Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 Serological Tests: How Well Do They Actually Perform?

Version 1 : Received: 17 June 2020 / Approved: 21 June 2020 / Online: 21 June 2020 (14:58:20 CEST)

How to cite: Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform?. Preprints 2020, 2020060278 (doi: 10.20944/preprints202006.0278.v1). Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform?. Preprints 2020, 2020060278 (doi: 10.20944/preprints202006.0278.v1).

Abstract

In only a few months after initial discovery in Wuhan, China, SARS-CoV-2 and the associated COVID-19 disease has become a global pandemic causing significant mortality and morbidity. In the absence of vaccines and effective therapeutics, reliable serological testing can be a key element of public health policy to control further spread of the disease and gradually ease quarantine measures. However, prior to launch of large-scale seroprevalence studies to assess herd immunity, it is critical to understand the limits and potential of current SARS-CoV-2 serological tests on the market. In this study, we provide an overview of serological testing and conduct a systematic review of independent evaluations of SARS-CoV-2 serological tests performance. Our findings show significant variability in the accuracy of marketed tests and highlight several lab-based and point-of-care rapid diagnostic tests with high performance level in detecting SRAS-CoV-2 specific antibodies. The findings of this review highlight the need for ongoing independent evaluations of commercialized COVID-19 diagnostic tests.

Subject Areas

COVID-19; serological diagnostic test; performance evaluation

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