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Preprint ESSAY | doi:10.20944/preprints202401.1453.v3

Valenti Rull

Subject: Biology And Life Sciences, Other Keywords: h-index; c-score; individual evaluation; citation scores; first authorship; multiauthorship; scientific misconduct

Online: 24 January 2024 (07:32:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0448.v1

C-reactive Protein as a Diagnostic and Prognostic Factor of Endometrial Cancer

Maciej W. Socha, Bartosz Malinowski, Mateusz Wartęga, Oskar Puk, Bartłomiej Wolski, Michał Wiciński

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: C-reactive protein; hs-CRP; albumins; Glasgow Prognostic Score; Endometrial Cancer; CRP to albumin ratio; CRP; Cancer; Inflammation

Online: 19 July 2020 (21:13:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2052.v1

Geomicrobiological Control on Arsenic Heterogeneity – The Taciturn Factor Controlled by Rural Sanitation System

Pinaki Ghosh, Debjani Mandal, Mina Aghababaei, Jishnu Adhikari, Indranil Saha, Jayanta Kumar Biswas, Debashis Chatterjee, Abhishek Basu, Santanu Majumder

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Groundwater; Surface water; Arsenic; Sanitary risk score; Fecal coliform score

Online: 28 June 2023 (15:54:39 CEST)

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Arsenic (As) contamination of groundwater is a common problem in BDP. The alkaline pH of the groundwater provides favourable condition for geomicrobiochemical processes, where organic matter also plays an important role in mobilization of As. The total arsenic content (AsT) of the groundwater is in the range of 69-178 µgL-1 with mean value of 118.58 µgL-1. The groundwater quality of monitored drinking water wells are related to local land–use pattern and rural sanitation installation and practices (which can have a strong influence on microbial contamination). The study indicates that As heterogeneity, probably a consequence of microbial heterogeneity is a feature of the study area. The excessive total and fecal coliform (TC and FC) count of the ponds possibly suggest uncontrolled surface run offs and sewage leakage, notably from nearby pit-latrine, which increased the microbial contamination in these water sources. The tube wells located in close proximity (~ 2-3 m) of the surveyed ponds are also contaminated with high TC and FC values, due to faulty water supply system, pond water infiltration and cracked tube well platforms. Coliforms may influence geomicrobiological processes in groundwater and thereby, contribute in As release and mobilization. The TC and FC values of monitored tube wells and ponds show seasonal variation, with high TC and FC values during wet season. Attempt has been made to focus on sanitation risk of the monitored wells (based on sanitation and fecal coliform scores) which is usually less explored. The sanitary risk score reveal the need of immediate attention to all the sites, as 25.0 %, 58.3 %, 11.1 % and 5 % of tube wells of the six sites fell under very high risk (sanitary risk score ≥ 9), high risk (sanitary risk score 6-8), intermediate risk (sanitary risk score 3-5) and low risk category (sanitary risk score 0-2), respectively. Fecal coliform score classified all the sites under intermediate risk category (FC count 10-100 per 100 ml of water). The predominance of As heterogeneity particularly in areas under high risk category (showing high TC and FC contamination) is observed along with the similar sinusoidal pattern of TC, FC and AsT content. Finally, this study shed light on the factors responsible for unsafe nature of monitored tube wells and the influence of anthropogenic activities on the microenvironment of the groundwater, which could be a probable reason behind the As heterogeneity in the groundwater of the study area.

Preprint ARTICLE | doi:10.20944/preprints202210.0002.v1

Therapeutic Approach of Anticoagulants and Acute Blood Purification for Patients with Sepsis-Induced Disseminated Intravascular Coagulation: Post-marketing Surveillance Data of Antithrombin Supplementation

Yutaka Eguchi, Hiroyuki Nagafuchi, Toshiaki Ikeda

Subject: Medicine And Pharmacology, Hematology Keywords: antithrombin; recombinant thrombomodulin; SOFA score; JAAM DIC score; PMX-DHP

Online: 1 October 2022 (07:09:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0456.v1

Systemic Inflammatory Response and the Noble and Underwood (Nun) Score as Early Predictors of Anastomotic Leakage after Esophageal Reconstructive Surgery

Elke Van Daele, Hanne Vanommeslaeghe, Flo Decostere, Louise Beckers Perletti, Esther Beel, Yves Van Nieuwenhove, Wim Ceelen, Piet Pattyn

Subject: Medicine And Pharmacology, Surgery Keywords: NUn score; esophagectomy; anastomotic leakage; risk score; esophageal cancer; inflammatory biomarkers

Online: 5 January 2024 (10:38:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0209.v1

Characterization of Microbiota in Bronchiectasis Patients with Different Disease Severities

Sang Hoon Lee, YeonJoo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Choon-Taek Lee, Jae Ho Lee

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: bronchiectasis; FACED score; microbiome

Online: 10 October 2018 (08:14:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1409.v1

C-S and Strongly C-S Orthogonal Matrices

Xiaoji Liu, Ying Liu, Hongwei Jin

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: C-S inverse; C-S orthogonality; Strongly C-S orthogonality; C-S additivity; C-S partial order

Online: 19 December 2023 (10:46:12 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202209.0409.v1

Comparison of 0.12% Chlorhexidine and a New Bone Bioactive Liquid, BBL, Mouthrinses on Oral Wound Healing: A Randomized, Double Blind Clinical Human Trial

Eduard Ferrés-Amat, Ashraf Al Madhoun, Elvira Ferrés-Amat, Neus Carreo, Miguel Barrajas, Areej Said Al-Madhoun, Eduard Ferrés-Padró, Carles Marti, Maher Atari

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chlorhexidine; bioactive liquid; oral wound healing; pain index score; early wound healing score

Online: 27 September 2022 (03:37:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0351.v1

Smoking Topography among Korean Smokers: Intensive Smoking Behavior with Larger Puff Volume and Shorter Interpuff Interval

Sungroul Kim, Sol Yu

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: topography; cotinine; fagerstrom score; addiction

Online: 27 April 2018 (06:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1318.v1

Naples Prognostic Score Is a Useful Tool to Assess the Surgical Treatment in Non-small Cell Lung Cancer

Stefano Elia, Alexandro Patirelis, Georgia F. Hardavella, Antonella Santone, Federica Carlea, Eugenio Pompeo

Subject: Medicine And Pharmacology, Surgery Keywords: Non-small cell lung cancer; prognosis; Naples Prognostic Score; thoracic surgery; survival; prognostic score.

Online: 22 November 2023 (07:45:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0320.v1

Performance Analysis of Segmentation and Classification of CT scanned Ovarian Tumours using UNet and Deep Convolutional Neural Networks

Ashwini Kodipalli, Vaishnavi Gururaj, Shriya VR, Steven L Fernandes, Santosh Dasar

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Ovarian Tumours; UNet; Convolutional Neural Networks; VGG 16; DenseNet; ResNet; Dice score; Jaccard score

Online: 13 April 2023 (10:50:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0120.v1

The World of Cyclic Dinucleotides in Bacterial Behavior

Aline Dias da Purificação, Nathalia Marins de Azevedo, Gabriel Guarany de Araujo, Robson Francisco de Souza, Cristiane Rodrigues Guzzo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GGDEF; SMODS; DAC; c-di-GMP; c-GAMP; c-di-AMP

Online: 12 January 2020 (14:37:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1832.v1

Development and Validation of a Machine Learning Model for Predicting Endoscopic Intervention in Upper Gastrointestinal Bleeding

Omran A. Abu-Dhaim, Abdel-Latif Mughrabi Sabbagh, Yaman B. Ahmed, Daoud O. Al Aruri, Owais Ghammaz, Yaser M. Rayyan, Omar Alqudah, Mu'taz M Massad, Karam I. Khraim, Mustafa Q. Khasawneh, Laith F. Alquran, Batool N. AlQadri, Qasim N. Mhaidat, Hamza Alhawamleh, Own M. Al-Ajlouni, Khalil I. Hamarneh, Mohammad A. Hussein, Lina N. Mustafa, Basel E. Al-Bkoor, Amro Alkhatib, Layla Abu Joudeh, Osama Alghafri, Niazy Abu Farsakh

