Hydrogenated water has emerged as a novel approach in the field of health and wellness. It is be-lieved to have potent antioxidant properties that can neutralize harmful free radicals in the hu-man body. It has also been shown to be beneficial in mitigating oxidative stress-induced damage through its anti-inflammatory and anti-apoptotic pathways. We aim to conduct a systematic re-view to evaluate the potential benefits of hydrogenated water. The review protocol was uploaded on PROSPERO. After the initial search criteria, the articles were reviewed by two blinded inves-tigators, and a total of 25 articles were included in the systematic review. The potential benefits of hydrogenated water on various aspects of health, including exercise capacity, physical endurance, liver function, cardiovascular disease, mental health, COVID-19, oxidative stress, and anti-aging research, are a subject of growing interest and ongoing research. Although preliminary results in clinical trials and studies are encouraging, further research with larger sample sizes and rigor-ous methodologies is needed to substantiate these findings. Current research needs to fully ex-plain the mechanisms behind the potential benefits of hydrogenated water. Continued scientific exploration will provide valuable insights into the potential of hydrogenated water as an adjunc-tive therapeutic approach in the future.

To alleviate the contradiction between the increasing demand for water and the shortage of resources and to provide a favorable institutional environment for water rights trading, the Chinese government has strengthened the top-level design of water management system. However, the water-rich regions (southern regions of China) have good water resource endowment and a surplus of total water consumption indicators. Does this mean that there is no incentive and no need to conduct water rights trading in these regions? Through the investigation of water rights circulation cases in the Taihu Basin, a typical water-rich region of China, we established the existence of trading demand and some difficulties in conducting transactions. This paper argues that the needs of trading include alleviating the water gap in regional development, solving the water demand for large new projects, coordinating trans-jurisdiction water disputes. The plight of trading includes the lack of awareness, irregular process, excessive administrative intervention, and imperfect trading system.

Rural areas are not only faced with the problems of rural depopulation but also with the problem of water supply and water quality which is a basic necessity of life. In light of this, this paper assesses the rural water supply situation and the bacteriological quality of different water sources in the Obokun Local Government Area of Osun State, Nigeria. The safety of the water sources for human consumption and possible occurrence of the water borne diseases in the study area were determined. The study employed descriptive and analytical methods of data analysis to achieve the objectives of the inquiry. Findings showed that the study area suffered from inadequate water supply and poor locations of the sources of water: The study also revealed that the microbiological quality of the water sources used was unsafe, poor and not acceptable for human consumption. In addition, many man- days-hours were wasted in search of water. It is therefore recommended that the government should make the rural water supply and the maintenance of water quality a priority in its policy formulation.

Molecular hydrogen (H2) has been shown to have antioxidant and anti-inflammatory activities that may reduce the development and progression of many diseases. In this study, Hydrogen-rich water (HRW) was obtained by reacting hybrid magnesium-carbon hydrogen storage materials with water. Then the effects of intake of HRW on the activities of xenobiotic-metabolizing enzymes, membrane transporters, and oxidative stress in rats were investigated. Rats were given HRW ad libitum for 4 weeks. Results showed that intake of HRW had no significant effect on the activities of various cytochrome P450 (CYP) enzymes (CYP1A1, 1A2, 2B, 2C, 2D, 2E1, 3A, 4A), glutathione-S-transferase and UDP-glucuronosyltransferase. Except for a slight lower plasma glucose concentration, intake of HRW had no effect on other plasma biochemical parameters in rats. P-Glycoprotein and multidrug resistance-associated protein (Mrp)2 protein expressions in liver were elevated after intake of HRW. However, HRW had no significant effects on glutathione, glutathione peroxidase, or lipid peroxidation in liver. Results from this study suggest that consumption of HRW may not affect xenobiotic metabolism or oxidative stress in liver. However, intake of HRW may increase the efflux of xenobiotics or toxic substances from the liver into bile by enhancing the expression of p-glycoprotein and Mrp2 protein.

Saltwater intrusion in the rapidly developing city of Da Nang in central Vietnam is currently causing various water-related challenges, including inadequate water supply and water pollution. An integrated SWAT-MODFLOW numerical model was used to investigate the origin and mechanism of saltwater in Holocene and Pleistocene aquifers. Geophysical and isotopic approaches were used to validate the SEAWAT model applied for simulating saltwater intrusion. The results suggest that the ebb and flow of tides, as well as water levels in rivers primarily impact coastal aquifers. However, effective water resource planning and management, along with maintaining the natural recharge of fresh water from local rain during the rainy season, could enable the rational and efficient utilization of groundwater, reducing saltwater intrusion in many areas. During the dry season, groundwater is recharged from higher altitude areas. The current saltwater intrusion mainly occurs along the rivers up to the hydraulic dam. Simulated models, using scenarios of stop abstracting groundwater, but changing to the use of surface water for drinking water, show that the area of saline water shrinks quickly after 30 years, reducing from 59.6 km2 to 39.5 km2 and from 40.2 km2 to 28.6 km2 in Holocene and Pleistocene, respectively.

The concept of ecosystem services (ESs) provides a valuable approach to communicate societies' dependence on natural ecosystems, assisting in the evaluation of measures to protect vegetation in watersheds that promote water-related ESs. Vegetation cover and land use are important factors related to the capacity of ecosystems to provide soil loss regulation and sediment retention services, which are highly relevant for sediment management in watersheds draining into reservoirs with multiple water uses. This study aims to assess the relationship between potential changes in land use and land cover and the sediment retention service provided by riparian vegetation in a watershed draining into a hydroelectric reservoir in the Brazilian Cerrado. Sediment load was selected as a physical variable that affects different water uses in reservoirs, with these uses being dependent on the quality or quantity of stored water. Scenarios were analyzed to represent landscape reconfigurations from a baseline condition in order to account for the recovery of riparian vegetation by the agricultural sector, as foreseen in the Brazilian Forest Code. To map and quantify variations in annual sediment retention, the InVEST model was used, which allows estimating an integrated response of the drainage basin to large-scale land use changes over time and space. The results show that for the drainage basin of the Corumbá IV Hydroelectric Power Plant (HPP), the recovery of riparian areas occupied by annual crops has the potential to generate greater benefits to water use in the reservoir. In the studied catchment area, 14% of the total vegetation deficit in riparian areas is occupied by crops, while 86% is occupied by pastures. This highlights the buffering role of riparian vegetation as an effective practice for managing sediment flows originating from sheet erosion in agricultural landscapes. The methodology employed in this study allows for the quantification and mapping of the effects of soil and water conservation measures in river basins. This enables the prioritization of sectoral efforts for the restoration of native vegetation, considering the highest returns in benefits perceived by water users affected by sediment input in reservoirs. The study's results reinforce the importance of conserving vegetation in riparian areas and their surroundings for sediment retention, highlighting the role of these areas as assets in providing water-related ecosystem services.

Based on the analysis of hydrochemical data of 18 samples of shallow groundwater around Hancheng mining area in Guanzhong Basin, Gibbs semi-logarithmic diagram and Piper diagram were used to study the hydrogeochemical behavior of shallow groundwater around Hangcheng mining area in Guanzhong Basin. Chemical composition analysis showed that most of the groundwater was SO₄ · Cl-Ca · Mg type, accounting for 61.1 %. Hydrogen and oxygen isotope data show that groundwater in the study area is recharged by modern precipitation. The main chemical components of most groundwater are Ca²⁺, Mg²⁺, HCO₃^-, Cl^-and SO₄^2-. Ca²⁺, Mg²⁺, and HCO₃^- are mainly dolomite, calcite, and gypsum dissolution precipitation results. Na⁺ and Cl^- originate from the dissolution of halite. The main ion chemistry of shallow groundwater in this area is controlled by rock weathering, and pyrite oxidation is an important factor affecting SO₄^2-concentration. The research results will help analyze the formation mechanism of chemical components and provide some basic data for the evolution of mine water in this area in the future.

The problem of water drinking supply is very important in the world, especially for developing countries, in particular Algeria. In this work we propose to study a distillation system based on solar energy process using an artificial intelligence approach in order to enhance the performance and the daily production. For this purpose, a conventional solar still and capillary film solar still was used. The operating parameters of the two distilleries are analyzed and the neural network approach was used to predict the performance through the amount of distillate, solar radiation and ambient temperature. The sensitivity between the operating parameters of the solar still for two case have been studied through the artificial neuron network model. The obtained results are promising, analyzed and discussed.

The participation of civil society is essential for environmental health policies to be effective. The objective of this study was to know the perceptions of government officials, members of civil society, and academics about environmental health problems and its governance in Bucaramanga Metropolitan Area, Colombia. In the region there is a strong citizen movement that defends the moorland ecosystem (paramo) as source of drinking water, of large-scale mining projects. A multi-method study was carried out including the review of newspaper and scientific articles, a citizen survey, and interviews and focus groups with identified key stakeholders. The findings indicate that government officials prioritize their actions on issues related to air and water pollution and environmental education. In contrast, citizens prioritize water availability from the moorland ecosystem. There are some advances in the management of environmental health, mainly related to greater citizen awareness. The participation of civil society in the environmental health governance must be enforced to broaden the issues of interest and prioritize the activities in the short- and long-term policy planning. An experience between high school students and the academy that measures air pollutants can be the first meeting point with government officials in the pathway to improve the environmental governance in the territory.

Platelet and fibrin-rich orthobiologic products, such as autologous platelet concentrates, have been extensively studied and appreciated for their beneficial effects in multiple conditions. PRP and its derivatives, including PRF, have demonstrated encouraging outcomes in clinical and laboratory settings, particularly in the treatment of musculoskeletal disorders such as OA. Although PRP and PRF have distinct characteristics, they share similar properties. The relative abundance of platelets, peripheral blood cells and molecular components in these orthobiologic products stimulate numerous biological pathways. These include inflammatory modulation, augmented neovascularization, and delivery of pro-anabolic stimuli that regulate cell recruitment, proliferation, and differentiation. Furthermore, the fibrinolytic system, which is sometimes overlooked, plays a crucial role in musculoskeletal regenerative medicine by regulating proteolytic activity and promoting the recruitment of inflammatory cells and MSCs in areas of tissue regeneration, such as bone, cartilage, and muscle. PRP acts as a potent signaling agent; however, it diffuses easily, while the fibrin from PRF offers a durable scaffolding effect that promotes cell activity. The combination of fibrin with hyaluronic acid, another well-studied orthobiologic product, has been shown to improve its scaffolding properties, leading to more robust fibrin polymerization. This supports cell survival, attachment, migration, and proliferation. Therefore, the administration of the "power mix" containing HA and autologous PRP + PRF may prove to be a safe and cost-effective approach in regenerative medicine.

In order to formulate a reasonable water input model for cotton fields in southern Xinjiang, scientific and rational fertilization, reduce soil carbon leaching, and improve soil carbon sequestration capacity, the undisturbed soil column leaching test was used to simulate the current field management method in the study area. Two methods of drip irrigation and flood irrigation were set up, and three irrigation and three nitrogen fertilizer levels were used to carry out the undisturbed soil column leaching test. The results showed that the amount and mode of water and nitrogen input affected the distribution and leaching loss of organic carbon and inorganic carbon in soil. When the nitrogen application rate increased from 270 kg·hm-2 to 450 kg·hm-2, the leaching loss of soluble organic carbon and soluble inorganic carbon increased significantly. When the water input increased from 6000 m3·hm-2 to 9000 m3·hm-2, the leaching loss of DOC and DIC increased significantly. The carbon leaching loss under drip irrigation was higher than that under flood irrigation. The leaching rates of DOC and DIC were the fastest under the conditions of high water ( 9000 m3·hm-2 ) and high fertilizer ( 450 kg·hm-2 ). It shows that water and nitrogen input and irrigation methods are important factors affecting soil carbon leaching. In the case of excessive water input, long-term high-frequency irrigation is the main factor affecting carbon leaching.

