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Preprint ARTICLE | doi:10.20944/preprints202304.1270.v1

Effect of Meloxicam in a Protocol of Balanced Anaesthesia with Propofol and Sevoflurane on the α- δ- γ-Tocopherols in Response to Inflammatory Oxidative Stress Induced by Ovariectomy in Dogs

Giovanna Lucrezia Costa, Simona Di Pietro, Vincenzo Nava, Patrizia Licata, Nicola Maria Iannelli, Fabio Leonardi, Francesco Macrì, Diego Iannelli, Federica De Paoli, Daniele Macrì, Vincenzo Ferrantelli, Vito Angileri, Giuseppe Bruschetta, Claudia Interlandi

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Analgesia; Dog; Meloxicam; Oxidative stress; Ovariectomy; Surgery; Tocopherols

Online: 30 April 2023 (09:15:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1223.v1

Effects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases

Ram B. Singh, Alex Tarnava, Jan Fedacko, Ghizal Fatima, Sunil Rupee, Zuzana Sumbalová, Arsha Moshiri

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Hydrogen; cardiovascular; metabolic diseases; diet; oxidative stress; inflammation

Online: 29 April 2023 (07:44:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1128.v1

Mitochondrial Function-Associated APOE Locus and its Implication in Alzheimer’s Disease and Aging

Eun-Gyung Lee, Lesley Leong, Sunny Chen, Jessica Tulloch, Chang-En Yu

Subject: Biology And Life Sciences, Aging Keywords: APOE locus; TOMM40; APOE; oxidative stress; mitochondrial dysfunction; mitochondrial DNA copy number; gene expression; Alzheimer’s disease; aging

Online: 28 April 2023 (07:08:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0832.v1

Age of Onset Moderates the Association Between Total Antioxi-Dant Capacity and Cognitive Deficits in Patients With Drug-Naïve Schizophrenia

Jiaxin Li, Deyang Li, Junru Guo, Dongmei Wang, Xiangyang Zhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; age of onset; TAOC; cognitive function; oxidative stress

Online: 24 April 2023 (06:22:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0674.v1

Hexavalent Chromium Induces Infertility in Rats by Elevating Oxidative Stress, DNA Double-Strand Breaks, Microtubule Disruption, and Aberrant Segregation of Chromosomes in the Metaphase-II Oocytes

Liga Wuri, Robert C Burghardt, Joe A Arosh, Charles R Long, Sakhila K. Banu

Subject: Biology And Life Sciences, Toxicology Keywords: oocyte; oxidative stress; DNA double strand break, hexavalent chromium, RAD51, microtubule, polar body extrusion

Online: 21 April 2023 (05:42:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0414.v1

Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023

Louise Weiwei Lu, Siew-Young Quek, Shiping Lu, Jie-Hua Chen

Subject: Biology And Life Sciences, Life Sciences Keywords: N3PUFA; EPA; DHA; omega-3; cardiovascular; coagulation; thrombosis; COVID-19; inflammation; oxidative stress.

Online: 17 April 2023 (07:01:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0394.v1

Performance of Thermal-Oxidative Aging on the Structure and Properties of Ethylene Propylene Diene Monomer (EPDM) Vulcanizates

Hu Quanchao, Chen Qiang, Song Peiru, Gong Xingyu, Chen Junyi, Zhao Yongxian

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: EPDM vulcanizates; thermal-oxidative aging; thermal decomposition kinetics; antioxidant

Online: 17 April 2023 (04:07:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0299.v1

Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate -Induced PCOS in Rat

Seyede Fatemeh Hosseini, Forouzan Khodaei, Zeynab Hasansagha, Hamidreza Khosravizadeh, Mostafa Abdollahi, Ehsaneh Azaryan

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: Polycystic ovary syndrome; Chitosa; Propolis; Nanoparticle; Oxidative Stress; Immune system malfunctions.

Online: 13 April 2023 (05:40:52 CEST)

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Background: Endocrine conditions that impact women define polycystic ovary syndrome. Previous studies have demonstrated a connection between PCOS and insulin intolerance, oxidative stress, and immune system dysfunction. Additionally, some reports have indicated that propolis has antioxidant properties and that chitosan nanoparticles have beneficial effects on the reproductive system. The goal of the present study is to compare metformin (Met) to chitosan-propolis nanoparticles and explain how they protect against a rat PCOS model caused by estradiol valerate (EV). (as a control treatment). Methods: In order to cause PCOS in rodents, a single subcutaneous injection of estradiol valerate was used, followed by a 42-day oral administration of 500 mg/kg of chitosan-propolis nanoparticles. Four sets of rats were created: the control, PCOS, metformin (PCOS and 150 mg/kg metformin), and chitosan-propolis nanoparticle (PCOS and 500 mg/kg chitosan-propolis nanoparticle) groups. The histopathological examination of the ovaries and measurement of serum ferctors were performed on all of the animals. Estradiol valerate caused PCOS, but chitosan-propolis nanoparticle therapy reversed it. Results: After chitosan-propolis nanoparticle intervention, the body weight and ovarian morphology had improved, and the serum biochemical parameters, including esretogen, progestron, vitamin D, calcium, and the insulin resistance index, had been corrected. These EV-induced changes include decreased SOD activity, elevated MDA levels, and evidence that oxidative stress was increased by EV when chitosan-propolis nanoparticle/Met were administered for 42 straight days. Additionally, certain relative mRNA transcripts, including those for the MCP, IL18, and CRP genes, were markedly upregulated in EV-treated animals. These findings unequivocally demonstrate the beneficial effects of chitosan-propolis nanoparticles/Met in inflammatory disorders. Conclustion: Together, the study's end findings, which are presented here, are consistent with the hypothesis that chitosan-propolis nanoparticle/Met offered protective activity against the harmful effects of EV. Although ameliorative effects may have been implicated, the primary pathway or pathways still need to be clarified.

Preprint ARTICLE | doi:10.20944/preprints202304.0288.v1

The Enhancement of Overall Performance of Lubricating Grease by Adding Layered Double Hydroxides

Yong Li, Weidong Zhou, Wanan Xue, Yongwang Huang, Qiang Zhang, Jingbin Han

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Layered double hydroxides; grease; antioxidant; oxidative induction time

Online: 13 April 2023 (03:28:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0199.v1

Effect of Filtration Process on Oxidative Stability and Minor Compounds of the Cold-Pressed Hempseed Oil during Storage

Vincenzo Lo Turco, Federica Litrenta, Vincenzo Nava, Ambrogina Albergamo, Rossana Rando, Giovanni Bartolomeo, Angela Giorgia Potortì, Giuseppa Di Bella

Subject: Chemistry And Materials Science, Food Chemistry Keywords: hempseed oil; cold-pressed oils; oxidative stability; minor compounds; filtration process; storage

Online: 11 April 2023 (05:20:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0500.v1

The Role of Autophagy, Oxidative Damage, and Antioxidants in Eye Diseases, and the Need for Government Interventions and Education to Prevent Eye Diseases in the Digital Era

