Version 1
: Received: 18 January 2023 / Approved: 19 January 2023 / Online: 19 January 2023 (15:10:23 CET)
How to cite:
Tuell, D.S.; Los, E.A.; Ford, G.A.; Stone, W.L. The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes. Preprints2023, 2023010365. https://doi.org/10.20944/preprints202301.0365.v1
Tuell, D.S.; Los, E.A.; Ford, G.A.; Stone, W.L. The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes. Preprints 2023, 2023010365. https://doi.org/10.20944/preprints202301.0365.v1
Tuell, D.S.; Los, E.A.; Ford, G.A.; Stone, W.L. The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes. Preprints2023, 2023010365. https://doi.org/10.20944/preprints202301.0365.v1
APA Style
Tuell, D.S., Los, E.A., Ford, G.A., & Stone, W.L. (2023). The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes. Preprints. https://doi.org/10.20944/preprints202301.0365.v1
Chicago/Turabian Style
Tuell, D.S., George A. Ford and William L. Stone. 2023 "The Role of Natural Factors that Optimize Redox Status in Combating Type 2 Diabetes" Preprints. https://doi.org/10.20944/preprints202301.0365.v1
Abstract
The worldwide prevalence of type 2 diabetes (T2D) and prediabetes is rapidly increasing, particularly in children, adolescents, and young adults. Oxidative stress (OxS) has emerged as a likely initiating factor in T2D. The role of natural antioxidant products in combating T2D is best evaluated in the context of the complex physiological processes that modulate T2D-OxS such as glycemic control and exercise. The role of natural antioxidant compounds such as vitamin E in T2D must likewise be considered beyond their roles as inhibitors of OxS. In addition to antioxidant properties, vitamin E vitamers (tocopherols and tocotrienols) also exhibit distinct abilities to regulate cellular signal transduction pathways important to T2D progression. Most research on the role of vitamin E in T2D or prediabetes has been limited to tocopherols (Ts) but emerging trials with tocotrienols (T3s) show promise. Minimizing factors that induce chronic damaging OxS and maximizing natural antioxidant protective factors may provide a means of preventing or slowing T2D progression. This “optimal redox” (OptRedox) approach also provides a framework in which to discuss the potential benefits of natural antioxidant factors such as antioxidant products. Since early, effective intervention is critical, the OptRedox strategy would be optimally effective if implemented in the pediatric population.
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
