Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation

Version 1 : Received: 29 December 2022 / Approved: 3 January 2023 / Online: 3 January 2023 (07:35:39 CET)

How to cite: Fatehi, M. Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation. Preprints 2023, 2023010012. https://doi.org/10.20944/preprints202301.0012.v1 Fatehi, M. Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation. Preprints 2023, 2023010012. https://doi.org/10.20944/preprints202301.0012.v1

Abstract

Insulin signaling plays a crucial role in cellular uptake of glucose and different metabolic pathways. Impairment in cellular insulin sensitivity due to various molecular pathways leads to Insulin resistance (IR) as well as fatty liver. In this review, mechanisms by which zinc involved in decreasing IR are described, focusing on oxidative stress, inflammation, immune system, gut flora and hepatic lipophagy. This study reviews the cause of IR and highlights the role of zinc in mechanisms diminishing IR and fatty liver.

Keywords

Insulin Resistance; Zinc supplementation; Oxidative stress; Inflammation; Gut microbiome; Hepatic lipophagy

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

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