Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Multinucleated Giant Cell Formation as a Portal to Chronic Bacterial Infections

Version 1 : Received: 18 September 2020 / Approved: 20 September 2020 / Online: 20 September 2020 (14:31:03 CEST)

A peer-reviewed article of this Preprint also exists.

Stockton, J.L.; Torres, A.G. Multinucleated Giant Cell Formation as a Portal to Chronic Bacterial Infections. Microorganisms 2020, 8, 1637. Stockton, J.L.; Torres, A.G. Multinucleated Giant Cell Formation as a Portal to Chronic Bacterial Infections. Microorganisms 2020, 8, 1637.

Journal reference: Microorganisms 2020, 8, 1637
DOI: 10.3390/microorganisms8111637

Abstract

This review provides a snapshot of chronic bacterial infections through the lens of Burkholderia pseudomallei; detailing its ability to establish multi-nucleated giant cells (MNGC) within the host, leading to the formation of pyogranulomatous lesions. We explore the role of MNGC in melioidosis disease progression and pathology by comparing the similarities and differences of melioidosis to tuberculosis, outlining the concerted events in pathogenesis that lead to MNGC formation, discussing the factors that influence MNGC formation and how they fit into clinical findings reported in chronic cases. Finally, we speculate about future models and techniques that can be used to delineate the mechanisms of MNGC formation and function.

Subject Areas

Burkholderia pseudomallei; Mycobacterium tuberculosis; Multi nucleated giant cell; persistence; chronic infection

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