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Preprint REVIEW | doi:10.20944/preprints202306.0168.v1

A Critical Reassessment of the Kidney Risk Caused by Tetrastarch Products in the Perioperative and Intensive Care Environments

Csaba Kopitkó, Tibor Fülöp, Mihály Tapolyai, Tibor Gondos

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: hydroxyethyl starch; acute kidney injury; hemodynamic monitoring; sepsis; cardiac; postoperative

Online: 2 June 2023 (09:28:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0063.v1

A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management

Ashish Shetty, Gayathri Delanerolle, Heitor Cavalini, Yinshan Qui, Amy Boyd, Yassine Bouchareb, Anish Thillainathan, Seung Kim, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; non-pharmaceutical pain management; interventions

Online: 1 June 2023 (08:13:11 CEST)

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Background: Chronic, non-cancer pain represents a serious public health and economic issue affecting approximately 20% of the global population. Chronic pain can affect many aspects of patient’s lives, including mental health, employment, and relationships. Current medical management is largely focussed on investigating and managing acute pain. Patients and clinicians are now increasingly aware of the potential benefits of combined treatments or complex interventions in alleviating chronic pain. These approaches include both physical interventions, such as exercise or yoga, as well as psychological support including cognitive behavioural therapy (CBT) and talking therapies. Methods: This study used network meta-analyses to explore the prevalence of complex interventions in pain management, and the effects of these interventions on quality of life, using outcome measures including intensity of chronic pain, assessment of functional disability and participant’s psychological state. Results: Psychological interventions were associated with improvements in pain intensity and depression. Exercise and manipulation technique-based treatments provided a statistically significant reduction in pain intensity. This effect was enhanced when exercise and CBT were combined. Mensendieck somatocognitive therapy (MSCT) plus standard gynaecological treatment (STGT) treatments appeared to have a better effect on chronic pain than multimodal exercise plus CBT treatment. Combined MSCT and STGT treatment, and multimodal exercise plus CBT treatments, reduced pain intensity, whilst MSCT+STGT treatments had a slightly better effect than exercise plus CBT treatment.Conclusions: Complex interventions have become more popular with patients as the risks associated with other interventions including surgery and pharmacological management have become better understood. These interventions can have a significant positive effect both on the physical and psychological health of patients. The analysis presented in this study suggests that further work is warranted in this area and that additional studies are required, both in more geographically diverse locations, and with larger cohorts.

Preprint ARTICLE | doi:10.20944/preprints202305.1584.v1

Prospective Comparative Analysis of Zero-Heat-Flux Thermometer (SpotOn®) Compared with Tympanic Thermometer and Bladder Thermometer in Extremely Aged Patients Undergoing Lower Extremity Orthopedic Surgery

Chunghyun Park, Taeyeun Kim, Soojeong Oh, Yun-Sic Bang

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Body temperature; Elderly patient; Orthopedic surgery; Zero-Heat-Flux thermometer

Online: 23 May 2023 (05:32:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1152.v1

Postoperative Hypothermia in Patients Undergoing Major Abdominal Surgery: A Cohort Study

Ashuin Kammar-García, Leidy Katerin Romero-Chacón, Sara Gabriela Guadarrama-Tovar, Javier Mancilla-Galindo, Manuel Alberto Guerrero-Gutiérrez, Diego Escarramán-Martínez, Fernando Aguilar-Silva

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Hypothermia; abdominal surgery; Risk factors

Online: 16 May 2023 (10:33:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0562.v1

Intra-Articular Facet Joint Injection of Normal Saline for Chronic Low Back Pain: A Systematic Review and Meta-Analysis

Areerat Suputtitada, Tanawin Nopsopon, Thanitsara Rittiphairoj, KRIT Pongpirul

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Facet joint injection; Chronic low back pain; Normal saline; Meta-analysis; Patient Reported Clinical Outcomes

Online: 9 May 2023 (04:22:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0264.v1

Exploring Artificial Intelligence in Anesthesia: A Primer on Ethics, and Clinical Applications

Marco Cascella, Maura C Tracey, Emiliano Petrucci, Elena Giovanna Bignami

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Artificial Intelligence; Machine Learning; Anesthesia; Ethics

Online: 4 May 2023 (11:11:19 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202304.0789.v1

Minimally-Invasive Postero-Inferior Sacroiliac Joint Fusion: Surgical Technique and Procedural Details

Usman Latif, Paul J Hubbell, Goran Tubic, Luis A Guerrero, Ioannis M Skaribas, Jon E Block

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: sacroiliac; fusion; intra-articular; minimally invasive

