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Preprint REVIEW | doi:10.20944/preprints202305.2112.v1

An Energy-Saving Distribution of Mitochondria Activation of ATP Production in Skeletal Muscle. A Design That Minimizes Mitochondria Ros Production

Alejandra E Espinosa, Mariana Casas, Enrique Jaimovich

Subject: Biology And Life Sciences, Aging Keywords: ATP production; mitochondrial network; mitochondria dynamics, MCU

Online: 30 May 2023 (10:32:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1990.v1

The Central Role of the Kynurenine Pathway of Tryptophan Metabolism in the Pathophysiology of Frailty, Sarcopenia and Osteoporosis

Juan Ballesteros, Daniel Rivas, Gustavo Duque

Subject: Biology And Life Sciences, Aging Keywords: Tryptophan; Kynurenine pathway; Aging; older adults; Inflammation; Osteoporosis; Sarcopenia; Frailty; Biomarkers; Osteosarcopenia

Online: 29 May 2023 (07:32:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1776.v1

Disruption of Mitochondrial Unfolded Protein Response Results in Telomere Shortening in Mouse Oocytes and Somatic Cells

Mauro Cozzolino, Yagmur Ergun, Emma Ristori, Akanksha Garg, Gizem Imamoglu, Emre Seli

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; aging; Clpp; mitochondrial dysfunction; unfolded protein response

Online: 25 May 2023 (08:50:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1260.v1

Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1 KO Model of Mitochondrial Dysfunction and Oxidative Stress

Winston JT Tan, Joseph Santos-Sacchi, Jane Tonello, Anil Shanker, Alla V Ivanova

Subject: Biology And Life Sciences, Aging Keywords: Age-related hearing loss; cochlea; Fus1/Tusc2; mitochondria; mitochondrial dysfunction; oxidative stress; 2-deoxy-D-glucose; Rapamycin; Seahorse Metabolism Analysis

Online: 18 May 2023 (02:25:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1128.v1

Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and Disease

Kuniyasu Soda

Subject: Biology And Life Sciences, Aging Keywords: Polyamine; Spermine; Spermidine; Lifespan extension; Polyamine-rich food; age-related disease; Inflammation; Gene methylation; LFA-1

Online: 16 May 2023 (08:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0655.v1

Cognitive Aging in Older Breast Cancer Survivors

James C Root, Yuelin Li, Elizabeth Schofield, Irene Orlow, Elizabeth Ryan, Tiffany Traina, Sunita Patel, Tim A Ahles

Subject: Biology And Life Sciences, Aging Keywords: cancer; cognition; aging; deficit accumulation

Online: 9 May 2023 (12:37:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0598.v1

Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Wei Xu, Xiaodong Li

Subject: Biology And Life Sciences, Aging Keywords: circadian rhythms; aging; suprachiasmatic nucleus; peripheral clock; inflammatory response

Online: 9 May 2023 (08:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1128.v1

Mitochondrial Function-Associated APOE Locus and its Implication in Alzheimer’s Disease and Aging

Eun-Gyung Lee, Lesley Leong, Sunny Chen, Jessica Tulloch, Chang-En Yu

Subject: Biology And Life Sciences, Aging Keywords: APOE locus; TOMM40; APOE; oxidative stress; mitochondrial dysfunction; mitochondrial DNA copy number; gene expression; Alzheimer’s disease; aging

Online: 28 April 2023 (07:08:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1049.v1

How Aging Affects Insulin Resistance, Insulin Secretion, and Glucose Effectiveness in Subjects with Normal Blood Glucose and Body Weight

Li-Ying Huang, Chi-Hao Liu, Fang-Yu Chen, Chun-Heng Kuo, Pietro Pitrone, Jhih-Syuan Liu

Subject: Biology And Life Sciences, Aging Keywords: first-phase insulin secretion; second-phase insulin secretion; insulin resistance; glucose effectiveness; type 2 diabetes

Online: 27 April 2023 (05:23:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0336.v1

Plankton Genes and Extracellular Organic Substances in the Ocean

Ian R. Jenkinson

Subject: Biology And Life Sciences, Aging Keywords: ocean; phytoplankton; bacteria; biogeochemistry; rheology; genomics

Online: 20 March 2023 (03:07:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0255.v3

How Much of Aging Is Simply a Trash Collection Problem?