Sakthishreenidhi Manivel

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Oxidative stress and cell death; Reactive oxygen species; ROS; ROS cell death; autophagy; role of antioxidants; eye disease; cornea; lens; epithelium; retinal ganglion cells; retinal pigment epithelium; macular degeneration; antioxidants in the macula; oxidative stress prevention with antioxidants; lifestyle changes; digital eye strain; glaucoma; cataracts; dry eye disease; computer vision syndrome; digital eye strain; diabetic retinopathy; Vitamin A; Vitamin C; copper; glutathione; zinc; selenium; magnesium; blue light damage; UV light damage; blue light reactive oxygen species; autophagy; ferroptosis; ROS cell death; superoxide dismutase; optic nerve gliomas; food deserts; myopia; free radicals

Online: 29 March 2023 (03:33:55 CEST)

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Increased screen time during the COVID-19 pandemic and the accelerated incorporation of technology into daily practices have directly contributed to the increased prevalence of eye disease. The human eye is not built for continual technological use and must adjust to exposure to digital screens. Overexposure to technology can result in eye strain and an increased risk of eye diseases such as myopia with complications later in life, including retinal tears, cataracts, and macular degeneration. As vision and ocular diseases become more prevalent, the study of eye diseases, including their causes and treatments, is especially relevant. There is a need to prevent ocular diseases before they become a burden to individuals, their families, and their communities by better understanding the pathophysiology of ocular diseases. Several ocular diseases are thought to be caused by imbalances in reactive oxygen species (ROS) and autophagy. ROS refers to a class of highly reactive oxygen-containing molecules that can undergo damaging reactions with other molecules in the cell. Autophagy is a cellular process of self-eating whereby damaged, harmful, or dead material in cells is broken down to maintain cellular homeostasis. This paper discusses the role of ROS and autophagy in the pathogenesis of computer vision syndrome (CVS), digital eye strain (DES), myopia, cataracts, glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), optic nerve crush injury (OCN), optic nerve gliomas, and retinoblastoma. Lifestyle changes such as limiting screen time, ensuring adequate exposure to evening sunlight, and using blue light protection measures or protective eyewear are important in the prevention of eye disease. Nutrition also contributes significantly to eye health. A balanced diet rich in vitamins and antioxidants may help to prevent ROS and autophagy imbalance-induced eye disease. Medical and surgical treatments become necessary when preventative measures fail. This paper also addresses how government measures to decrease the onset of eye disease, including targeted programs to increase access to fresh vegetables and fruits in food deserts, are a critical macro-level avenue to reduce eye disease prevalence in the US, which according to the National Eye Institute, costs $139 billion yearly.

Preprint REVIEW | doi:10.20944/preprints202302.0454.v1

Cell-Type Specific Mitochondrial Quality Control in the Brain: A Precise Mechanism of Neurodegeneration

Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodia

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Astrocytes, Microglia, Mitochondria, Neurons, Oligodendrocytes, Oxidative stress

Online: 27 February 2023 (07:34:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0287.v1

HAX1 Is a Novel Binding Partner of Che-1/AATF. Implications in Oxidative Stress Cell Response

Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Simona Iezzi, Roberta De Angelis, Maurizio Fanciulli, Andrea Colizza, Marco De Vincentiis, Maria Grazia Di Certo, Claudio Passananti, Nicoletta Corbi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HAX1; Che-1/AATF; apoptosis; mitochondria; oxidative stress; breast cancer; ERα

Online: 17 February 2023 (01:50:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0227.v1

Repurposing Simvastatin in Parkinson's Disease Model: Protection is throughout Modulation of the Neuro-inflammatory Response in the Substantia Nigra

Moisés Rubio-Osornio, Carmen T. Goméz-De León, Sergio Montes, Carmen Rubio, Camilo Ríos, Antonio Monroy-Noyola, Jorge Morales-Montor

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Parkinson’s Disease; MPP+; Neuroinflammation; Oxidative Stress Proinflammatory cytokines

Online: 14 February 2023 (03:18:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0084.v1

A Comparative Analysis of Hypothalamic Pituitary Gonadal Axis Alterations by Chronic Consumptions of Broiler and Domestic Chicken Meats in Postnatal Sprague Dawley Male Rats

Muhammad Aslam

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Domestic chicken; Broiler chicken; Testosterone; Oxidative stress

Online: 6 February 2023 (07:38:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0006.v1

Plant-Based Antioxidant Activity in the Human Body: A Comprehensive Review of Hormetic Influences Driving Positive Clinical Outcomes

Julie Wendt, Benjamin Knudsen, Leigh A. Frame

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: hormesis; polyphenols; clinical trials; antioxidants; reactive oxygen species; oxidative stress; plant-derived antioxidants; dietary antioxidants; nutritional hormesis; free radicals

Online: 1 February 2023 (03:03:40 CET)

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A consistent factor in the epidemic of chronic disease is a pro-inflammatory metabolic state. The ability of clinicians to use nutrients to balance inflammation by supporting oxidant homeostasis rests on the quality of research within the field of antioxidants. Understanding the intersection of two prominent theories regarding the role of antioxidants in quelling inflammation, nutritional hormesis and oxidant scavenging, will enable the therapeutic use of antioxidants in clinical practice. This review investigates the less well-established theory, nutritional hormesis, which has not been comprehensively reviewed recently to our knowledge. To understand the state of research on the hormetic response, we conducted a comprehensive literature review describing the relationship between dietary antioxidants, hormesis, and chronic disease. We used an adaptive search strategy in PubMed and Scopus, retrieving a total of 343 articles, of which 218 were unique. Title and abstract screenings were conducted by two reviewers independently with a third as a tiebreaker, resulting in 152 articles included in this review. Most studies reviewed the hormetic response in plant and cell models (73.6%) while only 2.2% were conducted in humans. Limitations exist in translating plant/cell/animal models into the complexities of human biochemistry and physiology that warrant consideration before extrapolating such results into clinical practice. A critical hurdle in our literature review process is the lack of standardized nomenclature describing the hormetic effect in the research community that challenges the ability to comprehensively review the subject matter. Further, aA knowledge gap exists between the cell culture and animal model research that shows a biphasic, hormetic quality to the role of antioxidants and the observational human studies, which have yet to corroborate these findings. Therefore, we cannot accurately translate this research into clinical care at this time.

Preprint REVIEW | doi:10.20944/preprints202301.0515.v2

The Double-edged Sword of Antioxidant Supplements on Metabolic Diseases, A Necessity for Quantification of Oxidative Status

Wei-Zheng Zhang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: antioxidant supplements; ROS; oxidative stress analysis; metabolic diseases

Online: 30 January 2023 (02:46:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0461.v1

Transcription Factors and Intracellular Proteins Orchestrate Phenotypic Adaptation in Cryptococcus neoformans for Survival and Human Infections

Olufemi Samuel Folorunso, Olihile Moses Sebolai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cryptococcus; transcription factor; thermotolerance; virulence factors; antifungal; oxidative and osmotic stress; capsule; melanin; monokaryotic fruiting; mating and filamentation

Online: 26 January 2023 (02:54:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0373.v1

No Chance to Survive: Mo-CBP3-PepII Synthetic Peptide Acts on Cryptococcus neoformans by Multiple Mechanisms of Action

