Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Efficacy of Intrathecal Dexmedetomidine VS Fentanyl on Post-Operative Pain: A Retrospective Study

Lou’i Al-Husinat
ORCID logo ,
Sarah Al Sharie
ORCID logo ,
Mohammad Araydah
ORCID logo ,
Lana Talafha
,
Abbas Baydoun
,
Zaid AL Modanat
ORCID logo ,
Giovanna Grasso
,
Silvia Tripepi
,
Maria Rosaria Cuomo
,
Mohammad Wasfi Amir
,
Domenico Gammaldi
,
Antonella Paladini
* ,
Giustino Varrassi
* ORCID logo
Version 1 : Received: 29 December 2023 / Approved: 12 January 2024 / Online: 12 January 2024 (05:23:00 CET)

How to cite: Al-Husinat, L.; Al Sharie, S.; Araydah, M.; Talafha, L.; Baydoun, A.; AL Modanat, Z.; Grasso, G.; Tripepi, S.; Cuomo, M.R.; Amir, M.W.; Gammaldi, D.; Paladini, A.; Varrassi, G. The Efficacy of Intrathecal Dexmedetomidine VS Fentanyl on Post-Operative Pain: A Retrospective Study. Preprints 2024, 2024010958. https://doi.org/10.20944/preprints202401.0958.v1 Al-Husinat, L.; Al Sharie, S.; Araydah, M.; Talafha, L.; Baydoun, A.; AL Modanat, Z.; Grasso, G.; Tripepi, S.; Cuomo, M.R.; Amir, M.W.; Gammaldi, D.; Paladini, A.; Varrassi, G. The Efficacy of Intrathecal Dexmedetomidine VS Fentanyl on Post-Operative Pain: A Retrospective Study. Preprints 2024, 2024010958. https://doi.org/10.20944/preprints202401.0958.v1

Abstract

Background and aims: For many surgical procedures, spinal anesthesia is a reliable and efficient anesthetic approach. Numerous drugs have been reported to be administered to intrathecal local anesthetics as adjuvants to increase the efficacy of spinal anesthesia. There is little evidence of the effect of intrathecal dexmedetomidine on pain scores and the consumption of analgesia postoperatively. Methods: After obtaining ethical approval, demographical and clinical data of patients who underwent surgical procedures under spinal anesthesia with intrathecal dexmedetomidine or fentanyl was collected and analyzed. Results: In this study with 96 patients, intrathecal dexmedetomidine (group D) resulted in significantly lower post-operative pain scores compared to intrathecal fentanyl (group F) (p=0.000). Across various surgical types, including Orthopedic, General, Urology, and Obs/Gyne procedures, group D consistently displayed reduced pain scores (p<0.001). The number of patients who needed post-operative analgesia was significantly higher in group (F) than in group (D) (40 vs 23, p=0.002). Conclusion: Compared to fentanyl, intrathecal dexmedetomidine as an adjuvant to local anesthesia was found to lower post-operative pain scores and decrease the need for post-operative analgesia.

Keywords

dexmedetomidine; fentanyl; spinal anesthesia; post-operative pain; VAS score

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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