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: upper gastrointestinal bleeding; machine learning; endoscopic intervention; gradient boosting classifier; Glasgow Blatchford Score; Rockall Score

Online: 29 March 2024 (11:53:25 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202203.0203.v1

Estimation of Vitamin C Intake Requirements Based on Body Weight

Anitra C. Carr, Gladys Block, Jens Lykkesfeldt

Subject: Biology And Life Sciences, Food Science And Technology Keywords: vitamin C; ascorbate; obesity; body weight; vitamin C intake; plasma ascorbate concentrations; vitamin C requirements; dietary vitamin C

Online: 15 March 2022 (10:45:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1533.v1

Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience

Masaya Ito, Chiyoko Makita, Takayuki Mori, Hirota Takano, Tomoyasu Kumano, Masayuki Matsuo, Koji Iinuma, Makoto Kawase, Keita Nakane, Masahiro Nakano, Tomoyasu Kumano

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; brachytherapy; lower urinary tract symptom; international prostate symptom score (IPSS); overactive bladder symptom score (OABSS)

Online: 22 May 2023 (16:28:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0475.v2

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Tatiane Lobato Da Silva, Apio Ricardo Nazareth Dias, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis C virus; Genetic; Chronic Hepatitis C; Liver; Elastography

Online: 22 May 2023 (13:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0313.v1

Catalysis of Henry Reaction by Plasmid DNA

Xiangjun Di, Xiaowen Zhang, Yingwu Wang, Yan Wang, Chunguang Lai, Xiaoqiang Wu, Ping Liu, Shuang Liu, Renjun Gao

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: ssDNA; plasmid; pcDNA3.1; Henry Reaction; C-C bond formation

Online: 13 November 2018 (11:26:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0821.v1

Prediction of Difficult Airway Using Arne Score and Flexible Laryngoscopy in Patients with Laryngeal Pathology

Danica Zlatimir Markovic, Maja Šurbatović, Dušan Milisavljević, Vesna Marjanović, Biljana D. Stošić, Milan Stankovic

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Laryngoscopy; Airway Assessment; Intubation; difficult; Risk Score

Online: 14 March 2024 (09:32:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0495.v1

Movement Analysis to Predict Broiler Walking Ability

Danilo Florentino Pereira, Irenilza de Alencar Nääs, Nilsa Duarte da Silva Lima

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: computing image analysis; gait score; unrest index

Online: 19 April 2021 (14:17:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0164.v1

Decentralization and Transboundary Pollution: Evidence from the Change of Water Pollution Levels in China

Yongliang Yang, Manhong Shen

Subject: Business, Economics And Management, Economics Keywords: Boundary effect; Transboundary pollution; Propensity Score Matching

Online: 20 March 2017 (17:33:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0262.v1

Ligandless Palladium-catalyzed Direct C-5 arylation of azoles Promoted by Benzoic Acid in Anisole

Elisabetta Rosadoni, Federico Banchini, Sara Bellini, Marco Lessi, Luca Pasquinelli, Fabio Bellina

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: azoles; direct arylation; C–C coupling; palladium; aromatic solvents; regioselectivity

Online: 15 November 2022 (01:11:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0423.v1

Detection of c.375A>G, c.385A>T, c.571C>T, and Sedel2 of FUT2 by Real-time PCR in a Single Tube

Mikiko Soejima, Yoshiro Koda

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Alu-mediated nonhomologous recombination; FUT2; sedel2; c.375A>G; c.385A>T; c.571C>T; Polynesian population

Online: 17 April 2023 (07:43:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0145.v1

Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations

Anitra C. Carr, Jens Lykkesfeldt

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: vitamin C; ascorbic acid; vitamin C requirements; vitamin C recommendations; body weight; obesity; smoking; aging; socioeconomic status; NHANES

Online: 8 March 2023 (03:47:32 CET)

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Vitamin C status is known to be associated with several demographic and lifestyle factors. These include gender, age, ethnicity, pregnancy/lactation, body weight, smoking status and dietary habits. In the present study, our aim was to interrogate the National Health and Nutrition Examination Survey (NHANES) 2017-2018 datasets to assess the impact of these factors on vitamin C dose-concentration relationships to establish if there are higher requirements for vitamin C in certain subpopulations and the possible extent of these additional requirements. The relevant data were extracted from the NHANES 2017-2018 datasets, the final cohort of which comprised 2828 non-supplementing adult males and females (aged 18 – 80+ years) with both vitamin C serum concentrations and dietary intake data available. The data was subsequently stratified by gender, age tertiles (≤36, 37-58, ≥59 years), ethnicity (non-Hispanic white, non-Hispanic black, and total Hispanic), socioeconomic tertiles (poverty income ratios: >3.0, 1.36 – 3.0, ≤1.35), weight tertiles (≤72, 72-91, ≥91 kg), BMI tertiles (≤26, 26-32, ≥32 kg/m2) and smoking status. Sigmoidal (four parameter logistic) curves with asymmetrical 95% confidence intervals were fitted to the dose-concentration data. We found that males required vitamin C intakes ~1.2-fold higher than females to reach ‘adequate’ serum concentrations of 50 µmol/L. Males had both higher body weight and a higher prevalence of smoking than females. Smokers required vitamin C intakes ~2.0-fold higher than non-smokers to reach adequate vitamin C concentrations. Relative to adults in the lighter weight tertile, adults in the heaver weight tertile required ~2.0-fold higher dietary intakes of vitamin C to reach adequate serum concentrations. We did not observe any impact of ethnicity or socioeconomic status on the vitamin C dose-concentration relationship, and although no significant difference between younger and older adults was observed at vitamin C intakes > 75 mg/day, at intakes < 75 mg/day, older adults had an attenuated serum response to vitamin C intake. In conclusion, certain demographic and lifestyle factors, specifically gender, smoking and body weight, have a significant impact on vitamin C requirements. Overall, the data indicate that the general population must consume ~110 mg/day of vitamin C to attain adequate serum concentrations, smokers require ~165 mg/day relative to non-smokers, and heavier people (100+ kg) require ~155 mg/day to reach the same vitamin C concentrations. These findings have important implications for global vitamin C dietary recommendations.

Preprint ARTICLE | doi:10.20944/preprints202004.0243.v1

Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevated Oxidative Stress

Anitra C. Carr, Emma Spencer, Liane Dixon, Steve Chambers

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: vitamin C; ascorbic acid; ascorbate; pneumonia; community acquired pneumonia; oxidative stress; protein carbonyls; hypovitaminosis C; vitamin C deficiency

Online: 15 April 2020 (10:12:26 CEST)

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Pneumonia is a severe lower respiratory tract infection that is a common complication and a major cause of mortality of the vitamin C-deficiency disease scurvy. This suggests an important link between vitamin C status and lower respiratory tract infections. Due to the paucity of information on the vitamin C status of patients with pneumonia, we assessed the vitamin C status of 50 patients with community-acquired pneumonia and compared these with 50 healthy community controls. The pneumonia cohort comprised 44 patients recruited through the Acute Medical Assessment Unit (AMAU) and 6 patients recruited through the intensive care unit (ICU); mean age 68 ± 17 years, 54% male. Clinical, microbiological and haematological parameters were recorded. Blood samples were tested for vitamin C status using HPLC with electrochemical detection and protein carbonyl concentrations, a marker of oxidative stress, using ELISA. Patients with pneumonia had depleted vitamin C status compared with healthy controls (23 ± 14 µmol/L vs 56 ± 24 µmol/L, P <0.001). The more severe patients in the ICU had significantly lower vitamin C status than those recruited through AMAU (11 ± 3 µmol/L vs 24 ± 14 µmol/L, P = 0.02). The total pneumonia cohort comprised 62% with hypovitaminosis C and 22% with deficiency, compared with only 8% hypovitaminosis C and no cases of deficiency in the healthy controls. The pneumonia cohort also exhibited significantly elevated protein carbonyl concentrations compared with the healthy controls (P < 0.001), indicating enhanced oxidative stress in the patients. We were able to collect subsequent samples form 28% of the cohort (mean 2.7 ± 1.7 days; range 1-7 days). These showed no significant differences in vitamin C status or protein carbonyl concentrations compared with baseline values (P = 0.6). Overall, the depleted vitamin C status and elevated oxidative stress observed in the patients with pneumonia indicates an enhanced requirement for the vitamin during their illness. Due to the important roles that vitamin C plays in the immune system, low vitamin C status is possibly both a cause and a consequence of the disease. Therefore, these patients would likely benefit from additional vitamin C supplementation to restore their blood and tissue levels to optimal. This may decrease oxidative stress and aid in their recovery.

