Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Version 1 : Received: 15 October 2021 / Approved: 15 October 2021 / Online: 15 October 2021 (16:57:40 CEST)

A peer-reviewed article of this Preprint also exists.

Dietert, R.R. Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering. Biomedicines 2021, 9, 1581. Dietert, R.R. Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering. Biomedicines 2021, 9, 1581.

Journal reference: Biomedicines 2021, 9, 1581
DOI: 10.3390/biomedicines9111581

Abstract

The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to co-morbid NCDs.

Keywords

microbiome; public health; chronic diseases; microimmunosome; eating disorders; subtance use disorder; commensals; pathobionts; sensory receptors; developmental programming

Subject

MEDICINE & PHARMACOLOGY, Pharmacology & Toxicology

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