enhancement

Geronimo Macias, Kooktae Lee

Subject: Engineering, Mechanical Engineering Keywords: Hybrid Drone; Helium UAV; Drone Design; Flight Time Increase; UAV Stability and Performance Analysis

Online: 29 September 2021 (09:50:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0441.v1

A Feasibility Review of innovative Prefabricated Footing Systems for Residential Structures

Bertrand Teodosio, Shanaka Kristombu Baduge, Tuan Duc Ngo, Priyan Mendis, Maral Tecer, David Heath

Subject: Engineering, Architecture, Building And Construction Keywords: prefabricated footing system; residential structures; reactive soils; modular construction; design for manufacture and assembly

Online: 24 July 2018 (05:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0061.v1

Normative Data Collection of the Combined Elevation Test (CET) in Swimmers and Non-Swimmers

James Furness, Ben Schram, Darren Corea, Zachary Turner, Hannah Cairns

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: combined elevation test; musculoskeletal screening test; normative data; swimming; adolescent

Online: 3 May 2018 (09:05:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0117.v1

Significance Tests for Binomial Experiments: Ordering the Sample Space by Bayes Factors and Using Adaptive Significance Levels for Decisions

Carlos A. de B. Pereira, Adriano Polpo, Eduardo Y. Nakano

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: significance level; sample size; bayes ratio; likelihood function; optimal decision; significance test

Online: 25 September 2017 (08:33:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0376.v1

Measuring Organizational Skills in the General Population: Development and Preliminary Validation of the DOSQ

Guillaume Durand

Subject: Social Sciences, Psychology Keywords: Organizational skills, test development, general population, goal-directed behaviors, psychometric validation

Online: 18 August 2020 (05:12:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0044.v1

Optimization of Pump Hydraulic Performance Based on the Response Surface Method

Shengli Xu, Shaowei Zhong, Haixin Zhao

Subject: Engineering, Mechanical Engineering Keywords: pump hydraulic performance; optimization design; response surface method; parameterization; meridional plane

Online: 5 February 2018 (16:05:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201705.0003.v3

Introducing Sustainability in Value Models to Support Design Decision Making: A Systematic Review

Marco Bertoni

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: sustainability; value modeling; decision support; value driven design; review

Online: 12 June 2017 (13:51:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0327.v1

A Cost-Benefit Analysis of the COVID-19 Asymptomatic Mass Testing Strategy in the North Metropolitan Area of Barcelona

Francesc López Seguí, Oriol Estrada Cuxart, Oriol Mitjà i Villar, Guillem Hernández Guillamet, Núria Prat Gil, Josep Maria Bonet, Mar Isnard Blanchar, Nemesio Moreno Millan, Ignacio Blanco Guillermo, Marc Vilar Capella, Martí Català Sabaté, Anna Aran Solé, Josep Maria Argimon Pallàs, Bonaventura Clotet, Jordi Ara del Rey

Subject: Biology And Life Sciences, Virology Keywords: test-tracking-quarantine; cost benefit analysis; economic analysis; COVID-19; asymptomatic screening; mass testing; non-pharmacological interventions

Online: 14 May 2021 (11:48:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0534.v1

Application of Jute Fiber in Soil Stabilization

Shwetha Prasanna, Nevil Macedon Mendes

Subject: Engineering, Civil Engineering Keywords: jute fibre; reinforcement; modified compaction test; California bearing ratio test; stabilization; shear strength

Online: 25 August 2020 (03:30:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0608.v1

Investigation of Micro Gas Turbine Systems for High Speed Long Loiter Tactical Unmanned Air Systems

James Large, Apostolos Pesyridis

Subject: Engineering, Mechanical Engineering Keywords: Unmanned Air Vehicles; Micro Gas Turbine Performance; Low Pressure Compressor; Preliminary Design

Online: 25 October 2018 (13:09:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0088.v1

Signal-to-Noise Ration Evaluation of Luojia 1-01 Satellite Nighttime Light Remote Sensing Camera Based on Time Sequence Images

Wei Wang, Xing Zhong, Zhiqiang Su, Deren Li, Guo Zhang

Subject: Engineering, Control And Systems Engineering Keywords: signal-to-noise ratio; nighttime light imaging; time sequence images; Luojia 1-01; radiative transfer model; radiometric calibration; in-orbit test

Online: 9 January 2019 (15:43:53 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202106.0091.v1

Use of the Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDs

Enqing Tan, Erica Frew, Jeff Cooper, John Humphrey, Matthew Holden, Amanda Restell Mand, Jun Li, Shaya Anderson, Ming Bi, Julia Hatler, Anthony Person, Frank Mortari, Kevin Gould, Shelly Barry

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2 variant; lateral flow immunoassay; spike protein; receptor binding domain (RBD); neutralizing antibody; therapeutic antibody cocktail; epitope binning; rapid neutralization test; ACE2

Online: 2 June 2021 (16:11:29 CEST)

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