Fatima, G.; Fedacko, J.; Raza, A.M.; Hadi, N.R. Decoding Oxidative Stress and Antioxidative Parameters in Patients with Spinal Cord Injury. Preprints2021, 2021070042. https://doi.org/10.20944/preprints202107.0042.v1
APA Style
Fatima, G., Fedacko, J., Raza, A.M., & Hadi, N.R. (2021). Decoding Oxidative Stress and Antioxidative Parameters in Patients with Spinal Cord Injury. Preprints. https://doi.org/10.20944/preprints202107.0042.v1
Chicago/Turabian Style
Fatima, G., Ammar Mehdi Raza and Najah R. Hadi. 2021 "Decoding Oxidative Stress and Antioxidative Parameters in Patients with Spinal Cord Injury" Preprints. https://doi.org/10.20944/preprints202107.0042.v1
Abstract
Introduction:In this study we evaluated the connivance of oxidative and antioxidative parameters in the pathogenesis of spinal cord injury (SCI). Although the etiology and pathogenesis of SCI remain to be fully understood, it has been suggested that reactive oxygen species (ROS) and oxidative stress may play a significant role in the pathophysiology of SCI. Furthermore, there is little information available in scientific literature about oxidative and antioxidative parameters in SCI patients. Methods:Oxidative stress was determined by measuring the levels of Lipid Peroxides (LPO) and Protein carbonyl in plasma and antioxidative parameters like Glutathione Reductase (GR), catalase and Glutathione peroxidase (GPx) in lysate in 40 SCI patients and 40 healthy subjects without SCI. However, pain was measured by McGill pain questionnaire. Results: Concentrations of catalase (p<0.01), GR (p<0.01) and GPx (p<0.01) were significantly lower in patients with SCI than in controls, and levels of oxidative stress parameters, LPO (p<0.01), Protein carbonyl (p<0.01) were significantly higher in patients than in controls. A significant positive correlation was found between LPO and pain score among SCI patients group. Furthermore, a significant positive correlation was also found between Protein carbonyl and pain score among SCI patients group than in control group. Conclusion: The present results indicate that SCI patients are exposed to oxidative stress and this escalated oxidative stress may play a role in the etiopathogenesis of the disease. Moreover, our results also show that increased oxidative stress parameters are more strongly amalgamated with pain in SCI patients.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
2 July 2021
Commenter:
Mohd Kahf Abbas
The commenter has declared there is no conflict of interests.
Comment:
This is a wonderful article, I have one query could you please tell me wheter you have taken new or old SCI patients, if old then how old and if new then how new.
Commenter: Mohd Kahf Abbas
The commenter has declared there is no conflict of interests.