This paper presents the design and experimental results of a long cavity length Nd: YAG laser with large stable zone for water jet guided laser (WJGL) applications. The design is based on the light transmission matrix and resonator stability conditions, aiming to achieve a large stable zone and a short cut-off thermal focal length (CTFL). A folded concave resonator is researched to enhance the cavity length, and the influence of the tun-able cavity arm length on the oscillating beam in the resonator and in the YAG crystal is theoretically studied. Moreover, the effects of the output mirror curvature and the cavity arm length on the range of the stable area and the cut-off thermal focal length are also investigated. Experimental results show that a stable green laser output is obtained after second harmonic generation (SHG), with a pulse width ranging from 43ns to 143ns within the laser operating frequency range of 5-20kHz. At an operation frequency of 10kHz, the output power is 21.33W, and the instability of the output power within 400 minutes is 0.88%. The laser source achieves a maximum power of 25.7W at 20kHz, and the maximum single pulse energy reaches 2.7mJ at 6kHz. Finally, this is used as the laser source to couple with a water jet with a diameter of 100 microns, achieving a lossless water conductivity transmission over 60mm length with a peak power density of 0.742GW/cm2. These results demonstrate the suitability of the designed laser source for WJGL technology research.

Three decades ago, human arsenic (As) contamination has been recognized in Ron Phibun, a sub-district with tin mining activity in southern Thailand. Since then different government bodies have attempted to mitigate the As-contamination problem by providing safe water in households. The most recent study conducted during 2000-2002 reported only a small fraction of population still had high urinary As level. Less attention has been paid to this issue afterwards. The present study aimed to re-assess the current situation, including human As contamination, water use behavior as well as identify risk factors of elevated As concentration among residents of Ron Phibun. The survey of 560 participants living in Ron Phibun with urinary As assessment was conducted. The median urinary As concentration of study participants was higher than normal. Consumption of shallow well water, a source generally considered as As-contaminated, was higher than a previous survey. A significant association was observed between urinary As concentrations and water sources for drinking and cooking. Gender and educational level were found to be associated with urinary As concentration. Significant associations between urinary As concentration and certain diseases (respiratory diseases, dermatitis, and dyslipidemia) were observed. The findings suggested further investigation of all water sources in the area for As contamination.

Autologous platelet-rich plasma (PRP) preparations are prepared at point of care. Centrifugation cellular density separation sequesters a fresh unit of blood into three main fractions: a platelet-poor plasma (PPP) fraction, a stratum rich in platelets (platelet concentrate) and, bioformulation dependent, also leukocyte and erythrocyte fractions. The employment of autologous platelet concentrates facilitates the biological potential to accelerate and support in numerous cellular activities that can lead to tissue repair, tissue regeneration, wound healing, and ultimately functional structural repair. Normally, after PRP preparation the PPP fraction is discarded. One of the less well known, but equally important features of PPP is that particular growth factors (GFs) are not abundantly present in PRP, as they reside outside the platelet alpha granules. Precisely, insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) are mainly present in the PPP fraction. In addition to their roles as angiogenesis activators, these plasma-based GFs are also known to inhibit inflammation, fibrosis, and they promote keratinocyte migration and support in tissue repair and wound healing. Additionally, PPP is known for the presence of exosomes and other macrovesicles, exerting cell-cell communication and cell signaling. Newly developed ultrafiltration technologies incorporate PPP processing methods by eliminating in a fast and efficient manner plasma water, cytokines, molecules, and plasma proteins with a molecular mass (weight) less than the pore size of the fibers. Consequently, a viable and viscous protein concentrate of functional, total proteins, like fibrinogen, albumin, and alpha-2-macroglobulin is created. Consolidating a small volume of high platelet concentrate with a small volume of highly concentrated protein-rich PPP creates a protein rich platelet concentrate (PRPC) biological preparation. After the activation of proteins, mainly fibrinogen, the PRPC matrix retains and facilitates interactions between invading resident cells, like macrophages, fibroblast, and mesenchymal stem cells (MSCs), and the embedded concentrated PRP cells and molecules. The administered PRPC biologic will ultimately undergo fibrinolysis, leading to a sustained release of concentrated cells and molecules that have been retained in the PRPC matrix until the matrix is dissolved. We will discuss the unique biological and tissue reparative and regenerative properties of PRPC matrix.

With the rapid development of urbanization, the chemical evolution of groundwater is significantly affected by human activities. However, the driving mechanisms of groundwater chemical evolution at different stages of urbanization remain unclear, severely impacting the implementation of groundwater protection. This study investigated the driving mechanisms of groundwater chemical evolution based on the long-term series (from 1985 to 2015) of hydrochemical data from 19 groundwater monitoring sites in rapidly urbanizing areas (Shijiazhuang, Hebei Province, China). The results show that the concentrations of various chemical components in groundwater gradually increase with the acceleration of urbanization process, especially NO3-, which has increased from 13.7 mg/L in the primary stage of urbanization (PSU) to 65.1mg/L in the advanced stage of urbanization (ASU), exceeding the WHO drinking water standard (50mg/L), indicating that the groundwater chemistry has been significantly affected by human activities. It is interesting to find that the main hydrochemical types have changed from HCO3•SO4-Ca•Mg type water in the PSU to SO4•HCO3-Ca•Mg type water in the ASU. It is worth noting that there were obvious differences in driving factors of groundwater chemical evolution at different urbanization stages. In the PSU, the driving factors of groundwater chemical evolution were carbonate and rock salt dissolution, cation exchange, and industrial activities. However, in the intermediate stage and advanced stage, the driving factors of groundwater chemical evolution were changed to carbonate and gypsum dissolution, groundwater over-exploitation, agricultural fertilization, and domestic sewage. Based on the above conclusions, it is suggested that future groundwater management should control the amount of agricultural fertilizers, apply scientific fertilization, and prohibit the discharge of various types of non-compliant sewage, while strengthening the supervision of groundwater extraction to reduce the impact of urbanization development on the groundwater chemical evolution process.

Water area segmentation in remote sensing is of great importance for flood monitoring. To overcome some challenges in this task, we construct the Water Index and Polarization Information (WIPI) multi-modality dataset and propose a multi-Modality Fusion and Gated multi-Filter U-Net (MFGF-UNet) convolutional neural network. The WIPI dataset enhances the water information and reduces the data dimension. In particular, the Cloud-Free label provided in the database effectively mitigates the issue of scarcity of labeled samples Since a single form or uniform kernel size cannot handle the variety in size and shape of water bodies, we proposed the gated multi-filter inception (GMF-Inception) module in our MFGF-UNet. Moreover, we utilize the attention mechanism by introducing the Gated Channel Transform (GCT) skip connection and integrating GCT into GMF- Inception to further improve model performance. Extensive experiments on three benchmarks, including WIPI, Chengdu and GF2020 datasets demonstrate that our method achieves favorable performance with lower complexity and better robustness against six competing approaches. For example, on WIPI, Chengdu and GF2020 datasets, the proposed MFGF-UNet model achieves F1 of 0.9191, 0.7410, and 0.8421, respectively, which average F1 on three datasets is 0.0045 higher than the U-Net model and reduces 62% average GFLOPs. New WIPI dataset, code and trained models have been released on GitHub

We enhanced the agro-hydrologic VegET model to include snow accumulation and melt processes and the separation of runoff into surface runoff and deep drainage. Driven by global weather datasets and parameterized by Land Surface Phenology (LSP), the enhanced VegET model was implemented in the cloud to simulate daily soil moisture (SM), actual evapotranspiration (ETa), and runoff (R) for the conterminous United States (CONUS) and the Greater Horn of Africa (GHA). Evaluation of the VegET model with independent data showed satisfactory performance, capturing the temporal variability of SM (Pearson correlation r: 0.22–0.97), snowpack (r: 0.86–0.88), ETa (r: 0.41–0.97), and spatial variability of R (r: 0.81–0.90). Absolute magnitudes showed some biases, indicating the need of calibrating the model for water budget analysis. The seasonal Landscape Water Requirement Satisfaction Index (L-WRSI) for CONUS and GHA showed realistic depictions of drought hazard extent and severity, indicating the usefulness of the L-WRSI for the convergence of evidence toolkit used by the Famine Early Warning System Network to monitor potential food insecurity conditions in different parts of the world. Using projected weather datasets and landcover-based LSP, the VegET model can be used not only for global monitoring of drought conditions, but also for evaluating scenarios on the effect of a changing climate and land cover on agriculture and water resources.

Light and heat resources are ample in Xinjiang plain oasis region. Planting structure is single in irrigation area, which leads to severe seasonal water shortages due to high concentration of water utilization. Therefore, how to make full use of light and heat resources to develop oasis agriculture without expanding planting scale has become the focus of research. The biannual cropping patterns are possible solutions to the problem. Manas River Irrigation area, which is located on the northern slope of Tianshan Mountain in Xinjiang in China is regarded as a typical case study to analyze the suitable planting structure and planting scale for biannual cropping pattern. The effects of optimizing planting patterns on alleviating the contradiction between water supply and water need，and the efficiency of water resources utilization was also studied. The results of the study show that：(1) the suitable planting scales of Manas River irrigation area in wet year (P = 25%), normal year (P = 50%), and low flow year (P = 75%) are about 72.66%, 78.73% and 83.91% of the current planting scale. (2) After the planting structure was optimized, the water use process in the irrigation area extends from May to August at present to April to November. The water use ratio at the peak period of water use decreased from 0.847 to 0.601, and the water use peak was significantly dispersed. (3) Economic benefits per cubic metre of water of the biannual cropping patterns increased from 8.65 yuan·m⁻³ at present to 9.45 yuan·m⁻³, 10.31 yuan·m⁻³ and 11.43 yuan·m⁻³ in wet year (P = 25%), in normal year (P = 50%) and low flow year (P = 75%) respectively, which proved that replanting crops could improve the efficiency of water resources utilization in irrigated areas. Therefore, the optimal planting pattern can be implemented to improve the utilization efficiency of soil and water resources in irrigation area in the arid oasis with single planting pattern with excessive concentration of water use peak and serious water shortage.