Tawanny K.B. Aguiar, Felipe P. Mesquita, Nilton A. S. Neto, Francisco I. R. Gomes, Cleverson D. T. Freitas, Rômulo F. Carneiro, Celso S. Nagano, Luciana M.R. Alencar, Ralph Santos-Oliveira, Jose T. A. Oliveira, Pedro F. N. Souza

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: alternative drugs; cryptococcosis; oxidative stress; synthetic peptides

Online: 20 January 2023 (15:17:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0365.v1

The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes

Dawn S. Tuell, Evan A. Los, George A. Ford, William L. Stone

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: antioxidants; oxidative stress; reactive oxygen species; type 2 diabetes; pediatrics; redox; glycemic control; exercise; vitamin E; glutathione

Online: 19 January 2023 (15:10:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0321.v1

Use of the Zebrafish Model as a Tool to Evaluate the Anti-Inflammatory and Antioxidant Activity of Molecules. Literature Review

Alberto Bustillos, Cristina Arteaga, Luis Felipe Contreras, Ruth Borja, Carolina Campoverde

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Anti-inflamotry; antioxidant; oxidative stress; zebrafish

Online: 18 January 2023 (07:06:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0274.v1

Chrysoeriol Improves Embryo Development by Reducing Oxidative Stress and Autophagy in Vitro Porcine

Chao-Rui Wang, He-Wei Ji, Sheng-Yan He, Rong-Ping Liu, Xin-Qin Wang, Jing Wang, Chu-Man Huang, Yong-Nan Xu, Ying-Hua Li, Namhyung Kim

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chrysoeriol; embryo development; porcine; oxidative stress; autophagy

Online: 16 January 2023 (07:54:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0100.v1

Are Antarctic Fish Adapted to Face Global Changes? A Study on Antioxidant Enzymes Gene Expression in Trematomus newnesi from Ross Sea, Experimentally Exposed to PFOA

Sara Pacchini, Elisabetta Piva, Sophia Schumann, Paola Irato, Daniela Pellegrino, Gianfranco Santovito

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Antarctic fish; antioxidant enzymes; oxidative stress; gene expression; PFAS

Online: 5 January 2023 (04:50:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0012.v1

Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation

Mojdeh Fatehi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Insulin Resistance; Zinc supplementation; Oxidative stress; Inflammation; Gut microbiome; Hepatic lipophagy

Online: 3 January 2023 (07:35:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0526.v1

Gymnema Sylvestre Supplementation Restores Normoglycemia and Corrects Dyslipidemia through Transcriptional Modulation of ßeta Cells and Hepatocytes in the Alloxan-Induced Hyperglycemic Rats

Humaira Muzaffar, Iqra Qamar, Muhammad Bashir, Farhat Jabeen, Shahzad Irfan, Haseeb Anwar

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: hyperglycemia; dyslipidemia; oxidative stress; Gymnema Sylvestre

Online: 28 December 2022 (03:31:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0449.v1

Behind the Curtain: In silico and in vitro Experiments Brought to Light New Insights Into the Anticryptococcal Action of Synthetic Peptides

Tawanny K. B. Aguiar, Nilton A. S. Neto, Romério R.S. Silva, Cleverson D. T. Freitas, Felipe Pantoja Mesquita, Luciana Magalhães Rebelo Alencar, Ralph Santos-Oliveira, Gustavo H. Goldman, Pedro Filho Noronha Souza

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: redox system; cryptococcal meningitis; oxidative stress; ergosterol; resistance

Online: 23 December 2022 (07:56:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0287.v1

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Luis L. Ayusso, Ana Paula Girol, Emmanuel A. Burdmann

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Online: 15 December 2022 (15:48:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0087.v1

Interrelation Midst Low T3 Levels, Type 3 Deiodinase, Oxidative Stress And Mortality In Sepsis and Septic Shock: Defining Patient Outcome

Josi Vidart, Luiza Axelrud, Andre Cardozo Braun, Rafael A. Marschner, Simone Magagnin Wajner

Subject: Medicine And Pharmacology, Hematology Keywords: low T3 syndrome, oxidative stress, sepsis, septic shock, thyroid hormone, type 3 deiodinase

Online: 6 December 2022 (02:18:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0410.v1

Selenylated imidazo[1,2-a]pyridine induces cell senescence and oxidative stress in chronic myeloid leukemia cells

Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero1, Jamal Rafique, Eduardo Benedetti Parisotto

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Leukemia; imidazo[1,2-a]pyridines; selenide; oxidative stress; senescence; chronic myeloid leu-kemia.

Online: 22 November 2022 (07:49:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0350.v2

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

Laura García-Quintanilla, Lorena Rodríguez-Martínez, Enrique Bandín-Vilar, María Gil-Martinez, Miguel González-Barcia, Cristina Mondelo-García, Anxo Fernández-Ferreiro, Jesús Mateos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Proteomics, Age-related macular degeneration, inflammation, biomarker, oxidative stress.

Online: 21 November 2022 (02:35:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0458.v1

Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to MSG-Induced Obesity Model

Matheus Felipe Zazula, Diego Francis Saraiva, João Lucas Theodoro, Mônica Maciel, Eliel Vieira dos Santos Sepulveda, Bárbara Zanardini de Andrade, Mariana Laís Boaretto, Jhyslayne Ignácia Hoff Nunes Maciel, Gabriela Alves Bronczek, Gabriela Moreira Soares, Sara Cristina Sagae Schneider, Gladson Ricardo Flor Bertolini, Márcia Miranda Torrejais, Lucineia Fatima Chasko Ribeiro, Luiz Claudio Fernandes, Katya Naliwaiko

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: hyperinsulinemia; monosodium glutamate; metabolic syndrome; distress oxidative; pro-inflammatory profile; skeletal muscle fibre types.

Online: 31 October 2022 (01:00:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0300.v1

Spatio-Temporal and Cell Type-Specific Expression of Nrf2 Following an Acute Epileptic Seizure in Rats

Sereen Sandouka, Aseel Saadi, Rhoda Olowe, Prince Kumar Singh, Tawfeeq Shekh-Ahmad

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Nrf2; Oxidative stress; Antioxidants; Pentylenetetrazol; Epilepsy; Seizure

Online: 20 October 2022 (08:29:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0195.v2

Antioxidants and Long Covid

Patrick Chambers

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Warburg effect, oxidative stress, magnesuria, inflammasome, butyrate

Online: 14 October 2022 (12:56:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0145.v1

Oxidative Stress-Induced Overactivation of Frog Eggs Triggers Calcium-Dependent Non-Apoptotic Cell Death

Alexander A. Tokmakov, Yudai Morichika, Ryuga Teranishi, Ken-Ichi Sato

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: oxidative stress; Xenopus laevis; eggs; overactivation; cell death

Online: 11 October 2022 (07:08:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0013.v1

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: selenium; oxidative stress; serotonin; glutamate; anxiety disorders; obsessive-compulsive disorders; post-traumatic stress disorder

Online: 3 October 2022 (15:17:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0180.v2

Redox Homeostasis and Nitro-Oxidative Stress in Obesity-Linked Inflammation

Guillaume Treiber, Hanen Samouda, Estelle Nobécourt, Serge P. Bottari

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: oxidative stress; nitrative stress; reactive oxygen species; reactive nitrogen species; nitric oxide inflammation; obesity; peroxynitrite; adipose tissue

