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Preprint ARTICLE | doi:10.20944/preprints201907.0064.v1

Microcystins and Daily Sunlight: Predictors of Chronic Liver Disease and Cirrhosis Mortality

Rajesh Melaram

Subject: Environmental And Earth Sciences, Environmental Science Keywords: microcystins; climatic factors; chronic liver disease and cirrhosis; daily sunlight; enzyme-linked immunosorbent assay

Online: 3 July 2019 (11:46:09 CEST)

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Working Paper ARTICLE

Randomized Clinical Trial Is Biased and Invalid In Studying Chronic Diseases, Compared with Multiple Factors Optimization Trial

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: clinical trial; statistical analysis; experimental error; chronic diseases; cancer; health optimization; hypothesis test; variance analysis; covariance; stratification; randomization

Online: 21 November 2019 (04:04:15 CET)

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Working Paper ARTICLE

Physical Activity and Sedentary Behaviour Patterns in 326 Persons With COPD Before Starting a Pulmonary Rehabilitation: A Cluster Analysis

Wolfgang Geidl, Johannes Carl, Samuel Cassar, Eriselda Mino, Nicola Lehbert, Michael Wittmann, Rupert Wagner, Konrad Schultz, Klaus Pfeifer

Subject: Social Sciences, Behavior Sciences Keywords: chronic obstructive pulmonary disease; exercise; motor activity; lung diseases; classificatory approach; sitting

Online: 21 August 2019 (09:59:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0190.v1

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli, Sandra Atlante, Tiziana Bacchetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

Online: 16 November 2019 (00:59:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0123.v1

Falls Incidence and Associated Risk Factors among People with Chronic Obstructive Pulmonary Disease (COPD)

Mehrdad Davoudi, Seyyed Mohammadreza Shokouhyan, Mohsen Abedi, Mehdi Rezaei, Mohamad Parnianpour, Kinda Khalaf, Masood Mazaheri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic obstructive pulmonary disease; COPD; fall risk factor; gait; balance; cognition; daily activity; muscle dysfunction

Online: 8 September 2022 (10:35:01 CEST)

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Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a systemic disease rather than a mere disorder of the lungs. Central (respiratory) and peripheral (limb) muscle weakness are among the main pronounced systemic effects of COPD. While the disease primarily affects the lower limb muscles and contributes to gait impairment, COPD is also associated with an increasing risk of falls in patients (COPDp). Previous studies have reported higher rates of falls among COPDp (1.17 to 1.20 falls/person-year), amounting to four times higher than an age-matched healthy group. Potential fall risk factors include muscle weakness, impaired daily activities, cognitive dysfunction, and gait and balance impairment. Although COPDp often manifest many of these risk factors, there remains a gap in literature regarding falls during walking in this population. This study aimed to 1. analyze the literature to identify the risk factors of falling in COPDp, and 2. investigate the underlying mechanisms by which these risk factors can lead to increased prevalence of falling. The results suggest that in addition to the known risk factors of falling, low back pain and mental fatigue should also be considered as relevant risk factors in the treatment process of these patients. Moreover, respiratory problems, which are common in this population, have demonstrated pronounced effects on energy expenditure, gait, and other types of activities of daily living (ADLs), leading to reduced intensity, disrupted coordination of the trunk-pelvic structure with the lower limbs during gait, and altered motor control performance due to activation of muscles in an inefficient synergic manner. These problems potentially lead to the increased vulnerability of these patients to external disturbances and higher incidence risk of falls and injuries. Cognitive problems, which are typically due to reduced oxygen received by the brain, as well as general inflammation caused by COPD, also play a significant role in gait disruption and balance. Future research is warranted to determine the prevalence of falls in COPDp by examining the response of these patients to Medio-Lateral (ML) and Anterior-Posterior (AP) disturbances during gait in association with traditional and recommended fall risk factors.

Preprint REVIEW | doi:10.20944/preprints202401.1486.v1

Herpesvirus Infection as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Jean M Nunes, Douglas B Kell, Etheresia Pretorius

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Endothelial cells; Herpesvirus

Online: 19 January 2024 (13:13:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0967.v1

Ecological Sorrow: Types of Grief and Loss in Ecological Grief

Panu Pihkala

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate grief; solastalgia; bereavement; eco-anxiety; chronic sorrow; nonfinite loss; sadness; disenfranchised grief; anticipatory mourning; ambiguous loss

Online: 15 November 2023 (16:34:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0395.v1

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Antonello Sica, Beniamino Casale, Caterina Sagnelli, Armando Calogero, Maria Teresa Di Dato, Alessandro Spada, Marco Rispoli, Mario Santagata, Pietro Buonavolontà, Alfonso Fiorelli, Vincenzo Tammaro, Massimo Ciccozzi, Anna Salzano, Evangelista Sagnelli, Elisabetta Saracco, Dario Tammaro, Alfonso Papa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: physical activity; elderly population; chronic pain; mediastinal lymphomas

Online: 30 December 2019 (09:44:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0201.v1

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB and Wnt/Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis andChronic Fatigue Syndrome: A Review and New Hypothesis Based on Results of Network, Enrichment and Annotation Analyses

Michael Maes, Marta Kubera, Magdalena Kotańska

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; Myalgic Encephalomyelitis; inflammation; neuro-immune; oxidative and nitrosative stress; antioxidants

Online: 13 September 2021 (10:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0144.v1

Air Pollution-Related Health Impacts on Individuals Experiencing Homelessness: Environmental Justice and Health Vulnerability in Salt Lake County, Utah

Angelina DeMarco, Rebecca Hardenbrook, Jeff Rose, Daniel Mendoza

Subject: Social Sciences, Anthropology Keywords: Air pollution; environmental justice; chronic homelessness; unsheltered homelessness; marginalized populations; hidden populations

Online: 7 October 2020 (08:22:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0283.v1

Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge

Nayara Araújo dos Reis, Rosalina Aparecida Partezani Rodrigues, Darlene Mara dos Santos Tavares, Jack Roberto Silva Fhon, Jair Sindra Virtuoso Júnior

Subject: Medicine And Pharmacology, Hematology Keywords: chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health

Online: 25 October 2019 (04:16:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0319.v2

Factors Associated with Mortality Among Elderly People in the COVID-19 Pandemic (SARS-CoV-2): A Systematic Review and Meta-Analysis

Vicente Alves, Francine Casemiro, Bruno Araujo, Marcos Lima, Rayssa Oliveira, Fernanda Fernandes, Ana Vitória Gomes, Dario Gregori

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; COVID-19; Non-Communicable Chronic Diseases (NCCDs); Clinical features; Institucionalized or hospitalized elderly; meta-analisys.