Michael Renteln

Subject: Biology And Life Sciences, Aging Keywords: Anti-aging therapy; lipofuscin; SENS; oncolytic vector; telomerase; TFEB; intracellular microbe

Online: 22 February 2023 (15:24:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0255.v2

How Much of Aging Is Simply a Trash Collection Problem?

Michael Renteln

Subject: Biology And Life Sciences, Aging Keywords: Anti-aging therapy; lipofuscin; SENS; oncolytic vector; telomerase; TFEB; intracellular microbe

Online: 22 February 2023 (10:46:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0021.v1

Traumatic Brain Injury Induced Microglial and Caspase3 Activation in the Retina

Tamás Kovács-Öller, Renáta Zempléni, Boglárka Balogh, Gergely Szarka, Bálint Fazekas, Ádám J Tengölics, Krisztina Amrein, Endre Czeiter, István Hernádi, András Büki, Béla Völgyi

Subject: Biology And Life Sciences, Aging Keywords: TBI; brain; injury; microglia; caspase; apoptosis; retina; degeneration

Online: 3 January 2023 (08:38:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0326.v1

Unravelling Effects of Anti-aging Drugs on C. elegans using Liposomes

Aihan Zhang, Kuei Ching Hsiung, Carina Kern, Yuting Wang, Anna Girtle, Nuo Xu, David Gems

Subject: Biology And Life Sciences, Aging Keywords: C. elegans; drug; infection; lifespan; liposome; methodology

Online: 19 December 2022 (06:47:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0313.v1

Proteomic Analysis of Anti-Aging Effects of Dendrobium Nobile Lindl. Alkaloids in Aging-Accelerated SAMP8 Alzheimer’s Mice

Bo Liu, Ling-li Lv, Ping Liu, Yun-yan Xu, Jie Liu, Jing-Shan Shi

Subject: Biology And Life Sciences, Aging Keywords: SAMP8 and SAMR1 mice; DNLA (Dendrobium nobile Lindl. alkaloids); Cognition; Nissl staining; Phosphorylated Proteomics; Bioinformatics

Online: 19 December 2022 (03:32:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0564.v1

Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases

Francesca Faggioli, Micheal Velarde, Christopher D. Wiley

Subject: Biology And Life Sciences, Aging Keywords: cellular senescence; metastasis; metabolic adaptation; invasion

Online: 30 November 2022 (04:23:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0248.v1

Resolving Darwin’s Dilemma over Natural Selection, Individual Benefit and Aging-on the Natural Selection of Organismal Aging

Richard Walker

Subject: Biology And Life Sciences, Aging Keywords: Trade-off of survival for reproduction; natural selection of aging; regulatory redundancy; aging’s individual benefit; regulatory molecular biology; Darwin’s dilemma; aging-reproduction trade-off; aging declines force of selection; master gene; holistic regulatory mechanism

Online: 18 October 2022 (04:36:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0055.v1

Anticancer and Apoptotic Activity in Cervical Adenocarcinoma HeLa using Crude Extract from Spike of Stomopneustes variolaris

Anley Teferra Kiddane, Weerathunga Arachchige Shiran Chamika, Min-Jae Kang, Maheshkumar Prakash Patil, Byung-Soo Chun, Gun-Do Kim

Subject: Biology And Life Sciences, Aging Keywords: Adenocarcinoma HeLa; Anticancer; Apoptosis; Crude extract; Stomopneustes variolaris

Online: 5 September 2022 (09:31:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0317.v1

Chickpea Water and Chickpea Polyphenols Induce Apoptosis and Alleviate Cell Migration In Vitro in Human Colon Adenocarcinoma Cells

Heidi Bochenek, Nidhish Francis, Abishek B. Santhakumar, Christopher L. Blanchard, Kenneth A. Chinkwo

Subject: Biology And Life Sciences, Aging Keywords: chick pea; chick pea water; apoptosis; cytotoxicity; colorectal cancer; polyphenols

Online: 22 June 2022 (11:50:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0116.v1

