Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Wound Healing Versus Metastasis: Role of Oxidative Stress

Version 1 : Received: 20 September 2022 / Approved: 23 September 2022 / Online: 23 September 2022 (03:28:28 CEST)

How to cite: Lopez, T.; Wendremaire, M.; Lagarde, J.; Duquet, O.; Alibert, L.; Paquette, B.; Garrido, C.; Lirussi, F. Wound Healing Versus Metastasis: Role of Oxidative Stress. Preprints 2022, 2022090354 (doi: 10.20944/preprints202209.0354.v1). Lopez, T.; Wendremaire, M.; Lagarde, J.; Duquet, O.; Alibert, L.; Paquette, B.; Garrido, C.; Lirussi, F. Wound Healing Versus Metastasis: Role of Oxidative Stress. Preprints 2022, 2022090354 (doi: 10.20944/preprints202209.0354.v1).

Abstract

Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators.

Keywords

Wound healing; metastasis; oxidative stress; macrophage; HIF; NF-kB; Nrf2

Subject

MEDICINE & PHARMACOLOGY, Other

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