Online: 1 July 2021 (11:21:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0735.v1

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)

Derek Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig Hughes, Rachael Hunter, Dominic Trepel, Xia Wang-Steverding

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ME/CFS; myalgic encephalomyelitis; chronic fatigue syndrome; primary care; GP knowledge and understanding

Online: 30 November 2020 (15:44:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0195.v1

Occurrence of Balínt Syndrome in a Patient with Hypereosinophilic Syndrome

Philipp Klocke, Anna Whalen-Browne, Elliot Hepworth, Mohamed Panju

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Hypereosinophilic Syndrome; PDGFR-A; Balínt Syndrome; micro-emboli; chronic eosinophilic leukaemia

Online: 15 June 2020 (13:22:06 CEST)

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Working Paper COMMUNICATION

Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia

Francisco Javier Falaguera-Vera, María Garcia-Escudero, Javier Bonastre-Férez, Mario Zacarés, Elisa Oltra

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Fibromyalgia; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Pressure Point Threshold (PPT); Physiotherapy; Manual Therapy (MT)

Online: 15 September 2020 (09:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0039.v1

Racial Disparities in Post-Acute Home Health Care Referral and Utilization Among Older Adults with Diabetes

Jamie M. Smith, Olga F. Jarrín, Haiqun Lin, Tina Dharamdasani, Jennifer Tsui, Charlotte Thomas-Hawkins

Subject: Public Health And Healthcare, Nursing Keywords: Chronic conditions; diabetes; older adults; race or ethnicity; health care access; home health care; social determinants of health; inequalities or inequities

Online: 1 February 2021 (14:03:38 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.2264.v1

Chronic Fatigue Syndrome and Multiple Sclerosis have Reduced Craniospinal Compliance and Dilated Pressurized Bridging Cortical Veins: A Hypothesis Illustrated with Two Case Studies

Grant Bateman, Alexander Bateman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chronic fatigue syndrome; myalgic encephalomyelitis; multiple sclerosis; cortical vein; venous pressure

Online: 31 May 2023 (14:31:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint REVIEW | doi:10.20944/preprints202103.0571.v3

Effects of Calorie Restriction on Health Span and Insulin Resistance: Classic Calorie Restriction Diet vs Ketosis-Inducing Diet

Ana Napoleão, Lívia Fernandes, Cátia Miranda, Ana Paula Marum

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: diet; calorie restriction; ketosis; fasting; health span; lifespan; metabolic syndrome; insulin resistance; chronic non-communicable diseases; low-calorie; low-carb

Online: 12 April 2021 (13:06:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0471.v1

Multinucleated Giant Cell Formation as a Portal to Chronic Bacterial Infections

Jacob L. Stockton, Alfredo G. Torres

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Burkholderia pseudomallei; Mycobacterium tuberculosis; Multi nucleated giant cell; persistence; chronic infection

Online: 20 September 2020 (14:31:03 CEST)

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Working Paper REVIEW

CANOMAD : A Multi-Faceted Disease

Júlia Machado Rickli, Gabriela Pomaleski, Marcus Vinícius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic-ataxic neuropathy; anti-disialosyl; IgM monoclonal gammopathy; CANOMAD

Online: 5 October 2020 (11:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0177.v1

Clinical Importance of Drug Adherence during Tyrosine Kinase Inhibitor Therapy for Chronic Myelogenous Leukemia in Chronic Phase

Yasuhiro Maeda, Atsushi Okamoto, Kenta Yamamoto, Go Eguchi, Yoshitaka Kanai

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; tyrosine kinase inhibitor; adverse drug event; quality of life; second-generation tyrosine kinase inhibitor; nilotinib

Online: 16 August 2019 (08:09:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0703.v1

Middle Ear Packing and External Ear Packing with Fibrin Glue Enhances the Success of Fat Myringoplasty without Hyaluronic Acid Disc

Jongmin Kim, Chul Ho Jang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: tympanic membrane; chronic perforation; fat myringoplasty; success rate; middle ear packing; fibrin glue packing

Online: 30 July 2021 (13:25:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0217.v1

Factors Associated with the Prevalence of Malnutrition among Adult Haemodialytic Patients: A Two-Centre Study in Jeddah Region, Saudi Arabia

Firas S. Azzeh, Waad M. Turkistani, Mazen M. Ghaith, Lujain A. Bahubaish, Osama A. Kensara, Hussain A. Almasmoum, Abdullah F. Aldairi, Anmar A. Khan, Ahmad A. Alghamdi, Ghalia Shamlan, Maha H. Alhussain, Reham M. Algheshairy, Abdullah M. AlShahrani, Maysoun S. Qutob, Awfa Y. Alazzeh, Haitham M. Qutob

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chronic Kidney Disease; Protein-Energy Wasting; Modified-Subjective Global Assessment

Online: 25 April 2022 (04:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0493.v1

Long-term recovery of the fecal microbiome and metabolome of dogs with steroid-responsive enteropathy

Rachel Pilla, Blake Guard, Amanda B Blake, Mark Ackermann, Craig Webb, Steve Hill, Jonathan A Lidbury, Joerg M Steiner, Albert Jergens, Jan Suchodolski

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Chronic diarrhea, idiopathic inflammatory bowel disease, microbiota, dysbiosis

Online: 21 June 2021 (08:56:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0491.v1

Towards an Artificial Intelligence Based Chronic Disease Management

William Alberto Cruz Castañeda, Pedro Bertemes Filho

Subject: Engineering, Electrical And Electronic Engineering Keywords: Smart Health; Internet of Medical Things; Healthcare 4.0; Chronic-Disease Management; Artificial Intelligence

Online: 18 April 2023 (05:20:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0127.v1

Ten years (2011-2021) of the Regional ADHD Centre-Based Network Project for the Diagnosis and Treatment of Children and Adolescents with ADHD

Maurizio Bonati, Francesca Scarpellini, Massimo Cartabia, Michele Zanetti

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Attention deficit disorder with hyperactivity; child; adolescent; mental health; chronic disease; register; clinical protocol

Online: 4 June 2021 (09:04:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0271.v1

The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Nationwide Population-Based Study

Yookyung Lee, SuYeon Kwon, JongJoo Moon, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; disease progression; end stage renal disease; mortality; health-related behaviors; physical activity; smoking; alcohol

Online: 26 June 2019 (15:38:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0080.v1

Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian context using the GRADE-ADOLOPMENT methodology

Khalid Abdulaziz Alhasan, Juan José Yepes-Nuñez, Sumayah Askandarani, Yasser Sami Amer, Muneera Al-Jelaify, Khalid I. Almatham, Mohammed Al-Ghonaim, Sultan Al Dalbhi, Jameela Abdulaziz Kari, Ahmed Mitwalli, Ziad Memish, Joanna Sara Valson, Ximena Alvira, Khushnam Bilimoria, Ruchi Chawla, Sheila Feit, Skye Bickett, Klara Brunnhuber

