Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Green Synthesis, Structural, In Vitro and Vivo Bioactivity Properties of ZnO Nanoparticles for Biomedical Applications

Essam H. Ibrahim
ORCID logo ,
Obaid Albulym
,
Omer Kaygili
,
Mona Kilany
,
Mohd Shkir
* ,
Mai S.A. Hussien
,
Niyazi Bulut
,
I.S. Yahia
Version 1 : Received: 25 April 2019 / Approved: 26 April 2019 / Online: 26 April 2019 (11:00:21 CEST)

How to cite: Ibrahim, E.H.; Albulym, O.; Kaygili, O.; Kilany, M.; Shkir, M.; Hussien, M.S.; Bulut, N.; Yahia, I. Green Synthesis, Structural, In Vitro and Vivo Bioactivity Properties of ZnO Nanoparticles for Biomedical Applications. Preprints 2019, 2019040299. https://doi.org/10.20944/preprints201904.0299.v1 Ibrahim, E.H.; Albulym, O.; Kaygili, O.; Kilany, M.; Shkir, M.; Hussien, M.S.; Bulut, N.; Yahia, I. Green Synthesis, Structural, In Vitro and Vivo Bioactivity Properties of ZnO Nanoparticles for Biomedical Applications. Preprints 2019, 2019040299. https://doi.org/10.20944/preprints201904.0299.v1

Abstract

Owing to fascinating applications of ZnO in modern devices, it is interesting to explore its more features for future devices. Hence, herein, we have synthesized the high quality ZnO spherical nanoparticles (SNPs) through a facile green synthesis route and robust structural and biomedical studies are carried out. Hexagonal phase with 93.2% crystallinity was confirmed through XRD analysis. ZnO nanoparticles were tested for their bioactivities both in vivo (acute cytotoxicity test) and in vitro (Anti-cancer activities on liver (HepG2) and cervical (Hela) cancer cell lines, stimulatory/inhibitory effects on normal rat splenic cells and hemolytic effects on red blood cells). Results showed that ZnO SNPs has no cytotoxic effects on vital organ like liver and has no hemolytic action on red blood cells. ZnO SNPs showed inhibitory consequence on normal rat splenic cells growth at all tested concentrations. ZnO nanoparticles showed an inhibitory effect on HepG2 cell line. While showed stimulatory effect on Hela cell line. Current study presents the synthesized ZnO SNPs as highly applicable in bio-optoelectronics.

Keywords

X-ray diffraction; bioactivities; cytotoxicity test; Anti-cancer activities

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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