Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds

Version 1 : Received: 12 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (11:37:17 CEST)

How to cite: Adu-Frimpong, M.; Abugri, J.; Osei Henewaah Annor, B. Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds . Preprints 2021, 2021080328 (doi: 10.20944/preprints202108.0328.v1). Adu-Frimpong, M.; Abugri, J.; Osei Henewaah Annor, B. Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds . Preprints 2021, 2021080328 (doi: 10.20944/preprints202108.0328.v1).

Abstract

Methotrexate (MTX) is a potent drug for the treatment of various diseases globally amidst being a chemotherapeutic and immunosuppressant agent. However, hepatotoxicity induced by MTX could be life-threatening if left untreated. Folate supplementation is concurrently applied to reduce the adverse effects of MTX, albeit efficacy compromise. Therefore, there is the need to understand the process for the prevention and treatment strategies for MTX induced hepatotoxicity (MIH). In recent times, preliminary preclinical and clinical findings indicate the potential of natural phytobioactive compounds for MIH prevention and treatment. This mini review therefore summarizes proposed mechanisms of MIH and recent advances in the prevention and treatment prospects of natural phytobioactive compounds on MIH.

Keywords

Phytobioactive compounds; anti-inflammatory; anti-oxidant; methotrexate; hepatotoxicity; oxidative stress

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.