Version 1
: Received: 22 November 2021 / Approved: 23 November 2021 / Online: 23 November 2021 (15:05:47 CET)
How to cite:
Nantachai, G.; Vasupanrajit, A.; Tunvirachaisakul, C.; Solmi, M.; Michael Maes, M.M. Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. Preprints2021, 2021110432. https://doi.org/10.20944/preprints202111.0432.v1
Nantachai, G.; Vasupanrajit, A.; Tunvirachaisakul, C.; Solmi, M.; Michael Maes, M.M. Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis . Preprints 2021, 2021110432. https://doi.org/10.20944/preprints202111.0432.v1
Nantachai, G.; Vasupanrajit, A.; Tunvirachaisakul, C.; Solmi, M.; Michael Maes, M.M. Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. Preprints2021, 2021110432. https://doi.org/10.20944/preprints202111.0432.v1
APA Style
Nantachai, G., Vasupanrajit, A., Tunvirachaisakul, C., Solmi, M., & Michael Maes, M.M. (2021). Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis<strong> </strong>. Preprints. https://doi.org/10.20944/preprints202111.0432.v1
Chicago/Turabian Style
Nantachai, G., Marco Solmi and Michael Maes Michael Maes. 2021 "Oxidative Stress and Antioxidant Defenses in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis<strong> </strong>" Preprints. https://doi.org/10.20944/preprints202111.0432.v1
Abstract
This study aims to systematically review and meta-analyze the nitro-oxidative stress (O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of people with mild cognitive impairment (MCI). We searched PubMed, Scopus, Google Scholar, and Web of Science for articles published from inception until July 31, 2021. Forty-six studies on 3.798 MCI individuals and 6.063 healthy controls were included. The O&NS/ANTIOX ratio was significantly higher in MCI than in controls with a Standardized Mean Difference (SMD)=0.378 (95% CI: 0.250; 0.506). MCI individuals showed increased lipid peroxidation (SMD=0.774, 95%CI: 4.416; 1.132) and O&NS-associated toxicity (SMD=0.621, CI: 0.377; 0.865) and reduced glutathione (GSH) defenses (SMD=0.725, 95%CI: 0.269; 1.182) as compared with controls. MCI was also accompanied by significantly increased homocysteine (SMD=0.320, CI: 0.059; 0.581), but not protein oxidation, and lowered non-vitamin (SMD=0.347, CI: 0.168; 0.527) and vitamin (SMD=0.564, CI: 0.129; 0.999) antioxidant defenses. The results show that MCI is at least in part due to increased neuro-oxidative toxicity and suggest that treatments targeting lipid peroxidation and the GSH system may be used to treat or prevent MCI.
Keywords
Oxidative and nitrosative stress; antioxidants; biomarkers; neuro-immune; neurocognition
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