A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease, Frontotemporal Dementia, Subjective Cognitive Decline, and the Evaluation of Candidate Proteins for Immunoassay Calibration

Shreyasee Das, Nele Dewit, Dirk Jacobs, Yolande A.L. Pijnenburg, Sjors G.J.G. In 't Veld, Salomé Coppens, Milena Quaglia, Christophe Hirtz, Charlotte E Teunissen, Eugeen J.M. Vanmechelen

Subject: Biology And Life Sciences, Aging Keywords: Neurofilament-light; biomarker; immunoassay; ELISA; calibrator

Online: 9 May 2022 (10:14:52 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202109.0437.v2

The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’s

Victor Lau, Leanne Ramer, Marie-Ève Tremblay

Subject: Biology And Life Sciences, Aging Keywords: Alzheimer's; Cellular senescence; Neurodegeneration; Microglia; Astrocytes; Oligodendrocyte Progenitor Cells; TREM2; Braak staging; Oxidative stress; Phapoptosis; Amyloid-beta; Tau; Neuritic plaques

Online: 7 March 2022 (14:22:25 CET)

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Alzheimer’s disease (AD) predominantly occurs as a late-onset form (LOAD), involving neurodegeneration and cognitive decline with progressive memory loss. Over time, risk factors and aging promote accumulation of well-known AD pathologies in oxidative stress, amyloid-beta and tau protein pathology, as well as inflammation. Homeostatic glial functions regulate and suppress these AD pathologies; however, other glial states involve increased pro-inflammatory cytokine release and further pathology accumulation. Different stresses can additionally induce cellular senescence, or an irreversible differentiation process resulting in decreased supportive functions and increased, pro-inflammatory cytokine release. While these pathophysiological underpinnings all contribute to LOAD, they require temporal and mechanistic integration. This perspective hypothesizes that when individuals have threshold senescent glia accumulation, they transition from healthy cognition into mild cognitive impairment and LOAD diagnosis. Particularly, senescent microglia are predicted to represent a final threshold required for the tau pathology burden and spreading that corresponds to sustained neurodegeneration and dementia severity. We first explore age-related decline in glia that promote increases in AD pathologies, and then discuss emerging evidence linking oxidative stress, neurons containing tau pathology, and amyloid-beta to microglia, oligodendrocyte progenitor cell, and astrocyte senescence. Our hypothesis proposes that senescent astrocytes and oligodendrocyte progenitors pressure microglia to phagocytose neurons containing tau pathology. The resulting senescent microglia would form neuritic plaques and induce paracrine senescence transitioning into a progressive clinical dementia presentation. This predictive hypothesis can potentially account for why medications used to treat LOAD fail, as previous treatments have not reduced senescent glial burden. It is also coherent with the predominant hypotheses surrounding LOAD, generates testable hypotheses about LOAD, and increases rationale in testing senolytics as targeted treatments for LOAD arrest and reversal.

Preprint HYPOTHESIS | doi:10.20944/preprints202202.0033.v1

Dietary Restriction And Lifespan: Adaptive Reallocation Or Somatic Sacrifice?

Matthew Piper, Brooke Zanco, Carla Sgrò, Margo Adler, Christen Mirth, Russell Bonduriansky

Subject: Biology And Life Sciences, Aging Keywords: life histories; ageing; fecundity; nutrient balance; evolution

Online: 2 February 2022 (12:55:42 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202109.0437.v1

How Senescent Glia Drive And Underlie Alzheimer’s Disease: A Predictive Model

Victor Lau, Leanne Ramer, Marie-Ève Tremblay

Subject: Biology And Life Sciences, Aging Keywords: Alzheimer's; Cellular senescence; Neurodegeneration; Microglia; Astrocytes; Oligodendrocyte Progenitor Cells; TREM2; Braak staging; Oxidative stress; Phapoptosis, Amyloid-beta; Tau; Neuritic plaques

Online: 24 September 2021 (14:08:13 CEST)