Preprint ARTICLE | doi:10.20944/preprints202404.0892.v1

Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors

Lara M. Ruiz Belmonte, Patricia Carrera-Lasfuentes, Alberto Cebollada-Solanas, Carmelo Scarpignato, Angel Lanas, Carla J. Gargallo-Puyuelo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: colorectal neoplasia; cardiovascular risk; risk factors; predictive score

Online: 15 April 2024 (08:56:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1599.v1

Şengül Demiral, Meltem Nazıroğlu, Nurper Özbar, Cüneyt Taşkın

Subject: Social Sciences, Other Keywords: score analysis; competitive performance; performance analysis; covid-19

Online: 28 February 2024 (07:59:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1394.v1

Distributed Subgraph Query Processing Using Filtering Scores on Spark

Kyoungsoo Bok, Minyoung Kim, Hyeonbyeong Lee, Dojin Choi, Jongtae Lim, Jaesoo Yoo

Subject: Computer Science And Mathematics, Computer Science Keywords: subgraph query; search order; distributed graph; filtering score

Online: 20 July 2023 (08:17:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0539.v1

Communication Networks used by Smallholder Livestock Farmers in Disease Outbreaks: Case Study of the Free State, South Africa

Christopher Nwafor, Ifeoma Nwafor

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Correlation; Disease; Extension; Information-Score; Livestock; Perceived-Usefulness

Online: 25 August 2020 (05:01:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0431.v2

Prediction of Postoperative Outcomes Following Hip Fracture Surgery: Independent Validation and Recalibration of the Nottingham Hip Fracture Score

William J. Doherty, Thomas A. Stubbs, Andrew Chaplin, Mike R. Reed, Avan A. Sayer, Miles D. Witham, Antony K. Sorial

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Hip fracture; Casemix; Validation; Discrimination; Risk score; Calibration

Online: 9 July 2020 (17:23:04 CEST)

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Objectives Independent validation of risk scores after hip fracture is uncommon, particularly for evaluation of outcomes other than death. We aimed to assess the Nottingham Hip Fracture Score (NHFS) for prediction of mortality, physical function, length of stay and postoperative complications. Design Analysis of routinely collected prospective data partly collected by follow-up interviews. Setting and Participants Consecutive hip fracture patients were identified from the Northumbria hip fracture database between 2014-2018. Patients were excluded if they were not surgically managed or if scores for predictive variables were missing. Methods C-statistics were calculated to test the discriminant ability of the NHFS, Abbreviated Mental Test Score (AMTS), and ASA grade for in-hospital, 30- and 120-day mortality, functional independence at discharge, 30-days and 120-days, length of stay, and postoperative complications. Results We analysed data from 3208 individuals, mean age 82.6 (SD 8.6). 2192 (70.9%) were female. 194 (6.3%) died during the first 30-days, 1686 (54.5%) were discharged to their own home, 211 (6.8%) had no mobility at 120-days, 141 (4.6%) experienced a postoperative complication. The median length of stay was 18 days (IQR 8-28). For mortality, c-statistics for the NHFS ranged from 0.68-0.69, similar to ASA and AMTS. For postoperative mobility, the c-statistics for the NHFS ranged from 0.74-0.83, similar to AMTS (0.61-0.82) and better than the ASA grade (0.68-0.71). Length of stay was significantly correlated with each score (p<0.001 by Jonckheere-Terpstra test); NHFS and AMTS showed inverted U-shaped relationships with length of stay. For postoperative complications, c-statistics for NHFS (0.54-0.59) were similar to ASA grade (0.53-0.61) and AMTS (0.50-0.58). Conclusions and Implications The NHFS performed consistently well in predicting functional outcomes, moderately in predicting mortality, but less well in predicting length of stay and complications. There remains room for improvement by adding further predictors such as measures of physical performance in future analyses.

Preprint ARTICLE | doi:10.20944/preprints201810.0171.v3

Clinical Relevance of Genome-Wide Polygenic Score may Be Less than Claimed

David Curtis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genome-wide polygenic score; coronary artery disease; AUC

Online: 6 December 2018 (07:06:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0398.v1

Trajectory of Type 2 Diabetes in Sepsis Outcome: Impacts of Diabetic Complication Burdens, Initial Glucose Level, and HbA1c: Population-Based Cohort Study Combining with Nationwide and Hospital-Based Database

Ming-Shun Hsieh, Sung-Yuan Hu, Chorng-Kuang How, Yi-Tzu Lee, Chen-June Seak, Vivian Chia-Rong Hsieh, Jen-Huai Chiang, Chiann-Yi Hsu, Sheng-Hsiang Ma, Pau-Chung Chen

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes mellitus; sepsis; diabetes complication severity index score

Online: 22 July 2018 (10:54:29 CEST)

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Background Diabetic patients have an increased risk of infections; however, the association between type 2 diabetes and hospital outcomes of sepsis remains controversial when the diabetes severity is not considered. We examined this association using nationwide and hospital-based databases concomitantly. Methods The first part of this study was conducted using 2 nationwide databases: the Longitudinal Cohort of Diabetes Patients and the Longitudinal Health Insurance Database 2000. The diabetic complication burden was evaluated using the adapted Diabetes Complications Severity Index score (aDCSI score). In the second part, we used the hospital-based database with laboratory data, such as initial blood glucose and HbA1c levels, to make comparisons between surviving and dead patients with type 2 diabetes and sepsis. Results The nationwide study included 19,719 type 2 diabetic sepsis patients and an equal number of non-diabetic patients. The diabetic sepsis patients had an increased odds ratio (OR) of 1.14 (95% CI 1.1-1.19) for hospital mortality. The OR for mortality increased as the complication burden increased (diabetic sepsis patients with aDCSI scores of 0, 1, 2, 3, 4, and ≥5 had ORs of 0.91, 0.87, 1.14, 1.25, 1.56, and 1.77 for mortality, respectively (all P<0.001 and P for trend <0.001)). A total of 1,054 diabetic sepsis patients were included from the hospital-based database. Initial blood glucose levels in the surviving and dead diabetic sepsis patients did not differ significantly: 273.9 ± 180.3 versus 266.1 ± 200.2 (mg/dL) (P=0.095). Moreover, the surviving diabetic sepsis patients did not have a lower HbA1c (%): 8.4 ± 2.6 versus 8.0 ± 2.5 (P=0.078). Conclusions In the case of type 2 diabetic sepsis patients, the diabetes-related complication burden is the major determinant of hospital mortality rather than the diabetes itself. Contrary to popular belief, initial blood glucose and HbA1c levels may not be as important as previously thought.