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; antihypertensive; practice guidelines; recommendations; performance measures; GRADE; adolopment; AGREE II; RIGHT-Ad@pt; evidence-based healthcare; Saudi Arabia

Online: 6 April 2023 (08:59:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1898.v1

First-line Treatment of the Older Patients with CLL: A New Approach in the Chemo-free Era

Antonio Urso, Francesco Cavazzini, Maria Pia Ballardini, Silvia Gambara, Sara Consolo, Gian Matteo Rigolin, Antonio Cuneo

Subject: Medicine And Pharmacology, Hematology Keywords: chronic lymphocytic leukemia; older patient; ibrutinib; acalabrutinib; zanubrutinib; venetoclax; sustainabiity

Online: 27 June 2023 (12:04:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1585.v1

A Proposed Explainable Artificial Intelligence-Based Machine Learning Model for Discriminative Metabolites for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Fatma Hilal Yagin, Abedalrhman Alkhateeb, Ali Raza, Nagwan Abdel Samee, Noha F. Mahmoud, Cemil Colak, Burak Yagin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Explainable artificial intelligence; Myalgic encephalomyelitis/chronic fatigue syndrome; Metabolomics data; Clinical classification.

Online: 25 July 2023 (04:33:22 CEST)

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Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating disease with a significant global prevalence of over 65 million individuals. It affects various systems, including the immune, neurological, gastrointestinal, and circulatory systems. Studies have shown abnormalities in immune cell types, increased inflammatory cytokines, and brain abnormalities. Further research is needed to identify consistent biomarkers and develop targeted therapies. A multidisciplinary approach is essential for diagnosing, treating, and managing this complex disease. The current study aims at employing explainable artificial intelligence (XAI) and machine learning (ML) techniques to identify discriminative metabolites for ME/CFS. Material and Methods: The present study used a metabolomics dataset of CFS patients and healthy controls, including 26 healthy controls and 26 ME/CFS patients aged 22-72. The dataset encapsulated 768 metabolites, classified into nine metabolic super-pathways: amino acids, carbohydrates, cofactors, vitamins, energy, lipids, nucleotides, peptides, and xenobiotics. Random forest-based feature selection and Bayesian Approach based-hyperparameter optimization were implemented on the target data. Four different ML algorithms [Gaussian Naive Bayes (GNB), Gradient Boosting Classifier (GBC), Logistic regression (LR) and Random Forest Classifier (RFC)] were used to classify individuals as ME/CFS patients and healthy individuals. XAI approaches were applied to clinically explain the prediction decisions of the optimum model. Performance evaluation was performed using the indices of accuracy, precision, recall, F1 score, Brier score, and AUC. Results: The metabolomics of C-glycosyltryptophan, oleoylcholine, cortisone, and 3-hydroxydecanoate were determined to be crucial for ME/CFS diagnosis. The RFC learning model outperformed GNB, GBC, and LR in ME/CFS prediction using the 1000 iteration bootstrapping method, achieving 98% accuracy, precision, recall, F1 score, 0.01 Brier score, and 99% AUC. Conclusion: RFC model proposed in this study correctly classified and evaluated ME/CFS patients through the selected biomarker candidate metabolites. The methodology combining ML and XAI can provide a clear interpretation of risk estimation for ME/CFS, helping physicians intuitively understand the impact of key metabolomics features in the model.

Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0103.v1

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

Rodney R. Dietert, Janice M. Dietert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: microbiome; adverse childhood experiences (ACEs); gerobiotics, microimmunosome; healthspan; circadian rhythms; sleep disorders; noncommunicable diseases and conditions (NCDs); chronic disorders; early life programming

Online: 7 December 2021 (12:48:17 CET)

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Working Paper ARTICLE

Gut Microbiota as a Source of Uremic Toxins

Vasily A Popkov, Anastasia A Zharikova, Evgenia A Demchenko, Nadezda V Andrianova, Dmitry B Zorov, Egor Y Plotnikov

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: uremia; uremic toxins; microbiome; chronic kidney disease

Online: 14 July 2021 (13:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0236.v1

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.

Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Acute exacerbation chronic obstructive pulmonary disease (AECOPD); platelet-to-lymphocyte ratio (PLR); neutrophil-to-lymphocyte ratio (NLR); monocyte-to-lymphocyte ratio (MLR); baso-phil-to-lymphocyte ratio (BLR); eosinophil-to-lymphocyte ratio (ELR); in-hospital mortality; nom-ogram; decision curve analysis (DCA); clinical impact curve (CIC)

Online: 14 November 2022 (04:42:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0142.v1

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Ana C. Gonçalves, Amícal Falcão, Gilberto Alves, João A. Lopes, Luís R. Silva

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: bioactive compounds; anthocyanins; drug delivery system; nanoparticles; chronic diseases; health benefits

Online: 11 October 2022 (05:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0112.v1

High Vegetables Intake and Response to COPD Rehabilitation Treatment. The Role of Oxidative Stress, Inflammation and DNA Damage

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Diet; DNA damage; Genomic Instability; Oxidative stress; Inflammation

Online: 3 June 2021 (12:21:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202106.0486.v1

The Oxygen Transport Triad in High Altitude Pulmonary Edema: a Perspective from the High Andes

Gustavo Zubieta-Calleja, Natalia Zubieta-DeUrioste

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: high altitude, chronic hypobaric hypoxia, physiologic adaptation, travel to high altitude cities, high altitude physiology, pulmonary hypertension, lung disease, hemoglobin, tolerance to hypoxia, oxygen content.

Online: 18 June 2021 (15:22:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0420.v1

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM)

James N Baraniuk, Alison Amar, Haris Pepermintwala, Stuart D Washington

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Midbrain; postexertional malaise; PEM, arousal; exercise; fMRI; autonomic; postural tachycardia; Myalgic Encephalomyelitis / Chronic Fatigue Syndrome; ME/CFS; Gulf War Illness; GWI

Online: 23 November 2021 (10:53:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0602.v1

Epigenetic Alterations in Pediatric Sleep Apnea

Emily Catherine Cheung, Matthew Wyatt Kay, Kathryn Jaques Schunke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: epigenetic mechanisms of disease; fetal programming; obstructive sleep apnea; DNA methylation; histone modifications; chronic disease

Online: 27 July 2021 (11:45:08 CEST)

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Working Paper ARTICLE

A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury

Drew Watson, Joshua Y.C. Yang, Reuben D. Sarwal, Tara K. Sigdel, Juliane Liberto, Izabella Damm, Devon Livingstone, Katherine Soh, Arjun Chakraborty, Michael Liang, Pei-Chen Lin, Victoria Louie, Shristi Sigdel, Minnie M. Sarwal

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: KIT assay; chronic kidney disease; biomarker; non-invasive; urine; eGFR; cfDNA

Online: 20 March 2019 (02:12:19 CET)