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Alzheimer’s disease (AD) predominantly occurs as a late-onset form (LOAD), involving neurodegeneration and cognitive decline with progressive memory loss. Over time, risk factors and aging promote accumulation of well-known AD hallmarks in oxidative stress, amyloid-beta and tau protein pathology, as well as inflammation. Homeostatic glial functions regulate and suppress these AD hallmarks; however, other glial states involve increased pro-inflammatory cytokine release and further hallmark accumulation. Different stresses can additionally induce cellular senescence, or an irreversible differentiation process resulting in decreased supportive functions and increased, pro-inflammatory cytokine release. While these pathophysiological underpinnings all contribute to LOAD, they require temporal and mechanistic integration. This Perspective proposes that traditional AD hallmarks induce glial senescence in LOAD, where sufficient senescent glia exacerbate ongoing AD pathology and primarily drive LOAD into clinical, cognitive decline. We first explore age-related increases in pro-inflammatory glial activity, and then discuss emerging evidence linking oxidative stress, neurons containing tau pathology, and amyloid-beta to microglia, oligodendrocyte progenitor, and astrocyte senescence. Our evidence-based model mainly predicts that senescent astrocytes and oligodendrocyte progenitors together pressure microglia to phagocytose neurons containing tau pathology, where resulting senescent microglia create neuritic plaques and induce paracrine senescence transitioning into and progressing clinical, dementia presentation. This predictive model accounts for why medications used to treat LOAD fail, as previous treatments have not reduced senescent glial burden. It is also coherent with the predominant hypotheses surrounding LOAD involving the amyloid cascade, tau, glia and inflammation, creates testable hypotheses about LOAD, and increases rationale in testing senolytics as targeted treatments for LOAD arrest and reversal.

Preprint REVIEW | doi:10.20944/preprints202109.0087.v1

Regenerating Damaged Myocardium: A Review of Stem-Cell Therapies for Heart Failure

Dihan Fan, Hanrong Wu, Huashan Peng, Kaichao Pan, Rongxue Wu

Subject: Biology And Life Sciences, Aging Keywords: iPSCs; ESC; differentiation; Cardiovascular disease, Myocardial repair

Online: 6 September 2021 (12:03:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0256.v1

Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells

Raquel Luna-Yolba, Justine Marmoiton, Véronique Gigo, Xavier Marechal, Emeline Boet, Ambrine Sahal, Nathalie Alet, Ifat Abramovich, Eyal Gottlieb, Virgile Visentin, Michael R. Paillasse, Jean-Emmanuel Sarry

Subject: Biology And Life Sciences, Aging Keywords: OxPHOS 1; Immune-checkpoints 2; AML 3.

Online: 9 June 2021 (10:58:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0564.v1

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Vincenzo Nobile, Irene Schiano, Ana Peral, Silvana Giardina, Eleanora Sparta, Nuria Caturla

Subject: Biology And Life Sciences, Aging Keywords: air pollution; skin; nutraceutical; natural compound; polyphenols; antioxidant; skin barrier; anti-agein; clinical trial

Online: 24 September 2020 (04:38:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0485.v1

Analysis of Age-Based Bone Mineral Density in the Koran Adult population using Dual Energy X-ray Absorptiometry

Jung Chul Lee, Hee-Joo Lee, Jaeyong Park

Subject: Biology And Life Sciences, Aging Keywords: DEXA; BMD; BMC; Osteoporosis; BMI; Aging

Online: 21 August 2020 (11:29:10 CEST)

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Working Paper REVIEW

Death Happy: Adaptive Ageing and Its Evolution by Kin Selection in Organisms with Colonial Ecology

David Gems, Evgeniy Galimov

Subject: Biology And Life Sciences, Aging Keywords: adaptive death; ageing; altruism; C. elegans; kin selection; salmon

Online: 4 August 2020 (11:26:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0741.v1

Habitual Exercise Attenuates the Aging Associated Muscle Atrophy and Muscle Strength Decline in SAMP8

Kai Aoki, Masaki Konno, Katsunari Honda, Takuya Abe, Takeshi Nagata, Masaaki Takehara, Takehito Sugasawa, Kazuhiro Takekoshi, Hajime Ohmori

Subject: Biology And Life Sciences, Aging Keywords: Aging; Habitual exercise; SAMP8; Sarcopenia

Online: 31 July 2020 (09:55:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0672.v1

