Working Paper Article Version 1 This version is not peer-reviewed

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial: Assessing the Effects of Angelica gigas Nakai Extract on Blood Triglycerides

Version 1 : Received: 21 December 2019 / Approved: 22 December 2019 / Online: 22 December 2019 (13:56:42 CET)

A peer-reviewed article of this Preprint also exists.

Jung, S.-J.; Kim, W.-R.; Oh, M.-R.; Cha, Y.-S.; Park, B.-H.; Chae, S.-W. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides. Nutrients 2020, 12, 377. Jung, S.-J.; Kim, W.-R.; Oh, M.-R.; Cha, Y.-S.; Park, B.-H.; Chae, S.-W. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides. Nutrients 2020, 12, 377.

Journal reference: Nutrients 2020, 12, 377
DOI: 10.3390/nu12020377

Abstract

Background: Angelica gigas Nakai, Korean dang-gui, has long been widely used in traditional treatment methods. There have been a number of studies of the health effects of A. gigas and related compounds, but studies addressing effects on blood triglycerides (TG) are lacking. To investigate the effects of A. gigas Nakai extract (AGNE) on TG in Korean subjects, we carried out a 12-week, randomized, double-blind, placebo-controlled clinical trial. Methods: Subjects who met the inclusion criterion (130 mg/dL ≤ fasting blood TG ≤ 200 mg/dL) were recruited for this study. One hundred subjects were assigned to the AGNE group (n=50) or the placebo group (n=50), who were given 1g/day of AGNE (as a gigas Nakai extract 200mg/d) in capsules, and the control group for 12 weeks. Outcomes were efficacy TG, lipid profiles, atherogenic index, and safety parameters were assessed initially for a baseline measurement and after 12 weeks. Results: After 12 weeks of supplementation, TG and very low-density lipoprotein cholesterol (VLDL-C) concentration and TG/HDL-C ratio in the AGNE group were significantly reduced compared to the placebo group (p <0.05). No significant changes in any safety parameter were observed. Conclusions: These results suggest that ingestion of AGNE may improve TG and be useful to manage or prevent hypertriglyceridemia.

Subject Areas

Angelica gigas Nakai; triglycerides; VLDL-C; TG/HDL-C; atherogenic index

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.