Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Comparison of 0.12% Chlorhexidine and a New Bone Bioactive Liquid, BBL, Mouthrinses on Oral Wound Healing: A Randomized, Double Blind Clinical Human Trial

Eduard Ferrés-Amat
,
Ashraf Al Madhoun
ORCID logo ,
Elvira Ferrés-Amat
,
Neus Carreo
,
Miguel Barrajas
ORCID logo ,
Areej Said Al-Madhoun
,
Eduard Ferrés-Padró
,
Carles Marti
,
Maher Atari
* ORCID logo
Version 1 : Received: 26 September 2022 / Approved: 27 September 2022 / Online: 27 September 2022 (03:37:27 CEST)

A peer-reviewed article of this Preprint also exists.

Ferrés-Amat, E.; Al Madhoun, A.; Ferrés-Amat, E.; Carrió, N.; Barajas, M.; Al-Madhoun, A.S.; Ferrés-Padró, E.; Marti, C.; Atari, M. Comparison of 0.12% Chlorhexidine and a New Bone Bioactive Liquid, BBL, in Mouthwash for Oral Wound Healing: A Randomized, Double Blind Clinical Human Trial. J. Pers. Med. 2022, 12, 1725. Ferrés-Amat, E.; Al Madhoun, A.; Ferrés-Amat, E.; Carrió, N.; Barajas, M.; Al-Madhoun, A.S.; Ferrés-Padró, E.; Marti, C.; Atari, M. Comparison of 0.12% Chlorhexidine and a New Bone Bioactive Liquid, BBL, in Mouthwash for Oral Wound Healing: A Randomized, Double Blind Clinical Human Trial. J. Pers. Med. 2022, 12, 1725.

Abstract

After surgery, oral cavity healing occurs in a hostile environment and requires proper oral care and hygiene to accelerate recovery. The aim of the current study is to investigate and compare the bioreactivity characteristics of chlorhexidine based (CHX) mouth rinse and a novel bone bioactive liquid (BBL) mouth rinse on oral healing within seven days application post-surgery. A randomized, double blind clinical trial conducted in 81 patients. The mouth rinses were applied twice a day for a period of 7 days. The visual analog scale (VAS) protocol was applied to measure pain index. Early wound healing score (EHI) was determined in evaluate the oral cavity healing progress. No adverse effects were observed using the mouth washes, but CHX resulted in teeth staining. CHX and BBL were sufficient to reduce pain over a period of 7 days. However, the BBL group demonstrated a statistically significant reduction in VAS stating day 4. Relative to CHX group, the EHI scores were significantly higher in the BBL group, independent from the tooth location. No gender differences were observed in both VAS and EHI scores. Relative to the commercially available CHX, BBL mouth rinse reduced pain and accelerated oral cavity healing. Suggesting an improvements of oral cavity microenvironment at the wound site that mediates soft tissue regeneration.

Keywords

chlorhexidine; bioactive liquid; oral wound healing; pain index score; early wound healing score

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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