Online: 23 April 2023 (08:03:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0123.v2

Deciphering Pain in Vulnerable People with Chronic Conditions

Charlotte Faurie, Demi Cheng, Claire Duflos, Liset E.M. Elstgeest, Rosanna Ferreira, Hein Raat, Verushka Valsecchi, Alberto Pilotto, Graham Baker, Marta María Pisano-Gónzalez, Yves-Marie Pers

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; patient education; vulnerable populations; low income; quality of life

Online: 14 March 2023 (01:42:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0123.v1

Deciphering Pain in Vulnerable People with Chronic Conditions

Charlotte Faurie, Demi Cheng, Claire Duflos, Liset E.M. Elstgeest, Rosanna Ferreira, Hein Raat, Verushka Valsecchi, Alberto Pilotto, Graham Baker, Marta María Pisano-Gónzalez, Yves-Marie Pers

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; patient education; vulnerable populations; low income; quality of life

Online: 7 March 2023 (03:06:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0433.v1

Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models: Introduction of the “Ratox” Oxygenator and Preliminary In-Vitro Results

Lasse J Strudthoff, Jannis Focke, Felix Hesselmann, Andreas Kaesler, Ana Martins Costa, Peter Christian Schlanstein, Thomas Schmitz-Rode, Ulrich Steinseifer, Niklas Balduin Steuer, Bettina Wiegmann, Jutta Arens, Sebastian V. Jansen

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: ECLS; ECMO; animal model; rodent; rat; mouse; hamster; CPB; in-vivo; oxygenator

Online: 27 February 2023 (02:41:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0344.v1

Endothelial Function and Hypoxic-Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Irina A. Mandel, Yuriy K. Podoksenov, Sergey L. Mikheev, Irina V. Suhodolo, Yulia S. Svirko, Vladimir M. Shipulin, Andrey G. Yavorovskiy, Andrey I. Yaroshetskiy

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: oxygen transport; cardioprotection; hypoxic-hyperoxic preconditioning; ischemia-reperfusion injury; cardiopulmonary bypass; endothelial damage markers

Online: 20 February 2023 (15:14:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0338.v1

Intraoperative Beat-to-Beat Pulse Transit Time (PTT) Monitoring via Non-invasive Piezoelectric/Piezocapacitive Peripheral Sensors Can Predict Changes in Invasively Acquired Blood Pressure in High-Risk Surgical Patients

M Nordine, M Pille, J Kraemer, C Berger, P Brandhorst, P Kaeferstein, R Kopetsch, N Wessel, R Trauzeddel, S Treskatsch

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Piezoelectric; Piezocapacitive; Pulse transit time; Non-invasive hemodynamics; Intraoperative blood pressure; Anesthesiology

Online: 20 February 2023 (09:43:32 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202302.0023.v1

Pericapsular Nerves Group (PENG) Block in Children under Five Years of Age for Analgesia in Surgery for Hip Dysplasia: Case Report

Małgorzata Domagalska, Katarzyna Wieczorowska-Tobis, Tomasz Reysner, Alicja Geisler-Wojciechowska, Monika Grochowicka, Grzegorz Kowalski

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: pain; myelomeningocele; paralytic dislocation of the hip; congenital dislocation of the hip; Dega transiliac osteotomy

Online: 2 February 2023 (02:49:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0007.v1

Safety and Efficacy of Autologous Stem Cell Treatment for Facetogenic Chronic Back Pain

Ralf Dirk Rothoerl, Junee Tomelden, Eckhard Udo Alt

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Facet joint syndrome; adipose tissue-derived regenerative cells

Online: 1 February 2023 (04:40:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0488.v1

Chronic Use of the Synthetic Cannabinoid WIN 55,212-2 55 Modifies the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine

José Antonio Ibancovichi, Julio Raúl Chávez-Monteagudo, Pedro Sánchez-Aparicio, Marco Antonio De Paz-Campos

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: minimum alveolar concentration MAC; isoflurane; dexmedetomidine; morphine; synthetic cannabinoid WIN 55,212-2; rats

Online: 27 January 2023 (06:16:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0575.v1

New Perspectives on the Adverse Effects of NSAIDs in Cancer Pain: An Italian Delphi Study from the Rational Use of Analgesics (RUA) Group

Giustino Varrassi, Flaminia Coluzzi, Diego Fornasari, Flavio Fusco, Walter Gianni, Vittorio Guardamagna, Filomena Puntillo, Giovanni Sotgiu

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Cancer pain; NSAIDs; paracetamol; adverse events

Online: 30 November 2022 (14:11:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0215.v2

