Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli; Sandra Atlante; Tiziana Bacchetti; Fabio Martelli; Antonella Farsetti; Carlo Gaetano

doi:10.20944/preprints201911.0190.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 14 November 2019 / Approved: 16 November 2019 / Online: 16 November 2019 (00:59:04 CET)

RNA epigenetics is perhaps the most recent aspect of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combination whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes into RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.

epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

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Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

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