Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy

Elisenda Moliner-Calderón
,
Sergio Verd
* ORCID logo ,
Alfonso Leiva
,
Jaume Ponce-Taylor
,
Gemma Ginovart
ORCID logo ,
Pia Moll-McCarthy
,
Catian Gelabert
,
Josep Figueras-Aloy
Version 1 : Received: 20 August 2022 / Approved: 22 August 2022 / Online: 22 August 2022 (08:11:06 CEST)

A peer-reviewed article of this Preprint also exists.

Moliner-Calderón, E.; Verd, S.; Leiva, A.; Ponce-Taylor, J.; Ginovart, G.; Moll-McCarthy, P.; Gelabert, C.; Figueras-Aloy, J. Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy. Children 2022, 9, 1450. Moliner-Calderón, E.; Verd, S.; Leiva, A.; Ponce-Taylor, J.; Ginovart, G.; Moll-McCarthy, P.; Gelabert, C.; Figueras-Aloy, J. Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy. Children 2022, 9, 1450.

Abstract

Background. It is well established that human milk feeding contributes in limiting lung disease among vulnerable neonates. The primary aim of this research was to compare the need for mechanical ventilation of human milk-fed sick neonates with that of formula-fed sick neonates. Methods. All late preterm and full term infants from a single center with findings of sepsis, from 2002 to 2017, were identified. Data regarding infant feeding during hospital admission were recorded. Multivariate logistic regression analyses were performed to assess the impact of the type of milk on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260, exclusive formula group = 62). On bivariate analysis, 72% of human milk-fed neonates did not need oxygen therapy nor respiratory support versus 55% of their formula-fed counterparts (P<0.0001). Accordingly, invasive mechanical ventilation was required by 9.2% of human milk-fed infants versus 32% of their formula-fed counterparts (P=0.0085). These results hold true in multivariate analysis, indeed human milk-fed neonates were more likely to require less respiratory support (OR=0.44; 95% CI: 0.22, 0.89) when compared to those who were exclusively formula-fed. Conclusion. Human milk feeding might minimize exposure to mechanical ventilation.

Keywords

newborn infant; sepsis; premature infant; oxygen therapy; oxidative stress; ventilation support

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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