Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Version 1 : Received: 14 November 2019 / Approved: 16 November 2019 / Online: 16 November 2019 (00:59:04 CET)

A peer-reviewed article of this Preprint also exists.

Mongelli, A.; Atlante, S.; Bachetti, T.; Martelli, F.; Farsetti, A.; Gaetano, C. Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases. Int. J. Mol. Sci. 2020, 21, 509. Mongelli, A.; Atlante, S.; Bachetti, T.; Martelli, F.; Farsetti, A.; Gaetano, C. Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases. Int. J. Mol. Sci. 2020, 21, 509.

Journal reference: Int. J. Mol. Sci. 2020, 21, 509
DOI: 10.3390/ijms21020509

Abstract

RNA epigenetics is perhaps the most recent aspect of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combination whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes into RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.

Subject Areas

epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

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