Online: 30 September 2022 (11:10:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0437.v1

Investigation of Changes in Spermatozoa Characteristics, Chromatin Structure, and Antioxidant/Oxidant Parameters after Freeze-Thawing of Hesperidin (Vitamin P) Doses Added to Ram Semen

Deniz Yeni, Şükrü Güngör, Fatih Avdatek, Mehmet Fuat Gülhan, Kemal Tuna Olğaç, Muhammed Enes ̇İnanç, Barış Denk, Umut Taşdemir

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Semen; hesperidin; cryopreservation; oxidative stress; antioxidant; ram

Online: 28 September 2022 (09:35:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0360.v1

Synergistic Interaction of A Healthy Lifestyle Index and Antioxidant Genes on Breast Cancer Risk

Liliana Gomez Flores Ramos, Luisa María Sánchez Zamorano, Ángelica Ángeles-Llerenas, Gabriela Torres-Mejía

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Breast cancer; Oxidative stress; Healthy lifestyle; Catalase; Gene–environment interaction

Online: 23 September 2022 (07:11:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0354.v1

Wound Healing Versus Metastasis: Role of Oxidative Stress

Tatiana Lopez, Maeva Wendremaire, Jimmy Lagarde, Oriane Duquet, Line Alibert, Brice Paquette, Carmen Garrido, Frédéric Lirussi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Wound healing; metastasis; oxidative stress; macrophage; HIF; NF-kB; Nrf2

Online: 23 September 2022 (03:28:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0066.v1

Silicon-Rich Materials Detoxify Multiple Heavy Metals in Wheat by Regulating Oxidative Stress and Heavy Metal Subcellular Distribution

Zheyong Li, Yajun Yuan, Luojing Xiang, Qu Su, Zhenyan Liu, Wenguang Wu, Yihao Huang, Shuxin Tu

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Silicon; Heavy metals; Oxidative stress; Wheat; Cellular

Online: 5 September 2022 (13:44:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0485.v1

Biochemical and Behavioural Alterations Induced by Arsenic and Temperature in Hediste Diversicolor of Different Growth Stages

Pedro Valente, Paulo Cardoso, Valéria Giménez, M.S.S. Silva, Carina Sá, Etelvina Figueira, Adília Pires

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Arsenic; global warming; invertebrates; behavior; oxidative stress

Online: 29 August 2022 (10:43:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0468.v1

Mechanistic insights into the biochemical and pharmacological profile of esculetin

Sourbh Suren Garg, Jeena Gupta, Debasis Sahu, Chuan Ju Liu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: esculetin; cancer; oxidative stress; inflammation; arthritis; diabetes; fatty liver

Online: 29 August 2022 (05:25:05 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202208.0379.v1

Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy

Elisenda Moliner-Calderón, Sergio Verd, Alfonso Leiva, Jaume Ponce-Taylor, Gemma Ginovart, Pia Moll-McCarthy, Catian Gelabert, Josep Figueras-Aloy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn infant; sepsis; premature infant; oxygen therapy; oxidative stress; ventilation support

Online: 22 August 2022 (08:11:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0352.v1

A Novel Mitophagy Enhancer Protects Cardiomyocytes against Hypoxia/Reoxygenation

Xin Yan, Xiang Gao, Shanshan Hou, Steffen Jockusch, K Michael Gibson, Lanrong Bi

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Oxidative Stress, Free radical scavenging, Autophagy, Ischemia/reperfusion injury, Hypox-ia/reoxygenation, Mitophagy

Online: 18 August 2022 (14:33:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0133.v1

Arbuscular Mycorrhizal Fungi and Biofilm Forming Bacteria Act Synergistically to Modulate Proline Metabolism, Antioxidant Defense System and Aquaporin Genes Expression Under Drought Stress

Iqra Siddique, Tariq Shah, Ahmad Ali, Ijaz Ahmad, Roberto D'amato, Fazal Munsif

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Abscisic acid biosynthetic genes; aquaporins; Biofilm forming bacteria; growth traits; oxidative injury; Tomato

Online: 8 August 2022 (05:48:17 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202208.0022.v1

Can Biomarkers of Oxidative Stress in Serum Predict Disease Severity in West Nile Virus Infection? A Pilot Study

Maxim Van Herreweghe, Annelies Breynaert, Tess De Bruyne, Corneliu Petru Popescu, Simin-Aysel Florescu, Yaniv Lustig, Eli Schwartz, Federico Giovanni Gobbi, Nina Hermans, Ralph Huits

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Oxidative stress; West Nile virus; West Nile Fever; West Nile Neuroinvasive disease; Flaviviridae; biomarkers

Online: 1 August 2022 (11:21:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0316.v1

Neurological Outcomes Following Mitoquinone Supplementation in Mice, 3 and 7 Days Post Repeated Mild Traumatic Brain Injury

Mohammad Amine Reslan, Maya Jammoul, Leila Nasrallah, Maha Tabet, Marya El-Kurdi, Sarin Mekhjian, Judith Nwaiwu, Mona Goli, Yehia Mechref, Kevin K Wang, Firas Kobeissy, Riyad El Khoury

Subject: Social Sciences, Cognitive Science Keywords: acute injury; antioxidant; behavior; mitochondria; mitoquinone; neuroinflammation; oxidative stress; repeated mild TBI

Online: 21 July 2022 (08:17:28 CEST)

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Mild traumatic brain injury (mTBI) or concussion accounts for the bulk of all head injuries and represents a major health concern. Although an mTBI event may not manifest in neurobehavioral impairment, repeated injuries, known as repeated mTBI (rmTBI), can result in a cumulative effect that may progress to long-term cognitive and functional deficits. To date, there is no FDA-approved drug for TBI in general and rmTBI in particular. In previous studies, we have demonstrated the neuroprotective role of mitoquinone (MitoQ), a mitochondrial antioxidant, in an open head injury model and a model of repeated mild TBI (rmTBI) at a chronic time point (30 days). In this work, we set out to assess the neuroprotective potential of MitoQ at acute (3 days) and subacute time points (7 days) post-injury in a controlled cortical impact model of rmTBI. C57BL/6 male mice were injected intraperitoneally with MitoQ (5 mg/kg) one hour after the first mTBI, and three days after the first injury in both the 3-day and 7-day MitoQ + rmTBI subgroups, with an additional injection four days after the second injection in the 7-day group. Cognitive function was evaluated using the Morris water maze (MWM) while gross and fine motor functions were evaluated by the pole climbing, grip strength, and ladder rung tests. Dihydroethidium (DHE) staining was performed to evaluate oxidative stress while qRT-PCR was used to measure the gene expression of different antioxidant enzymes. Also, immunofluorescence staining was performed on brain tissue to assess the degree of microgliosis and astrocytosis. Our results showed that MitoQ conferred significant protection on days 3 and 7 post-injury against fine motor function impairment induced by rmTBI. Moreover, MitoQ enhanced cognitive function and reduced astrogliosis, microgliosis, and levels of oxidative stress on day 7 post-injury. However, antioxidant gene expression generally remained unaffected. In light of our results, MitoQ administration may be considered a preventive approach that helps to alleviate the neurological manifestations associated with rmTBI early before symptoms progress to long-term deficits.

