Version 1
: Received: 19 May 2023 / Approved: 25 May 2023 / Online: 25 May 2023 (07:27:31 CEST)
How to cite:
Shetty, A.; Delanerolle, G.; Deng, C.; Cavalini, H.; Yang, X.; Thillainathan, A.; Bouchareb, Y.; Boyd, A.; Phiri, P.; Shi, J. A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management. Preprints2023, 2023051753. https://doi.org/10.20944/preprints202305.1753.v1
Shetty, A.; Delanerolle, G.; Deng, C.; Cavalini, H.; Yang, X.; Thillainathan, A.; Bouchareb, Y.; Boyd, A.; Phiri, P.; Shi, J. A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management. Preprints 2023, 2023051753. https://doi.org/10.20944/preprints202305.1753.v1
Shetty, A.; Delanerolle, G.; Deng, C.; Cavalini, H.; Yang, X.; Thillainathan, A.; Bouchareb, Y.; Boyd, A.; Phiri, P.; Shi, J. A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management. Preprints2023, 2023051753. https://doi.org/10.20944/preprints202305.1753.v1
APA Style
Shetty, A., Delanerolle, G., Deng, C., Cavalini, H., Yang, X., Thillainathan, A., Bouchareb, Y., Boyd, A., Phiri, P., & Shi, J. (2023). A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management. Preprints. https://doi.org/10.20944/preprints202305.1753.v1
Chicago/Turabian Style
Shetty, A., Peter Phiri and Jian Shi. 2023 "A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management" Preprints. https://doi.org/10.20944/preprints202305.1753.v1
Abstract
Chronic non-cancer pain is a highly debilitating condition affecting approximately 20% of the global population. Chronic pain may lead to significant physical disability, emotional distress, social isolation and financial burden. Whilst. pharmacological therapies remain the cornerstone of pain management in non-cancerous chronic pain, factors including the current opioid epidemic have led to non-pharmacological techniques becoming a more attractive proposition. We explored the prevalence of medical device use and their treatment efficacy in non-cancer pain management. A systematic methodology was developed, peer reviewed and published in PROSPERO (CRD42021235384). Key words of medical device, pain management devices, chronic pain, lower back pain, back pain, leg pain and chronic pelvic pain using Science direct, PubMed, Web of Science, PROSPERO, MEDLINE, EMBASE, PorQuest and ClinicalTrials.gov. All clinical trials, epidemiology and mixed methods studies that reported the use of medical devices for non-cancer chronic pain management published between the 1st of January 1990 and the 30th of April 2022 were included. 13 studies were included in systematic review, of these 6 were used in the meta-analysis with 173 participants. Our meta-analysis for pain reduction in each study showed that transcutaneous electrical nerve stimulation combined with instrument-assisted soft tissue mobilization treatment and pulsed electromagnetic therapy produced significant treatment on chronic lower back pain patients. Pooled evidence revealed the use of medical device related interventions resulted in 0.7 degree of pain reduction under a 0-10 scale. Significant improvement in disability scores, with a 7.44 degree reduction in disability level compared to a placebo using a 50 score range was also seen. The application of medical devices in patients with chronic pain has gained popularity due to increasingly cost effective techniques, minimally invasiveness and greater awareness of risks associated with pharmacological management. Our analysis has shown that the optimal use of medical devices in a sustainable manner requires further extensive research, needing larger cohort studies with greater gender parity, in a more diverse range of geographical locations.
Keywords
Chronic pain; Medical Devices; Neuromodulation; Clinical trials; Bayesian
Subject
Medicine and Pharmacology, Internal Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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