Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

Tram Thi Ngoc Hoang; Thi Thu Huong Bui; Thi Thuy Pham; Thi Lan Anh Luong; Thi Kim Phuong Doan; Thu Lan Hoang; Cam Tu Ho; Nina Koerber; Khanh Lam Ho; Duc Hinh Nguyen; Tanja Bauer; Ulrike Protzer; Tien Dung Nguyen

doi:10.20944/preprints202208.0292.v1

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preprints.org > medicine and pharmacology > gastroenterology and hepatology > doi: 10.20944/preprints202208.0292.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

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Version 1 : Received: 15 August 2022 / Approved: 16 August 2022 / Online: 16 August 2022 (14:17:53 CEST)

How to cite: Hoang, T.T.N.; Bui, T.T.H.; Pham, T.T.; Luong, T.L.A.; Doan, T.K.P.; Hoang, T.L.; Ho, C.T.; Koerber, N.; Ho, K.L.; Nguyen, D.H.; Bauer, T.; Protzer, U.; Nguyen, T.D. Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method. Preprints 2022, 2022080292. https://doi.org/10.20944/preprints202208.0292.v1 Hoang, T.T.N.; Bui, T.T.H.; Pham, T.T.; Luong, T.L.A.; Doan, T.K.P.; Hoang, T.L.; Ho, C.T.; Koerber, N.; Ho, K.L.; Nguyen, D.H.; Bauer, T.; Protzer, U.; Nguyen, T.D. Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method. Preprints 2022, 2022080292. https://doi.org/10.20944/preprints202208.0292.v1

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MDPI and ACS Style

Hoang, T.T.N.; Bui, T.T.H.; Pham, T.T.; Luong, T.L.A.; Doan, T.K.P.; Hoang, T.L.; Ho, C.T.; Koerber, N.; Ho, K.L.; Nguyen, D.H.; Bauer, T.; Protzer, U.; Nguyen, T.D. Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method. Preprints 2022, 2022080292. https://doi.org/10.20944/preprints202208.0292.v1

APA Style

Hoang, T.T.N., Bui, T.T.H., Pham, T.T., Luong, T.L.A., Doan, T.K.P., Hoang, T.L., Ho, C.T., Koerber, N., Ho, K.L., Nguyen, D.H., Bauer, T., Protzer, U., & Nguyen, T.D. (2022). Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method. Preprints. https://doi.org/10.20944/preprints202208.0292.v1

Chicago/Turabian Style

Hoang, T.T.N., Ulrike Protzer and Tien Dung Nguyen. 2022 "Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method" Preprints. https://doi.org/10.20944/preprints202208.0292.v1

Abstract

BACKGROUND&AIMS: Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We compared the correlation between the subclinical index and PBMCs concentration in two groups of pregnant women (HBsAg positive), which are different in HBV DNA concentration in Vietnam. METHODS: The Hierarchical cluster analysis (HCA) was run with 20 different clustering methods on data collected from 80 Vietnamese pregnant women and their babies (60/80 cord blood). RESULTS: In the high viral load group (HBV DNA ≥ 5x10^7 copies/ml), a strong correlation between CBMCs with serum maternal Haemoglobin concentration and maternal platelet and maternal ALT. Their R values are: -0.88, 0.82, and 0.84 with p=8.97E-03, 2.41E-02 and 1.75E-01, respectively. CONCLUSIONS: We found a significant correlation shift of subclinical index between the two groups, which may be important in diagnosing pregnant women with chronic hepatitis B virus infection.

Keywords

Chronic Hepatitis B Virus Infection; Liver; Pregnant Women; Cord blood; PBMCs (Peripheral Blood Mononuclear Cells); subclinical index

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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