Recent Advances in Double-Lumen Tube Malposition in Thoracic Surgery: A Bibliometric Analysis and Narrative Literature Review

Xi Zhang, Dong-Xu Wang, Jing-Qiu Wei, He Liu, Si-Ping Hu

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Double lumen tube; Malposition; Thoracic surgery; Airway management; One-lung ventilation; Fiberoptic bronchoscopy; Bibliometric analysis

Online: 23 November 2022 (07:20:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0219.v1

A Mixed Comparison of Non-surgical Interventions for Pain Caused by Temporomandibular Disorders: Systematic Review and Network Meta-analysis

KOMNIVOC THARMO

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: TMDs; temporomandibular; TMJ; network meta-analysis; systematic review

Online: 11 November 2022 (07:04:36 CET)

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Abstract: Background: Pain management is one of the main parts of treatments for Temporomandibular Disorders (TMDs). However, there is still a lack of high-quality evidence that compare the overall effects of these non-surgical treatments. The objective of this systematic review is to identify the most potential treatment protocol in dealing with pain caused by TMDs through a mixed comparison of interventions based on network meta-analysis. Methods: A systematic review and network meta-analysis of studies identified by searching PubMed, Embase, Medline, Ovid, and CINAHL. All the included studies should have characteristics that: (1) participants with TMDs of any age; (2) non-surgical treatments; (3) score of Visual Analog Scale (VAS) as the outcome measure; (4) randomized controlled trials. The Cochrane Bias Assessment Toll was used to assess the bias, the CINeMA website was applied to rate the confidence of evidence, and ADDIS software was used to conduct the network meta-analysis. Results: 46 studies were included in this review. The agreement between authors reached a kappa value of 0.78. The results of the network meta-analysis showed that wearable therapy devices are more likely to be the best choice for reducing the pain of patients with myogenic TMDs, whereas a combination of platelet-rich plasma injection and wearable therapy devices is more likely to be the best choice for reducing the pain in a long term after treatment for patients with mix-type TMDs. Moreover, the application of therapy equipment has the most potential in reducing pain in a long term after treatment for patients with articular TMDs. Discussion: Wearable devices have a great potential for pain syndrome caused by TMDs, the mechanism might come from a biomechanical perspective. However, the overall confidence rating of evidence is low. Studies with high quality are still needed in the future. Other: The PROSPERO Registration Number of this systematic review is CRD42021253442.

Preprint ARTICLE | doi:10.20944/preprints202211.0172.v1

Identification of the Optimal Position of a Nasal Oxygen Cannula for Apneic Oxygenation - A Technical Simulation

Wolfgang A. Wetsch, Daniel C. Schröder, Susanne J. Herff, Bernd W. Böttiger, Volker Wenzel, Holger Herff

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: airway manikin; apnoeic oxygenation; denitrogenisation; desaturation; oxygen insufflation; test lung

Online: 9 November 2022 (09:05:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0215.v1

Recent Advances in Double-Lumen Tube Malposition in Thoracic Surgery: A Bibliometric Analysis and Narrative Literature Review

Xi Zhang, Dong-Xu Wang, Jing-Qiu Wei, He Liu, Si-Ping Hu

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Double lumen tube; Malposition; Thoracic surgery; Airway management; One-lung ventilation; Fiberoptic bronchoscopy; Bibliometric analysis

Online: 14 October 2022 (14:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0349.v1

Isoflurane Rescue Schizophrenia-related Deficits through Parvalbumin-positive Neurons in the Dentate Gyrus

Hualing Peng, Jie Jia, Yi-Sheng Lu, Hua Zheng

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: isoflurane; schizophrenia; adult neurogenesis; synaptic plasticity; parvalbumin-positive interneuron

Online: 23 September 2022 (02:05:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0194.v1

Pronounced Declines in Meperidine in the US: Is the End Imminent?

Lavinia R Harrison, Rhudjerry E. Arnet, Anthony Soto Ramos, Poul A. Chinga, Trinidy R. Anthony, John M. Boyle, Kenneth L. McCall, Stephanie D. Nichols, Brian J. Piper

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: opiate; pain; neurotoxicity; misuse

Online: 14 September 2022 (05:55:26 CEST)

