Liu, L.; Chen, H.; Yang, Z.; Wei, J.; Xi, Z. C,C- and C,N-Chelated Organocopper Compounds. Molecules2021, 26, 5806.
Liu, L.; Chen, H.; Yang, Z.; Wei, J.; Xi, Z. C,C- and C,N-Chelated Organocopper Compounds. Molecules 2021, 26, 5806.
Copper-catalyzed and organocopper-involved reactions are of great significance in organic synthesis. To have a deep understanding of the reaction mechanisms, the structural characterizations of organocopper intermediates become indispensable. Meanwhile, the structure-function relationship of organocopper compounds would advance rational design and development of new Cu-based reactions and organocopper reagents. Compared to the mono-carbonic ligand, the C,N- and C,C-bidentate ligands better stabilize the unstable organocopper compounds. The bidentate ligands can chelate to the same copper atom via ?2-mode, forming a mono-cupra-cyclic compounds with at least one acute C-Cu-C angle. When the bidentate ligands bind to two copper atoms via ?1-mode at each coordinating site, the bimetallic macrocyclic compounds will form nearly linear C-Cu-C angles. The anionic coordinating sites of the bidentate ligand can also bridge two metals via ?2-mode, forming organocopper aggregates with Cu-Cu interactions and organocuprates with contact ion pair structures. The reaction chemistry of some selected organocopper compounds is highlighted, showing their unique structure-reactivity relationships.
organocopper; C,N-chelated; C,C-chelated; bidentate; butadienyl; intramolecular coordination; three center-two electron bonds; structure-reactivity relationship
CHEMISTRY, Inorganic & Nuclear Chemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.