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The standard of care measures for kidney function, proteinuria, and serum creatinine (SCr) are poor predictors of early stage kidney disease. Measures that can detect chronic kidney disease in its earlier stages are needed to enable therapeutic intervention and reduce adverse outcomes of chronic kidney disease. We have developed the Kidney Injury Test (KIT) and a novel KIT Score based on the composite measurement and validation of multiple biomarkers across a unique set of 397 urine samples. The test is performed on urine samples that require no processing at the site of collection and without target sequencing or amplification. We sought to verify that the pre-defined KIT test, KIT Score, and clinical thresholds correlate with established chronic kidney disease (CKD) and may provide predictive information of early kidney injury status above and beyond proteinuria and renal function measurements alone. Statistical analyses across six DNA, protein, and metabolite markers were performed on a subset of residual spot urine samples with CKD that met assay performance quality controls from patients attending the clinical labs at the University of California, San Francisco (UCSF) as part of an ongoing IRB approved prospective study. Inclusion criteria included selection of patients with confirmed CKD and normal healthy controls; exclusion criteria included incomplete or missing information for sample classification, logistical delays in transport/processing of urine samples or low sample volume, and acute kidney injury. Multivariate logistic regression of kidney injury status and likelihood ratio statistics were used to assess the contribution of the KIT Score for prediction of kidney injury status and stage of CKD as well as assess the potential contribution of the KIT Score for detection of early stage CKD above and beyond traditional measures of renal function. Urine samples were processed by a proprietary immunoprobe for measuring cfDNA, methylated cfDNA, clusterin, CXCL10, total protein, and creatinine. The KIT Score and stratified KIT Score Risk Group (High versus Low) had a sensitivity and specificity for detection of kidney injury status (healthy or CKD) of 97.3% (95% CI: 94.6%–99.3%) and 94.1% (95% CI: 82.3%–100%). In addition, in patients with normal renal function [eGFR ≥ 90], the KIT Score clearly identifies those with predisposing risk factors for CKD, which could not be picked up by eGFR or proteinuria (p < 0.001). The KIT Score uncovers a burden of kidney injury that may yet be incompletely recognized, opening the door for earlier detection, intervention and preservation of renal function.

Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Working Paper HYPOTHESIS

The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: incurable disease; chronic disease; cancer theory; central nervous system; state memory; mutation; tissue ecosystem; emotion; stress; exercise; baseline biochemical and cellular processes

Online: 24 November 2019 (14:50:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0005.v2

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog

Francesco Menichetti

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Covid-19; post-COVID syndrome; neuroendocrine disorders; chronic fatigue; brain fog; phospholipids; phospholipid liposome; phosphatidylserine

Online: 15 August 2023 (05:03:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0298.v1

Insights of Endocytosis Signaling in Health and Disease

Chandramani Pathak, Foram U. Vaidya, Bhargav N. Waghela, Pradeep Kumar Jaiswara, Vishal Kumar Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu Ranjan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endocytosis; Phagocytosis; Pinocytosis; Receptor endocytosis signaling; Chronic diseases

Online: 16 December 2022 (08:07:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0292.v1

Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

Tram Thi Ngoc Hoang, Thi Thu Huong Bui, Thi Thuy Pham, Thi Lan Anh Luong, Thi Kim Phuong Doan, Thu Lan Hoang, Cam Tu Ho, Nina Koerber, Khanh Lam Ho, Duc Hinh Nguyen, Tanja Bauer, Ulrike Protzer, Tien Dung Nguyen

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Chronic Hepatitis B Virus Infection; Liver; Pregnant Women; Cord blood; PBMCs (Peripheral Blood Mononuclear Cells); subclinical index

Online: 16 August 2022 (14:17:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0233.v1

Relationship Between ACE I/D Polymorphism and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease

Hendri Susilo, Budi Susetyo Pikir, Mochammad Thaha, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Ifan Ali Wafa, Cennikon Pakpahan, Delvac Oceandy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic kidney disease; gene polymorphism; angiotensin-converting enzyme; cardiovascular disease; cardiovascular mortality risk; genotype

Online: 26 April 2022 (10:05:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202208.0398.v1

Use of Rotavirus Vaccine as a Containment Measure for SARS-CoV-2 Coronavirus (COVID-19): A Study of Possible Cross and Trained Immunity

Nuria Lorite - Ayan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: rotavirus; coronavirus; vaccine; SARS-CoV-2; COVID-19; cross immunity; trained immunity; vaccinated breakthrough infections; COVID variants; long-Covid; post-viral syndrome; chronic fatigue; booster

Online: 23 August 2022 (10:50:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0180.v1

Management of Anemia of Chronic Disease: Beyond Iron-Only Supplementation.

Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic diseases; iron deficiency; haemoglobin; anaemia; aminoacids; rehabilitation

Online: 8 December 2020 (06:58:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0213.v1

High Sensitivity Cardiac Troponin T in Patients with Severe Chronic Kidney Disease and suspected Acute Coronary Syndrome

Brunilda Alushi, Fabian Jost-Brinkmann, Adnan Kastrati, Salvatore Cassese, Massimiliano Fusaro, Karl Stangl, Ulf Landmesser, Holger Thiele, Alexander Lauten

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: troponin; high-sensitivity; chronic kidney disease; renal insufficiency; myocardial infarction; acute coronary syndrome

Online: 10 August 2021 (08:45:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0416.v1

Chronic Diseases Associated with Malassezia Yeast

Abdourahim Abdillah, Stéphane Ranque

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Malassezia; Chronic diseases; psoriasis; atopic dermatitis; chronic rhinosinusitis; asthma; cystic fibrosis; HIV infection; inflammatory bowel disease; colorectal cancer; neurodegenerative diseases

Online: 24 September 2021 (08:13:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0484.v1

Disinhibited-Like Behavior Correlates With Frontal Cortex Damage in Alcohol-Induced Wernicke-Korsakoff Syndrome

Marta Moya, Leticia López-Valencia, Borja García-Bueno, Laura Orio

Subject: Social Sciences, Behavior Sciences Keywords: Chronic alcohol; Thiamine Deficiency; Disinhibition; Wernicke´s Encephalopathy; Recognition memory; Nitrosative stress; Lipid peroxidation; Apoptosis; Cell damage; Nutritional deficit

Online: 25 November 2021 (16:03:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0361.v1

Combining Awake Anesthesia with Minimal Invasive Surgery Optimizes Intraoperative Surgical Spinal Cord Stimulation Lead Placement

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Chantal Wood, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Emmanuel Cuny, Jimmy Voirin, Denys Fontaine, Sylvie Raoul, Patrick Mertens, Philippe Peruzzi, François Caire, Nadia Buisset, Romain David, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: PSPS; FBSS; SCS; surgical lead; SCS implantation; MAST (for Minimal Access Spine Technologies); TCIVA (for Target Controlled Intra-Veinous Anesthesia); composite score; pain mapping; neuropathic pain; chronic pain; quality of life; anesthesia; hypnosis

Online: 25 July 2022 (08:34:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0008.v1

CRISPR/Cas9-directed Gene Trap Constitutes a Selection System for Corrected BCR/ABL Leukemic Cells in CML

Elena Vuelta, José Luis Ordoñez, David José Sanz, Sandra Ballesteros, Jesús María Hernández-Rivas, Lucía Méndez-Sánchez, Manuel Sánchez-Martín, Ignacio García-Tuñón

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chronic Myeloid Leukaemia; BCR/ABL; CRISPR; Gene therapy; CRISPR-Trap.