Mathematical Connection Between Short Telomere Induced Senescence Calculation and Mortality Rate Data

Jerry B. Torrance, Steve Goldband

Subject: Biology And Life Sciences, Aging Keywords: aging; telomeres; senescence; mortality; disease

Online: 28 July 2020 (10:07:22 CEST)

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Working Paper ARTICLE

Inhibition of DNA Repair Pathways and Induction of ROS are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

Suzanne Bakewell, Isabel Conde, Yassi Fallah, Mathew McCoy, Lu Jin, Ayesha Shajahan-Haq

Subject: Biology And Life Sciences, Aging Keywords: breast cancer; BOLD-100; olaparib; triple negative breast cancer

Online: 22 July 2020 (10:00:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0182.v2

COVID-19 and Crosstalk With the Hallmarks of Aging

Shabnam Salimi, John M. Hamlyn

Subject: Biology And Life Sciences, Aging Keywords: COVID-19; pandemic; comorbidity; aging; hallmarks of aging; anti-aging

Online: 16 May 2020 (18:25:28 CEST)

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Working Paper ARTICLE

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Xing Li, Tomohiro Matsumoto, Miho Takuwa, Mahmood Saeed Ebrahim Shaikh Ali, Takumi Hirabayashi, Hiroyo Kondo, Hidemi Fujino

Subject: Biology And Life Sciences, Aging Keywords: astaxanthin; antioxidant; skin; ultraviolet; photoaging; capillary

Online: 20 January 2020 (09:55:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0105.v1

Protective Effect of New Formulation of Carnosine+Hyaluronic Acid on the Inflammation and Cartilage Degradation in the Experimental Model of Osteoarthritis

Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Alessio F. Peritore, Enrico Gugliandolo, Ramona D'Amico, Roberta Fusco, Rosalia Crupi, Enrico Rizzarelli, Salvatore Cuzzocrea, Susanna Vaccaro, Mariafiorenza Pulicetta, Valentina Greco, Sebastiano Sciuto, Antonella Schiavinato, Luciano Messina, Rosanna Di Paola

Subject: Biology And Life Sciences, Aging Keywords: osteoarthritis; carnosine; hyaluronic acid; inflammation; oxidative stress

Online: 11 January 2020 (11:17:18 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202001.0090.v1

CaReMoOC: Capacity, Reserve, Movement Objectives, and Compensation. A New Framework to Describe Mechanisms of Movement Limitations, Demonstrated for Ageing

Eline van der Kruk, Anne K Silverman, Louis Koizia, Peter Reilly, Michael Fertleman, Anthony M J Bull

Subject: Biology And Life Sciences, Aging Keywords: Biomechanics; Ageing; Human Movement; Mobility Impairments; Capacity; Reserve; Compensation; Geriatrics; Modelling; Rehabilitation

Online: 9 January 2020 (14:03:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0089.v1

The Effect of Ageing on the Standing Up Movement Analysed using the Capacity, Reserve, Movement Objectives, and Compensation (CaReMoOC) Framework

Eline van der Kruk, Anne K Silverman, Peter Reilly, Anthony M J Bull

Subject: Biology And Life Sciences, Aging Keywords: Ageing; CaReMoOC; Biomechanics; Motor Control; Rehabilitation; movement limitations; movement impairments

Online: 9 January 2020 (14:00:26 CET)

