Version 1
: Received: 9 September 2020 / Approved: 12 September 2020 / Online: 12 September 2020 (04:14:19 CEST)
Version 2
: Received: 14 September 2020 / Approved: 15 September 2020 / Online: 15 September 2020 (09:01:16 CEST)
How to cite:
Falaguera-Vera, F.J.; Garcia-Escudero, M.; Bonastre-Férez, J.; Zacarés, M.; Oltra, E. Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia. Preprints2020, 2020090264
Falaguera-Vera, F.J.; Garcia-Escudero, M.; Bonastre-Férez, J.; Zacarés, M.; Oltra, E. Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia. Preprints 2020, 2020090264
Falaguera-Vera, F.J.; Garcia-Escudero, M.; Bonastre-Férez, J.; Zacarés, M.; Oltra, E. Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia. Preprints2020, 2020090264
APA Style
Falaguera-Vera, F.J., Garcia-Escudero, M., Bonastre-Férez, J., Zacarés, M., & Oltra, E. (2020). Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia. Preprints. https://doi.org/
Chicago/Turabian Style
Falaguera-Vera, F.J., Mario Zacarés and Elisa Oltra. 2020 "Pressure Point Threshold Scores and ME/CFS Comorbidity as Indicators of Patient´s Response to Manual Physiotherapy in Fibromyalgia" Preprints. https://doi.org/
Abstract
Current pharmacological treatments of Fibromyalgia (FM) are merely symptom palliative, as clinical trials have so far failed to provide overall benefits without associated harms. Polypharmacy often leads to patient´s health deterioration and chronic drug use to an eventual lack of patient´s response. Emerging evidence support that physiotherapy treatments based on mechanical triggers improve FM symptoms and therefore could be used for therapeutic purposes by themselves, or in combination with current pharmacological treatments, as part of integrative medicine programs. However, a paucity of studies rigorously and systematically evaluating this possibility exists. This study uses scores from validated standardized questionnaires, algometer pressure point threshold (PPT) readings and responses from a custom self-developed questionnaire to determine the impact of a pressure-controlled manual protocol on FM hyperalgesia/allodynia, fatigue and patient´s quality of life. The results show that patient´s baseline sensitivity to pain inversely correlates with treatment response in FM. Moreover, patients presenting comorbid ME/CFS do not seem to respond to the applied therapy as those presenting FM only. Thus, pre-treatment PPTs and ME/CFS comorbidity may serve as indicators to predict patient´s response to physiotherapy programs based on mechanical triggers, as the one evaluated here. These unexpected findings grant further explorations including the study of gene expression profiles associating to patient´s treatment response in the blood collection of samples generated by this study.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Elisa Oltra
Commenter's Conflict of Interests: Author