Version 1
: Received: 12 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (11:37:17 CEST)
How to cite:
Adu-Frimpong, M.; Abugri, J.; Osei Henewaah Annor, B. Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds. Preprints2021, 2021080328. https://doi.org/10.20944/preprints202108.0328.v1
Adu-Frimpong, M.; Abugri, J.; Osei Henewaah Annor, B. Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds . Preprints 2021, 2021080328. https://doi.org/10.20944/preprints202108.0328.v1
Adu-Frimpong, M.; Abugri, J.; Osei Henewaah Annor, B. Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds. Preprints2021, 2021080328. https://doi.org/10.20944/preprints202108.0328.v1
APA Style
Adu-Frimpong, M., Abugri, J., & Osei Henewaah Annor, B. (2021). Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds<strong> </strong>. Preprints. https://doi.org/10.20944/preprints202108.0328.v1
Chicago/Turabian Style
Adu-Frimpong, M., James Abugri and Bridget Osei Henewaah Annor. 2021 "Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds<strong> </strong>" Preprints. https://doi.org/10.20944/preprints202108.0328.v1
Abstract
Methotrexate (MTX) is a potent drug for the treatment of various diseases globally amidst being a chemotherapeutic and immunosuppressant agent. However, hepatotoxicity induced by MTX could be life-threatening if left untreated. Folate supplementation is concurrently applied to reduce the adverse effects of MTX, albeit efficacy compromise. Therefore, there is the need to understand the process for the prevention and treatment strategies for MTX induced hepatotoxicity (MIH). In recent times, preliminary preclinical and clinical findings indicate the potential of natural phytobioactive compounds for MIH prevention and treatment. This mini review therefore summarizes proposed mechanisms of MIH and recent advances in the prevention and treatment prospects of natural phytobioactive compounds on MIH.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
