Version 1
: Received: 20 July 2023 / Approved: 20 July 2023 / Online: 20 July 2023 (09:38:36 CEST)
How to cite:
Ding, Z.; Wei, Y.; Peng, J.; Wang, S.; Chen, G.; Sun, J. The Role of C-reactive Protein in Aging associated NAFLD. Preprints2023, 2023071406. https://doi.org/10.20944/preprints202307.1406.v1
Ding, Z.; Wei, Y.; Peng, J.; Wang, S.; Chen, G.; Sun, J. The Role of C-reactive Protein in Aging associated NAFLD. Preprints 2023, 2023071406. https://doi.org/10.20944/preprints202307.1406.v1
Ding, Z.; Wei, Y.; Peng, J.; Wang, S.; Chen, G.; Sun, J. The Role of C-reactive Protein in Aging associated NAFLD. Preprints2023, 2023071406. https://doi.org/10.20944/preprints202307.1406.v1
APA Style
Ding, Z., Wei, Y., Peng, J., Wang, S., Chen, G., & Sun, J. (2023). The Role of C-reactive Protein in Aging associated NAFLD. Preprints. https://doi.org/10.20944/preprints202307.1406.v1
Chicago/Turabian Style
Ding, Z., Guixi Chen and Jiazeng Sun. 2023 "The Role of C-reactive Protein in Aging associated NAFLD" Preprints. https://doi.org/10.20944/preprints202307.1406.v1
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a liver metabolism-associated steatohepatitis caused by non-alcoholic factors. NAFLD is currently the most prevalent liver disease in the world, affecting one-fourth of the world's population, and its prevalence increases with age. There are no approved drugs specifically for the treatment of NAFLD, and one important reason hindering drug development is the lack of effective biomarkers. C-reactive protein (CRP), a marker of inflammation, has been linked to NAFLD and aging in recent studies. Coincidentally, hepatocytes are responsible for the major CRP production, and the levels of CRP increase with age. Therefore, CRP is not only a potential marker, but also acts as a key factor driving liver aging and NAFLD. Herein, we reviewed the biological function and production mechanism of CRP and the relationship between CRP and NAFLD. We also comprehensively described the potential molecular mechanisms of CRP-mediated signaling in aging-associated NAFLD. Finally, we proposed possible therapeutic approaches based on the mechanism of CRP signaling in the pathogenesis of NAFLD. We hope this study can provide new insights into the development of aging associated NAFLD biomarkers and suggest that modulation of CRP signaling is a potential therapeutic target.
Keywords
NAFLD; C-reactive Protein; Aging
Subject
Biology and Life Sciences, Aging
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