This article explores the intricate journey of neural progenitor cells from the ventricular zones of the embryonic brain, focusing on their pivotal role in the formation of rich club networks, which are integral to the brain's functional architecture. Initially, the ventricular zones, particularly the cerebral ventricular zone, serve as the primary sites for the proliferation and differentiation of neural progenitors, giving rise to various types of neurons and glial cells. We delve into the sequential migration patterns of these cells, emphasizing how early-migrating neurons, destined to form deeper cortical layers, establish extensive and robust connections, potentially evolving into rich club nodes. These nodes are characterized by their high-degree connectivity and serve as crucial hubs for integrating and disseminating information across disparate brain regions.The article further discusses the implications of this developmental pathway in the context of brain network efficiency, resilience, and cognitive function. We highlight how disruptions in early cell migration can lead to anomalies in rich club formation, drawing connections to various neurodevelopmental disorders such as autism, ADHD and schizophrenia. Additionally, the significance of rich club nodes in maintaining efficient information transfer and network resilience is elucidated, underscoring their role in supporting complex cognitive processes and overall brain dynamics.In summary, this article offers a comprehensive overview of the developmental trajectory from the ventricular zones to the establishment of rich club networks, providing insights into the fundamental processes that shape the brain's intricate connectivity and functional capabilities. Ric

Pterygium is a common ocular disease caused by abnormal cellular proliferation leading to abnormal fibrovascular growth of the conjunctiva. The main treatment is surgical removal; however, despite the improvement of surgical techniques and development of adjuvant therapies, postoperative recurrence, which can be as high as 89%, remains a challenge. Currently, pterygium excision with conjunctival autograft remains the preferred surgical technique to decrease recurrence, especially when combined with ciclosporin eye drops. Nevertheless, there is no gold standard surgical technique to prevent pterygium recurrence. Therefore, this review aims to assess the safety, effectiveness and, applicability of platelet-rich fibrin membrane for primary pterygium surgery and assess its possible benefits in resource-limited settings.

In order to develop waterborne silicate anticorrosive coatings to replace solvent-based anticorrosive coatings used widely in ship’s industry, epoxy modified silicate emulsions were synthesized with different content of epoxy resin, then aqueous silicate zinc-rich coatings were prepared with synthesized silicate emulsion, triethylamine and zinc powder. The influence of the content of epoxy on the properties and chemical structure of modified emulsion, mechanical properties of silicate coatings, and the corrosion behavior of silicate zinc-rich coatings in 3.5% NaCl solution were investigated. The coating samples on steel were measured by immersion test, Tafel polarization test and electrochemical impedance spectroscopy (EIS) test with different immersion time. The results showed that epoxy modified silicate emulsions were successfully synthesized. With the increase of epoxy content, the viscosity and the solid content of modified emulsion increases, the impact resistance of the silicate coating raises, the pencil hardness decreases, but the adhesion is not affected. Epoxy modification can reduce to s certain extent the corrosion driving force of zinc rich coating and increase the impedance of the zinc-rich coating decreases with the increase of immersion time in 3.5% NaCl solution. With the increase of the epoxy content, the resistance value of the zinc-rich coating increases, indicating the ability of the coating to resist corrosive media is enhanced.

Urban development and planning are increasingly centered on matters of sustainability, balancing economic development with ecosystem services and biotic structures within urban environments. In addition to these institutional and structural factors, the decision-making process within individual households must be understood to address rising concerns about water use. Therefore, individual characteristics and preferences that influence the use of water also warrant examination. In response to a survey of occupants of single-family residences in the Fresno Clovis Metropolitan Area of California, contextual interviews and focus group interviews with a homeowner sub-sample, we find evidence of an interplay of social-structural, institutional, and cultural factors involved in influencing individual water use behaviors and landscape decision making. The complexity of residential behaviors and decision-making poses some potential issues with regards to the interactions between individual households and institutional actors in matters of water usage and landscaping, as survey respondents indicate relatively little confidence in institutions and groups to make wise water policy decisions. We conclude that the promotion and implementation of sustainable water use practices will require not only environmental education for the citizenry, but also a tailoring of information for environmental educational initiatives that address the particularities of individual neighborhoods and communities.

Soil moisture reserve is a key factor in maintaining soil fertility and all other related ecosystem services (including carbon sequestration, soil biodiversity, soil erosion control). In semiarid blown-sand areas under aridification water preservation is a particularly crucial task for agriculture. The international Diverfarming project (2017–2022) within the EU Horizon 2020 Program focused on the impacts of crop diversification and low-input practices in all pedoclimatic regions of Europe. In the three-year experiment conducted in the Pannonian region the impacts of intercropping asparagus with different herbs on some provisioning and regulating ecosystem services were evaluated in the Kiskunság sand regions. Relying on the findings based on a range of measured physical and chemical soil parameters and on crop yields and qualitative properties, advice was formulated for farmers. The message drawn from the experiment is somewhat ambiguous. The local farmer agrees that crop diversification improves soil quality, but he denies that it would directly influence farm competitiveness, which primarily depends on cultivation costs (such as fertilization, plant protection and labour). Further analyses are needed to prove the long-term benefits of diversification through enriching soil microbial life and the possible reduction of fertilizer use while water demand is kept at a low level and the same crop quality is ensured.

In this paper an overview of waste materials in underground coal mines is presented, whereas waste materials can be of anthropogenic or geogenic origin. Complex interactions with mine water and waste materials take place, especially during mine water level rebound. Bearing in mind that under the increasing societal pressure most, if not all underground coal mines are going to be closed rather sooner than later, it is important to understand these interactions and to predict the composition and dynamics of mine water lever rebound in underground coal mines to prevent adverse effects to the environment, especially receiving waters and drinking water resources. The second part of this article focusses on the experiences gained in the Ruhr area, a closed underground coal mining region in Western Germany, where mine water rebound has been ongoing for decades. In this regard, the modelling program DMT-Boxmodel has been developed and applied to predict the hydrodynamics and hydrogeochemical development of the water rebound. As an example, simulation results of water rebound as well as solute and PCB transport in central province of Ruhr mining area are compared to the monitoring data, and predictions over 3 decades are given. The experiences gained in the mine water management in Ruhr area can be applied in mining areas worldwide.

Numerical modeling of sedimentation and erosion in reservoirs is an active field of reservoir research. However, simulation of bed-load transport phenomena has rarely been applied to other water bodies, in particular, the fluctuating backwater area. This is because the complex morphological processes between hydrodynamics and sediment transport are generally challenging to accurately predict. In this study, the refinement and application of a two-dimensional shallow-water and bed-load transport model to the fluctuating backwater area is described. The model employs the finite volume method of the Godunov scheme and saturated sediment transport equations. The model was verified against experimental data of a scaled physical model. It was then applied to actual reservoir operation, including reservoir storage, reservoir drawdown and continuous flood process, to predict the morphology of reservoir sedimentation and sediment transport rates and bed level changes in the fluctuating backwater area. It was found that the location and morphology of sedimentation effected by the downstream water level results in random evolution of the river bed, and bed-load sedimentation is transported from upstream to downstream with the slope of the longitudinal section of the river bed generally reduced. Moreover, the sediment is mainly deposited in the main channel and the elevation difference between the riverbank and channel decreases gradually.

To be CMOS-compatible, a low preparation temperature (< 500 °C) of ferroelectric films is required. In this study, BiFeO3 films were successfully fabricated at a low annealing temperature (< 450 °C) on aluminum foils by a metal-organic decomposition process. The annealing atmosphere on performance of BiFeO3 films was assessed at 440 ± 5℃. By replacing an O2-rich atmosphere with an N2-rich one, a better crystalline morphology was achieved in BiFeO3 films, resulting in better electric properties targeted for high-density ferroelectric random-access memory applications. These properties included a large remnant polarization (Pr~78.1 μC/cm2 @ 1165.2 kV/cm) and a high rectangularity (~91.3% @ 1165.2 kV/cm) of the P-E loop, along with excellent charge-retaining ability up to 1.0 × 103 s and a fatigue resistance reaching 1.0 × 109 switching cycles. The enhanced performance of BiFeO3 film in an N2-rich atmosphere maybe originated from the slightly high content of oxygen vacancies during the annealing process. Furthermore, decent electrical properties (Pr~70 μC/cm2 @ 1118.1 kV/cm) of the BiFeO3 films were achieved at a very low annealing temperature of 365 ±5 °C on aluminum foil substrates. These results offer a new idea for lowering the annealing temperature for integrated ferroelectrics in high-density FeRAM applications.

This work aimed to synthesize new N-rich triazole compounds. In this article we describe the synthesis of three different 1,2,4-triazole-based systems starting from 1,3-diaminoguanidine hydrochloride monohydrate. The structure of the obtained crystals was established by single-crystal X-Ray diffraction. The high nitrogen content of the synthetized compounds makes them building blocks for the application in the High-Energy-Density material science.

Peri-implant diseases are defined as pathological inflammatory reactions in the tissue surrounding the osseointegrated implants. They are classified into two categories: mucositis - defined as peri-implant soft tissue inflammation and peri-implantitis - bone loss in the peri-implant region. A clinical case of a 61-years-old woman with an implant in the 46 anatomical position and a 5-year follow-up is presented. A probe depth of 5mm and a bone defect length of 35% was observed. The Implacure® Protocol was applied, with the main objective of eliminating the biofilm present on the exposed implant surface. There are multiple approaches to treat peri-implant diseases. While non-surgical treatment is essential for mucositis control, the treatment of peri-implantitis surgical treatment should be considered. Regenerative bone reconstruction promotes bone repair in the defect area and reduces bleeding during probing. To achieve that, autologous fibrin combined with Cerasorb M® was used. The proposed approach in the exposed clinical case involves the application of Implacure® Protocol, whose combination of the physical decontamination technique, together with the use of chlorhexidine and orthophosphoric acid, added with the combination Piperacillin + Tazobactam together with hyaluronic acid, provide a base that allows to regenerate bone using platelet-rich fibrin with Cerasorb M® and increase the survival time of the implant.

Study assessed the wind potential of three sites in Chad: Koro Toro, Salal and Nedeley. Analysis of the Weibull distribution curves reveals marked seasonal variability in wind speed, concentrated around the mean. Three models of high-power wind turbines were analyzed. At Koro Toro, the Siemens Gamesa SG 14-222 DD has a capacity factor of between 0.52 and 0.682, allowing a daily flow of pumped water of between 1.4 and 6.1 million m³. The Enercon E-126 EP4 performs slightly less well. At Salal, the Siemens Gamesa has a capacity factor of between 0.4463 and 0.6605, with a water flow rate of between 0.9 and 3.7 million m³/day. The Vestas V164-10.0 MW has a higher capacity factor (0.6327 to 0.8115) but a lower water flow rate (0.5 to 1.9 million m³/day). Enercon's performance is comparable to that of Siemens Gamesa. The Nedeley study reveals favorable conditions, with seasonal variations in wind speed and capacity factor indicating good wind potential, and maximum daily water flows of between 3 and 6 million m³. Analysis of the wind roses shows interesting potential in these towns, with a dominant east-north-easterly wind at maximum frequencies of 40%. The absence of calm winds is promising, although Nedeley and Salal have a residual presence. This study shows that the sites offer good wind potential This, enabling the production of electricity and heat.

The South-to-North Water Transfer Jiangsu Water Supply Area (JWSA) is a mega inter-basin water transfer area (water source) that provides water resources from JiangHuai, combines drainage and flooding management, and regulates nearby rivers and lakes. Analyzing the spatiotemporal soil moisture dynamics in the area will inform agricultural drought and flood disaster assessment and early warning studies. Therefore, we evaluated the quality of European Space Agency Climate Change Initiative Soil moisture (ESA CCI_SM) data in the South-North Water Transfer JWSA. Then, we used ensemble empirical modal decomposition, Mann-Kendall tests, and regression analysis to study the spatiotemporal variation in soil moisture for the past 29 years. The CCI _SM data showed a high correlation with local soil measurements at nine sites. We then analyzed the CCI_SM data from three pumping stations (the Gaogang, Hongze, and Liushan stations) in the South-North Water Transfer JWSA. These stations had similar periodic characteristics of soil moisture, with significant periodic fluctuations around 3.1 d. The overall soil moisture at the three typical pumping stations showed an increasing trend. We then investigated whether there were abrupt soil moisture changes at each station. The spatial distribution of soil moisture in the South-North Water Transfer JWSA was characterized by “dry north and wet south”, with higher soil moisture in winter, followed by autumn, and low soil moisture in spring and summer. Although the linear trend of soil moisture in the South-North Water Transfer JWSA varied in significance, the overall soil moisture in the JWSA has increased over the past 29 years. The areas with significantly enhanced soil moisture are mainly distributed in the Yangzhou and Huai'an areas in the southeastern part of the study area. The areas with significantly decreased soil moisture are small in size and mainly located in northern Xuzhou.