Online: 4 May 2022 (12:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0339.v1

The Language of Pain in the Hypermobile Ehlers-Danlos Syndrome: Metaphors as a Key to Understand the Experience of Pain and a Rehabilitation Tool

Filippo Camerota, Rachele Mariani, Giulia Cordiano, Michela Di Trani, Valentina Lodato, Alessandro Ferraris, Massimo Pasquini, Claudia Celletti

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Chronic Pain; Hypermobile Ehlers–Danlos syndrome; Linguistic content analysis; Metaphors; Pain; Symbolizing process

Online: 5 June 2023 (14:36:19 CEST)

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Working Paper ARTICLE

Timing of Home Health Care Initiation and 30-Day Rehospitalizations among Medicare Beneficiaries with Diabetes by Race and Ethnicity

Jamie M. Smith, Haiqun Lin, Charlotte Thomas-Hawkins, Jennifer Tsui, Olga F. Jarrín

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic conditions; diabetes; older adults; race or ethnicity; social determinants of health; in-equalities or inequities; policy; health care access; home health care

Online: 6 April 2021 (14:40:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0237.v1

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

Sadiq Maifata, Fauzah Abd Ghani, Rafidah Hod, Nor Fadhlina Zakaria

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Membranous glomerulonephritis; remission; nephrotic syndrome; chronic kidney disease; end-stage kidney diseases

Online: 18 February 2022 (14:49:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0558.v1

High Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and Dna Damage.

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Vegetables; DNA damage; Genomic Instability; Oxidative stress; Inflammation.

Online: 23 June 2021 (10:08:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0622.v1

Short-term Effects of Manual Therapy Plus Capacitive and Resistive Electric Transfer Therapy in Individuals with Chronic Non-specific Low Back Pain: A Randomized Clinical Trial Study

Konstantinos Kasimis, Paris Iakovidis, Dimitrios Lytras, Georgios Koutras, Ioanna P. Chatziprodromidou, Antonis Fetlis, Stefania Rafailia Ntinou, Natalia-Maria Keklikoglou, Antigoni Samiotaki, Georgios Chasapis, Georgia Tarfali, Thomas Apostolou

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Keywords: Chronic Low back pain; Manual therapy; Capacitive and Resistive Electric Transfer Therapy

Online: 8 June 2023 (10:13:14 CEST)

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Background: Chronic non-specific low back pain (CNSLBP) is defined as back pain that lasts longer than 12 weeks. Objectives: To investigate the efficacy of manual therapy (MT) program combined with Capacitive and Resistive Electric Transfer (TECAR) therapy in individuals with CNSLBP. Method: Sixty adults with CNSLBP were randomly equally divided into three groups. The first group followed an MT protocol in the lumbar region (MT group), the second group followed the same MT protocol combined with TECAR therapy (MT + TECAR group) using a conventional capacitive electrode as well as a special resistive electrode bracelet and the third group (Control group) received no treatment. Both intervention programs included six treatments over two weeks. Pain in the last 24 hours with the Numeric Pain Rating Scale (NPRS), functional ability with the Roland-Morris Disability Questionnaire (RMDQ), Pressure Pain Threshold (PPT) in the lumbar region with pressure algometry, and mobility of the lumbo-pelvic region through fingertip-to-floor distance (FFD) test were evaluated before and after the intervention period with a one-month follow-up. Analysis of variance with repeated measures was applied. Results: In the NPRS score, both intervention groups showed statistically significant differences compared to the control group both in the second week as well as in the one-month follow-up (p < .001). Between-groups differences were also noticed between the two intervention groups in the second week (p < .05). Differences in the RMDQ score in the second week and on the one-month follow-up were detected between the intervention groups and the control group (p < .001), while differences between the two intervention groups were only detected in the one-month follow-up (p < .001). Regarding the PPT values, differences were found mainly between the MT + TECAR and the control group and between the MT + TECAR and the MT group (p < .05), with the MT + TECAR group in most cases showing the greatest improvement compared to the other two groups, which remained statistically significant in the one-month follow-up (p < .05). Finally, both intervention groups improved the mobility of the lumbo-pelvic region in both time points compared to the control group without, however, statistically significant differences between them (p> .05). Conclusion: The application of an MT protocol with TECAR therapy appeared more effective than conventional MT as well as compared to the control group in reducing pain and disability and improving PPT in individuals with CNSLBP. No further improvement was noted in mobility of the lumbo-pelvic region by adding TECAR to the MT intervention.

Preprint REVIEW | doi:10.20944/preprints202009.0706.v1

A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B

Hira Hanif, Muzammil Khan, Mukarram Ali, Pir Shah, Jinendra Satiya, Daryl Lau, Aysha Aslam

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic hepatitis B; NAFLD; NASH; biomarkers; magnetic resonance technology; NAFLD therapy

Online: 29 September 2020 (10:40:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1680.v1

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Vincenzo Losappio, Infante Barbara, Annamaria Maiorano, Serena Simiele, Sara Rosato, Silvia Mercuri, Dario Troise, Giovanni Stallone, Paola Pontrelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Chronic kidney disease; Pentraxin-3; Renal Replacement Therapies; Inflammaging.; innate immunity

Online: 24 May 2023 (03:59:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0182.v1

In Schizophrenia, Chronic Fatigue Syndrome- and Fibromyalgia-Like Symptoms are Driven by Breakdown of the Paracellular Pathway with Increased Zonulin and Immune Activation-Associated Neurotoxicity

Michael Maes, Laura Andrés-Rodríguez, Aristo Vojdani, Sunee Sirivichayakul, Décio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic fatigue syndrome; Myalgic encephalomyelitis; oxidative stress; neuro-immune; inflammation; bacterial translocation

Online: 10 May 2021 (12:27:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0392.v1

Incorporating Point-of-Care Bacterial Fluorescence into a Wound Clinic Antimicrobial Stewardship Program

Thomas Serena

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antimicrobial stewardship; detection of bacteria in chronic wounds, chronic wounds, clinical decision support; diagnostic pathway; joint commission; fluorescence imaging; wound clinic

Online: 19 October 2020 (15:35:25 CEST)