Preprint ARTICLE | doi:10.20944/preprints202402.1714.v1

Candida tropicalis critically affects Candida albicans virulence by limiting its capacity to adhere to the host intestinal surface leading to decreased susceptibility to colitis in mice

Kyle Roberts, Abdullah Osme, Carlo De Salvo, Eleonora Zoli, Janet Herrada, Thomas McCormick, Mahmoud Ghannoum, Fabio Cominelli, Luca Di Martino

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: C. albicans; colitis; C. tropicalis; mycobiome; biofilm

Online: 29 February 2024 (10:53:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0311.v1

Retrospective Cross-Sectional Study on Chronic Hepatitis C in Estonia, Latvia, Lithuania, and Ukraine: Virus, Patient, and Disease Characteristics in Patients under Care (RESPOND-C Study)

Ligita Jančorienė, Baiba Rozentāle, Ieva Tolmane, Agita Jēruma, Riina Salupere, Arida Buivydienė, Jonas Valantinas, Limas Kupčinskas, Jolanta Šumskienė, Eglė Čiupkevičienė, Arvydas Ambrozaitis, Olga Golubovska, Larysa Moroz, Robert Flisiak, Borys Bondar

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Baltic states; chronic hepatitis C; epidemiology; hepatitis C virus; genotype; Ukraine

Online: 5 July 2023 (12:30:04 CEST)

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Background and objectives: Since 2013, highly effective direct-acting (DAA) chronic hepatitis C (CHC) antiviral therapy became available, which has cure rates of over 95%. For choice of optimal CHC treatment, assessment of hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage are necessary. Information about distribution of these parameters among CHC patients in Baltic states and especially in Ukraine is scarce. This study was performed to obtain epidemiological data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (Baltic states) and lower-middle income (Ukraine) countries. Materials and Methods: This was an epidemiological, retrospective, cross-sectional study that included 1451 CHC patients. Demographic and disease information from medical charts was collected for each patient during a single visit. Results: Most frequent suspected mode of viral transmission was blood transfusions (17.8%), followed by injection drug use (15.7%); however, in 50.9% of patients exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%) transmission by the injection drug use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1 - 66.4%; GT3 - 28.1; and GT2 - 4.1%. The prevalence of GT1 was the highest in Latvia (84%), and the lowest in Ukraine (63%, p<0.001). Liver fibrosis stages were distributed as follows: F0 - 12.2%, F1 - 26.3%, F2 - 23.5%, F3 – 17.1% and F4 - 20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p <0.001). Conclusions: This study contributes to the knowledge of epidemiological characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy.

Working Paper ARTICLE

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial: Assessing the Effects of Angelica gigas Nakai Extract on Blood Triglycerides

Su-Jin Jung, Woo-Rim Kim, Mi-Ra Oh, Youn-Soo Cha, Byung-Hyun Park, Soo-Wan Chae

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Angelica gigas Nakai; triglycerides; VLDL-C; TG/HDL-C; atherogenic index

Online: 22 December 2019 (13:56:42 CET)

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Working Paper REVIEW

C,C- and C,N-Chelated Organocopper Compounds

Liang Liu, Hui Chen, Zhenqiang Yang, Junnian Wei, Zhenfeng Xi

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: organocopper; C,N-chelated; C,C-chelated; bidentate; butadienyl; intramolecular coordination; three center-two electron bonds; structure-reactivity relationship

Online: 2 September 2021 (12:01:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1131.v1

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis and Clinically Diagnosed Postnatal Infection

Jordan T. Ewald, Baiba Steinbrekera, Jennifer R. Bermick, Donna A. Santillan, Tarah T. Colaizy, Mark K. Santillan, Robert D. Roghair

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adipokine; chemokine (C-C motif) ligand 2; interleukin-6; leptin; neonatal; preeclampsia

Online: 16 May 2023 (09:00:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0146.v1

Absolutely Summing Morphisms between Hilbert C*-Modules and Modular Pietsch Factorization Problem

K. MAHESH KRISHNA

Subject: Computer Science And Mathematics, Analysis Keywords: Absolutely summing operator; Commutative C*-algebra; Hilbert C*-module; Hilbert-Schmidt operator

Online: 8 February 2023 (10:58:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0016.v1

MgAl-Layered Double Hydroxide Solid Base Catalysts for Henry Reaction: A Green Protocol

Magda H. Abdellattif, Mohamed Mokhtar

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: C-C bond formation; henry reaction; solid base catalyst; layered double hydroxide

Online: 2 March 2018 (04:05:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1756.v1

Effects on Soil Chemical Properties Two Years after Application of Compost in a Hedged Olive Grove

Carlos A. Alexandre, Rui Bajouco Lopes, Jacqueline S. Leal, José O. Peça, And António B. Dias

Subject: Environmental And Earth Sciences, Soil Science Keywords: organic amendments; soil organic carbon (SOC); particulate organic matter (POM-C); permanganate oxidizable carbon (POX-C); C-stock; micronutrients cations

Online: 26 June 2023 (07:13:53 CEST)

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Working Paper REVIEW

Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective

Anitra C. Carr, Sam Rowe

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: vitamin C; vitamin C status; vitamin C deficiency; global health; dietary intake; obesity; smoking; communicable disease; infection; non-communicable disease

Online: 4 June 2020 (03:49:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0958.v1

The Efficacy of Intrathecal Dexmedetomidine VS Fentanyl on Post-Operative Pain: A Retrospective Study

Lou’i Al-Husinat, Sarah Al Sharie, Mohammad Araydah, Lana Talafha, Abbas Baydoun, Zaid AL Modanat, Giovanna Grasso, Silvia Tripepi, Maria Rosaria Cuomo, Mohammad Wasfi Amir, Domenico Gammaldi, Antonella Paladini, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: dexmedetomidine; fentanyl; spinal anesthesia; post-operative pain; VAS score

Online: 12 January 2024 (05:23:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0816.v1

Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population

Thirunavukkarasu Sathish, Midhun Sasikumar, Getu Debalkie Demissie, Thyparambil Aravindakshan ParmodKumar, Brian Oldenburg, Anu Mary Oommen

Subject: Public Health And Healthcare, Other Keywords: Framingham Risk Score; cardiovascular disease; prediction; risk factors; recalibration

Online: 12 October 2023 (16:24:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1083.v1

Impact of Policy Packages on Beef Cattle Breeding in China: Evidence from 297 Beef Cattle Farmers

Junru Li, Zizhong Shi

Subject: Business, Economics And Management, Economics Keywords: beef cattle farming; supportive policies; evaluation; propensity score matching

Online: 18 September 2023 (05:52:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0820.v1

Dietary Pattern, Nutrition-Related Knowledge and Attitudes of Working Women in Western Province, Sri Lanka

Ayesha Salwathura, Faruk Ahmed

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Dietary Pattern; Dietary Diversity Score; Nutrition Knowledge; Nutrition Attitudes

Online: 12 June 2023 (10:13:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0305.v1

Polygenic Risk Score and Risk Factors for Gestational Diabetes

Marija Majda Perisic, Klemo Vladimir, Mario Storga, Ali Mostashari, Raya Khanin

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: gestational diabetes; pregnancy; polygenic risk score; gwas; machine learning

Online: 20 July 2022 (12:09:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0441.v1

The Moderating Role of CSR On the Antecedents And Out Come of Earnings Management in The Iraqi Firm

Mohammed Ghanim Ahmed, Yuvaraj Ganesan, Fathyah Hashim

Subject: Business, Economics And Management, Accounting And Taxation Keywords: board independence; audit committee; meeting frequency; M-score model

Online: 24 November 2021 (08:08:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0289.v3

Internet Access and Nutritional Intake: Evidence from Rural China

Ping Xue, Xinru Han, Ehsan Elahi, Yinyu Zhao, Xiudong Wang

Subject: Business, Economics And Management, Economics Keywords: internet access; nutritional intake; rural China; propensity score matching

Online: 11 June 2021 (14:54:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0314.v3

Financial Performance Analysis of Distressed Banks in Ghana: Exploration of Financial Ratios and Z-score

Juabin Matey

Subject: Business, Economics And Management, Economics Keywords: Bank; , Debt; Distress; Performance; Credit Management Practice; Z-score

Online: 19 December 2019 (13:05:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0091.v1

The Government Support and the Innovation of the New Energy Firms

Weijian Du, Mengjie Li

Subject: Business, Economics And Management, Economics Keywords: Government support; Innovation probability; Innovation destiny; Propensity score matching

Online: 10 May 2017 (18:04:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1845.v1

The Current State of Application of Machine Learning for Development of MgO-C Refractories: A Review

Sebastian Sado, Ilona Jastrzębska, Wiesław Zelik, Jacek Szczerba

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: machine learning; MgO-C; refractories

Online: 30 October 2023 (10:15:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1406.v1