Preprint ARTICLE | doi:10.20944/preprints202207.0152.v1

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Alzheimer’s disease; oxidative stress; presenilin; mitochondria; calcium; neuronal dysfunction; Nrf2

Online: 11 July 2022 (08:03:08 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202207.0144.v1

PKCeta Promotes Stress-induced Autophagy and Senescence in Breast Cancer Cells, Presenting A Target for Therapy

Noa Rotem-Dai, Amitha Muraleedharan, Etta Livneh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Protein Kinase C; PKCeta; autophagy; senescence; chemoresistance; oxidative stress; ER stress; 3MA; chloroquine

Online: 10 July 2022 (06:42:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0118.v1

Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection

Jessica Maiuolo, Rosamaria Bulotta, Francesca Oppedisano, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Martina Nicita, Rosamaria Caminiti, Francesca Bosco, Roberta Macrì, Adriano Carnevali, Vincenzo Scorcia, Vincenzo Mollace

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Eyes diseases; Oxidative damage; Antioxidant compounds; Vitamin A; Vitamin C; Lutein; Curcumin; Quercetin; Coenzyme Q10; PUFAs; BPF; Grape seed

Online: 7 July 2022 (09:04:14 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202206.0324.v1

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Ruth Diez, Sergio Verd, Jaume Ponce-Taylor, Antonio Gutierrez, Maria Llull, Maria-Isabel Martin-Delgado, Olga Cadevall, Jan Ramakers

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: circadian clock; otitis media; late dinner; common cold; Mediterranean diet; oxidative stress; chronotype

Online: 23 June 2022 (10:37:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0257.v1

High Exogenous Antioxidant, Restorative Treatment for Prevention of Heart Failure: The Heart Diet

Ram B. Singh, Jan Fedacko, Dominik Pella, Daniel Pella, Ghizal Fatima, Yulia Gushchina, Aminat Magomedova, Galal Elkilany, Mahmood Moshiri, Krassimira Hristova, Viliam Mojto, Patrik Jakabcin, Natalia Vanova

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Western diet; oxidative stress; cardiomyocyte; micronutrients; dietary fat

Online: 20 June 2022 (03:38:07 CEST)

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Heart failure (HF) has become a public health problem, but exact pathophysiology is still unknown. Western diet characterised with high sugar, high fat, red meat and processed meat, eggs, fried foods and sweetened beverages, may cause oxidative stress and inflammation, leading to oxidative dysfunction and adverse effects on cardiac-ultra-structure. However, only little is known about oxidative function of the of the myocardium and how oxidative dysfunction predispose Ca-overloading resulting in to physio-pathological remodelling leading to HF. Antioxidants such as flavonoids and polyphenolics, omega-3 fatty acids, vitamins, minerals as well as essential and nonessential amino acids that are rich in Indo-Mediterranean type of diets, may have protective roles in maintaining oxidative functions of the heart. The cardiac cells use fatty acids and glucose for the metabolic functions depending upon physiological and metabolic requirements. Apart from glucotoxicity, lipotoxicity is also damaging to cardiac cells which worsen in presence of deficiency of endogenous antioxidants and lower exogenous antioxidants in the diet. There is increased production of ceramide, advanced glycation end products (AGE) and triamino-methyl-N-oxide (TMAO) due to high sugar and high fat diets, leading to oxidative dysfunction and Ca-overloading. The biological changes may begin with physiological remodelling to pathological remodelling due to oxidative damages. High fat diet in combination with inducible nitric oxide synthase (NOSi) via N-arginine methyl ester has been found to preserve ejection fraction in a mouse model of HF. It is possible that increased supplementation of High Exogenous Antioxidant Restorative Treatment (HEART) diet; polyphenolics and flavonoids, vitamins, minerals, arginine, with omega-3 fatty acids, and cessation of red meat and egg may further improve the oxidative function of cardiac cells, resulting in the prevention and improvement in the earliest of the Six Stages of HF. Cohort studies and randomised, controlled trials would be necessary for demonstration of the role of HEART diet in the management of HF.

Preprint ARTICLE | doi:10.20944/preprints202206.0129.v1

The Modification of Detrimental Biochemical Anomalies May Reduce the Rate of Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Subhasish Pramanik, Kaustav Banerjee, Lakshmi Kanta Mondal

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetic retinopathy; Oxidative stress; Advanced glycation end products (AGEs); Antioxidant enzymes; Vascular endothelial growth factor; B-vitamins; Vitamin-C; Vitamin- E

Online: 8 June 2022 (12:40:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0294.v2

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways. Crosstalk on Perioperative Antioxidant Therapy

Stelian Adrian Ritiu, Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Marius Papurica, Sonia Elena Popovici, Daiana Toma, Robert Iulian Ivascu, Raluca Ramona Velovan, Dragos Nicolae Garofil, Dan Corneci, Melania Lavinia Bratu, Elena Mihaela Pahontu, Adriana Pistol

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: general anesthesia; redox; inflammation; antioxidants; hypermetabolism; microRNAs; biomarkers; oxidative stress; Vitamin C

Online: 6 June 2022 (05:09:14 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202203.0104.v3

High Atmospheric CO₂ Concentration Causes Increased Respiration by the Oxidative Pentose Phosphate Pathway in Chloroplasts

Thomas Wieloch

Subject: Biology And Life Sciences, Plant Sciences Keywords: Calvin-Benson cycle; carbon metabolism; CO2 fertilisation; glucose-6-phosphate shunt; hydrogen stable isotopes; oxidative pentose phosphate pathway; photosynthesis; respiration

Online: 16 May 2022 (12:14:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0154.v1

Antioxidant Responses Induced by PFAS Exposure in Freshwater Fish in the Veneto Region

Elisabetta Piva, Sophia Schumann, Serena Dotteschini, Ginevra Brocca, Giuseppe Radaelli, Andrea Marion, Paola Irato, Daniela Bertotto, Gianfranco Santovito

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: antioxidant enzymes; freshwater fish; oxidative stress; PFAS; Veneto region

Online: 12 May 2022 (02:47:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0166.v1

Mediators of Regional Kidney Perfusion during Surgical Pneumoperitoneum Creation and the Risk of Acute Kidney Injury – A Review of Basic Physiology

Csaba Kopitkó, László Medve, Tibor Gondos, Karim Magdy Mohamed Soliman, Tibor Fülöp

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney injury; intra-abdominal pressure; oxidative stress; renal cortical blood flow; renal medullar blood flow; renal lymphatic drainage; venous congestion

Online: 18 April 2022 (10:45:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0107.v1

On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Francesca Costabile, Stefano Decesari, Roberta Vecchi, Franco Lucarelli, Gabriele Curci, Dario Massabò, Matteo Rinaldi, Maurizio Gualtieri, Emanuela Corsini, Elena Menegola, Silvia Canepari, Lorenzo Massimi, Stefania Argentini, Maurizio Busetto, Gianluca Di Iulio, Luca Di Liberto, Marco Paglione, Igor Petenko, Mara Russo, Angela Marinoni, Gianpietro Casasanta, Sara Valentini, Vera Bernardoni, Federica Crova, Gianluigi Valli, Alice Corina Forello, Fabio Giardi, Silvia Nava, Giulia Pazzi, Paolo Prati, Virginia Vernocchi, Teresa La Torretta, Ettore Petralia, Milena Stracquadanio, Gabriele Zanini, Gloria Melzi, Emma Nozza, Martina Iulini, Donatella Caruso, Lucia Cioffi, Gabriele Imperato, Flavio Giavarini, Maria Battistoni, Francesca Di Renzo, Maria Agostina Frezzini, Cinzia Perrino, Maria Cristina Facchini

