Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (The Terasen® nutraceutical) Increases the Lifespan of Caenorhabditis Elegans

Ester Lopes De Melo; Bruno A. M. Tavares; Nayara N.D. Colares; Aline Lopes Do Nascimento; Helison de Oliveira Carvalho; Andres Navarrete Castro; Arlindo Cesar Matias Pereira; Carlos E. Winter; Iracirema da Silva Sena; Luiz F Moreira; Jose Carlos Tavares Carvalho

doi:10.20944/preprints202309.1569.v1

A peer-reviewed article of this Preprint also exists.

de Melo, E.L.; Tavares, B.A.M.; Colares, N.N.D.; do Nascimento, A.L.; Carvalho, H.O.; Castro, A.N.; Pereira, A.C.M.; Winter, C.E.; Sena, I.S.; Moreira, L.F.; Carvalho, J.C.T. Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (the Terasen^® Nutraceutical) Increases the Lifespan of Caenorhabditis elegans. J. Ageing Longev. 2023, 3, 494-504. de Melo, E.L.; Tavares, B.A.M.; Colares, N.N.D.; do Nascimento, A.L.; Carvalho, H.O.; Castro, A.N.; Pereira, A.C.M.; Winter, C.E.; Sena, I.S.; Moreira, L.F.; Carvalho, J.C.T. Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (the Terasen® Nutraceutical) Increases the Lifespan of Caenorhabditis elegans. J. Ageing Longev. 2023, 3, 494-504.

Abstract

Aging is a complex process associated with tissue degeneration and an increased risk of age-related diseases. This study aimed to evaluate the impact of Terasen®, a nutraceutical containing standardized extracts of Euterpe oleracea, Myrciaria dubia, and purified oil of Bixa orellana and Astrocaryum aculeatum on the lifespan of Caenorhabditis elegans, a widely used model organism for aging research. The findings demonstrated that Terasen® exhibited significant antioxidant activity and influenced the feeding behavior of C. elegans, leading to a reduced pharyngeal pumping rate and a decreased number of offspring produced by treated individuals. Notably, Terasen® also displayed a remarkable ability to extend the lifespan of C. elegans. These findings suggest that Terasen® may possess promising anti-aging effects in vivo, warranting further investigation.

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Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (The Terasen® nutraceutical) Increases the Lifespan of Caenorhabditis Elegans

Abstract

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