Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection

Jessica Maiuolo; Rosamaria Bulotta; Francesca Oppedisano; Vincenzo Musolino; Micaela Gliozzi; Cristina Carresi; Federica Scarano; Saverio Nucera; Miriam Scicchitano; Martina Nicita; Rosamaria Caminiti; Francesca Bosco; Roberta Macrì; Adriano Carnevali; Vincenzo Scorcia; Vincenzo Mollace

doi:10.20944/preprints202207.0118.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202207.0118.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection

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Version 1 : Received: 5 July 2022 / Approved: 7 July 2022 / Online: 7 July 2022 (09:04:14 CEST)

How to cite: Maiuolo, J.; Bulotta, R.; Oppedisano, F.; Musolino, V.; Gliozzi, M.; Carresi, C.; Scarano, F.; Nucera, S.; Scicchitano, M.; Nicita, M.; Caminiti, R.; Bosco, F.; Macrì, R.; Carnevali, A.; Scorcia, V.; Mollace, V. Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection. Preprints 2022, 2022070118. https://doi.org/10.20944/preprints202207.0118.v1 Maiuolo, J.; Bulotta, R.; Oppedisano, F.; Musolino, V.; Gliozzi, M.; Carresi, C.; Scarano, F.; Nucera, S.; Scicchitano, M.; Nicita, M.; Caminiti, R.; Bosco, F.; Macrì, R.; Carnevali, A.; Scorcia, V.; Mollace, V. Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection. Preprints 2022, 2022070118. https://doi.org/10.20944/preprints202207.0118.v1

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MDPI and ACS Style

Maiuolo, J.; Bulotta, R.; Oppedisano, F.; Musolino, V.; Gliozzi, M.; Carresi, C.; Scarano, F.; Nucera, S.; Scicchitano, M.; Nicita, M.; Caminiti, R.; Bosco, F.; Macrì, R.; Carnevali, A.; Scorcia, V.; Mollace, V. Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection. Preprints 2022, 2022070118. https://doi.org/10.20944/preprints202207.0118.v1

APA Style

Maiuolo, J., Bulotta, R., Oppedisano, F., Musolino, V., Gliozzi, M., Carresi, C., Scarano, F., Nucera, S., Scicchitano, M., Nicita, M., Caminiti, R., Bosco, F., Macrì, R., Carnevali, A., Scorcia, V., & Mollace, V. (2022). Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection. Preprints. https://doi.org/10.20944/preprints202207.0118.v1

Chicago/Turabian Style

Maiuolo, J., Vincenzo Scorcia and Vincenzo Mollace. 2022 "Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection" Preprints. https://doi.org/10.20944/preprints202207.0118.v1

Abstract

Abstract Eye health is crucial and the onset of diseases can reduce vision and affect the quality of life of patients. The main causes of progressive and irreversible vision loss include various pathologies such as cataracts, ocular atrophy, corneal opacity, age-related macular degeneration, uncorrected refractive error, posterior capsular opacification, uveitis, glaucoma, diabetic retinopathy, retinal detachment, undetermined disease and other disorders involving oxidative stress and inflammation. The eyes are constantly exposed to the external environment and, for this reason, must be protected from damage from the outside. Many drugs, including cortisonics and antinflammatory drugs have widely been used to counteract eye disorders. However, recent advances have been obtained via supplementation of patients with natural antioxidants and nutraceuticals. In particular, evidence has been accumulated that polyphenols (mostly deriving from Citrus Bergamia) represent a reliable source of antioxidants able to counteract oxidative stress accompanying early stages of eye diseases. Luteolin, in particular, has been found to protect foto-receptors thereby improving vision in many disease states. Moreover, a consistent anti-inflammatory response was found to occur when curcumin is used alone or in combination with other nutraceuticals. On the other hand, CoQ10 has been demonstrated to produce consistent effect in reducing ocular pressure thereby leding to protection in patients undergoing glaucoma. Finally, both grape seed extract rich in anthocyanosides and polynsatured fatty acids (PUFAs) seem to contribute in the prevention of retinal disorders. Thus, combination of nutraceuticals and anti-oxidants may represent the right solution for a multiaction activity in eye protection to be associated to current drug therapies, and this will be of potential interest in early stages of eye disorders.

Keywords

Eyes diseases; Oxidative damage; Antioxidant compounds; Vitamin A; Vitamin C; Lutein; Curcumin; Quercetin; Coenzyme Q10; PUFAs; BPF; Grape seed

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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