Preprint Brief Report Version 2 Preserved in Portico This version is not peer-reviewed

I Can Achieve Intrauterine Growth Rete if You Give Me Enough Nutrition: Preterm Infant Born at ≤29 Weeks Gestation

Version 1 : Received: 16 May 2021 / Approved: 18 May 2021 / Online: 18 May 2021 (09:50:29 CEST)
Version 2 : Received: 30 July 2021 / Approved: 30 July 2021 / Online: 30 July 2021 (15:00:25 CEST)

How to cite: Hoyos, A. I Can Achieve Intrauterine Growth Rete if You Give Me Enough Nutrition: Preterm Infant Born at ≤29 Weeks Gestation. Preprints 2021, 2021050402 (doi: 10.20944/preprints202105.0402.v2). Hoyos, A. I Can Achieve Intrauterine Growth Rete if You Give Me Enough Nutrition: Preterm Infant Born at ≤29 Weeks Gestation. Preprints 2021, 2021050402 (doi: 10.20944/preprints202105.0402.v2).

Abstract

Introduction: In general, everyone believes that the smallest preterm infants should achieve normal intrauterine growth rates, but many thinks that this is not possible with current nutrition guidelines. There is resistance to giving enough nutrition for fear of "toxicity". The difference in weight Z-score between birth and a corrected gestational age (CGA) at discharge is assess in postnatal growth in our unit. Material and methods: An observational study was done between January 2018 and December 2020 where all cases that had ≤ 29 weeks of GA at birth and survived to 36 weeks corrected GA or that were discharged home. An aggressive nutrition protocol including parenteral as well as enteral nutrition was followed. Patients and their weight trajectory was plotted on the Fenton 2013 growth curve. The patients who had had a smaller WZP difference were also plotted. Results: A total of 32 cases were found. The median change in Z-score between birth and discharge of the whole group was -0.52 (IQR 0.53). Six of 32 (19%) had a more than one WZP, all of whom had severe pathologies. The median decline in Z score for this group with poor growth was 1.24 (IQR 0.22). There were 26 cases with a < 1 WZP (81%) and a median Z score fall of 0.39 (IQR 0.55). No important complications secondary to the ingested volumes or parenteral nutrition were reported. Conclusion: The group of cases with a > 1 WZP drop had severe pathologies. All the other cases had adequate growth parallel to normal weight growth charts and a few cases had some catch-up growth. The study showed that it is possible for many preterm infants to achieve normal intrauterine growth rates if they are given enough nutrition, but bigger multicenter studies are needed to confirm these findings.

Keywords

Very preterm infants; Z-score on weight; neonatal nutrition; appropriate intrauterine neonatal growth

Comments (1)

Comment 1
Received: 30 July 2021
Commenter: Angela Hoyos
Commenter's Conflict of Interests: Author
Comment: The article was peer-reviewed but ultimately not accepted by the editor
+ Respond to this comment

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 1
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.