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Background: In 2014 the World Health Organization (WHO) warned of an emerging world-wide crisis of antibiotic resistant microorganisms. In response, government and professional organizations recommended that health care systems adopt antimicrobial stewardship programs (ASPs). In the United States, the Centers for Medicare Services (CMS) mandated antimicrobial stewardship in the hospital inpatient setting. Effective January 1, 2020, the Joint Commission required ambulatory centers that prescribe antibiotics, such as wound centers, to institute an ASP. Chronic wounds often remain open for months, during which time patients may receive multiple courses of antibiotics and numerous antimicrobial topical treatments. The wound clinician plays an integral role in reducing antimicrobial resistance in the outpatient setting: antibiotics prescribed for skin and soft tissue infections are among the most common in an outpatient setting. One of the most challenging aspects of antimicrobial stewardship in treating chronic wounds is the inaccuracy of bacterial and infection diagnosis. Methods: Joint Commission lists five elements of performance (EP): (1) Identifying an antimicrobial stewardship leader, (2) establishing an annual antimicrobial stewardship goal, (3) implementing evidence-based practice guidelines related to the antimicrobial stewardship goal, (4) providing clinical staff with educational resources related to the antimicrobial stewardship goal, and (5) collecting, analyzing, and reporting data related to the antimicrobial stewardship goal. This article focuses on choosing and implementing an evidence-based ASP goal for 2020. Discussion: Clinical trials have demonstrated the ability of fluorescence imaging (MLiX) to detect clinically significant levels of bacteria in chronic wounds. Combined with clinical examination of signs and symptoms of infection, the MLiX procedure improves the clinician’s ability to diagnose infection and can guide antimicrobial use. In order to satisfy the elements of performance, the MLiX procedure was incorporated into the annual ASP goal for several wound care centers. Clinicians were educated on the fluorescence imaging device and guidelines were instituted. Collection of antimicrobial utilization data is underway.

Preprint ARTICLE | doi:10.20944/preprints202011.0170.v1

Functional Disability in Adolescents with Chronic Pain: Comparing an Interdisciplinary Exposure Program to Usual Care

Carolien Dekker, Mariëlle Goossens, Bjorn Winkens, Silvia Remerie, Caroline Bastiaenen, Jeanine Verbunt

Subject: Social Sciences, Psychology Keywords: Chronic musculoskeletal pain; Adolescents; functional disability; multidisciplinary rehabilitation.

Online: 3 November 2020 (15:41:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0458.v2

Cost-sensitive Ensemble Feature Ranking and Automatic Threshold Selection for Chronic Kidney Disease Diagnosis

Syed Imran Ali, Bilal Ali, Jamil Hussain, Musarrat Hussain, Fahad Ahmed Satti, Gwang Hoon Park, Sungyoung Lee

Subject: Computer Science And Mathematics, Computer Science Keywords: Cost-sensitive feature selection; ensemble models; decision tree classifiers; chronic kidney disease; random forests; gradient boosted trees

Online: 6 July 2020 (09:56:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0599.v1

Development of the Survey of the Concept of Pain: A Measure to Study How Children Conceptualize Pain

Isabel Salvat, Cristina Adillón, Eva Maria Andrés, Sonia Monterde, Jordi Miró

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Survey; children; health knowledge; chronic pain; pain education.

Online: 26 February 2021 (09:30:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0045.v1

Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

Michele Fabrazzo, Rosa Zampino, Martina Vitrone, Gaia Sampogna, Lucia Del Gaudio, Daniela Nunziata, Salvatore Agnese, Anna Santagata, Emanuele Durante-Mangoni, Andrea Fiorillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic hepatitis C; Direct-acting antiviral agents; Hepatitis C virus; Consultation-liaison psychiatry; Depression; Anxiety

Online: 5 July 2020 (05:15:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint ARTICLE | doi:10.20944/preprints202108.0545.v1

A Novel Multi-dimensional Clinical Response Index Dedicated to Improving Global Assessment of Pain in Patients with Persistent Spinal Pain Syndrome After Spinal Surgery, Based on a Real-life Prospective Multicentric Study (PREDIBACK) and Machine Learning

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Nicolas Naiditch, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Nelly Grimaud, Nihel Adjali, Kevin Nivole, Mathilde Many, Romain David, Chantal H. Wood, Raphael Rigoard, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Composite score; Machine learning; PSPS; Failed Back Surgery Syndrome (FBSS); Chronic pain; Pain Intensity; Quality of Life; Pain Mapping; Pain Surface; Functional Capacity; Psychological Distress; Anxiety and Depression

Online: 30 August 2021 (13:04:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0511.v1

Oxygen, pH, Lactate, and Metabolism- How Old Knowledge and New Insights Might be Combined for New Wound Treatment

Herbert Leopold Haller, Frank Sander, Sebastian Philipp Nischwitz, Daniel Popp, Matthias Rapp, Bernd Hartmann, Mehmet Demircan, Lars Peter Kamolz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Wound; chronic wound; hypoxia; Lactate; Acidosis; Alkalosis; neoangiogenesis; ECM; Polylactide; polylactide membranes

Online: 30 September 2021 (12:18:52 CEST)

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: Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metallopro-teinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized "biorector," disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and pro-liferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound's pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wound. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0236.v1

A Mathematical Model of the Transition from the Normal Hematopoiesis to the Chronic and Accelerated Acute Stages in Myeloid Leukemia

Lorand Gabriel Parajdi, Radu Precup, Eduard Alexandru Bonci, Ciprian Tomuleasa

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: mathematical modeling; dynamic system; steady state; stability; hematopoiesis; chronic myeloid leukemia; stem cells

Online: 21 January 2020 (10:16:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1662.v1

A Systematic Review and Meta-Epidemiology study on Multimorbidity

Gayathri Delanerolle, Yassine Bouchareb, Priyanka Jagadeesan, Guanpeng Li, Xiaojie Yang, Heitor Cavalini, Shaheen Kazali, Alain Zemokoho, David Benfield, Ashish Shetty, Peter Phiri, Jian qing Shi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Multimorbidity; Chronic condition; Health Inequalities; Global health; Epidemiology

Online: 23 August 2023 (11:25:08 CEST)