The Role of C-reactive Protein in Aging associated NAFLD

Zheng Ding, Yuqiu Wei, Jing Peng, Siyu Wang, Guixi Chen, Jiazeng Sun

Subject: Biology And Life Sciences, Aging Keywords: NAFLD; C-reactive Protein; Aging

Online: 20 July 2023 (09:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0532.v1

Uniform Convergence of Cesaro Averages for Uniquely Ergodic $C^*$-Dynamical Systems

Francesco Fidaleo

Subject: Computer Science And Mathematics, Analysis Keywords: ergodic theorems; C*-dynamical systems

Online: 22 November 2018 (04:17:04 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints201703.0219.v1

Chemosyndrome Variation in Mycobiont Culture and Thallus of Parmelina carporrhizans and Parmelina quercina

David Alors, Pradeep K. Divakar, Anjuli Meiser, Imke Schmitt, Ana Crespo, M. Carmen Molina

Subject: Biology And Life Sciences, Plant Sciences Keywords: Parmelina; phenols; HPLC; myeloconone C

Online: 30 March 2017 (16:58:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1430.v1

Design, Synthesis and Photophysical Properties of 5-Aminobiphenyl Substituted [1,2,4]triazolo[4,3-c]- and [1,2,4]triazolo[1,5-c]quinazolines

Tatyana N. Moshkina, Alexandra E. Kopotilova, Marya A. Ivan’kina, Ekaterina S. Starnovskaya, Denis A. Gazizov, Emiliya V. Nosova, Dmitry S. Kopchuk, Oleg S. El´tsov, Pavel A. Slepukhin, Valery N. Charushin

Subject: Organic Chemistry, Chemistry And Materials Science Keywords: [1,2,4]Triazolo[4,3-c]quinazoline; [1,2,4]triazolo[1,5-c]quinazoline; cross-coupling; fluorescence; solvatochromism

Online: 23 April 2024 (08:00:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1960.v1

Directional Breeding Generates Distinct Genetic Diversity in Hybrid Turf Bermudagrass as Probed with SSR Markers

Desalegn D. Serba, Tilin Fang, Yanqi Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: C. dactylon; C. transvaalensis; interspecific hybrids; cluster analysis; genetic similarity; genetic diversity; directional breeding

Online: 29 May 2023 (08:55:06 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202302.0181.v1

Modular Dvoretzky, Type-Cotype, Khinchin-Kahane and Grothendieck Inequality Problems

K. MAHESH KRISHNA

Subject: Computer Science And Mathematics, Analysis Keywords: Dvoretzky Theorem; Type-Cotype; Khinchin-Kahane Inequality; Grothendieck Inequality; C*-algebra; Hilbert C*-module

Online: 10 February 2023 (06:19:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1052.v1

Identification of the Best Predictive Model for Mortality in Outborn Neonates – Retrospective Cohort Study

MARIA LIVIA OGNEAN, IOANA ANDRADA RADU, BIANCA COSMINA COTOVANU, DUMITRU ALIN TEACOE, SAMUEL BOGDAN TODOR, CRISTIAN ICHIM, IRIS CODRUTA MURESAN, ADRIAN GHEORGHE BOICEAN, RADU GALIS, MANUELA CUCEREA

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; outborn; sick neonatal score; mortality; neonatal transportation; scoring system

Online: 17 October 2023 (12:06:27 CEST)

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Background: Neonatal transportation of sick newborns is a major predictor of outcome. Prompt identification of the sickest newborns allows immediate corrective intervention and outcome optimization. Multiple severity scores were developed, however an optimal score has not yet been identified. Aim: To identify a rapid, accurate, and easy to perform score predictive for neonatal mortality in outborn neonates. Material and methods: All neonates, irrespective of gestational age, admitted by transfer in our level III regional neonatal unit between 01.01.2015 and 31.12.2021 were included. Infants with congenital critical abnormalities were excluded. Sick neonatal score (SNS) was calculated and compared between survivors and non-survivors. Gestational age (GA), birth weight (BW), gender, Apgar score, place of birth, time between delivery and admission (AT), early onset sepsis were collected from medical records and compared between study groups. Subgroup analysis was performed based on gestational age (preterm versus term infants). A new score was elaborated, including GA, BW, and AT, namely MSNS-AT score, to further improve mortality prediction. The main outcomes were mortality prediction using SNS and MSNS-AT score. Univariable and multivariable analysis, including Cox regression, were performed using SPSS Statistic 22.0. P-value was considered statistically significant if <0.05, 95% confidence intervals, odds ratio and hazard ratios were calculated were appropriate. Results: A total of 418 outborn infants were admitted during study period; 15 infants were excluded due to critical congenital defects. Out of 403 outborn infants, 217 born prematurely (53.8%), 224 males (55.6%), 20 died (4.96%). Compared to the survivors, the non-survivor neonates had significantly lower GA, BW, and SNS score (p<0.05), although only SNS score remained significantly lower in all subgroups (preterm vs term infants). A SNS score ≤8 was associated with mortality both in the whole study group and in subgroups (p<0.001). Time to admission was significantly associated with increased mortality rate in the whole group (p<0.05) and in preterm infants but not in term ones (p>0.05). In univariable and multivariable Cox regression models, MSNS-AT score, with a cut-off optimal value of ≤10 was more precise in predicting mortality compared to SNS (AUC 0.735 vs. 0.775) when applied to the entire group, had a lower accuracy in the term infants (AUC 0.765 vs 0.809) and a better accuracy the preterm infants group (AUC 0.885 vs. 0.810). Conclusions: The MSNS-AT score – calculated by adding GA, BW, and AT to the SNS score - significantly improved mortality prediction at admission in the whole study group as compared to SNS score. The best accuracy prediction of MSNS-AT score was observed in preterm infants suggesting that, besides GA and BW, TA may be decisive for the outcome of outborn preterm infants. Further studies are necessary to confirm the predictive value of MSNS-AT score and to identify variables that can improve its value in term infants without affecting the simplicity, ease, and rapidity of the scoring system.

Preprint REVIEW | doi:10.20944/preprints202307.0111.v1

Interpretation of Tumor Response Grade Following Preoperative Therapy for Gastric Cancer: An Overview

Vasileios Tsagkalidis, Maryjka B. Blaszczyk, Haejin In

Subject: Medicine And Pharmacology, Surgery Keywords: tumor response grade (TRG); gastric cancer; RECIST; tumor regression score

Online: 3 July 2023 (14:25:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0010.v1

Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA≤6

Jaume Baldirà, Juan Carlos Ruiz-Rodríguez, Adolfo Ruiz-Sanmartin, Luis Chiscano, Alejandro Cortés, Diego Angeles-Sistac, Roser Ferrer-Costa, Imma Comas, Yolanda Villena, M.Nieves Larrosa, Juan José González-López, Ricard Ferrer

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Sepsis biomarkers; mortality; MR-proADM; SOFA score; Lactate; molecular diagnosis

Online: 3 July 2023 (08:10:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2111.v1

Impact of Homegrown School Feeding Program on Smallholders' Farmer Household Food Security in Northeastern Nigeria

Bulus Barnabas, Sylvester Amoako Agyemang, Edwin Zhllima, Miroslava Bavorova

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: smallholder farmers; food security; school feeding; Nigeria; propensity score matching

Online: 30 May 2023 (10:31:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0251.v1

Comprehensive Study of Thunderstorm Indices Threshold Favorable for Thunderstorms During Monsoon Season Using WRF-ARW Model and ERA5 Over India

Unashish Mondal, Anish Kumar, S. K. Panda, Devesh Sharma, Someshwar Das

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Thunderstorm Indices; WRF-ARW; Lightning; Optimal Threshold; Model Skill Score

Online: 4 May 2023 (10:01:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0187.v1

Workload in the Care of a Patient with Congenital Diaphragmatic Hernia and the Patient’s Need for Nursing Care

Paulina Szydłowska-Pawlak, Dorota Maria Kilańska, Remigiusz Kozlowski, Roman Załuska, Monika Borzuchowska, Michał Marczak

Subject: Public Health And Healthcare, Nursing Keywords: nurse; workload; staff workload; nursing intensive care; nursing activities score