This study throws more light on the new Co-free and Ni-rich LiNi0.8Mn0.1Fe0.1O2 cathode material for lithium-ion batteries. This cobalt-free cathode material is prepared using a two-step process: the formation of an oxalate precursor by co-precipitation followed by a solid-state reaction with lithium hydroxide and iron citrate. The physico-chemical properties of LiNi0.8Mn0.1Fe0.1O2 are characterized using X-ray diffraction, Raman spectroscopy, scanning electron microscopy, thermal gravimetric analysis, and energy dispersive X-ray spectroscopy, respectively. The LiNi0.8Mn0.1Fe0.1O2 electrode tested at at C/2 rate within voltage window of 3.0-4.4 V vs. Li+/Li delivers a specific capacity of ~80 mAh g-1 and retain about 45% of its initial capacity after 100 cycles.

The present study aimed to elucidate the neural mechanisms underpinning the visual recognition of morphologically complex verbs in Korean, a morphologically rich, agglutinative language with inherent polymorphemic characteristics. In an fMRI experiment with a lexical decision paradigm, we investigated whether verb inflection types (base, regular, and irregular) are processed through separate mechanisms or a single system. Furthermore, we explored the semantic influence in processing inflectional morphology by manipulating semantic ambiguity (homonymous vs. unambiguous) of inflected verbs. The results showed equivalent activation levels in the left inferior frontal gyrus for both regular and irregular verbs, challenging the dichotomy. Graded effects of verb regularity were observed in the occipitotemporal regions, with regular inflections eliciting increased activation in the fusiform and lingual gyri. In the middle occipital gyrus, homonyms showed decreased activation relative to unambiguous words, specifically for base and irregular forms. Furthermore, the angular gyrus exhibited significant modulation by all verb types, indicating a semantic influence during morphological processing. These findings support single-system theories and the connectionist framework, challenging the assumptions of purely orthographic morphological decomposition and dual-mechanism accounts. Furthermore, they provided evidence for a semantic influence during morphological processing, with differential reliance on semantic activation for regular and irregular inflections.

The employment of PRP in regenerative medicine has not generated the promised grandiose outcomes. Nonetheless, it currently remains the gold standard strategy for tissue regeneration. Therefore, scientific research has focused on identifying other matrices rich in growth factors and cytokines to improve the efficacy of PRP. In the present study, a new technology called AMPLEX PLUS -compound derived from colostrum enriched with exosomes- was applied in combination with PRP to evaluate the concentration trend of 20 bioactive molecules. The results show that the concentration of all the compounds analyzed increased significantly in PRP samples with AMPLEX PLUS technology compared with samples containing only plasma or PRP, suggesting how this new strategy could improve the performance of PRP and make significant advances in regenerative medicine.

The accuracy of estimating changes in terrestrial water storage (TWS) using Gravity Recovery and Climate Experiment (GRACE) level-2 products is limited by the leakage effect resulting from post-processing and the weaker signal magnitude in adjacent areas. TWS anomaly in Dnieper River basin, where characteristic with medium scale and adjacent weak TWS anomaly, is estimate in this work. Two categories of leakage error repaired method (including forward modeling, Data-driven, single and multiple scaling factor) are employed. Root mean square error (RMSE) and Nash-Sutcliffe Efficiency (NSE) are used to evaluate the efficiency of methods. Compare to independent methods, TWS anomaly inverted by multiple scaling factor depending on CPC Soil Moisture model is more accurate in terms with RMSE 2.32 and NSE 0.88, which scaling factors corresponding to trend term 1.02, annual term 1.04, and semi-annual term 1.14. Further, comprehensive climate insights behind of the TWS anomaly were confirmed. The temperate continental climate of this River basin is shown, according to the variation of TWS anomaly in spatial domain. Snowmelt is significant role in TWS anomaly of Dnieper River basin, which is accord with the precipitation record and the 14 years temperature spatial distribution of February. Overall, we compare TWS anomaly recovered by single and multiple scaling method, the leakage signal originates mainly from semi-annual term of the TWS anomaly.

This study examines the DCMA concerning the future risk of the water security status. We considered three risk factors: population growth, economic growth, and natural water supply demand differences. In the risk analysis part, we consulted with experts from several sectors including academia, Non-Governmental Organization (NGOs), and industry, to predict that the probability of future water stresses in high, medium, and low scenarios are 0.73, 0.24, and 0.03, respectively. In the decision analysis part, we adopted two Multiple Criteria Decision Analysis (MCDA) approaches that include Multiple Attribute Value Theory (MAVT) and Analytic Hierarchy Process (AHP) methods to evaluate the best alternative decision to alleviate future water stresses in the DCMA. The sensitivity analysis demonstrates the best option closely connects to the weighting scheme of the criteria considered in the framework. This study provides a valuable risk and decision analysis framework to analyze the water security status associated with the future water supply and demand gap decrease caused by three risk factors: population growth, climate change, and natural water supply.

Background: Traditional root canal therapy (RCT) has been the primary method for treating necrotic pulp, but it presents limitations such as loss of vitality and postoperative fractures. Recent advancements in regenerative endodontics offer alternative strategies to restore pulp tissue vitality and function. These approaches involve stem cell transplantation, cell homing, and the use of organic scaffolds to promote pulp regeneration. Highlight: This article reviews various regenerative endodontic techniques, including autogenic and allogenic dental pulp transplantation, the use of amniotic membrane scaffolds, platelet-rich fibrin therapy, specialized pro-resolving mediators, nanofibrous and bioceramic-based scaffolds, injectable scaffolds, and dentin matrix proteins. These strategies leverage stem cells, growth factors, and biomaterials to create conducive microenvironments for cell attachment, proliferation, and differentiation, thereby facilitating pulp tissue regeneration. Methods: The literature search was conducted using databases such as PubMed, Scopus, and Google Scholar, employing keywords like "regenerative endodontics," "pulpitis," "pulp regeneration," and "platelet-rich fibrin." Conclusion: The reviewed approaches in regenerative endodontics show promising potential for overcoming the limitations of traditional RCT and promoting pulp tissue regeneration. However, further research is needed to optimize protocols, address challenges, and translate these advancements into routine clinical practice. Ultimately, these innovations have the potential to enhance patient outcomes in endodontic treatment by restoring pulp vitality and function effectively.

Bulk composition, mineralogy and microchemistry of various fractions of the filling of the Crater No. 4 at Emmerting were investigated. Here we present mainly the fine fractions, which, in contrast to pebbles larger than ca. 4 cm, are relatively poor in material affected by melting. A 0.1 mm long meteorite fragment without ablation features was found, and remelted fragments of the same body have been identified. The projectile was dominated by enstatite, also containing forsterite, basic plagioclase, Ni-rich pyrrhotite and troilite, kamacite, silica, and probably merrillite. The molten fragments contain porous Mg-rich glass (indicating temperature > 1500 °C), minor Fe oxides, and occasionally uncommon Ni-rich minerals. The bulk composition and electron microprobe show that the amount of meteoritic material is low (<< 1 %), and it is not unequivocally manifested even in platinum-group elements abundances and osmium isotope ratios (the latter, however, were only measured in two samples). This can be explained by dilution of the filling by particles brought after the crater formation, and by probably achondritic composition of the projectile. Relatively large hollow spheroid Fe oxide particles were observed in thin sections from the magnetic fraction. A Mn oxide hollow spherule has also been found. In magnetically separated filling from the nearby Crater No. 5, bulk chemical composition points to contamination with several metals and metalloids probably due to influence of recent alluvial sediments. Therefore, the extent of meteoritic contamination in this crater may be even smaller.

Musculoskeletal disorders are increasingly prevalent worldwide, causing significant socioeconomic burdens and diminished quality of life. Notably, patellar chondropathy (PC) is among the most widespread conditions affecting the joint structures, resulting in profound pain and disability. Hyaluronic acid (HA) and platelet-rich plasma (PRP) have emerged as reliable, effective, and minimally invasive alternatives. Continuous research spanning from laboratory settings to clinical applications demonstrate the numerous advantages of both products. These encompass lubrication, anti-inflammation, and stimulation of cellular behaviors linked to proliferation, differentiation, migration, and the release of essential growth factors. Cumulatively, these benefits support the rejuvenation of bone and cartilaginous tissues, which are otherwise compromised due to the prevailing degenerative and inflammatory responses characteristic of tissue damage. While existing literature delves into the physical, mechanical, and biological facets of these products, as well as their commercial variants and distinct clinical uses, there is limited discussion on their interconnected roles. We explore basic science concepts, product variations, and clinical strategies. This comprehensive examination provides physicians with an alternative insight into the pathophysiology of PC as well as biological mechanisms stimulated by both HA and PRP that contribute to tissue restoration.

An 11-month-old castrated male Pomeranian presented with nonunion following a femoral fracture that occurred after femoral head and neck osteotomy. Radiography and computed tomography revealed severe atrophy of the proximal bone fragment and retardation of the ipsilateral distal fragment and tibia. An autogenous bone graft using coccygeal bone was performed, in which three-and-a-half coccyges were placed in series and fixed using an orthogonal locking plate. To promote bone healing and facilitate proper weight bearing and ambulation, bone morphogenetic proteins, biphasic calcium phosphate, platelet-rich plasma, passive range of motion exercises, transcutaneous electrical nerve stimulation, neuromuscular electrical stimulation, and low level laser therapy were applied. During the four-year follow-up, it was observed that the previously engrafted bone healed well and maintained stability over a prolonged period, resulting in the patient being able to walk and trot comfortably with good outcomes. However, some degree of lameness was noted during galloping owing to limb shortening and joint contracture.

A framework for the review of existing water management systems and their transformation into robust water sharing systems is offered. The framework focuses on the need to develop efficient and equitable ways to manage water scarcity and plan to deal with the tensions scarcity imposes on any community. The framework identifies a way to bring together traditional community-managed systems with those typically used to allocate water to large water users and more commonly found in developed countries. So that use can be kept within sustainable limits while optimizing use, the framework includes mechanisms that enable the reallocation of water as demand and supply conditions change. Non-consumptive uses are recognized and environmental objectives can be delivered efficiently. Compliance with well-established accounting and hydro-logical concepts. Ways to increase the value of existing entitlements, encourage innovation and protect investments are included as options. It is recognized that the governance and legal arrangements necessary to underpin successful implantation are context specific.

