Moccia, M.; Piras, L.; Bellini, G.; Saviano, M.; Adamo, M.F.A. Synthesis and Characterization of Abasic β-Diol-C-Nucleosides. Chemistry2023, 5, 1343-1356.
Moccia, M.; Piras, L.; Bellini, G.; Saviano, M.; Adamo, M.F.A. Synthesis and Characterization of Abasic β-Diol-C-Nucleosides. Chemistry 2023, 5, 1343-1356.
Moccia, M.; Piras, L.; Bellini, G.; Saviano, M.; Adamo, M.F.A. Synthesis and Characterization of Abasic β-Diol-C-Nucleosides. Chemistry2023, 5, 1343-1356.
Moccia, M.; Piras, L.; Bellini, G.; Saviano, M.; Adamo, M.F.A. Synthesis and Characterization of Abasic β-Diol-C-Nucleosides. Chemistry 2023, 5, 1343-1356.
Abstract
Modified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for the development of novel catalytic species. Herein we describe the synthesis of a novel β-C-nucleoside bearing a diol group at anomeric position, amenable as metal ligand or as organo-catalyst. The abasic ligand was successfully prepared and inserted into complementary DNA strand.
Chemistry and Materials Science, Organic Chemistry
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