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Background: Once a widely used analgesic in the United States (US), meperidine offered an alternative to other opioids as a pain reliever. However, within the last two decades, meperidine has gone from a drug to be utilized only when patients exhibit atypical reactions to opioids (e.g., morphine and hydromorphone) to being taken off the World Health Organization List of Essential Medications and receiving strong recommendations for the overall avoidance. The aim of this study was to identify changes in meperidine distribution in the US and regional disparities as reported to the Drug Enforcement Administration’s Automation of Reports and Consolidated Orders System (DEA ARCOS) and Medicaid. Methods: Data related to the meperidine distribution was obtained through ARCOS (2001 –2021) and Medicaid public use files (2016 –2021). Heat maps were used to visualize regional disparities in distribution by state. States outside a 95% confidence interval were statistically significant. Results: Meperidine distribution between 2001 and 2021 decreased by 97.4% (R=.-97, P < .0001). There was a 34-fold state-level difference in meperidine distribution between Arkansas (16.8 mg/10 persons) and Connecticut (0.5 mg/ 10 persons) in 2020. Meperidine distribution in 2020 was elevated in Arkansas, Mississippi, and Alabama. In 2021, Meperidine distribution was highest in Arkansas ( 1.67 /10 persons) and lowest in Connecticut (0.08 /10 persons). Total prescriptions of meperidine as reported by Medicaid decreased by 73.8% (R= -0.67, P = 0.045) between 2016 and 2021. Conclusion: We observed a decrease in the overall distribution of meperidine in the past two decades with similar recent declines in prescribing to Medicaid enrollees. The shortage of some parenteral formulations is an important contributor to these declines. This data may reflect plans to phase out the use of this opioid, especially in the many situations where preferred opioids are available.

Preprint ARTICLE | doi:10.20944/preprints202209.0178.v1

A Prospective Cohort Study: Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting

Marcin Wiech, Sławomir Żurek, Arkadiusz Kurowicki, Beata Horeczy, Mirosław Czczuwar, Paweł Piwowarczyk, Kazimierz Widenka, Michał Borys

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic postoperative pain; erector spinae plane block; coronary artery bypass grafting; Neuropathic Pain Symptom Inventory

Online: 13 September 2022 (11:24:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0043.v1

Professional Obstacles to Anaesthesiology Practice in Punjab, Pakistan: Qualitative Study of Consultant Anaesthesiologists’ Perspectives

Sumbal Shahbaz, Rubeena Zakar, Natasha Howard, Florian Fischer

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: anaesthesia; workforce challenges; qualitative research; Pakistan

Online: 5 September 2022 (04:30:46 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202208.0453.v1

A Misleading Preoperative Electrocardiogram

Chihjen Lee, Christian Seif

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: electrocardiogram; pulmonary hypertension; right axis deviation; dextrocardia; technical errors

Online: 26 August 2022 (09:27:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0447.v1

Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Approach

Magdi Hanna, Serge Perrot, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: low-back pain (LBP); guidelines; gaps; evidence-based; acute pain; analgesics; multimodal analgesia; fixed doses combination (FDC)

Online: 26 August 2022 (04:36:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0141.v1

Update on Current Concepts in Management of Severe Hemorrhagic Shock and Optimal Individualized Fluid Therapy in Critically Ill Polytrauma Patients

Alexandru Florin Rogobete, Stelian Adrian Ritiu, Ovidiu Horea Bedreag, Marius Papurica, Sonia Elena Popovici, Daiana Toma, Maria Alina Lupu, Diana Loreta Paun, Dragos Nicolae Garofil, Dan Corneci, Adriana Pistol, Elena Mihaela Pahontu, Liana Valeanu, Dorel Sandesc

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: hemorrhagic shock; multimodal monitoring; individualized therapy; fluid therapy; critical care; trauma

Online: 8 August 2022 (09:56:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0361.v1

Combining Awake Anesthesia with Minimal Invasive Surgery Optimizes Intraoperative Surgical Spinal Cord Stimulation Lead Placement

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Chantal Wood, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Emmanuel Cuny, Jimmy Voirin, Denys Fontaine, Sylvie Raoul, Patrick Mertens, Philippe Peruzzi, François Caire, Nadia Buisset, Romain David, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: PSPS; FBSS; SCS; surgical lead; SCS implantation; MAST (for Minimal Access Spine Technologies); TCIVA (for Target Controlled Intra-Veinous Anesthesia); composite score; pain mapping; neuropathic pain; chronic pain; quality of life; anesthesia; hypnosis

Online: 25 July 2022 (08:34:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0258.v1

Comparison of the Use of Desflurane vs. Propofol in Aortic Valve Replacement Surgery: Differences in Nephroprotection

Jose Luis Guerrero Orriach, Alfredo Malo-Manso, Mercedes Nuñez Galo, Inmaculada Bellido Estevez, Amalio Ruiz Salas, Jose Cruz Mañas, Lourdes Garrido Sanchez, Laura Gonzalez-Alvarez