The term ovarian rejuvenation is used for treatments aiming to reactivate ovarian function in women suffering from premature ovarian insufficiency or women with poor ovarian response following ovarian stimulation treatments. Following Bologna criteria, patients with poor ovarian response (POR) are those patients with at least one previous stimulated cycle with POR, are of advanced maternal age, and have an abnormal ovarian reserve. Patients with at least 3 failed IVF cycles due to poor ovarian response (POR) and patients with POF with amenorrhea for at least 6 months, low estradiol, and high concentrations of LH and FSH were referred for ovarian PRP treatment. Out of 190 procedures, 15 were performed using the THL as there was an inaccurate visibility by vaginal ultrasound. Under direct visualization, PRP was injected in each ovary using a 19G needle. In the 53 patients referred for IVF, an embryo transfer was possible in 40% of the started cycles (n=21); the pregnancy rate per transfer was 52% with a live birth rate of 24%. The access to the pelvis by the THL enabled a direct visualization of both ovaries allowing a correct injection. Due to maternal age, patients should be informed of the elevated risks of 40% - 50% of biochemical pregnancies or miscarriages.

Mutations of PKD1 coding for polycystin-1 (PC1) account for most of the autosomal dominant polycystic kidney disease (ADPKD). The extracellular region of PC1 contains many evolutionarily conserved domains for ligand interactions. Among these is the leucine-rich repeats (LRR) in the far N-terminus of PC1. Using zebrafish (Danio rerio) as an in vivo model system, we explored the role of LRR in the function of PC1. Zebrafish expresses two human PKD1 paralogs, pkd1a and pkd1b. Knockdown of both genes in zebrafish by morpholino antisense oligonucleotides produced phenotypes of dorsal axis curvature and pronephric cyst formation. We found that overexpression of LRR suppressed both phenotypes in pkd1-morphant zebrafish. Purified recombinant LRR domain inhibited proliferation of HEK cells in culture and interacted with the heterotrimeric basement membrane protein laminin-511 (α5β1γ1) in vitro. Mutations of amino acid residues in LRR structurally predicted to bind laminin-511 disrupted LRR-laminin interaction in vitro and neutralized the ability of LRR to inhibit cell proliferation and cystogenesis. Our data support the hypothesis that the extracellular region of PC1 plays a role in modulating PC1 interaction with the extracellular matrix and contributes to cystogenesis of PC1-deficiency.

Ni-rich layered cathodes are regarded as a potential candidate for high energy-density lithium-ion batteries, but their high sensitivity to air during storage and poor thermal stability are a vital challenge for large-scale applications. In this paper, an effective solid-solution strategy was proposed to improve the surface and structural stability of Ni-rich layered cathodes by introducing Li2MnO3. The structural analysis results indicate that the formation of Li2CO3 inert layers on Ni-rich layered cathodes during storage in air is responsible for the increased electrode interfacial impedance, thereby resulting in the severe deterioration of electrochemical performance. The introduction of Li2MnO3 can reduce the surface reactivity of Ni-rich cathode materials, playing a certain suppression effect on the formation of surface Li2CO3 layer and the deterioration of electrochemical performances. Additionally, the thermal analysis results show that the heat release of Ni-rich cathodes strongly depends on the charge of states, and Li2MnO3 can suppress oxygen release and significantly improves the thermal stability of Ni-rich layered cathodes. This work provide a method to improve the storage performance and thermal stability of Ni-rich cathode materials.

Organic-rich shale deposits of the Paleocene-Eocene Palana Formation in western Rajasthan, India were systematically analyzed based on the elemental composition and organic geochemistry combined with microscopic examinations to evaluate the sedimentary paleoenvironmental conations and volcanic activity and their impact on the high organic carbon accumulation. The Palana shales are categorized by high OM and sulfur contents with total values up to 36.23 wt. % and 2.24 wt. %, respectively, suggesting marine setting and anoxic environmental conditions during the Paleocene-Eocene period. The richness of phytoplankton algae (i.e., telalginite and lamalginite) together with redox-sensitive trace elements further suggests anoxic environmental conditions. The significant low oxygen conditions may contributes to enhance preservation of organic matter during deposition. The mineralogical and inorganic geochemical indicators demonstrate that the Palana organic-rich shale facies was accumulated in warm and humid climate and low salinity stratification conditions of the water columns, thereby contributing to high bioproductivity of the phytoplankton algae blooms within the photic zone. The presence of the high concentrations of Fe-rich silica minerals such as olivine in most of the Palana organic-rich shales facility volcanic origin and supports hydrothermal activities during the Paleocene-Eocene period. These volcanic activities in this case are considered influx of large masses of nutrients into the photic zone due to the ash accumulation. Therefore, high bio-productivity associated with effective OM preservation contributed to the organic carbon accumulation in the Palana Formation during the Paleocene-Eocene.

Tooth extraction is the most common procedure in dental practice. However, in the long term, it may cause alveolar ridge atrophy. This systematic review aimed to evaluate the role of platelet-rich fibrin (PRF) in post-exodontic alveolar ridge preservation in terms of its effectiveness in the regeneration of bone tissue as assessed by imaging and its efficacy compared to physiological bone healing. The study is presented in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. This systematic review was conducted using electronic databases such as PubMed, Scopus, Web of Science, and Science Direct. The grey literature search was conducted in the New York Academy of Medicine Grey Literature Report. All the studies in this systematic review were randomized controlled trials (RCTs). The risk of bias was performed according to the Cochrane Handbook for Systematic Reviews of Interventions 6.2 (RevMan 6.2). Considering the inclusion and exclusion criteria, we included 17 randomized clinical trials, published up to 2022 investigating the efficacy of PRF in post-exodontic bone regeneration. Based on the results of clinical studies, it can be stated that despite not being statistically significant, PRF promotes neoformation and prevents bone loss between three and four months post-extraction.

Fe- and Al-rich metapelite from the Transangarian segment of the Yenisey Ridge (East Siberia, Russia) is a potential new source of high-alumina refractories. The rocks have relatively high average contents of Al2O3 (20 wt.%) and Fe2O3 (7.91 wt%), moderate K2O (3.44 wt%), and low CaO (0.74 wt%). Their dominant mineral assemblages are andalusite + muscovite + margarite + chlorite + biotite + quartz or staurolite + kyanite or/and andalusite + chlorite + muscovite + biotite + quartz with ±garnet and ±plagioclase. Al2SiO5 polymorphs occur as up to 1.5 cm andalusite porphyroblasts and partial or complete pseudomorphs after andalusite (kyanite and staurolite). Accessories include abundant Fe-Ti oxides and sporadic REE-, Y-, Ca-phosphates; sulfides are negligible. The composition of Al2SiO5 concentrates obtained in laboratory by heavy-media and magnetic separation from ≥0.06 mm fractions meet all requirements for raw material of this type: >56 wt% Al2O3, <42 wt% SiO2, <1 wt% Fe2O3, <1.2 wt% TiO2, and <0.2 wt% (CaO+MgO). The andalusite, kyanite, and mixed ores yield 0.7-4.1 wt%, 0.7-2.2 wt%, and 1.9-6.0 wt% of concentrate, respectively. The best-quality ores rich in Al2SiO5 polymorphs reside in zones of contact and/or dynamic metamorphism superimposed over regional metamorphism of Al-rich rocks.

Angiogenesis is new blood vessel formation from existing vessels and is a critical first step in tissue repair following chronic disturbances in healing and degenerative tissues. Chronic pathoanatomic tissues are characterized by a high number of inflammatory cells, overexpression of inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), the presence of mast cells, T cells, reactive oxygen species, and matrix metalloproteinases, and a decreased angiogenic capacity. Multiple studies have demonstrated that autologous orthobiological cellular preparations (e.g., platelet-rich plasma [PRP]) im-prove tissue repair and regenerate tissues. There are many PRP devices on the market. Unfortunately, they differ greatly in platelet numbers, cellular composition, and bioformulation. PRP is a platelet concentrate consisting of a high concentration of platelets with or without certain leukocytes, platelet-derived growth factors (PGFs), cytokines, molecules, and signaling cells. Several PRP products have immunomodulatory capacities that can influence resident cells in a diseased microenvironment, inducing tissue repair or re-generation. Generally, PRP is a blood-derived product, regardless of its platelet number and bioformulation, and the literature indicates both positive and negative patient treatment outcomes. Strangely, the literature does not designate specific PRP preparation qualifications that can potentially contribute to tissue re-pair. Moreover, the literature scarcely addresses the impact of platelets and leukocytes in PRP on (neo)angiogenesis other than a general one-size-fits-all statement that “PRP has angiogenic capabilities.” Here, we review the cellular composition of all PRP constituents, including leukocytes, and describe the importance of platelet dosing and bioformulation strategies in orthobiological applications to initiate angiogenic pathways that re-establish microvasculature networks, facilitating the supply of oxygen and nutrients to impaired tissues.

Converting biowaste into biochar and subsequently putting it into the soil are considered to be an effective approach to sequestrate carbon (C). However, biochar will inevitably undergo the aging process in soil, which influences its stability, and ultimately threatens its carbon sequestration ability. This study selected CaCl2 as exogenous additive of sewage sludge and bone dreg to quantify both surface C and bulk C stability in Ca-rich biochars under three aging processes (dry-wet aging, freeze-thaw aging, and natural aging in farmland soil), and revealed the influence mechanisms of exogenous Ca on biochar stability. Results showed that after dry-wet aging (25 rounds), freeze-thaw aging (25 rounds), and natural aging in different farmland soils (5 months), oxidized surface C in Ca-rich biochar decreased by 10~23%, 28~41%, and 0~74%, respectively, compared to that in pristine biochar, while oxidized bulk C decreased by 6~10%, 0~1%, and 0~35%, respectively. Under three aging processes, the surface C and bulk C stability in Ca-rich biochar were superior to that in corresponding pristine biochar, which was attributed to the “protective effect” of Ca-containing crystals on biochar surface, including CaO, Ca5(PO4)3Cl, Ca5(PO4)3(OH), Ca8H2(PO4)6·H2O and Ca10(PO4)6(OH)2. These Ca-containing crystals could block the connection between biochar-C and the external oxidizing environment, intervening the oxidation of C-C/C=C in biochar, but also prevented aging from damaging C structure of biochar, reducing the generation of fragmented structure. By comprehensively assessing surface C and bulk C stability under three aging processes, final C sequestration in Ca-rich biochar increased to 27~80%, compared to that in pristine biochar (23~74%). Therefore, Ca-rich biochar is more dominant than pristine biochar, considering C sequestration potential during long-term aging in soil.

Spider toxin SNX-482 is a cysteine-rich peptide that interferes with calcium channel activity by binding to voltage-sensing domains of CaV2.3 subtype. Two general binding mechanisms are present in nature: direct binding from the aqueous phase or through lateral diffusion from the membrane, the so-called reduction in dimensionality mechanism. In this work, via coarse-grained and atomistic molecular dynamics simulations, we have systematically studied the spontaneous partitioning of SNX-482 with membranes of different anionic compositions and explored via diffusional analysis both binding mechanisms. Our simulations revealed a conserved protein patch that inserts within the membrane, a preference for binding towards partially negatively charged membranes, and that electrostatics drives membrane binding. Finally, diffusivity calculations showed that the toxin diffusion along the membrane plane is an order of magnitude slower than the aqueous phase suggesting that the critical factor in determin-ing the SNX-482-CaV2.3 binding mechanism is the affinity between the membrane and SNX-482

At present, the drilling rig for deep seabed shallow strata is widely used in the exploration of ocean cobalt-rich crust resources and other fields, which not only can obtain solid core samples at a specific station, but the operation process is relatively safe. This paper mainly presents the structure and mechanism of mobile drilling rig in acquiring the seafloor cores (up to 1.5 m long). Based on the function of the AMESim software, the hydraulic propulsion system model of mobile drilling rig is established, which is the basis and core part of the mobile drilling rig. Moreover, the control methods of closed-loop and PID are respectively used to control the hydraulic propulsion system for simulation analysis. Through the comparison of simulation results, it is found that the PID control method is more convincing in verifying the design rationality of hydraulic propulsion system. In the simulation of the PID-controlled hydraulic propulsion system, the co-simulation technology of AMESim and Matlab/Simulink not only establishes the hydraulic model and control model, but also determines the relevant simulation parameters, which is helpful to improve the system simulation efficiency. In its verification deployment in the South China Sea, the mobile drilling rig has been operated for many times at different depths, and some cores have been successfully obtained. Furthermore, the mobile drilling rig has been used during the 55th Voyage of China Oceanic Scientific Expedition supported by China Ocean Mineral Resources R&D Association. Several sites were explored and a large number of cobalt-rich crust cores were obtained. The powerful theory and sea trails are provided to support for the further research on survey of the abyssal resource.

