Version 1
: Received: 17 June 2020 / Approved: 21 June 2020 / Online: 21 June 2020 (14:58:20 CEST)
How to cite:
Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform?. Preprints2020, 2020060278. https://doi.org/10.20944/preprints202006.0278.v1
Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform?. Preprints 2020, 2020060278. https://doi.org/10.20944/preprints202006.0278.v1
Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform?. Preprints2020, 2020060278. https://doi.org/10.20944/preprints202006.0278.v1
APA Style
Ghaffari, A., Meurant, R., & Ardakani, A. (2020). COVID-19 Serological Tests: How Well Do They Actually Perform?. Preprints. https://doi.org/10.20944/preprints202006.0278.v1
Chicago/Turabian Style
Ghaffari, A., Robyn Meurant and Ali Ardakani. 2020 "COVID-19 Serological Tests: How Well Do They Actually Perform?" Preprints. https://doi.org/10.20944/preprints202006.0278.v1
Abstract
In only a few months after initial discovery in Wuhan, China, SARS-CoV-2 and the associated COVID-19 disease has become a global pandemic causing significant mortality and morbidity.In the absence of vaccines and effective therapeutics, reliable serological testing can be a key element of public health policy to control further spread of the disease and gradually ease quarantine measures. However, prior to launch of large-scale seroprevalence studies to assess herd immunity, it is critical to understand the limits and potential of current SARS-CoV-2 serological tests on the market. In this study, we provide an overview of serological testing and conduct a systematic review of independent evaluations of SARS-CoV-2 serological tests performance. Our findings show significant variability in the accuracy of marketed tests and highlight several lab-based and point-of-care rapid diagnostic tests with high performance level in detecting SRAS-CoV-2 specific antibodies. The findings of this review highlight the need for ongoing independent evaluations of commercialized COVID-19 diagnostic tests.
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.