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: desflurane; cardiac surgery; halogenated; kidney; heart; preconditioning

Online: 20 June 2022 (04:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0339.v1

Update on Interventional Management of Neuropathic Pain: A Delphi Consensus of the Spanish Pain Society Neuropathic Pain Task Force

Ancor Serrano-Afonso, Rafael Gálvez, Elena Paramés, Ana Navarro, Dolores Ochoa, Concepción Pérez-Hernández

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Neuralgia; Interventional Pain Management; Intractable Pain; Delphi Technique; Review

Online: 25 March 2022 (07:41:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0273.v1

Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2

José Antonio Ibancovichi, Julio Raul Chavez-Monteagudo, Pedro Sanchez-Aparicio, Sergio Recillas-Morales, Jorge Osorio-Avalos, Marco Antonio DePaz-Campos

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: MAC; Isoflurane; WIN 55,212-2; Rat

Online: 22 February 2022 (11:28:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0116.v1

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and EPAC : A Role for the Mitochondrial Permeability Transition Pore

Martin John Lewis, Igor Khaliulin, Katie Hall, M.Saadeh Suleiman

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Ischaemia/reperfusion injury; Development; Mitochondria; Immature Heart

Online: 10 January 2022 (13:38:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0468.v1

Opioids in the Elderly Patients with Cognitive Impairment: A Narrative Review

Martina Rekatsina, Antonella Paladini, Dariusz Myrcik, Omar Viswanath, Ivan Urits, Joseph Pergolizzi, Frank Breve, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: aging; elderly; pain; opioids; dementia; cognitive impairment

Online: 29 December 2021 (13:42:02 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202110.0386.v1

Causes and Treatment of Hypoxia During Total Hip Arthroplasty in Elderly Patients: Case Report

Jae Young Ji, Jin Hun Chung, Nan Seol Kim, Yong Han Seo, Ho Soon Jung, Hea Rim Chun, Hyung Yoon Gong, Woo Jong Kim, Jae Min Ahn, Yu Jun Park

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Atelectasis; Hypoxia; Old age; Spontaneous respiration

Online: 26 October 2021 (12:36:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0339.v1

Anesthetic Preconditioning of Traumatic Brain Injury is Ineffective in a Drosophila Model of Obesity

Dena Johnson-Schlitz, Julie A. Fischer, Hannah J. Schiffman, Amanda R. Scharenbrock, Zachariah P. G. Olufs, David A. Wassarman, Misha Perouansky

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Drosophila melanogaster; TBI; obesity; volatile anesthetics; isoflurane; sevoflurane; preconditioning; mortality; toxicity

Online: 25 October 2021 (10:28:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0010.v1

Machine Learning Algorithms Provide Greater Prediction of Response to Scs Than Lead Screening Trial: A Predictive AI-Based Multicenter Study

Amine Ounajim, Maxime Billot, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Nihel Adjali, Kevin Nivole, Nicolas Naiditch, Chantal Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: spinal cord stimulation; screening trial; infection; supervised learning; machine learning; predictive modeling; patient outcome

Online: 1 September 2021 (12:05:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0545.v1

A Novel Multi-dimensional Clinical Response Index Dedicated to Improving Global Assessment of Pain in Patients with Persistent Spinal Pain Syndrome After Spinal Surgery, Based on a Real-life Prospective Multicentric Study (PREDIBACK) and Machine Learning

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Nicolas Naiditch, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Nelly Grimaud, Nihel Adjali, Kevin Nivole, Mathilde Many, Romain David, Chantal H. Wood, Raphael Rigoard, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Composite score; Machine learning; PSPS; Failed Back Surgery Syndrome (FBSS); Chronic pain; Pain Intensity; Quality of Life; Pain Mapping; Pain Surface; Functional Capacity; Psychological Distress; Anxiety and Depression

Online: 30 August 2021 (13:04:51 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202010.0085.v1

Variability in Anesthesia Models of Care In Cardiac Surgery

Dianne McCallister, Bethany Malone, Jennifer Hanna, Michael S Firstenberg

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Cardiothoracic Surgery; Anesthesia Staffing Models; Outcomes; Operating Room Staffing; Handoffs; Quality; Communication

Online: 5 October 2020 (12:55:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0568.v1

Peter Sherren, Marlies Ostermann, Sangita Agarwal, Chris Meadows, Nicholas Ioannou, Luigi Camporota

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: SARS-CoV-2; COVID-19; respiratory failure; ARDS; ventilation; MODS; ECMO

Online: 24 July 2020 (04:00:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0426.v1

Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?