There is a marked momentum towards the use of clean hydrogen energy as an alternative for fossil fuels. Renewable energies such as solar and wind are being used to generate hydrogen from the water hydrolysis process. Indeed, this approach stores renewable energies in the form of combustible hydrogen for other energy uses. The other alternative that could be economically more cost-effective at the current technology stage is to explore the natural “Hydrogen System” where the natural hydrogen is generated and accumulated within the earth system, the same that stands for a “Petroleum System”. The Discovery of a large accumulation of relatively pure natural hydrogen (H2) in Mali has triggered the opportunity of searching for natural hydrogen accumulations in other countries. The generation of hydrogen from a circular depression in Mali and some other countries is linked to the presence of geologically very old iron-rich basement rocks. Solid-liquid redox reactions between iron-rich minerals and groundwater that split water are a possible source of H2 in deep basement rocks. It is believed that the hydrogen degassing may be detected by surface topographic circular to sub-circular shallow depressions. Chemical processes such as dissolution by hydrogen are considered to play the main role in the formation of the circular depressions through preferential vertical hydrogen migration channel. Archean iron-rich Yilgarn Craton that covers a vast area of Western Australia (WA) contains abundant iron-rich mafic-ultramafic rocks. The craton reveals many surficial circular depressions visible through satellite images. The area has abundant fault systems and is blanketed with Eocene sedimentary rocks containing high-quality reservoir rocks. All these characteristics seem to provide most of the required elements, such as hydrogen source, migration pathway, and reservoir rock for a “Hydrogen System” in this area.

Rare earth rich magnesium alloys are used in aerospace and automotive fields because of their high specific strength and good castability. However, due to their low corrosion resistance, protective surface treatments, such as conversion coating or electroless plating are necessary, when they have to be used in humid or corrosive environments. The present study was aimed to evaluate the effect of Plasma Electrolytic Oxidation (PEO) and different surface roughness (Ra≈0.8 μm and Ra≈0.3 μm) on the rotating bending fatigue of an innovative Mg alloy, with a high content of Nd (up to 3.1 wt%) and Gd (up to 1.7 wt %). Fatigue tests revealed a 15% decrease in the fatigue strength of the PEO treated alloy (fatigue strength = 88 MPa) with respect to the bare alloy (fatigue strength = 103 MPa). The reduction of fatigue strength was mainly due to the residual tensile stresses induced by the PEO treatment. The effect of surface roughness on the bare alloy was, instead, negligible. The mechanisms of crack initiation were similar in the untreated and PEO treated alloy, with crack nucleation sites located in correspondence of large facets of the cleavage planes.

Fibrin rich of platelets (PRF^®) of Choukroun represents a new step in the therapeutic concept of platelet gel with a simplified processing and biochemical changes little artificial. A valid method of preparation of the PRF must effectively separate the plates by erythrocytes and concentrate without damaging or lysing the plates themselves. In this study the experimental design is to standardize the production of L-PRF in horse directing it to human production. Our hypothesis is that the L-PRF is easy to produce in the horse, without modifications of the human protocol, thus allowing a better standardization of the human protocol. A new device for the preparation and the standardization of L-PRF clots and membranes is the L-PRF Wound Box^®. The optical microscopy, most cell bodies were highlighted concentrated in the proximal portion of each membrane, the last 1/4 was observed at the center; the distal part had only residual traces of cell bodies. The L-PRF will form constantly when the phases described above are strictly adhered to. The success of the art L-PRF depends entirely on the speed of blood collection and transfer in centrifuge within a minute and by a temperature of centrifugation and compression is higher than 21°C (between 21 and 30°C). Our experiments on the horse will no doubt be able to improve our understanding on wound healing, in particularly in chronic skin lesions therapy.

Through the process of paradigm change (water as a resource towards water as a common), the authors examine, from a theoretic point of view, the water governability proposed by Agenda del Agua Cochabamba (AdA) – Cochabamba Water Agenda – in the Cochabamba Valley (Bolivia), identifying barriers and drivers to the process that could take place. The rise of Evo Morales in Government in 2006 suggested that policy making would somehow take a fundamental turn resulting in more poor environmental-oriented water policies. However, if that was indeed the case, the implementation of these policies remain controversial as strong power asymmetries still exist at a local level that interfere with national policies shaping the political area. The Cochabamba Water Agenda echoes this debate on the political arena and contributes a politically contested water management through a paradigm change envisaging the difficulties through its implementation. The question remains if this “political” solution to paradigm change in water management may reduce water conflicts.

Water scarcity is a significant challenge facing Jordan today. It is a challenge in all areas that use water, and it has become certain that water is the critical factor in the population/resources equation. The water resources in Jordan have become limited with the noticeable increase in the population, mostly resulting from forced migrations in neighboring countries because of the wars and until our time. The rising natural population growth rate, along with the massive influx of refugees, has turned into a state of disproportion between the daily consumption of the population and the amount of water available. That Jordan shares most of its surface water resources with neighboring countries has exacerbated the situation. The current use of water already exceeds its renewable supply. Excessive withdrawal from aquifers, which leads to a lowering of the water table and deterioration in water quality, covered the deficit. This paper focuses on assessing the water situation in Jordan, mainly evaluating this problem and the solution being considered, the true basis for a sustainable water solution requires awareness by the population, and several governmental and non-governmental organizations are actively involved in educating residents about water shortages. The most important and 'actionable' elements of comprehensive water solutions are discussed in this paper, and these elements exist, develop extra water supplies, water harvesting, water desalination, proper wastewater reuse in the agricultural sector, and reduce the demand for drinking water. This research provides specific recommendations to address the shortage of water resources in the Kingdom and highlights the importance of water conservation and optimal use.

The growing need for water has pressured society and governments to focus more on preservation, planning and management of this natural resource, in which is fundamental to ecosystems and especially to humans. In this sense, the goal of this study was to analyze the national policy of water resources in Brazil and Italy, figuring out aspects that could promote its improvement, aiming at the preservation of water sources, guaranteeing satisfactory quantity and quality. They were carried out in 2019 by the environmental agencies of both countries, listing the main disciplinary regulations. The results show that although they are countries with different realities, they resemble similarities in managerial aspects of water resources, with legislation addressing qualitative and quantitative aspects of water, with guiding principles, instruments and actions aimed at the defence of this natural resource.

Over the coming decades, global freshwater withdrawals are expected to grow, especially in low and middle-income countries. Unless there are significant improvements in the efficiency of water use by economies, freshwater stress, crises and scarcity will worsen. This paper explores further the economic relationship between water use efficiency and scarcity. Because growing scarcity of freshwater in many regions and countries is not adequately reflected in markets, there is often insufficient incentives for investment and innovation to improve the efficiency of water use. To explore further changes in water use efficiency across countries, we conduct a panel analysis of water productivity changes for 130 countries over 1995 to 2020. Countries with lower initial levels of water use efficiency tended to have higher water productivity growth, whereas more agriculturally dependent economies displayed lower improvements in water use efficiency. Better institutional quality and capacity for innovation may also increase water use efficiency. We discuss the implications of these results for improving water use productivity in economies, and in particular, the opportunities and challenges for improving water markets and trades to alleviate water scarcity. We conclude by identifying further areas of research.

Mexico is currently facing important water management challenges. Cities in the country are facing water scarcity and at the same time, they struggle with floods during the raining season. The water sensitive urban design (WSUD) approach has proved to be helpful in tackling urban water challenges such as floods and water scarcity and it is being implemented in cities around the world. The WSUD approach highlights the role of both the water cycle and the water utilities systems, when transitioning towards a water sensitive stage. Therefore, the objective of this research is to analyse the current situation of the water cycle and the water utility (SIAPA). To do so, we have selected the Metropolitan Area of Guadalajara (MAG) and proposes a case study approach. Within our case of study, we answer two questions: 1) What are the causes of water scarcity and flooding in the MAG? and 2) What are the proposals to solve these problems under a WSUD approach? By answering these questions, we identified that the water management in the MAG corresponds to a single purpose infrastructure. This type of management does not contribute to solve the problems of water scarcity and floods. The water supply policy is based only on the construction of large dams disregarding the storage and use of rainwater, and reuse of greywater, and water-conservation devices. In order to transition towards a water sensitive stage, a WSUD approach that includes multi-purpose infrastructure should be considered. Such as green roofs, swales, rainwater gardens, infiltration trenches, etc.

Background Legionella pneumophila is one of the causes of legionellosis. Water environments serve as the natural habitat and the main sources of Legionella pneumophila. Objectives The aims of this study was to understand the differences of Legionella pneumophila serogroups distribution in well water, tap water, ice cubes, hospital and hotel water in East Java-Indonesia. Methods a total of 60 water samples in east java-Indonesia; from well water (n=25), tap water (n=5), ice cubes (n=5), water from the hospital (n=16), and hotel water (n=9) were detected using polymerase chain reaction with mip gene spesific primers and then it was analyzed by phylogenetic tree. Results For the 60 water samples collected in East Java, 12% of the samples (7/60) were positively contaminated by L. pneumophila. In details, there was 8% of the well water samples (2/25), 2% of the tap water samples (1/5), 2% of the ice cubes samples (1/5), 0% of the hospital water samples (0/16) and 33.33% of the hotel water samples (3/9). The phylogenetic tree showed that Legionella pneumophila contaminating well water isolate 1 from Surabaya and tap water isolate from Sidoarjo was closer to L.pneumophila serogroup 2, 4, 6, 8, 10, 12, isolates from Brazil, China, Spain and Australia. L.pneumophila contaminating the ice cubes from Sidoarjo was closer to serogroup 1, 2, 4, 7, 8, 11, 13, 14, while the bacteria contaminating well water isolate 2 from Sidoarjo as well as water in hotel of Surabaya (hotel water isolate 1, 2 and 3) classified into their own group. Conclusion There is a difference in the distribution of L. pneumophila serogroups between well water, tap water, ice cubes, and hotels.