Online: 10 February 2023 (07:53:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0026.v1

Tracking Obesity Phenotypes in Korean Adults Based on KNHANES (2015-2019)

Jieun Shin, Okhyun Kim, Myoungsook Lee

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity phenotypes, obesogenic environments, metabolic syndrome, K-score, food pattern

Online: 1 November 2022 (09:36:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0108.v1

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS). Part II

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M. E. Pilatz, Kurt G. Naber, Florian M. E. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women

Online: 6 September 2021 (17:02:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0559.v1

Comparative Analysis of Lenvatinib and Hepatic Arterial Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multi-Center, Propensity Score Study

Jaejun Lee, Ji Won Han, Pil Soo Sung, Soon Kyu Lee, Hyun Yang, Hee Chul Nam, Sun Hong Yoo, Hae Lim Lee, Hee Yeon Kim, Sung Won Lee, Jung Hyun Kwon, Jeong Won Jang, Chang Wook Kim, Soon Woo Nam, Jung Suk Oh, Ho Jong Chun, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatocellular carcinoma; Lenvatinib; Hepatic arterial infusion chemotherapy; Propensity score matching

Online: 26 July 2021 (09:59:34 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202105.0402.v2

I Can Achieve Intrauterine Growth Rete if You Give Me Enough Nutrition: Preterm Infant Born at ≤29 Weeks Gestation

Angela Hoyos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Very preterm infants; Z-score on weight; neonatal nutrition; appropriate intrauterine neonatal growth

Online: 30 July 2021 (15:00:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0295.v1

Veridical Causal Inference for Comparative Effectiveness Research Using Medical Claims

Ryan Ross, Xu Shi, Megan Caram, Pheobe Tsao, Paul Lin, Amy Bohnert, Min Zhang, Bhramar Mukherjee

Subject: Medicine And Pharmacology, Other Keywords: insurance claims; reproducibility; propensity score; veridical data science; sensitivity analysis

Online: 24 June 2020 (09:51:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0298.v2

A Hierarchical Machine Learning Model to Discover Gleason Grade Group-specific Biomarkers in Prostate Cancer

Osama Hamzeh, Abedalrhman Alkhateeb, Julia Zheng, Srinath Kandalam, Crystal Lueng, Govindaraja Aikukke, Dora Cavallo-Medved, Nallasivam Palanisamy, Luis Rueda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: classification; prostate cancer; gleason score; machine learning; next-generation sequencing

Online: 26 November 2019 (04:01:21 CET)

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1) Background: One of the most common cancer that affects men worldwide and North American men is prostate cancer. Gleason score is a pathological grading system to examine the potential aggressiveness of the disease in the prostate tissue. The advancement in computing and next-generation sequencing technology now allow us to study the genomic profiles of patients in association with their different Gleason score more accurately and effectively. 2) Methods: In this study, we used a novel machine learning method to analyze gene expression of prostate tumors with different Gleason scores, and identify potential genetic biomarkers for each Gleason group. We obtained a publicly-available RNA-Seq dataset of a cohort of 104 prostate cancer patients from the National Center for Biotechnology Information’s (NCBI) Gene Expression Omnibus (GEO) repository, and categorized patients based on their Gleason scores to create a hierarchy of disease progression. A hierarchical model with standard classifiers in different Gleason groups, also known as nodes, was developed to identify and predict nodes based on their mRNA or gene expression. In each node, patient samples were analyzed via class imbalance and hybrid feature selection techniques to build the prediction model. The outcome from analysis of each node is a set of genes that can differentiate each Gleason group from the remaining groups. To validate the proposed method, the set of identified genes are used to classify a second dataset of 499 prostate cancer patients collected from cBioportal [1]. 3) Results: The overall accuracy of applying this novel method to the first dataset was 93.3%, and further validated to 87% accuracy using the second dataset. This method also identified genes that were not previously reported as potential biomarkers for specific Gleason groups. In particular, PIAS3 was identified as a potential biomarker for Gleason score 4+3=7, and UBE2V2 for Gleason score 6. 4) Insight: Previous reports show that the genes predicted by this newly proposed method strongly correlate with prostate cancer development and progression. Furthermore, pathway analysis shows that both PIAS3 and UBE2V2 share similar protein interaction pathways, the JAK/STAT signaling process.

Preprint ARTICLE | doi:10.20944/preprints201911.0223.v1

Identification and Preference of Game Styles in LaLiga Associated with Match Outcomes

Julen Castellano Paulis, Miguel Pic

Subject: Social Sciences, Education Keywords: match analysis; team sport; key performance indicator; interaction; elite; score

Online: 19 November 2019 (03:57:36 CET)

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Working Paper REVIEW

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?

Sam Rowe, Anitra C. Carr

Subject: Biology And Life Sciences, Food Science And Technology Keywords: vitamin C status; hypovitaminosis C; vitamin C deficiency; low and middle income countries; LMIC; dietary intake; supplement; non-communicable disease; communicable disease; infection

Online: 24 May 2020 (18:16:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0275.v1

Sequencing and Chromosome-Scale Assembly of Plant Genomes, Brassica rapa as a Use Case

Benjamin Istace, Caroline Belser, Cyril Falentin, Karine Labadie, Franz Boideau, Gwenaëlle Deniot, Loeiz Maillet, Corinne Cruaud, Laurie Bertrand, Anne-Marie Chèvre, Patrick Wincker, Mathieu Rousseau-Gueutin, Jean-Marc Aury

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Genome sequencing; de novo Assembly; Scaffolding; Chromosome-scale; Nanopore sequencing; Long reads; Optical maps; Bionano Genomics; Hi-C; Omni-C; Pore-C; Plant genomes

Online: 12 July 2021 (22:55:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0045.v1

Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

Michele Fabrazzo, Rosa Zampino, Martina Vitrone, Gaia Sampogna, Lucia Del Gaudio, Daniela Nunziata, Salvatore Agnese, Anna Santagata, Emanuele Durante-Mangoni, Andrea Fiorillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic hepatitis C; Direct-acting antiviral agents; Hepatitis C virus; Consultation-liaison psychiatry; Depression; Anxiety

Online: 5 July 2020 (05:15:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0291.v1

Multidimensional Machine Learning on 2173 COVID-19 Patients in Vietnam

Tue Trong Nguyen *, Tu Cam Ho *, Huong Thi Thu Bui *, Ulrike Protzer, Van Thanh Ta

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Multidimensional Analysis; HCA; Hierarchical cluster analysis; regression analysis; mild; moderate; severe; Age; Score index of the chest X-ray; percentage and quantity of neutrophils; Albumin; C reactive protein; ratio of Lymphocytes

Online: 20 September 2022 (04:50:36 CEST)