Carmela Falcone, Massimo Caracciolo, Pierpaolo Correale, Sebastiano Macheda, Eugenio Giuseppe Vadalà, Stefano La Scala, Marco Tescione, Roberta Danieli, Anna Ferrarelli, Maria Grazia Tarsitano, Lorenzo Romano, Antonino De Lorenzo

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: COVID-19; ARDS; Adenosine; CT-scan; Cytokines Storm

Online: 19 July 2020 (19:31:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0303.v1

Detecting Lower Back Pain Using Stacked Ensemble Approach

Samir Bandyopadhyay, Shawni Dutta

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Lower back pain; automated tool; ML; ensemble technique; stacked generalization

Online: 14 July 2020 (11:31:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0029.v1

Insights into the Epidemiology of the First Wave of COVID-19 ICU Admissions in South Wales – the Interplay between Ethnicity and Deprivation

Thomas Baumer, Emily Phillips, Amrit Dhadda, Tamas Szakmany, Gwent COVID-19 Group

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: COVID-19; ethnicity; BAME; deprivation

Online: 4 June 2020 (08:03:48 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0373.v1

COVID-19: Neutrophils “Unfriendly Fire” Imbalance Proteolytic Cascades Triggering Clinical Worsening and Viral Sepsis. Potential Role Explanation for Convalescent Plasma as “Fire Hose”

Pier Maria Fornasari

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: COVID-19; proteolytic cascades; thrombosis; viral sepsis

Online: 23 May 2020 (10:42:38 CEST)

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Working Paper CASE REPORT

Reducing Coughs in Weaning from Mechanical Ventilation Using the Supraglottic Airway Device I-gel in a Patient with COVID-19

Masayuki Ozaki, Yuma Yasuda, Naruhiro Jingushi, Yukari Goto, Atsushi Numaguchi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Covid-19; airway extubation; aerosols; laryngeal masks; occupational health

Online: 7 April 2020 (12:33:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0116.v1

Therapeutic Effects of Continuous Epidural Infusion of Local Anesthetics with Dexamethasone for Postherpetic Neuralgia

Eun Mi Choi, Mi Hwa Chung, Joo-Hyun Jun, Eun Hee Chun, In-Jung Jun, Jong Hee Park, Eun-Ha Choi, Jung Eun Kim

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: continuous epidural infusion; dexamethasone; dexamethasone pulse therapy; inflammation; local anesthetics; neuropathic pain; postherpetic neuralgia

Online: 7 March 2020 (03:22:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0020.v1

Situation Awareness–Oriented Patient Monitoring with Visual Patient Technology: A Qualitative Review of the Primary Research

David W. Tscholl, Julian Rössler, Sadiq Said, Alexander Kaserer, Donat R. Spahn, Christoph B. Noethiger

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: visual patient; patient monitoring; avatar-based technology; situation awareness; user-centered design

Online: 2 March 2020 (00:56:03 CET)

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Working Paper ARTICLE

The Role of Anesthesiologist and Selection of Effective Anesthesia Techniques in Lombok’s Earthquake Victim’s Management

Christrojogo Soemartono Sumartono, Soni Sunarso Sulistiawan, Bambang Pujo Semedi, Afifah Zahra Dzakiyah, Maria Arni Stella, Noryanto Ikhromi, Nahyani Nahyani, Elya Endriani, Eddy Rahardjo, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: effective anesthesia; earthquake; orthopedic; victim’s management

Online: 25 February 2020 (12:14:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0186.v1

Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study

Arturo Cuomo, Marco Cascella, Cira Antonietta Forte, Sabrina Bimonte, Gennaro Esposito, Stefano De Santis, Luigi Cavanna, Flavio Fusco, Mario Dauri, Silvia Natoli, Marco Maltoni, Alessandro Morabito, Rocco Domenico Mediati, Vito Lorusso, Sandro Barni, Giampiero Porzio, Sebastiano Mercadante, Anna Crispo

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: breakthrough cancer pain; cancer-associated pain; cancer; health-related quality of life; sleep disorders; transmucosal fentanyl

Online: 14 February 2020 (03:36:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0130.v1

Impact of General Anaesthesia - Guided by State Entropy (SE) and Response Entropy (RE) on Perioperative Stability in Elective Laparoscopic Cholecystectomy Patients. A Prospective Observational Randomized Monocentric Study

Anca Raluca Dinu, Alexandru Florin Rogobete, Sonia Elena Popovici, Ovidiu Horea Bedreag, Marius Papurica, Corina Maria Dumbuleu, Raluca Ramona Velovan, Daiana Toma, Corina Maria Georgescu, Lavinia Ioana Trache, Claudiu Barsac, Loredana Luca, Bettina Buzzi, Andra Maghiar, Mihai Alexandru Sandesc, Samir Rimawi, Madalin Marian Vaduva, Lavinia Melania Bratu, Paul Luminosu, Dorel Sandesc

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: state entropy; response entropy; general anaesthesia; patient safety; recovery.