Our skin is constantly exposed to blue light (BL), which is abundant in sunlight and emitted by digital devices. Prolonged exposure to BL can lead to oxidative stress-induced damages and skin hyperpigmentation. In this study, we investigated the protective effects of tocotrienol-rich fraction (TRF) on BL-induced oxidative stress and hyperpigmentation in B16-F1 melanocytes. Alpha-tocopherol (αTP) was used as a comparator. Our results showed that TRF effectively suppressed the formation of reactive oxygen species, and preserved the mitochondrial membrane potential. Additionally, TRF exhibited anti-apoptotic properties by reducing the activation of p38 mitogen-activated protein kinase molecule and downregulating the expression of cleaved caspase-3. Moreover, TRF modulated tyrosinase activity, resulting in a lowered rate of melanogenesis and reduced melanin production. In contrast, αTP did not exhibit the significant protective effects against skin damages and pigmentation in BL-induced B16-F1 cells. Therefore, this study indicates that TRF may offer superior protective effects over αTP against the effects of BL on melanocytes. These findings demonstrate the potential of TRF as a protective natural active against BL-induced skin damages and hyperpigmentation via its antioxidative and anti-melanogenic properties.

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and the risk of a major cardiovascular event is highest among those with established disease. Ongoing management of these patients relies on the accurate assessment of their response to any prescribed therapy, and their residual risk, in order to optimize treatment. Recent international guidelines and position statements concur that the plasma concentration of apolipoprotein B (apoB) is the most accurate measure of lipoprotein associated ASCVD risk. This is especially true for the growing number of individuals with diabetes, obesity or the metabolic syndrome, and those on statin therapy. Most guidelines, however, continue to promote LDL-C as the primary risk marker due to uncertainty as to whether the greater accuracy of apoB is sufficient to warrant a paradigm shift. Recommendations regarding apoB measurement vary, and the information provided on how to interpret apoB results is sometimes insufficient, particularly for the non-lipid specialist. Misinformation regarding the reliability of the assays is also frequently repeated despite its equivalent or better standardization than many other diagnostic assays. Thus, demand for apoB testing is relatively low, which means there is little incentive to increase its availability or reduce its cost. In this review, we examine the results of recent clinical outcomes studies and meta-analyses on the relative values of apoB, LDL-C and non-HDL-C as markers of ASCVD risk. Although there is seemingly minimal difference among these markers when only population-based metrics are considered, it is evident from our analysis that, from a personalized or precision medicine standpoint, a great many individuals would benefit, at a negligible total cost, if apoB measurement were better integrated into the diagnosis and treatment of ASCVD.

Wheat has a large and diverse repertoire of NLRs involved in disease resistance, with over 1,500 NLRs detected in some studies. These NLR genes occur as singletons or clusters containing copies of NLRs from different phylogenetic clades. The number of NLRs and cluster size can differ drastically among ecotypes and cultivars. Primarily, duplication has led to the evolution and diversification of NLR genes. Among the various mechanisms, whole genome duplication (WGD) is the most intense and leading cause, contributing to the complex evolutionary history and abundant gene set of hexaploid wheat. Tandem duplication or recombination is another major mechanism of NLR gene expansion in wheat. The diversity and divergence of duplicate NLR genes are responsible for the broad-spectrum resistance of most plant species with limited R genes. Understanding the mechanisms underlying the rapid evolution and diversification of wheat NLR genes will help improve disease resistance in crops. The present review focuses on the diversity and divergence of duplicate NLR genes and their contribution to wheat disease resistance. Moreover, we provide an overview of disease resistance-associated gene duplication and the underlying strategies in wheat.

Taking a socio-technical perspective, I focus on solar businesses (niche market actors) in Iran. As one of the key stakeholder groups whose business prosperity is tied to the development of solar PV, they play a crucial role in accelerating the energy transition. Given the incumbent fossil-based electricity sector in Iran and the least enabling policies, I am first interested to find (i) the main drivers and barriers of solar businesses; and (ii) the roles these solar businesses play in bringing solar PV deployment forward in Iran. I collected the data via 20 semi-structured interviews with solar businesses in Golestan, Guilan, Tehran, Khorasan Razavi, and Eastern Azerbaijan Provinces in Iran. Taking an inductive approach, I considered sustainability transition and social acceptance theories as sensitising concepts to investigate common and specific points of solar business acceptance in Iran. I find ecological awareness, belief in intergenerational justice, and willingness to innovate, as the main intrinsic drivers and socioeconomic opportunity and tackling the energy imbalance as extrinsic drivers; while the lack of a common vision with the energy governors, and the low knowledge of solar PV among the customers, escalating prices, and challenges to accessing good quality solar equipment are the most prior obstacles. Moreover, I understand educating people, driving the innovative deployment of solar PV, and facilitating the diffusion of it, as the major roles of solar businesses in Iran. I find that the sustainability transition literature overlooked the key role of solar businesses specially in fossil-based and developing economies. My findings suggest that the positive intrinsic mechanisms among the solar businesses, in combination with better-enabling policy frameworks and external factors, like lifting the sanctions and joining the global energy market, climate change mitigation commitments and standards, can help solar businesspeople to lead and accelerate solar PV development in Iran.

The supposition is that the usage of fibrin rich in leukocytes and platelets advanced (A-PRF) in ulcerative osteomyelitis of the diabetic foot allows rehabilitation from this critical illness. In this investigation, the focus was to normalize the use of PRF in patients with osteomyelitis not amputated, to use this second generation platelet concentrate as a regeneration enabler. The researchers submitted and utilized A-PRF membranes (1300 g × 8 min) in 7 patients (all diabetics) with osteomyelitis and cutaneous injury for 6 months. The membranes, in combination with the supernatant fluid produced by stress, have been integrated into the skin lesion down to the bone after surgical debridement. The advancement of the lesions after some period of time has been analyzed. All seven subjects had a Probe-to-Bone positive assay; MRI indicated a cortico-periosteal coagulation and/or foci of cortico-spongeous osteolysis contiguous to the lesion. Gram-positive bacterium were identified in our procedures in 52% of cases. Gram+ Cocci, for example, S. Aureus (15.6%), S. Hemolytic (12.1%), S. Viridans (7.1%), and Gram-negative Bacteria, for example, Pseudomonas (10.6%), Proteus (7.8%), Enterobacter (5.7%) are present. Candida Albicans is active in 2.8%. The blood count shows no relevant differences. To date, cutaneous lesions have cured in 6 of the seven subjects treated (one patient for more than five years) without any evidence of infection or recurrence. The results obtained on our subjects indicate that PRF membranes may be a therapeutic option in this problematic disease.

This study aimed to investigate the healing effect of advanced platelet-rich fibrin (A-PRF) clot membranes in the reduction of palatal wounds resulting from free gingival graft (FGG) harvesting, in the re-epithelization rate and in the pain experience after surgery. Twenty-five patients requiring soft tissue augmentation (gingival recession coverage or keratinized gingiva augmentation) participated in this prospective randomized clinical study. After FGG harvesting, the test group (n=14) received A-PRF clot membranes at the palatal wound and the control group (n=11) a gelatin sponge. Epithelialization rate of the palatal wound, wound healing area, correspondent percentage of reduction and post-surgical pain experience were assessed. The follow-up period was 90 days. There was a significantly higher reduction of the palatal wound area in the A-PRF group vs. the control group, at 7 (p<0.001), 14 (p=0.009) and 30 days (p<0.001) follow-up. The maximum difference between groups was attained at 30 days (91.5% for A-PRF vs. 59.0% for the control group). At 14 days a significant difference in the proportion of patients showing total epithelization was found: 64.3% for A-PRF vs. 9.1% for the control group (p=0.012). At 90 days, both groups showed total recovery. Overall, the control group experienced a higher level of pain and discomfort until the 14th day, being significantly higher on the second day (p=0.013). The results suggest that A-PRF membranes haste the healing process by promoting a greater reduction along the recovery period and an apparent less painful postoperative period.

Microporous organic polymers (MOPs) are promising materials for gas sorption because of the intrinsic and permanent porosity, designable framework and low density. The introduction of nitrogen-rich building block in MOPs will greatly enhance the gas sorption capacity. Here, we report the synthesis of MOPs from the 2,4,6-tris(4-ethynylphenyl)-1,3,5-triazine unit and aromatic azides linkers via click polymerization reaction. FTIR and solid state 13C CP-MAS NMR confirm the formation of the polymers. CMOP-1 and CMOP-2 exhibit microporous networks with BET surface area of 431 and 406 m2 g-1 and narrow pore size distribution under 1.2 nm. Gas sorption isotherms including CO2 and H2 were measured. CMOP-1 stores superior CO2 level of 8.2 wt% (1.88 mmol g-1) at 273 K/1.0 bar and H2 uptake up to 0.6 wt% at 77 K/1.0 bar, while CMOP-2 with smaller surface area shows lower CO2 adsorption capacity of 7.3 wt% (1.66 mmol g-1) and H2 uptake (0.5 wt%). In addition, I2 vapor adsorption was tested at 353 K. CMOP-1 shows higher gravimetric load of 160 wt%. Despite of the moderate surface area, the CMOPs display excellent sorption ability for CO2 and I2 due to the nitrogen-rich content in the polymers.

The world will experience an estimated 40% freshwater supply shortage by 2030, converting water scarcity into one of the principal global challenges that modern society face. Urban water-reuse is recognized as a promising and necessary measure to alleviate the growing water stress in many regions. The transformation to widespread application of water-reuse systems requires major changes in the way water is governed, and countries such as Spain already find themselves involved in this process. Through the systematic assessment of the city of Sabadell (Spain), we aim to identify the main barriers, opportunities and transferable lessons that can enhance governance capacity to implement systems for non-potable reuse of treated wastewater in cities. It was found that continuous learning, the availability and quality of information and level of knowledge and strong agents of change are the main capacity-building priorities. On the other hand, awareness, multilevel network potential and implementing capacity are already well-established. It is concluded that in order to undertake a widespread application of water-reuse practices, criteria examining water quality according to its use need to be developed, independently of the water’s origin. The development and implementation of such a legislative frame should be based on the experience of local water-reuse practices and continuous evaluation. Finally, the need for public engagement and adequate pricing mechanisms are emphasized.

This paper proposes an experimental design to publish on the Internet the measurements resulting from the use of four sensors: a sensor inside a cistern to measure the level of drinking water, a sensor inside a water tank to measure the water level, a sensor to measure the water flow or pressure brought by the pipes, and another sensor to measure the water quality. Using these sensors, data was collected and published in real-time on the Internet, and at the same time, it was recorded in a database. Several tests of filling and emptying the cistern were performed. A system analyzes, makes decisions, and acts on the data collected by the sensors. Finally, experimental results demonstrated that if the cistern perceived that there was no water in the tank, it turned on the water pump to fill the tank to 100\% of its storage capacity; while this was happening, the water level in the cistern and tank, the flow of water from the piped water, and the quality of the water could be visualized on a dashboard. In short, this proposal monitors water levels and flows through the Internet of Things.

Water availability is a major constraint for spring wheat production on the western Loess Plateau of China. The impact of tillage practices on water potential, water potential gradient, water transfer resistance, yield, and water use efficiency (WUEg) of spring wheat was monitored on the western Loess Plateau in 2016 and 2017. Six tillage practices were assessed, including conventional tillage with no straw (T), no-till with straw cover (NTS), no-till with no straw (NT), conventional tillage with straw incorporated (TS), conventional tillage with plastic mulch (TP), and no-till with plastic mulch (NTP). No-till with straw cover, TP, and NTP significantly improved soil water potential and root water potential at the seedling stage and leaf water potential at the seedling, tillering, jointing, and flowering stages, compared to T. These treatments also significantly reduced the soil-leaf water potential gradient at the 0-10 cm soil layer at the seedling stage and at the 30-50 cm soil layer at flowering, compared to T. Thus, NTS, TP, and NTP reduced soil-leaf water transfer resistance and enhanced transpiration. Compared to T, the NTS, TP, and NTP treatments significantly increased biomass yield (BY) by 18, 36, and 40%, respectively, and grain yield (GY) by 28, 22, and 24%, respectively, with corresponding increases in WUEg of 24, 26, and 24%, respectively. These results demonstrate that NTS, TP, and NTP improved GY and WUEg of spring wheat by decreasing the soil-leaf water potential gradient and soil-leaf water transfer resistance and enhancing transpiration, and are suitable tillage practices for sustainable intensification of wheat production in semi-arid areas.