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INTRODUCTION: The purpose of the study was to determine (a) the overall preclinical character; (b) the cumulative cutoff values and the risk ratio, and (c) the factors associated with severity by a unidimensional and multidimensional analysis on 2173 Sars-Cov2 patients. METHODS: The machine learning study population consisted of 2173 patients (1587 mild and non symptoms patients, 377 moderate patients, 209 severe patients). The status of the patients was recorded from September 2021 to March 2022. RESULTS: The Covid19 Severity directly links with a significant correlation to Age, Score index of the chest X-ray, percentage and quantity of neutrophils, Albumin, C reactive protein, and ratio of Lymphocytes. Their important cut off values (from regression analysis) respectively are: 77.56 years old (the mild-moderate group), 5.53 (the mild-moderate group) and 10.51 (the moderate-severe group), 84.80% (the mild-moderate group) and 87.74%(the moderate-severe group), 11.77G/L (the moderate-severe group), 29.73g/L (the moderate-severe group), 7.46mg/dL (the mild-moderate group), 6.32% (the moderate-severe group). Their significant (p<0.0001) R score correlation with the severity of Covid19, are: 0.44, 0.52 and 0.52, 0.33 and 0.44, 0.42, -0.43, 0.40, -0.41. Their significant risk ratio (p<0.00001) from the meta-analysis, respectively are: 4.19 [3.58-4.95], 3.29 [2.76-3.92] and 3.03 [2.4023;3.8314], 3.18 [2.73-3.70] and 3.32 [2.6480;4.1529], 3.15 [2.6153;3.8025], 3.4[2.91-3.97], 0.46 [0.3650;0.5752] (p<0.00001), 0.34 [0.2743;0.4210]. The pair ALT – Leucocytes and Transferrin – Anion Chloride get the most important correlation shift. ALT – Leucocytes show the important negative link (R=-1, p<0.00001) in the mild group to the significant positive correlation in the moderate group (R=1, p<0.00001). Transferrin–anion Chloride has an important positive association (R=1, p<0.00001) in the mild group with a significant negative correlation in the moderate group (R=-0.59, p<0.00001). The network map and HCA show that in the mild-moderate group, the closest neighbors with the Covid19 severity are ferritins, Age. Then there is C-reactive protein, SI of X-ray, Albumin, and Lactate dehydrogenase, which are the next close neighbors of these three factors. In the moderate-severe group, the closest neighbors with the Covid19 severity are Ferritin, Fibrinogen, Albumin, the quantity of Lymphocytes, SI of X-ray, white blood cells count, Lactate dehydrogenase, and quantity of neutrophils. CONCLUSIONS: Complete multidimensional study in 2173 Covid19 patients in Vietnam shows the whole picture of all the preclinical factors, which may become the clinical reference marker for surveillance and diagnostic management

Preprint ARTICLE | doi:10.20944/preprints202404.1025.v1

Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study

Natalia Stepanova, Lesya Korol, Tetyana Ostapenko, Valeriia Marchenko, Olga Belousova, Lyudmila Snisar, Iryna Shifris, Mykola Kolesnyk

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: long COVID; hemodialysis; controlling nutritional status score; undernutrition; oxidative stress; persistence

Online: 16 April 2024 (11:10:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1968.v1

Effect of Agricultural Production Trusteeship on Agricultural Carbon Emission Reduction

Xiaoyan Sun, Shuya Guang, Jingjing Cao, Fengying Zhu, Jianxu Liu, Songsak Sriboonchitta

Subject: Social Sciences, Other Keywords: agricultural production trusteeship; agricultural carbon emission reduction; propensity score matching (PSM)

Online: 28 June 2023 (08:34:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1847.v1

Inverse Association between Dairy Product Consumption and Lower Cognitive Function in Community-Dwelling Japanese Older Adults Based on a Cross-Sectional Study

Hunkyung Kim, Yosuke Osuka, Narumi Kojima, Hiroyuki Sasai, Kentarou Nakamura, Chisato Ohba, Mayuki Sasaki, Takao Suzuki

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: dairy product consumption; mini-mental state examination score; lower cognitive function

Online: 27 June 2023 (04:58:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1735.v1

Framework for Simulation Study Involving Volatility Estimation: The GAS Approach

Richard T. A. Samuel, Charles Chimedza, Caston Sigauke

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: consistency; efficiency; score driven model; simulation design; time-varying parameter estimation

Online: 26 June 2023 (04:40:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0484.v1

Promotion Effect of Agricultural Production Trusteeship on High-quality Production of Grain——Evidence from the Perspective of Farm Households

Xiaoyan Sun, Youchao Wang, Fengying Zhu, Xiaoyu Liu, Jianxu Liu, Songsak Sriboonchitta

Subject: Business, Economics And Management, Economics Keywords: agricultural production trusteeship; high-quality production of grain; propensity score matching

Online: 7 June 2023 (04:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0094.v1

A Randomized, Placebo Controlled, Double Blinded, Parallel Group Clinical Study to Evaluate the Efficacy and Safety of AEV01 for Mild COVID19 in Elderly Patients at Risk of Complications

RAMESH KANNAN, VANITHA MURALIKUMAR, VAMSEEDHAR ANNAM, SAKTHI BALAN, ARAVINDA KUMAR, SEKHAR MM, RENU MEDASANI

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; Picrorhiza kurroa; AEV01; NEW Score; Immunomodulatory; unvaccinated elderly population

Online: 7 May 2022 (05:47:32 CEST)

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Background: While several drugs are in the pipeline for treatment of various grades of COVID-19 disease, none of them have shown promise until now. Medicinal plants are crucial in developing and developed countries for their primary and basic health needs owing to better tolerability, superior compatibility with human body and having lesser side effects. AEV01 , a speciality extract of kutki (Picrorhiza kurroa), is one potential medicinal herb which can be effective for mild COVID19 in elderly patients at risk of complications and aging immunity. Purpose: The efficacy and safety of AEV01 for mild COVID-19 in elderly patients at risk of complications was investigated in this study. Study design: A prospective, phase 3, randomized, multicentric, placebo controlled double blinded parallel group interventional trial. Methods: This study was conducted in elderly patients diagnosed as COVID-19 with mild symptoms. 70 patients were randomized into two groups to receive AEV01 capsule (100mg) and placebo respectively thrice daily for 30 days along with standard care of treatment as per national WHO/ICMR guidelines. Clinical improvement timelines and corresponding scores using 8-point ordinal scale and NEWS were assessed for efficacy and safety of AEV01 in COVID-19 patients. Results: AEV01 group showed a significant improvement (P=0.0001) in the normalization of the SpO₂ rate and relief from cough. There was also significant difference in time to recovery, with patients in the AEV01 drugtreated group recovering in 4.5 days as compared to Placebo in 9.1 days. ESR, LDH, serum ferritin, Neutrophil-Lymphocyte ratio (NLR), TNF- alpha, IL-6 and CD4 cell counts, which are considered as prognostic markers in COVID19 infected patients, showed a significant improvement in patients treated with AEV01. The AEV01 drug treated group showed significant clinical improvement in the 8-point ordinal scale severity rating and NEW Score from day 3 onwards which continued up to end of study. Conclusion: AEV01 has shown a significant improvement in clinical and laboratory parameters. There was also reduction in the progression of the COVID-19 disease in unvaccinated elderly patients from mild to moderate when treated at an earlier stage.

Preprint CONCEPT PAPER | doi:10.20944/preprints202202.0114.v1

Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections Preliminary Considerations and Conclusions from a Non-interventional Study

Florian Wagenlehner, Horst Lorenz, Oda Ewald, Peter Gerke

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: urinary tract infection; cystitis; D-mannose; antibiotics; acute cystitis symptom score

Online: 8 February 2022 (13:25:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0211.v1

Development and Validation of a Risk Score to Predict Low Birthweight Using Characteristics of the Mother: A Prospective Cohort Study

Hamid Y. Hassen, Bilal S. Endris, Meselech A. Roro, Seifu H. Gebreyesus, Jean-Pierre Van Geertruyden

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: prediction; model; risk score; low birthweight; pregnant women; decision curve analysis

Online: 13 April 2020 (11:15:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0356.v1

Initial Review and Analysis of COVID-19 Host Genetics and Associated Phenotypes

Yosuke Tanigawa, Manuel Rivas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; host genetics; genetics; polygenic risk score

Online: 24 March 2020 (08:36:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0181.v1

A Democratic Method and Index to Rationalize Authorship Decisions and Determine the Order of Authors

Thorsten Schmidt

Subject: Social Sciences, Library And Information Sciences Keywords: Authorship contributions, Authorship Score, Authorship Conflicts, First Author, Decision Making, Bibliometry

Online: 9 October 2018 (09:45:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0245.v1

Carbon Dots for Future Prospects: Synthesis, Characterizations and Recent Applications: A Review (2019–2023)

Habtamu Fekadu Etefa, Aster Aberra Tessema, Francis Birhanu Dejene

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: C-dots; sythesis, Optical properties; Application

Online: 3 April 2024 (16:29:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0114.v1

Plasma Vitamin C Levels Associated with the Diet and Supplement Consumption

Svetlana Trifunschi, Melania Florina Munteanu, Florin Borcan, Gyöngyvér Tașcău, Elena Narcisa Pogurschi

Subject: Biology And Life Sciences, Food Science And Technology Keywords: vegetables; plasma vitamin C level; humans