Online: 10 February 2020 (15:24:34 CET)

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Study background and aims: Laparoscopic cholecystectomy is one of the most frequently performed interventions in departments of general surgery. One of the most important aims in achieving perioperative stability of these patients is diminishing the impact of general anesthesia on the hemodynamic stability and the optimization of anesthetic drug doses based on the individual clinical profile of each patient. The objective of this study is the evaluation of the impact monitoring the depth of anesthesia through Entropy (state entropy – SE and response entropy -RE) has on the hemodynamic stability and on the doses of volatile anesthetic. Material and Methods: This is a prospective, observational, randomized, monocentric study carried out between January 2019 and December 2019 in the Clinic of Anesthesia and Intensive Care from the “Pius Brînzeu” Emergency County Hospital in Timișoara, Romania. The patients included in the study were divided in two study groups; patients in Group A (target group) received multimodal monitoring that included monitoring of standard parameters and of Entropy (SE and RE), while patients in Group B (control group) only received standard monitoring. Anesthetic dose in group A were optimized to achieve a target entropy of 40-60. Results: 68 patients met the inclusion criteria and were allocated to one of the two study groups, Group A (N=43) and Group B (N=25). There were no statistically significant differences identified between the two groups for both demographical and clinical data (p>0.05). Statistically significant differences have been identified for the number of hypotensive episodes (p = 0.011, 95% CI 0.1851 to 0.7042) and for the number of episodes of bradycardia (p < 0.0001, 95% CI 0.3296 to 0.7923). Moreover, there was a significant difference in the Sevoflurane consumption between the two study groups (p = 0.0498, 95% CI -0.3942 to 0.9047). Conclusions: The implementation of the multimodal monitoring protocol that includes the standard parameters and the measurement of Entropy for determining the depth of anesthesia (SE and RE) lead to a considerable improvement in perioperative hemodynamic stability. Optimizing the doses of anesthetic drugs based on the individual clinical profile of each patient leads to a considerable decrease in drug consumption as well as to a lower incidence of hemodynamic side-effects.

Preprint ARTICLE | doi:10.20944/preprints202002.0093.v1

Paravertebral Block Versus Preemptive Ketamine Effect on Pain Intensity after Posterolateral Thoracotomies: A Randomized Controlled Trial

Michał Borys, Agata Hanych, Mirosław Czuczwar

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Ketamine; Paravertebral block; Posterolateral thoracotomy; Thoracotomy; Visual analog scale

Online: 7 February 2020 (09:28:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0378.v1

The Effect of Whole Blood Viscosity on Intraoperative Graft Flow during Coronary Artery Bypass Graft Surgery: An Observational Pilot Study

Sang-Wook Lee, Jun-Young Jo, Wook-Jong Kim, Dae-Kee Choi, In-Cheol Choi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: blood viscosity; transit-time flow measurement; coronary artery bypass surgery

Online: 29 December 2019 (10:22:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0101.v1

Association between Neuropathic Pain Characteristics and DNA Methylation of TRPA1 in Human Peripheral Blood

Shiho Takenaka, Norihiko Sukenaga, Mai Imasaka, Masaki Ohmuraya, Yuka Matsuki, Lynn Maeda, Yumiko Takao, Munetaka Hirose

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; epigenetics; neuropathic pain; postoperative pain; thoracic surgery; video-assisted

Online: 10 November 2019 (09:29:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0330.v1

Effects of Volatile Versus Total Intravenous Anesthesia on Occurrence of Myocardial Injury after Non-Cardiac Surgery

Jihye Kwon, Jungchan Park, Seung-Hwa Lee, Ah-ran Oh, Jong-Hwan Lee, Jeongjin Min

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: myocardial injury after non-cardiac surgery; anesthetic technique; high-sensitivity troponin i

Online: 29 September 2019 (07:08:24 CEST)