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric aerosol; chemical composition; secondary aerosol; source apportionment; ultrafine particles; oxidative potential; exposure; toxicology; forecasting; micrometeorology

Online: 12 April 2022 (09:54:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0011.v1

Adipose Tissue Plasticity in Response to Pathophysiological Cues: A Connecting Link between Obesity and Its Associated Comorbidities

Michelantonio De Fano, Desirèe Bartolini, Cristina Tortoioli, Cristiana Vermigli, Massimo Malara, Francesco Galli, Giuseppe Murdolo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: adipose tissue; adipose precursor cells; obesity; senescence; oxidative stress; type 2 diabetes; cardiovascular disease

Online: 4 April 2022 (07:34:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0309.v1

Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma

Frances Byrne, Ellen Olzomer, Nina Lolies, Kyle Lee Hoehn, Marthe-Susanna Wegner

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glycolysis; GEMs; oxidative phosphorylation; UGCG; glucosylceramide; normal liver cells; gangliosides; lacto/neo-lacto series GSLs; sulfatides

Online: 23 March 2022 (04:39:25 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202109.0437.v2

The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’s

Victor Lau, Leanne Ramer, Marie-Ève Tremblay

Subject: Biology And Life Sciences, Aging Keywords: Alzheimer's; Cellular senescence; Neurodegeneration; Microglia; Astrocytes; Oligodendrocyte Progenitor Cells; TREM2; Braak staging; Oxidative stress; Phapoptosis; Amyloid-beta; Tau; Neuritic plaques

Online: 7 March 2022 (14:22:25 CET)

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Alzheimer’s disease (AD) predominantly occurs as a late-onset form (LOAD), involving neurodegeneration and cognitive decline with progressive memory loss. Over time, risk factors and aging promote accumulation of well-known AD pathologies in oxidative stress, amyloid-beta and tau protein pathology, as well as inflammation. Homeostatic glial functions regulate and suppress these AD pathologies; however, other glial states involve increased pro-inflammatory cytokine release and further pathology accumulation. Different stresses can additionally induce cellular senescence, or an irreversible differentiation process resulting in decreased supportive functions and increased, pro-inflammatory cytokine release. While these pathophysiological underpinnings all contribute to LOAD, they require temporal and mechanistic integration. This perspective hypothesizes that when individuals have threshold senescent glia accumulation, they transition from healthy cognition into mild cognitive impairment and LOAD diagnosis. Particularly, senescent microglia are predicted to represent a final threshold required for the tau pathology burden and spreading that corresponds to sustained neurodegeneration and dementia severity. We first explore age-related decline in glia that promote increases in AD pathologies, and then discuss emerging evidence linking oxidative stress, neurons containing tau pathology, and amyloid-beta to microglia, oligodendrocyte progenitor cell, and astrocyte senescence. Our hypothesis proposes that senescent astrocytes and oligodendrocyte progenitors pressure microglia to phagocytose neurons containing tau pathology. The resulting senescent microglia would form neuritic plaques and induce paracrine senescence transitioning into a progressive clinical dementia presentation. This predictive hypothesis can potentially account for why medications used to treat LOAD fail, as previous treatments have not reduced senescent glial burden. It is also coherent with the predominant hypotheses surrounding LOAD, generates testable hypotheses about LOAD, and increases rationale in testing senolytics as targeted treatments for LOAD arrest and reversal.

Preprint ARTICLE | doi:10.20944/preprints202202.0357.v1

Transcriptomics Reveals Granulosa Cell’s Coping through Redox, Inflammatory, Metabolic and Cytoskeleton Mechanisms under Acute Heat Stress

Abdul Sammad, Hanpeng Luo, Lirong Hu, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; apoptosis; oxidative stress; RNA-seq; transcriptomics; differentially expressed genes; signaling pathways

Online: 28 February 2022 (11:08:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0221.v1

Diet, Oxidative Stress, and Blood Serum Nutrients in Various Types of Glaucoma: A Systematic Review

Maryla Młynarczyk, Martyna Falkowska, Zuzanna Micun, Iwona Obuchowska, Jan Kochanowicz, Katarzyna Socha, Joanna Konopińska

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: primary open angle glaucoma; primary angle-closure glaucoma; PEX glaucoma; diet; oxidative stress; nutrients serum level

Online: 18 February 2022 (03:38:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0312.v1

Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts

Yoshihiro Miyazaki, Nobuhito Mori, Yuka Akagi, Tatsuya Oda, Yasuyuki Kida

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: cancer-associated fibroblasts; tumor microenvironment; pancreatic cancer; intracellular metabolism; glycolysis; oxidative phosphorylation; cell differentiation

Online: 20 January 2022 (19:42:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0362.v1

Estrogen Receptors, ERK 1/2 Phosphorylation and Reactive Oxidizing Species in Red Blood Cells From Patients With Rheumatoid Arthritis

Manuela Di Franco, Lucrezia Gambardella, Camilla Cittadini, Martina Favretti, Chiara Gioia, Rosa Vona, Elisabetta Straface, Donatella Pietraforte

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: rheumatoid arthritis; inflammation, oxidative stress; red blood cells; estrogen receptors.

Online: 22 December 2021 (12:25:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0301.v1

The Tryptophan Catabolite or Kynurenine Pathway in Schizophrenia: Meta-Analysis Reveals Dissociations Between Central, Serum and Plasma Compartments

Abbas F. Almulla, Asara Vasupanrajit, Chavit Tunvirachaisakul, Hussein K. Al-Hakeim, Marco Solmi, Robert Verkerk, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; indoleamine-dioxygenase; inflammation; neuro-immune; oxidative and nitrosative stress; biomarkers

Online: 20 December 2021 (09:56:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0267.v1

Elovl2-Ablation Leads to Mitochondrial Membrane Fatty Acid Remodeling and Reduced Efficiency in Mouse Liver Mitochondria

Alexia Gómez Rodríguez, Emanuela Talamonti, Alba Naudi, Anastasia V. Kalinovich, Anna M. Pauter, Gustavo Barja, Tore Bengtsson, Anders Jacobsson, Reinald Pamplona, Irina G. Shabalina

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: docosahexaenoic acid (DHA) deficiency; mitochondrial function; polyunsaturated fatty acids; membrane permeabilization; oxidative damage markers; adenine nucleotide translocase

Online: 16 December 2021 (10:57:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0263.v1

Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts

Ana C. Gonçalves, Ana R. Costa, José D. Flores-Félix, Amílcar Falcão, Gilberto Alves, Luís Manuel Lopes Rodrigues da Silva

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: anti-inflammatory; cytotoxicity; oxidative stress; phenolic compounds; sweet cherries

Online: 16 December 2021 (08:18:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0179.v1