Online: 3 January 2024 (10:37:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0565.v1

High Copy Number from Pharyngeal Swab Is Not Associated with Different Presenting Features in 100 Children with Acute Adenovirus Infection from a Cluster in Italy

Anthea Mariani, Federica Cavallo, Saverio La Bella, Giusi Graziano, Martina Passarelli, Carlo Crescenzi, Daniela Trotta, Maurizio Aricò

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adenovirus; C-reactive protein; copy number

Online: 10 October 2023 (05:07:12 CEST)

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Adenoviruses are associated with respiratory tract, gastrointestinal or, less frequently, other involvement. Epidemics of adenovirus infections occur globally, in communities and in closed or crowded settings. In our institution, an outbreak of Adenovirus infection in infants and children was recently observed. Two main patterns of clinical presentation were observed: 68 patients had mainly respiratory symptoms (pharyngitis n=67, cough n=44; tonsillar exudate n=17; other respiratory signs n=4) while 26 patients showed prevalent gastrointestinal involvement (diarrhea n=26, vomiting n=8). Patients with respiratory symptoms had a significantly higher count of WBC, PMN and platelets, while CRP level approached statistical significance (p=0.07) for higher values in the patients with diarrhea. In order to explore the impact of selected presenting features, possible association between level of CRP and presence of pharyngeal exudate, cough, vomiting, diarrhea, duration of fever, number of neutrophils, and administration of antibiotics was analyzed. Patients falling in the tertile with more elevated CRP values had significantly more often tonsillar exudate and diarrhea, while those in the lower tertile had a 4.4 days duration of fever, vs. ≥5.0 days in the remaining patients. Antibiotic therapy was administered more frequently to patients with higher values of CRP (p=0.006). Duration of hospitalization was not associated with the CRP level. The median time from the receipt of positive adenovirus PCR test result to patient discharge was 1 day in 73% of cases. The number of copies of adenovirus detected by PCR ranged between 47 million and 15/L. Falling in the highest terzile of copy number was significantly associated with pharyngitis. The 24 patients with evidence of viral coinfection had no difference in the demographics or presenting features, with the only exception of a significantly higher leukocyte count. Rapid turn-around of results of molecular testing of adenovirus genome on pharyngeal swab allowed us to rapidly diagnose adenovirus infection, allowing stopping antibiotic therapy and immediate discharge, with reduced discomfort for the families and more appropriate use of hospital beds. A high copy number of adenovirus from pharyngeal swab should not be taken as an indicator of worse prognosis, thus allowing preferential use of qualitative rather than quantitaive assay.

Preprint ARTICLE | doi:10.20944/preprints202309.1569.v1

Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (The Terasen® nutraceutical) Increases the Lifespan of Caenorhabditis Elegans

Ester Lopes De Melo, Bruno A. M. Tavares, Nayara N.D. Colares, Aline Lopes Do Nascimento, Helison de Oliveira Carvalho, Andres Navarrete Castro, Arlindo Cesar Matias Pereira, Carlos E. Winter, Iracirema da Silva Sena, Luiz F Moreira, Jose Carlos Tavares Carvalho

Subject: Biology And Life Sciences, Aging Keywords: longevity; healthspan; lifespan; nutraceuticals; C. elegans

Online: 22 September 2023 (11:43:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0532.v1

Tumor-Infiltrating iNKT Cells Activated through C-Kit/Sca-1 Are Induced by Pentoxifylline, Norcantharidin, and Their Mixtures for Killing murine Melanoma Cells

Maximiliano V.M Correa-Lara, Israel Lara-Vega, Minerva Nájera-Martínez, María Lilia Domínguez-López, Elba Reyes-Maldonado, Armando Vega-López

Subject: Biology And Life Sciences, Toxicology Keywords: NK; iNKT; CD107a+; c+kit+; Lya6A+

Online: 7 September 2023 (10:59:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0274.v1

Synthesis and Characterization of Abasic β-Diol-C-Nucleosides

Maria Moccia, Linda Piras, Michele Saviano, Mauro F. A. Adamo

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: C-nucleosides; abasic nucleosides; functionalized DNAs

Online: 12 April 2023 (12:05:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0079.v1

Hepatitis C Core Protein Induces a Genotype-specific Susceptibility of Hepatocytes to TNF-induced Death in vitro and in vivo

Savvina Moustafa, Katerina Kassela, Maria Bampali, Nikolas Dovrolis, Athanassios Kakkanas, Apostolos Beloukas, Penelope Mavromara, Ioannis Karakasiliotis

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hepatitis C virus; core protein; TNFα

Online: 6 September 2022 (03:38:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0052.v1

The Association between Self-Reported Daily Energy Intake from Carbohydrates with Insulin Resistance in Healthy Weight Nor-Mal-Weight Individuals

Fatema Al-Rashed, Sardar Sindhu, Ashraf Al Madhoun, Fatemah Alzaqqah, Nadeem Akter, Fahd Al-Mulla, Rasheed Ahmad

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Carbohydrates; keto diet; IRS; C-peptide

Online: 7 April 2022 (04:03:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints201906.0007.v1

Relationship between Vitamin C and Periodontal Diseases: A Systematic Review

Akio Tada, Hiroko Miura

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Vitamin C, Periodontal disease, Periodontitis, Gingivitis

Online: 3 June 2019 (08:46:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0177.v1

A-to-I RNA Editing Affects lncRNAs Expression after Heat Shock

Roni Haas, Nabeel S. Ganem, Ayya Keshet, Angela Orlov, Alla Fishman, Ayelet T. Lamm

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: stress response; ADAR; C. elegans; transcriptomics

Online: 7 November 2018 (15:17:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0023.v1

On the Role of Paraoxonase-1, Chemokine (C-C motif) Ligand 2 and Metabolism in Oxidation, Inflammation and Disease. A 2021 Update

Jordi Camps, Helena Castañé, Elisabet Rodríguez-Tomàs, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Meritxell Arenas, Simona Iftimie, Jorge Joven

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cancer; cardiovascular disease; chemokine (C-C motif) ligand 2; fatty liver; infection; inflammation; metabolism; obesity; paraoxonase-1

Online: 1 June 2021 (10:46:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0488.v1

Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C

Valeriy Tsvetkov, Ivan Tokin, Dmitriy Lioznov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatitis C virus; Chronic viral hepatitis C; Liver fibrosis; Liver cirrhosis; Diagnosis of liver fibrosis; Machine learning

Online: 22 February 2021 (15:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0043.v1

CA-125 KELIM as a tool to identify which patients can benefit from PARPi in high grade serous advanced ovarian cancer: A retrospective diagnostic accuracy study.

Dimitrios Zouzoulas, Dimitrios Tsolakidis, Panagiotis Tzitzis, Kimon Chatzistamatiou, Vasilis Theodoulidis, Iliana Sofianou, Grigoris Grimbizis, Eleni Timotheadou

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: KELIM score; Homologous recombination deficiency (HRD); Poly (ADP-ribose) polymerase inhibitors (PARPi).

Online: 1 April 2024 (11:12:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0679.v1

Predicting and Analyzing Rainfall Patterns in Ethiopia Using Linear Regression Modeling

Moges Tsegaw Melesse, Gezahegn Mulusew Delele

Subject: Computer Science And Mathematics, Computer Science Keywords: Rainfall patterns; Ethiopia; Linear regression modeling; R-squared score; Mean squared error

Online: 14 March 2024 (05:28:48 CET)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202308.0886.v1

Estimating Multivariate models for Association between soil Major and minor Micronutrients

Rajarathinam Arunachalam, Ramji Madhaiyan

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Kaiser-Meyer-Olkin Test; Pearson correlation; Eigenvalue; Score plot; PCA; FA; CCA

Online: 11 August 2023 (03:39:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1106.v1

An Explainable Vision Transformer Model Based White Blood Cells Classification and Localization

Oguzhan Katar, Ozal Yildirim

Subject: Engineering, Other Keywords: Vision Transformers; white blood cells; explainable AI models; deep learning; Score-CAM

Online: 15 June 2023 (08:42:51 CEST)

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