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In healthy ageing, capacity declines in the neural, muscular, and skeletal systems, and each system decline has its effect on the execution of complex motor tasks. This decline in capacity can result in the inability to stand up (sit-to-stand, sit-to-walk), which is a key movement for independence. The mechanisms leading to mobility limitations or inabilities are complex, overlapping, and interdependent and the complementary fields of biomechanics, motor control, and physiology need to be combined to understand these mechanisms. The aim of this review is to provide an overview of the current knowledge of age-related compensation in standing up and to consider the limitations of these results when analysing standing up in daily life using the Capacity, Reserve, Movement Objectives, and Compensation (CaReMoOC) framework that combines biomechanics, motor control, and physiology. A literature search was performed in the search engine Scopus, using the keywords and their synonyms: strateg*(approach, technique, way) AND, sit-to-walk OR sit-to-stand OR rise (raise, arise, stand, stand-up) AND chair (seat). Inclusion criteria were: biomechanics or motor control on sit-to-stand or sit-to-walk in healthy and/or frail adults (<60y) and elderly (>60y), and/or osteoarthritis patients as a specific case of ageing related decline. The review shows that movement compensations in standing up manifest as changes in planned trajectory (Compensation by Selection) and in muscle recruitment (Compensation by Reorganisation). However, as most studies in the literature typically use standardized experimental protocols where movement compensation is restricted, these studies cannot be directly translated to functional tasks, such as the mobility of the elderly in their homes, communities, and clinic. Compensation must be included in future studies in order to facilitate clinical translation. Specifically, future studies in the standing up task should 1) determine the effect of varying arm use strategies (e.g., armrests, knees, chair, cane) on trunk and both lower limb and upper limb joint loading, 2) analyse control strategies in elderly people, 3) determine the biomechanical implications of asymmetry, and 4) incorporate assessments of age-related physical and neural decline as well as changes in psychological priorities.

Preprint ARTICLE | doi:10.20944/preprints201912.0390.v1

A Case Study of Familiar Gastrointestinal Pathologies at Risk of Cancer. Early Detection of Degenerative Signals by Oxidative Stress Biomarkers

Carla Ferreri, Maria Marone, Elena Confalone, Anna De Maio, Chrissostomos Chatgilialoglu, Maria Rosaria Faraone Mennella

Subject: Biology And Life Sciences, Aging Keywords: cancer; DNA damage; digestive tract diseases; fat profile; lipids; Poly(ADP-ribose) Polymerase; PARP; poly(ADP-ribose); PAR

Online: 30 December 2019 (04:09:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0132.v2

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Xing Li, Tomohiro Matsumoto, Miho Takuwa, Mahmood Saeed Ebrahim Shaikh Ali, Takumi Hirabayashi, Hiroyo Kondo, Hidemi Fujino

Subject: Biology And Life Sciences, Aging Keywords: astaxanthin; antioxidant; skin; ultraviolet; photoaging; capillary

Online: 12 December 2019 (12:26:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0132.v1

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Xing Li, Tomohiro Matsumoto, Miho Takuwa, Mahmood Saeed Ebrahim Shaikh Ali, Takumi Hirabayashi, Hiroyo Kondo, Hidemi Fujino

Subject: Biology And Life Sciences, Aging Keywords: astaxanthin; antioxidant; skin; ultraviolet; photoaging; capillary

Online: 10 December 2019 (14:48:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0028.v3

Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast

Yung-Hsiang Lin, Yung-Kai Lin, Shu-Ting Chan, Yu-Ming Chun, Yu-Ting Lin, Kai-Wen Kan, Chin-Hsiu Yu

Subject: Biology And Life Sciences, Aging Keywords: Chenopodium formosanum; human dermal fibroblast; UV exposure; antioxidant activity; anti-aging; red djulis

Online: 13 November 2019 (11:02:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0305.v1

Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts

Joong Hyun Shim

Subject: Biology And Life Sciences, Aging Keywords: PGE2; EP1; skin-aging; ERK1/2; intracellular calcium

Online: 27 October 2019 (11:04:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0028.v2

Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast

Yung-Hsiang Lin, Yung-Kai Lin, Shu-Ting Chan, Yu-Ming Chung, Yu-Ting Lin, Kai-Wen Kan, Chin-Hsiu Yu

Subject: Biology And Life Sciences, Aging Keywords: Chenopodium formosanum; human dermal fibroblast; UV exposure; antioxidant activity; anti-aging; red djulis

Online: 16 October 2019 (09:23:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0028.v1

Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast

Yung-Hsiang Lin, Yung-Kai Lin, Shu-Ting Chan, Kai-Wen Kan, Yu-Ting Lin, Chin-Hsiu Yu

Subject: Biology And Life Sciences, Aging Keywords: Chenopodium formosanum; human dermal fibroblast; UV exposure; antioxidant activity; anti-aging; red djulis

Online: 3 September 2019 (04:28:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0019.v1