Anti-diabetic, Antioxidants, Anti-hepatorenaltoxicity Activities of Cyperus rotundus Rhizome Extract in Alloxan-induced Diabetic Rats

Mohammed Al-Awar, Turki Alqabbani

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Cyperus rotundus rhizomes; Diabetes; Lipids Profile; Hepatorenalprotective; Oxidative marker

Online: 10 December 2021 (13:11:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0161.v1

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Vy Ngo, Nadun C. Karunatilleke, Anne Brickenden, Wing-Yiu Choy, Martin L. Duennwald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Nrf2; Keap1; oxidation; oxidative stress; protein misfolding

Online: 9 December 2021 (15:46:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0137.v1

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS Patients

Paola Montes, Ana Guerra-Librero, Paloma García, Mª Elena Cornejo-Calvo, Mª del Señor López, Tomás de Haro, Laura Martínez-Ruiz, Germaine Escames, Darío Acuña-Castroviejo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: myelodysplastic syndrome (MDS); oxidative stress; cytokines; inflammation; 5-Azacitidine; somatic alterations

Online: 8 December 2021 (14:36:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0578.v1

Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukaemia Cells by Blocking the Mitochondrial Respiratory Chain and Synergizes with Cytarabine

Hassan Dakik, Maya El Dor, Jérôme Bourgeais, Farah Kouzi, Olivier Herault, Fabrice Gouilleux, Kazem Zibara, Frédéric Mazurier

Subject: Medicine And Pharmacology, Hematology Keywords: DPI; Mitochondria; Leukaemia; Oxidative stress; OxPhos; Ara-C

Online: 30 November 2021 (21:37:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0432.v1

Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Gallayaporn Nantachai, Asara Vasupanrajit, Chavit Tunvirachaisakul, Marco Solmi, Michael Maes Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Oxidative and nitrosative stress; antioxidants; biomarkers; neuro-immune; neurocognition

Online: 23 November 2021 (15:05:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0384.v1

Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis

Hui Li, Wen Wen, Jia Luo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Alcohol abuse; cell signaling; FDA-approved drugs; oxidative stress; therapy

Online: 22 November 2021 (11:41:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0346.v1

Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets

Carmela Balistreri, Calogera Pisano, Giovanni Ruvolo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Ascending aorta aneurysm (AsAA); reactive oxygen species (ROS); oxidative stress; onset and progression of sporadic AsAA; management of AsAA; biomarkers and targets

Online: 19 November 2021 (11:19:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0287.v1

Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress

Kuang-Yao Chen, Yi-Ju Chen, Chien-Ju Cheng, Kai-Yuan Jhan, and Lian-Chen Wang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Excretory-secretory products; Angiostrongylus cantonensis; Astrocytes; Benzaldehydes; endoplasmic reticulum stress; oxidative stress

Online: 16 November 2021 (11:34:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0455.v1

TNF-α plus IL-1β Induces Opposite Regulation of Hemichannels and Gap Junctions in Mesangial Cells Through a RhoA/ROCK-dependent Pathway

Claudia M. Lucero, Marcelo A. León, Paola Fernández, Juan A. Orellana, Victoria Velarde, Juan C Sáez, Gonzalo I Gómez

Subject: Biology And Life Sciences, Biophysics Keywords: connexin hemichannel; gap junction; oxidative stress; Inflammatory receptors; Fasudil; Y-27632.

Online: 29 October 2021 (13:12:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0415.v1

Reductions in Hydrogen Sulfide Precede Onset of Mitochondrial Quality Control in the Corneal Kindled Mouse Model of Epilepsy

Christi Cho, Maxwell Zeigler, Stephanie Mizuno, Richard S. Morrison, Rheem Totah, Melissa Barker-Haliski

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: epilepsy; hydrogen sulfide; corneal kindled mice, mitochondrial dysfunction, oxidative stress, LC-MS/MS; temporal lobe epilepsy; neurological disorder; gasotransmitter

Online: 27 October 2021 (13:36:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0449.v1

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: glutathione; glutamate; psychosis; schizophrenia; redox; antioxidant; oxidative stress; myelin; spectroscopy

Online: 27 September 2021 (12:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0431.v1

mRNA Transcriptomic Profiling of Human Hepatocellular Carcinoma Cells HepG2 Treated with Catharanthus roseus-Silver Nanoparticles

Nur Asna Azhar, Siti Aishah Abu Bakar, Marimuthu Citartan, Nor Hazwani Ahmad

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: C. roseus; HepG2; silver nanoparticles; AgNPs; mRNA; transcriptomic; gene expression; oxidative stress; apoptosis; cell cycle.

Online: 24 September 2021 (12:44:00 CEST)

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Working Paper ARTICLE

Immunomodulatory Effect of Charak Immunity Tablets (CIT) On Healthy Participants: A Single Blind, Randomized, Placebo-Controlled, Exploratory Study

Akanksha Mourya, Amit Yadav, Suresh Khadke, Sarika Mane, Asavari Joshi, Poonam Gupte, Madhavi Mahajan, Supriya Bhalerao

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: CD4- CD8 counts; immunity; inflammation; oxidative stress; peak expiratory flow rate

Online: 14 September 2021 (14:43:16 CEST)

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Immunity has become an important aspect of concern, as the spread of corona virus, is on the rise. The strategies to boost and modulate the immunity have therefore become need of the hour. The present study was carried out to evaluate the effect of Charak immunity Tablets (CIT) on innate and adaptive immune response in healthy individuals. It was a single-blind, randomized, placebo-controlled, exploratory study. After obtaining Ethics Committee permission, 36 healthy individuals of either sex aged 18-35 years with prior consent were recruited in the study. They were randomly divided into 2 groups to receive either CIT or Placebo in 2:1 ratio. Both the interventions were given in a dose of 1 tab (500 mg) twice daily. The assessment variables were vitals [temperature, pulse, and blood pressure], respiratory health [respiratory rate, oxygen saturation and peak expiratory flow rate], questionnaire based assessment of immune status, perceived stress and quality of life along with objective assessment of immunity [CD4+, CD8+ counts, Interferon gamma (IFN γ), Tumor necrosis factor alpha (TNF-α) and Interleukin 10 (IL-10)] as well as oxidative stress; [Malondialdehyde (MDA) and Glutathione peroxidase], which were assessed at fixed time points. Of 36 recruited participants, only 18 participants completed the study. CIT treated individuals showed a statistically significant improvement in respiratory health, quality of life, perceived stress and subjective immune status. There was a decrease in the levels of serum IFN γ on day 60 compared to baseline. TNF-α and IL-10, both estimated from supernatant of Peripheral Blood Mononuclear Cells (PBMCs) stimulated with lipopolysaccharide (LPS), showed a decrease and a significant increase respectively on day 60 compared to baseline in CIT group. Further, CIT significantly decreased MDA levels.The present study indicates that CIT is an effective and safe drug to boost immunity. However, our findings need to be confirmed in larger sample size using more specific immune parameters.