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With enhanced life expectancy and ageing global populations, the prevalence of multimorbidity continues to increase. However, there is a dearth of evidence linked to multimorbidity diagnoses, treatments and health outcomes which remains a concern for future proofing optimal healthcare services. Generating evidence is critical to managing multimorbidity, promoting public health and minimizing health inequalities via effective healthcare policies that improve quality of life for vulnerable populations. This study assessed meta-epidemiology of multimorbidity to report the gaps in scientific knowledge and clinical practice. A systematic methodology was designed and published in PROSPERO (CRD42022347308) to report meta-epidemiology analyses using databases including PubMed, Web of Science, ScienceDirect, EMBASE, The Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials and MEDLINE for studies published between the 1^st of January 1980 - 31^st December 2022. A random-effects model was used to estimate the pooled proportion of multimorbidity in adults. Forest plots, pooled odds ratios and statistical heterogeneity metrics were used to assess the association between multimorbidity and investigated factors. Funnel plots and Egger’s regression were used to detect and correct for publication bias. Our findings identified women to be 0.32 times more likely to have multimorbidity in comparison to males. In regard to ethnicity, white people were 0.47 times less likely to develop comorbidities than black people. People who identified as a drinker or unmarried were more likely to develop comorbidities than those who are non-drinkers or married, respectively. Regardless of smoking status, people were equally likely to have comorbidity. In terms of environmental influences, people in rural areas were found to be 0.2 times less likely to have comorbidity in comparison to those living in urban areas. Interestingly, people with a higher education level were 0.57 times more likely to develop comorbidities than those with only a high school education. It is evident that multimorbidity has a significant burden globally and impacts the provision of care necessitated across populations given its association with several social determinants of health. Robust research and healthcare policies are required to better manage multimorbidity in patients. An example of such intervention includes employing prevention programs to reduce risk and incidence of multimorbidity within at-risk populations.

Preprint ARTICLE | doi:10.20944/preprints202311.1228.v1

Varvara Aleksandrovna Ryabkova, Artemiy Vladimirovich Rubinskiy, Valeriy Nikolaevich Marchenko, Vasiliy Ivanovich Trofimov, Leonid Pavlovich Churilov

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; COVID-19; Post-COVID; heart rate variability; autonomic dysfunction

Online: 20 November 2023 (07:51:21 CET)

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Background There is a considerable overlap between clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) . Many of their common symptoms can be linked to dysregulation of the autonomic nervous system (dysautonomia). This study aimed to objectively assess autonomic function in patients with PCC and in patients with ME/CFS whose disease was not related to COVID-19. Methods Synchronous recordings of an electrocardiogram, continuous dynamics of blood pressure in the digital artery using the Penaz method and ultrasound pneumotachography with the spirography function were obtained with spiroarteriocardiorhythmography method in 34 patients diagnosed with ME/CFS, in whom the onset of the disease was not associated with COVID-19, 29 patients meeting PCC definition and 32 healthy controls. Heart rate variability (HRV), systolic and diastolic blood pressure variability (RV), respiration variability were assessed at rest and in tests with fixed respiratory rates. At rest, indicators of baroreflex regulation were additionally determined (baroreflex effectiveness index and baroreflex sensitivity). Results The total power, power of very low frequency, low-frequency and high-frequency of RR interval variability at rest as well as baroreflex effectiveness index in up-ramps of arterial blood pressure and baroreflex sensitivity were significantly lower both in PCC and ME/CFS patients compared to HC. Several diagnostic prediction models for ME/CFS were developed based on HRV parameters. During slow breathing HRV parameters return to normal in PCC, but not in ME/CFS. Correlation analysis revealed a close relationship of HRV, RV parameters and baroreflex sensitivity with fatigue, but not with HADS depressive/anxiety symptoms in ME/CFS and PCC. Conclusion A similar pattern of HRV and baroreflex failure with signs of a pathological acceleration of age-dependant dysautonomia was identified in ME/CFS and PCC. The clinical, diagnostic and therapeutic implications of these findings are discussed, in light of previously described relationship between inflammation, vascular pathology, atherosclerotic cardiovascular disease and autonomic dysfunction.

Preprint ARTICLE | doi:10.20944/preprints202306.1395.v1

Sex, Age, and Regional Disparities in the Burden of Asthma in Mexico from 1990 to 2019: A Secondary Analysis of the Global Burden of Disease Study 2019

Ana Lopez-Bago, Ricardo Lascurain, Pavel E. Hernandez-Carreño, Francisco Gallardo-Vera, Jesus Argueta-Donohue, Francisco Jimenez-Trejo, David A. Fuentes-Zavaleta, Saul A. Beltran-Ontiveros, Delia M. Becerril-Camacho, Victor A. Contreras-Rodriguez, Daniel Diaz

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Allergic diseases; Atopic march; Burden of disease; Chronic respiratory diseases; DALYs; Epidemiology; Incidence; Prevalence

Online: 21 June 2023 (08:52:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0249.v1

Adult Presentation of X-Linked Hypophosphatemia

Nobuaki Ito

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: X-linked hypophosphatemia; fibroblast growth factor 23; osteomalacia; enthesopathy; secondary hyperparathyroidism; tertiary hyperparathyroidism; chronic kidney disease; oral disease; quality of life; burosumab

Online: 19 May 2022 (04:03:47 CEST)

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Working Paper ARTICLE

Oleuropein-Rich Leaf Extract as a Broad Inhibitor of Tumour and Macrophage iNOS in Apc Mutant Rat Model

Jessica Ruzzolini, Sofia Chioccioli, Noemi Monaco, Silvia Peppicelli, Elena Andreucci, Silvia Urciuoli, Annalisa Romani, Cristina Luceri, Katia Tortora, Lido Calorini, Giovanna Caderni, Chiara Nediani, Francesca Bianchini

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Oleuropein; colon cancer; activated macrophages; chronic inflammation; inducible nitric oxide synthetase (iNOS); cyclooxygenase-2 (COX-2); nitric oxide (NO)

Online: 2 August 2021 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0186.v1

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Nuria García-Magro, Yasmina B. Martin, Pilar Negredo, Francisco Zafra, Carlos Avendaño

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic pain; allodynia; trigeminocervical complex; glycine transporters

Online: 5 March 2021 (11:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0843.v2

Zanubrutinib: Coming of Age for BTK Inhibitors in the Treatment of Chronic Lymphocytic Leukemia?

Stefano Molica, Constantine Tam, David Allsup, Aaron Polliack

Subject: Medicine And Pharmacology, Hematology Keywords: CLL, Zanubrutinib, BTK inhibitors, efficacy, safety, chronic lymphocytic leukemia

Online: 22 May 2023 (16:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1953.v1

Restoration of Over-Ground Walking via Non-invasive Neuromodulation Therapy

Monzurul Alam, Yan To Ling, Md Akhlasur Rahman, Arnold Yu Lok Wong, Hui Zhong, V. Reggie Edgerton, Yong-Ping Zheng

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic spinal cord injury; sensorimotor rehabilitation; transcutaneous electrical stimulation; neuromodulation; over-ground walking

Online: 28 September 2023 (06:28:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0318.v1

Probiotics Role in Chronic Rhinosinusitis Treatment: an Update of the Current Literature

Maria Rita Bianco, Massimo Ralli, Domenico Michele Modica, Marta Amata, Salvatore Poma, Gianfranco Mattina, Eugenia Allegra

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic rhinosinusitis; probiotics; microbiome; nasal microbiota; microbiome therapy

