Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Version 1 : Received: 13 December 2022 / Approved: 15 December 2022 / Online: 15 December 2022 (15:48:03 CET)

How to cite: Ayusso, L.L.; Girol, A.P.; Burdmann, E.A. Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases. Preprints 2022, 2022120287. https://doi.org/10.20944/preprints202212.0287.v1 Ayusso, L.L.; Girol, A.P.; Burdmann, E.A. Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases. Preprints 2022, 2022120287. https://doi.org/10.20944/preprints202212.0287.v1

Abstract

Kidney diseases are a global health problem, and their frequency is continuously increasing. Available treatments provide limited kidney protection. The protective effect of the green tea polyphenol epigallocatechin-3-gallate (EGCG) in several diseases have been extensively investigated. Experimental and clinical studies have shown that the antioxidant, anti-inflammatory, and anti-apoptotic properties of EGCG are promising for the treatment and/or prevention of kidney diseases. This review analyzes the available evidence on the effects, and the likely protective mechanisms of action, of EGCG in a broad spectrum of kidney diseases, including acute kidney injury, drug-induced nephrotoxicity, kidney stone disease, diabetic nephropathy, chronic kidney disease, and kidney fibrosis.

Keywords

green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Subject

Medicine and Pharmacology, Urology and Nephrology

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