Preprint REVIEW | doi:10.20944/preprints202109.0201.v1

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB and Wnt/Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis andChronic Fatigue Syndrome: A Review and New Hypothesis Based on Results of Network, Enrichment and Annotation Analyses

Michael Maes, Marta Kubera, Magdalena Kotańska

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; Myalgic Encephalomyelitis; inflammation; neuro-immune; oxidative and nitrosative stress; antioxidants

Online: 13 September 2021 (10:57:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0159.v1

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Marco Solmi, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; neuro-immune; inflammation; oxidative and nitrosative stress; depression; mood disorders; schizophrenia; psychiatry

Online: 8 September 2021 (20:03:03 CEST)

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Working Paper ARTICLE

Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-analysis and Meta-regression

Elke van Westering-Kroon, Maurice J Huizing, Eduardo Villamor-Martínez, Eduardo Villamor

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: preterm birth; oxidative stress; sex differences; male disadvantage; female advantage; bronchopulmonary dysplasia; retinopathy of prematurity; necrotizing enterocolitis; intraventricular hemorrhage; periventricular leukomalacia; mortality.

Online: 3 September 2021 (11:08:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0537.v1

Use of Cerium Nitrate Nanoparticles in Biological Environment Along with the Factors Effecting It: An Empirical Overview

Zarish Fatima, Sameer Quazi, Shreelaxmi Gavas, Tomasz Karpiński

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cerium oxide nanoparticles; radicals; oxidative stress; physical and chemical properties and biological characteristics

Online: 30 August 2021 (10:22:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0328.v1

Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds

Michael Adu-Frimpong, James Abugri, Bridget Osei Henewaah Annor

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Phytobioactive compounds; anti-inflammatory; anti-oxidant; methotrexate; hepatotoxicity; oxidative stress

Online: 16 August 2021 (11:37:17 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202108.0302.v1

Nanoliposomes Reduce Stroke Injury Following Middle Cerebral Artery Occlusion in Mice

Saif Ahmad, Seth Truran, Nina Karamanova, Adam Kindelin, Maria Lozoya, Volkmar Weissig, Daniel Griffiths, Tyler Vail, Jonathan Lifshitz, Andrew F. Ducruet, Raymond Q. Migrino

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; liposome; cerebrovascular disease; oxidative stress; dementia

Online: 13 August 2021 (15:37:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0122.v1

Comparative Reactive Oxidative Species (ROS) Content among Disposable Flavored Vape Bars

Shaiesh Yogeswaran, Thivanka Muthumalage, Irfan Rahman

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Vaping, disposable e-cigarettes, vape bars, flavoring, flavoring chemicals, Reactive Oxidative Species (ROS), disposables, oxidative stress

Online: 4 August 2021 (21:48:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0361.v1

The Role of Antioxidants on Wound Healing: A Review of the Current Evidence

Inés María Comino-Sanz, María Dolores López-Franco, Begoña Castro, Pedro Luis Pancorbo-Hidalgo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: wound healing; oxidative stress; antioxidant dressing; reactive oxygen species.

Online: 15 July 2021 (13:32:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0333.v1

The Tardigrade Damage Suppressor Protein Promotes Transcription Factor Activation and Expression of DNA Repair Genes in Human Cells in Response to Hydroxyl Radicals and UV-C Exposure

Claudia Ricci, Giulia Riolo, Carlotta Marzocchi, Jlenia Brunetti, Alessandro Pini, Silvia Cantara

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Dsup; tardigrade; UV-C; Oxidative stress; DNA repair; transcription factors

Online: 14 July 2021 (12:49:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0042.v1

Decoding Oxidative Stress and Antioxidative Parameters in Patients with Spinal Cord Injury

Ghizal Fatima, Jan Fedacko, Ammar Mehdi Raza, Najah R. Hadi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Spinal Cord Injury; Oxidative stress; Antioxidants, Pain

Online: 2 July 2021 (09:05:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0726.v1

In Utero Exposure to 9-Tetrahydrocannabinol Leads to Postnatal Catch-up Growth and Dysmetabolism in the Adult Rat Liver

Shelby Louise Oke, Kendrick Lee, Rosemary Papp, Steven R. Laviolette, Daniel B. Hardy

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: 9-tetrahydrocannabinol, intrauterine growth restriction, liver, metabolism, triglycerides, oxidative stress, mitochondria, miR-203a-3p, miR-29a/b/c

Online: 30 June 2021 (09:50:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0558.v1

High Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and Dna Damage.

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Vegetables; DNA damage; Genomic Instability; Oxidative stress; Inflammation.

Online: 23 June 2021 (10:08:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0513.v1

Mild Cognitive Impairment is not a Valid Concept and Should be Replaced by a More Restrictive, Biologically Validated Class, Named Mild Cognitive Dysfunctions (MCD): A Nomothetic Network Approach

Michael Maes, Sookjaroen Tangwongchai

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dementia; neurocognition; neuroimmune; oxidative stress; antioxidants; psychiatry; ageing

Online: 21 June 2021 (13:58:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0464.v1

High Fructose Consumption: More Pain Than Gain to Human Health

Simon Isaiah, Oluwaseyi Olanrewaju, Abisola Sholeye, Modupe Ayilara

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Antioxidants; Free radicals; Fructose; Oxidative stress

Online: 17 June 2021 (14:40:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0337.v1

Biochemical Mechanisms Associating Alcohol Use Disorders with Cancers.

Francisco D. Rodriguez, Rafael Coveñas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alcohol use disorders (AUD); cancer, ethanol oxidative and nonoxidative metabolism, acetaldehyde, reactive oxygen species (ROS), DNA adducts, protein damage, cancer stem cells (CSC), epigenetic changes.

Online: 14 June 2021 (09:03:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0241.v1

Role of Astrocytes in Central Nervous System, Disease Implications and New Physiological Implications in Memory and Learning

Soraya L. Valles, Sandeep Kumar Singhb, Ignacio Campo, Adrian Jorda

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Neurons; Astrocytes; Neurodegeneration; Neurodevelopmental diseases; Memory; Learning; Inflammation; Oxidative Stress; sleep disorders

Online: 9 June 2021 (07:36:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0236.v1

Abscisic Acid and Nitrogen Showed Coordinated Action on Antioxidant System and Osmotic Adjustment to Alleviate Salinity Inhibited Photosynthetic Potential in Brassica juncea L.

Arif Majid, Bilal A. Rather, Asim Masood, Nafees A. Khan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Abscisic acid; , Brassica juncea; Nitrogen; Salinity; Oxidative stress; Photosynthetic functions

Online: 8 June 2021 (13:47:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0147.v1

Abscisic Acid and Nitrogen Showed Coordinated Action on Antioxidant System and Osmotic Adjustment to Alleviate Salinity Inhibited Photosynthetic Potential in Brassica juncea L.

Arif Majid, Bilal Rather, Asim Masood, Nafees Khan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Abscisic acid; Brassica juncea; Nitrogen; Salinity; Oxidative stress; Photosynthetic functions

Online: 7 June 2021 (07:47:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0112.v1

High Vegetables Intake and Response to COPD Rehabilitation Treatment. The Role of Oxidative Stress, Inflammation and DNA Damage

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milic, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic obstructive pulmonary disease (COPD); Pulmonary Rehabilitation; Diet; DNA damage; Genomic Instability; Oxidative stress; Inflammation

Online: 3 June 2021 (12:21:13 CEST)

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