Automodified Poly(ADP-Ribose) Polymerase Analysis to monitor DNA Damage in Peripheral Lymphocytes of Floricoltorists occupationally exposed to Pesticides

Serena Imperato, Carmela Mistretta, Maria Marone, Ilaria Migliaccio, Ilaria Pulcinelli, Maria Rosaria Faraone Mennella

Subject: Biology And Life Sciences, Aging Keywords: Poly(ADP-Ribose)Polymerase; automodified PARP (PAR-PARP); DNA damage; pesticides; growers; greenhouses

Online: 3 January 2019 (13:00:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0102.v1

Gene Polymorphisms, Activation of the Aryl Hydrocarbon Receptor, and DNA Damage: A Preliminary Investigation

Shadi Amini Nia, Giannina Satta, Grazianna Intranuovo, Sonia Sanna, Mariagrazia Zucca, Fabio Culurgioni, Maria Giuseppina Cabras, Valeria Sogos, Giovanni Maria Ferri, Maria Grazia Ennas, Pierluigi Cocco

Subject: Biology And Life Sciences, Aging Keywords: aryl hydrocarbon receptor; DNA damage; single nucleotide polymorphisms; BCL6; lymphoma

Online: 5 November 2018 (10:28:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201805.0294.v1

Scorpins in the DNA Damage Response

Dario Palmieri, Anna Tessari, Vincenzo Coppola

Subject: Biology And Life Sciences, Aging Keywords: RANBP9; RANBPM; RANBP10; Scorpins; DDR; GID complex; CTLH complex

Online: 22 May 2018 (09:40:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0156.v1

Protective Effects of Delphinidin against Proton Beam Induced Damage in Human Colon-Derived CCD-18Co Cells

Hyun Mi Kim, Seong Hee Kang, Suk Hee Kim, Bo Sun Kang

Subject: Biology And Life Sciences, Aging Keywords: delphinidin; radiation protective agent; proton beam therapy; CCD-18Co cells; reactive oxygen species; antioxidant enzyme; DNA damage

Online: 29 September 2017 (13:49:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0199.v1

Psychosocial Impact of Assistive Technologies for Mobility and Their Implications for Active Ageing

Anabela Martins, João Pinheiro, Beatriz Farias, Jeffrey Jutai

Subject: Biology And Life Sciences, Aging Keywords: active ageing; social participation; mobility; assistive technologies; service delivery

Online: 23 August 2016 (14:53:52 CEST)

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Active ageing is defined as the process of optimizing opportunities for physical, social and mental health to enable older people to take an active part in society without discrimination and to enjoy an independent and good quality of life. The World Health Organization assumed this as a process for increasing and maintaining an individual’s participation in activities to enhance his/her quality of life. In this survey, the authors addressed the following question: “Is assistive technology (AT) for mobility contributing to enhancement of lifelong capacity and performance?”. From June 2015 until February 2016, 96 community dwelling adults, AT users for mobility (powered wheelchairs, manual wheelchairs, lower limb prostheses, walkers, crutches and canes), aged 45-97, mean 67.02 +/- 14.24 years old, 56.3% female, were interviewed using the Psychosocial Impact of Assistive Devices Scale (P-PIADS), the Activities and Participation Profile related to Mobility (APPM) and demographics, clinical and questions about AT use and training. The participants’ profiles revealed moderate limitation and restrictions in participation, measured by the APPM (2.03). Most participants showed positive impact of AT; average scores obtained from the P-PIADS subscales were: Self-esteem 0.62, Competency 1.11 and Adaptability 1.10. P-PIADS total was 0.96, with the powered wheelchair users scoring the highest (1.53) and the walker users scoring the lowest (0.73). All subscales and P-PIADS total were positively correlated with the activities and participation profile. There was no relation between age and the psychosocial impact of AT or activities and participation profile. These results encourage the authors to follow these participants up for a lifelong intervention. To accomplish that aim, currently, the protocol is implemented at the AT prescribing centers in Coimbra, Portugal in order to assess the impact of AT on participation in society, one of the domains of the Active Ageing Index, a new analytical tool to help policy makers in developing policies for active and healthy ageing.

Biology and Life Sciences