Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections Preliminary Considerations and Conclusions from a Non-interventional Study

Version 1 : Received: 7 February 2022 / Approved: 8 February 2022 / Online: 8 February 2022 (13:25:24 CET)

A peer-reviewed article of this Preprint also exists.

Wagenlehner, F.; Lorenz, H.; Ewald, O.; Gerke, P. Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections—Preliminary Considerations and Conclusions from a Non-Interventional Study. Antibiotics 2022, 11, 314. https://doi.org/10.3390/antibiotics11030314 Wagenlehner, F.; Lorenz, H.; Ewald, O.; Gerke, P. Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections—Preliminary Considerations and Conclusions from a Non-Interventional Study. Antibiotics 2022, 11, 314. https://doi.org/10.3390/antibiotics11030314

Journal reference: Antibiotics 2022
DOI: 10.3390/antibiotics11030314

Abstract

Urinary tract infections (UTIs) are very frequent in women and can be caused by a range of pathogens. High recurrence rates and increasing antibiotic resistance of uropathogens make UTIs a severe public health problem. d-mannose is a monosaccharide that can inhibit bacterial adhesion to the urothelium after oral intake. Several clinical studies have shown the efficacy of d-mannose in the prevention of recurrent UTI; these also provided limited evidence for the efficacy of d-mannose in acute therapy. A recent prospective, non-interventional study in female patients with acute cystitis reported good success rates for treatment with d-mannose. Here we present data from a post-hoc analysis of this study to compare the cure rate of d-mannose monotherapy with that of antibiotics. The results show that d-mannose is a promising alternative to antibiotics in the treatment of acute uncomplicated UTIs in women.

Keywords

urinary tract infection; cystitis; D-mannose; antibiotics; acute cystitis symptom score

Subject

MEDICINE & PHARMACOLOGY, Urology

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