Online: 21 October 2021 (23:00:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0101.v1

Developing and Validating an Algorithm to Identify Incident Chronic Dialysis Patients Using Administrative Data

Dino Gibertoni, Claudio Voci, Marica Iommi, Benedetta D'Ercole, Marcora Mandreoli, Antonio Santoro, Elena Mancini

Subject: Computer Science And Mathematics, Information Systems Keywords: chronic dialysis; administrative data; hospital discharge records; ambulatory specialty visits; case definition; algorithm

Online: 6 May 2020 (15:26:06 CEST)

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Background: Administrative healthcare databases are widespread and are often standardized with regard to their content and data coding, thus they can be used also as data sources for surveillance and epidemiological research. Chronic dialysis requires patients to frequently access hospital and clinic services, causing a heavy burden to healthcare providers. This also means that these patients are routinely tracked on administrative databases, yet very few case definitions for their identification are currently available. The aim of this study was to develop two algorithms derived from administrative data for identifying incident chronic dialysis patients and test their validity compared to the reference standard of the regional dialysis registry. Methods: The algorithms are based on data retrieved from hospital discharge records (HDR) and ambulatory specialty visits (ASV) to identify incident chronic dialysis patients in an Italian region. Subjects are included if they have at least one event in the HDR or ASV databases based on the ICD9-CM dialysis-related diagnosis or procedure codes in the study period. Exclusion criteria comprise non-residents, prevalent cases, or patients undergoing temporary dialysis, and are evaluated only on ASV data by the first algorithm, on both ASV and HDR data by the second algorithm. We validated the algorithms against the Emilia-Romagna regional dialysis registry by searching for incident patients in 2014. Results: Algorithm 1 identified 680 patients and algorithm 2 identified 676 initiating dialysis in 2014, compared to 625 patients included in the regional dialysis registry. Sensitivity for the two algorithms was respectively 90.8% and 88.4%, positive predictive value 84.0% and 82.0%, and percentage agreement was 77.4% and 74.1%. Conclusions: These results suggest that administrative data have high sensitivity and positive predictive value for the identification of incident chronic dialysis patients. Algorithm 1, which showed the higher accuracy and has a simpler case definition, can be used in place of regional dialysis registries when they are not present or sufficiently developed in a region, or to improve the accuracy and timeliness of existing registries.

Preprint REVIEW | doi:10.20944/preprints202110.0233.v1

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Rodney R. Dietert

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: microbiome; public health; chronic diseases; microimmunosome; eating disorders; subtance use disorder; commensals; pathobionts; sensory receptors; developmental programming

Online: 15 October 2021 (16:57:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0287.v1

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Luis L. Ayusso, Ana Paula Girol, Emmanuel A. Burdmann

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Online: 15 December 2022 (15:48:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0495.v1

Deep Learning Approaches to Automatic Chronic Venous Disease Classification

Marina Barulina, Aschat Sanbaev, Sergey Okunkov, Ivan Ulitin, Ivan Okoneshnikov

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: chronic venous disease; deep leaning; data mining; Resnet50; DeiT; automatic classification; automatic CEAP classification

Online: 29 August 2022 (12:46:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0059.v1

Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Mariaconsiglia Santantonio, Carmela Riso, Simona Gaudino, Alessio Simonetti, Giuseppe Varcasia, Francesco Schimperna, Bruno Sergi, Eugenio De Corso, Marco Rossi, Jacopo Galli, Marco De Spirito, Giuseppe Maulucci, Giulio Cesare Passali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: olfactory rehabilitation; chronic pain; fMRI

Online: 1 March 2024 (18:18:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1753.v1

A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management

Ashish Shetty, Gayathri Delanerolle, Chunli Deng, Heitor Cavalini, Xiaojie Yang, Anish Thillainathan, Yassine Bouchareb, Amy Boyd, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Chronic pain; Medical Devices; Neuromodulation; Clinical trials; Bayesian

Online: 25 May 2023 (07:27:31 CEST)

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Chronic non-cancer pain is a highly debilitating condition affecting approximately 20% of the global population. Chronic pain may lead to significant physical disability, emotional distress, social isolation and financial burden. Whilst^.pharmacological therapies remain the cornerstone of pain management in non-cancerous chronic pain, factors including the current opioid epidemic have led to non-pharmacological techniques becoming a more attractive proposition. We explored the prevalence of medical device use and their treatment efficacy in non-cancer pain management. A systematic methodology was developed, peer reviewed and published in PROSPERO (CRD42021235384). Key words of medical device, pain management devices, chronic pain, lower back pain, back pain, leg pain and chronic pelvic pain using Science direct, PubMed, Web of Science, PROSPERO, MEDLINE, EMBASE, PorQuest and ClinicalTrials.gov. All clinical trials, epidemiology and mixed methods studies that reported the use of medical devices for non-cancer chronic pain management published between the 1^st of January 1990 and the 30^th of April 2022 were included. 13 studies were included in systematic review, of these 6 were used in the meta-analysis with 173 participants. Our meta-analysis for pain reduction in each study showed that transcutaneous electrical nerve stimulation combined with instrument-assisted soft tissue mobilization treatment and pulsed electromagnetic therapy produced significant treatment on chronic lower back pain patients. Pooled evidence revealed the use of medical device related interventions resulted in 0.7 degree of pain reduction under a 0-10 scale. Significant improvement in disability scores, with a 7.44 degree reduction in disability level compared to a placebo using a 50 score range was also seen. The application of medical devices in patients with chronic pain has gained popularity due to increasingly cost effective techniques, minimally invasiveness and greater awareness of risks associated with pharmacological management. Our analysis has shown that the optimal use of medical devices in a sustainable manner requires further extensive research, needing larger cohort studies with greater gender parity, in a more diverse range of geographical locations.

Preprint ARTICLE | doi:10.20944/preprints202302.0207.v1

Mild Chronic Kidney Disease Associated with Low Bone Formation and Decrease in Phosphate Transporters and Signaling Pathways Gene Expression

Evdokia Bogdanova, Airat Sadykov, Galina Ivanova, Irina Zubina, Olga Beresneva, Natalia Semenova, Olga Galkina, Marina Parastaeva, Vladimir Sharoyko, Vladimir Dobronravov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic kidney disease; bone remodeling; static bone histomorphometry; inorganic phosphate transporters; intracellular signaling

Online: 13 February 2023 (08:46:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202002.0342.v1

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

Gilles Lalmanach, Ahlame Saidi, Paul Bigot, Thibault Chazeirat, Fabien Lecaille, Mylène Wartenberg

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cathepsin; chronic obstructive pulmonary disease (COPD); cigarette smoke; cysteine; cysteine protease; emphysema; oxidation; proteolysis; ROS; thiol

Online: 24 February 2020 (02:48:00 CET)

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