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The cardioprotective effects of volatile anesthetics versus total intravenous anesthesia (TIVA) are controversial, especially in patients undergoing non-cardiac surgery. Using current generation high-sensitivity cardiac troponin (hs-cTn), we aimed to evaluate the effect of anesthetics on the occurrence of myocardial injury after non-cardiac surgery (MINS). From February 2010 to December 2016, 3555 patients without preoperative hs-cTn elevation underwent non-cardiac surgery under general anesthesia. Patients were grouped according to anesthetic agent; 659 patients were classified into a propofol-remifentanil total intravenous anesthesia (TIVA) group, and 2896 patients were classified into into a volatile group. To balance the use of remifentanil between groups, a balanced group (n=1622) was generated with patients who received remifentanil infusion in the volatile group, and two separate comparisons were performed (TIVA vs. volatile and TIVA vs. balanced). The primary outcome was occurrence of MINS, defined as rise of hs-cTn I ≥ 0.04 ng/mL within postoperative 48 hours. The secondary outcomes were 30-day mortality, postoperative acute kidney injury (AKI), and adverse events during hospital stay (mortality, type I myocardial infarction (MI), and new-onset arrhythmia). In propensity-matched analyses, the occurrence of MINS was lower in the TIVA group compared to the volatile group (OR 0.642; 95% CI 0.450-0.914; p = 0.014). However, after balancing the use of remifentanil, there was no difference between groups in the risk of MINS (OR 0.832; 95% CI 0.554-1.251; p-value = 0.377). There were no significant associations between the two groups in type 1 MI, new-onset atrial fibrillation, in-hospital and 30-day mortality before and after balancing the use of remifentanil. However, the incidence of postoperative AKI was lower in the TIVA group (OR 0.362; 95% CI 0.194-0.675; p-value = 0.001). After balancing the use of remifentanil, volatile anesthesia and TIVA showed comparable effects on MINS in patients undergoing non-cardiac surgery without preoperative myocardial injury. Further studies are needed on the benefit of remifentanil infusion.

Working Paper REVIEW

Non-Canonical Ion Channel Behaviour in Pain

Cosmin I. Ciotu, Christoforos Tsantoulas, Jannis Meents, Angelika Lampert, Steve McMahon, Andreas Ludwig, Michael J.M. Fischer

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: pharmacology; drug development; sodium channel; potassium channel; TRP channel; HCN channels

Online: 8 August 2019 (12:31:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0030.v1

Respiratory Variations in Electrocardiographic R-Wave Amplitude during Acute Hypovolemia Induced by Inferior Vena Cava Clamping in Patients Undergoing Liver Transplantation

Hee-Sun Park, Sun-Hoon Kim, Yong-Seok Park, Robert H Thiele, Won-Jung Shin, Gyu-Sam Hwang

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Brody effect; electrocardiographic variation; R-wave amplitude; hemodynamic monitoring; pulse pressure variation

Online: 2 April 2019 (12:19:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0005.v1

Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study

Sun-Joon Bai, Ki-Young Lee, Sung Soo Kim, Jung Hwa Hong, Hoon Jae Nam, Jae Chul Koh, Na Young Kim

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: anaesthesia, general; anaesthesia recovery period; single dose of rocuronium; sugammadex; neostigmine

Online: 8 November 2018 (14:00:01 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0134.v1

Chronic Pediatric Pain in Low and Middle Income Countries

Camila Walters, Matthew Kynes, Jenna Sobey, Tsitsi Chimhundu-Sithole, Kelly McQueen

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pediatric pain; low income country; middle income country; low and middle income country; pediatric palliative care.

Online: 8 June 2018 (12:45:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0083.v1

Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway

Jing Xu, R. Paige Mathena, Michael Xu, YuChia Wang, CheJui Chang, Yiwen Fang, Pengbo Zhang, Roger A. Johns, C. David Mintz

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: anesthesia; neurotoxicity; synapse; mTOR; neurodevelopment

Online: 6 June 2018 (10:36:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0364.v1

Preoperative and Postoperative Assessment of Ultrasonographic Measurement of Inferior Vena Cava: a Prospective, Observational Study

Ayhan Kaydu, Erhan Gökçek

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: ultrasonography; preoperative; postoperative; collabsibility index; inferior vena cava diameter

Online: 25 May 2018 (11:42:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0319.v1

Culture, ageing and the construction of pain

Pauline Lane, David Smith

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: culture, ageing, pain, idioms of distress, somatisation, cultural concepts of distress, stoicism

Online: 24 April 2018 (17:13:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints201712.0172.v1

Inhospital Palliative Care: Should We Need to Reconsider What Role Hospitals Should Have in Patients with End-Stage Disease or Advanced Cancer?

Paolo Cotogni, Andrea Saini, Anna De Luca

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: palliative care team; seriously ill patients; end-of-life; quality of life; symptom relief; acute palliative care unit; cost savings

Online: 25 December 2017 (08:50:18 CET)

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Medicine and Pharmacology