Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

Version 1 : Received: 15 August 2022 / Approved: 16 August 2022 / Online: 16 August 2022 (14:17:53 CEST)

How to cite: Hoang, T.T.N.; Bui, T.T.H.; Pham, T.T.; Luong, T.L.A.; Doan, T.K.P.; Hoang, T.L.; Ho, C.T.; Koerber, N.; Ho, K.L.; Nguyen, D.H.; Bauer, T.; Protzer, U.; Nguyen, T.D. Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method. Preprints 2022, 2022080292 (doi: 10.20944/preprints202208.0292.v1). Hoang, T.T.N.; Bui, T.T.H.; Pham, T.T.; Luong, T.L.A.; Doan, T.K.P.; Hoang, T.L.; Ho, C.T.; Koerber, N.; Ho, K.L.; Nguyen, D.H.; Bauer, T.; Protzer, U.; Nguyen, T.D. Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method. Preprints 2022, 2022080292 (doi: 10.20944/preprints202208.0292.v1).

Abstract

BACKGROUND&AIMS: Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We compared the correlation between the subclinical index and PBMCs concentration in two groups of pregnant women (HBsAg positive), which are different in HBV DNA concentration in Vietnam. METHODS: The Hierarchical cluster analysis (HCA) was run with 20 different clustering methods on data collected from 80 Vietnamese pregnant women and their babies (60/80 cord blood). RESULTS: In the high viral load group (HBV DNA ≥ 5x10^7 copies/ml), a strong correlation between CBMCs with serum maternal Haemoglobin concentration and maternal platelet and maternal ALT. Their R values are: -0.88, 0.82, and 0.84 with p=8.97E-03, 2.41E-02 and 1.75E-01, respectively. CONCLUSIONS: We found a significant correlation shift of subclinical index between the two groups, which may be important in diagnosing pregnant women with chronic hepatitis B virus infection.

Keywords

Chronic Hepatitis B Virus Infection; Liver; Pregnant Women; Cord blood; PBMCs (Peripheral Blood Mononuclear Cells); subclinical index

Subject

MEDICINE & PHARMACOLOGY, General Medical Research

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