The Cauto River Basin (CRB), the heartland of Cuban agriculture, has been hit hard by drought and water shortage. In response to this pressing issue, this study provides a comprehensive as-sessment of water supply, demand and balance within the Cauto River Basin, considering the baseline and projected socio-economic and climatic conditions by coupling of SWAT and WEAP models. The obtained results reveal that the annual flow in the CRB is projected to slightly de-crease (2.5%) in which the reduction in the rainy season (3.1%) is higher than that in the dry sea-son (1.3%). Total water demand in the baseline scenario is around 1.194 billion m3, dominated by agriculture (96%), with rice crop requiring nearly half. For the future scenario of 2050, the study shows a 16.6% surge in demand to 1.394 billion m3, driven by climate change and agricultural expansion. However, domestic use decreases by 10% due to population reduction. Water deficit in the future is projected to increase by 52% from 172.4 to 262.7 million m3 due to rising water demand and declining water supply. This study shows that integrating a hydrological model into a water allocation model is a promising approach to estimate the water supply, demand and balance, which is a crucial component of water resources management.

Calabar is a city where 65 per cent of people are living in poverty in informal settlements with low and decreasing access to improved water. In the low-income informal areas of the city, residents are being made responsible for securing their own water supply through several coping strategies. This paper explores the decreasing access to water and coping strategies to shortage in Calabar, Nigeria. It analyses two complementary pieces of data: (i) the households’ coping strategies and (ii) satisfaction with improved water services. A mixed method was introduced and data was collected via fieldwork at three settlements in Calabar. A household survey of 360 respondents, 27 in-depth interviews and 2 focus groups were conducted. Findings show that households engaged in different coping strategies to access water, including conservation (changing routine/reusing), purchasing (spent a significant proportion of their income on buying water) and pumping as a coping strategy. The household's tenure, socioeconomic status and water accessibility determines their decision to move if services are not provided. A crucial differentiation exists between a larger population being granted less access to water versus certain individuals receiving access to a greater quantity of water.

The aim were to determine the drinking water preferences of people applied to a family health center. This cross-sectional study was carried out from April 01st to May 31st, 2022. The data were evaluated using the chi-square test and percent ratios with a significant of P < 0.05. The mean age of all 432 respondents was 48.03±15.86. It was determined that those aged 31-45 had drunk more bottled water (p<0.01) and more spring water (p<0.001), that those aged 65 and over more purified water (p<0.001), that women more tap water (p<0.001), that married people had drunk more demijohn and tap water (p<0.001, each one), that divorced/widows had drunk more packaged and purified water (p<0.001, each one), that the illiterate/literate bottled water (p<0.001, per one), that those who had no income/people who lived on the state or municipal assistance only carboy water (p<0.001). This study suggests that the biggest factor that positively affected the drinking water preference was the packaging of the water. However, the drinking rates of mains water and spring water were quite low. Convincing the authorities to make the mains water drinkable is of great importance in terms of overcoming the public's distrust of mains water.

Water resources are under pressure because of human activities. Its management faces the challenge of enhancing long-term water security while minimizing undesirable economic, social, and environmental impacts along with its production chain. Since water and wastewater treatment plants are designed to maintain and conserve freshwater provisioning services, it is paramount to understand how it operates before proposing options for sustainability. At this point, the diagnosis phase claims for methods scientifically-based, systemic, and more objective to provide information for decision-makers towards strategic management of water resources. This work applies the five-sector sustainability model (5SenSu) to assess Brazil's twenty major water and wastewater treatment companies (WWTC) to quantify their sustainability levels that allow ranking procedures and the establishment of benchmarks for improvements. Under comparative basis, results identified the top-three sustainable companies, CORSAN, CASAN, and SANEPAR, which should be considered examples of best practices. Specifically, the following best-ranked companies in each sector within 5SenSu should be used as benchmark patterns for more oriented best practices: SANEAGO, sector 1; AGESISA, sector 2; CORSAN, sector 3; CASAL, sector 4; MA, sector 5. This work contributes to the advancement in modeling sustainability assessment of human-managed systems (applied in WWTCs in this present study) from a systemic and epistemologically rooted approach, avoiding shortcomings and misleading discussions on the sustainability issue. Quantifying sustainability of WWTCS from 5SenSu allows the identification of those sectors/indicators that requires immediate cleaner production practices by decision-makers to improve overall sustainability, besides identifying those companies more aligned with the requirements of UN SDGs.

This research contributes to the detailed discussion about the approach to secure, hygienic water and cleanliness in Uganda and its pastoral regions. The relationship between the sanitation and clean water access with destitution is also discussed. Although this document is not leading towards the policy recommendation but it is an overall idea of how Uganda progressed because of the provisions adopted by the government, local and international organizations, and NGOs, and how the country lacked before these steps taken. Most of the data mentioned is taken from the house surveys of a decade 2002-2013 alongside the qualitative data. Literature review is also considered and is divided in two sections: first included researches related to water accessibility and usage, while the second section included researches related to work done and progress for diarrheal diseases and sanitation. Afterwards, methodologies were discussed where, firstly, trends and then the limitations in access to the basic necessities of life that is clean water and hygiene are mentioned. At last, the implementations and how they affected the rural Ugandans was discussed.

This study was conducted generally by aiming assessment of the hydraulic performance of water distribution systems of Addis Ababa Science and Technology University (AASTU). In line with the main objective, this study addressed, (1) pinpointing problems of existing water supply versus demand deficit (2) evaluating the hydraulic performance of water distribution system using water GEMS and (3) recommended alternative methods for improving water demand scenarios. The University’s water supply distribution network layout was a looped system and the flow of water derived by both gravity and pressurized system. The gravity flow served for the academic and administrative staffs whereas the pressurized system of the network fed the students dormitories, cafeteria’s etc. The study revealed the existence of unmet minimum pressure requirement around the student dormitories which accounts 25.64% below the country’s building code standard during the peak hour consumption. The result of the water demand projection showed an increment of 2.5 liter per capita demand (LPCD) in every five years. Hence, first, the university’s water demand was projected and then hydraulic parameters such as; pressure, head loss and velocity were modeled for both the existing and the improved water supply distribution. The finding of the study was recommended to the university’s water supply project and institutional development offices for its future modification and rehabilitation works.

Hyaluronic acid, in the form of a gel or viscoelastic colloidal solution, is currently used for viscosupplementation of joints affected by osteoarthritis, but its effectiveness is under debate in relation to newer alternatives. Based on meta-analytical arguments, the present article reinforces the opinion that there are still no decisive arguments for its complete replacement, but for its use adapted to the peculiarities of the disease manifestation and of the patients. A “broad” comparison is first made with almost all alternatives studied in the last decade, and then a meta-regression study is performed to compare and predict the effect size induced by viscosupplementation and platelet-rich plasma therapies. If they are computerized, the developed models can represent tools for clinicians in determining the appropriateness of the option or not for viscosupplementation, in a manner adapted to the pain felt by the patients, to their age, or to other clinical circumstances. The models were generated using the latest algorithms for meta-analysis and meta-regression implemented in the R language and assembled in different R packages. All primary data and necessary R scripts are provided in accordance with the philosophy of reproducible research. Finally, HA-based products, currently under circumspection, are still clinically useful.

This research aims to elucidate the organizational patterns of interregional economic interdependence to enhance our comprehension of the national economy's structure at a regional scale. Employing a multilayer network model, this study represents economic interdependence among Indonesian regions, utilizing the InterRegional Input-Output (IRIO) table. Through the application of various metrics, such as degree and strength distribution, assortativity coefficient, and global and local rich club coefficient, to the multilayer IRIO network, we uncover the organizational patterns of economic exchanges between provinces and economic sectors within Indonesia. Our findings demonstrate that a multilayer network approach reveals the heterogeneous and complex structure of the national economy at the regional level. By analyzing the assortativity pattern and global rich-club coefficient, we illustrate that the IRIO network exhibits a hierarchical organization, where significant provincial-sector nodes are interconnected and form dense rich clubs, extending from a few structural cores to peripheral regions. Additionally, we identify distinct connectivity patterns of non-rich nodes based on their incoming and outgoing relations. The insights gained from this study have implications for the macro-control of regional development.

The aim of this study was to compare the effect of using L-PRF in patients undergoing impacted lower third molar surgery with either primary or secondary closure techniques. Methods: This prospective, randomised, double-blind, split-mouth clinical trial was conducted in patients with bilateral lower impacted third molars of similar position. Primary closure was performed in group 1 and secondary closure in group 2. Group 1 closure technique was applied to one side of the patients and group 2 closure technique was applied to the other side at different times. Nine pa-tients were excluded from the study due to alveolitis and failure to attend regular control visits out of the 45 patients evaluated. Results: Of the 36 patients included in the study, 23 were female and 13 were male and the mean age was 22.42±3.36 years. The secondary closure group had lower VAS scores at hour 6 (p

Abstract: Kiwifruit, a perennial horticultural crop known for its nutritional value, faces significant challenges due to biotic and abiotic stresses, affecting its yield and quality. Leucine-rich repeat receptor-like proteins (LRR-RLPs), a major group of receptor-like proteins in plants, have diverse functions in plant physiology, including growth, development, signal transduction, and stress responses. Despite their importance, the specific roles of kiwifruit LRR-RLPs in response to biotic and abiotic stresses remain poorly understood. In this study, we investigated the expression patterns of kiwifruit LRR-RLPs under various stress conditions, including pathogen stress, heat stress, waterlogging stress, and copper stress. Through genome and transcriptome analyses, we identified a total of 101, 164, and 105 LRR-RLPs in Actinidia Chinensis 'Hongyang', Actinidia eriantha 'Huate', and Actinidia chinensis 'Red5' kiwifruit, respectively, classified into 9 subgroups based on phylogenetic relationships. Synteny analysis revealed that the expansion of kiwifruit LRR-RLPs was primarily attributed to segmental duplication events. Using RNA-seq data from pathogen-infected kiwifruits, we identified specific LRR-RLP genes potentially involved in different stages of pathogen infection. Additionally, we observed the potential involvement of kiwifruit LRR-RLPs in abiotic stress responses, with upstream transcription factors possibly regulating their expression. Furthermore, protein interaction network analysis unveiled the participation of kiwifruit LRR-RLP genes in the regulatory network of abiotic stress responses. These findings highlight the crucial roles of LRR-RLPs in mediating both biotic and abiotic stress responses in kiwifruit, offering valuable insights for the breeding of stress-resistant kiwifruit varieties.

The present study evaluated the antioxidant, antidiabetic properties, and biocompatibility of Medicago sativa and Solidago virgaurea extracts enriched in flavonoid and isoflavonoid compounds. The extracts were obtained by accelerated solvent extraction and laser irradiation. Then, nanofiltration was used for the concentration of flavonoid and isoflavonoid compounds from extracts. The extracts were analyzed for antioxidant capacity using DPPH radical scavenging and reducing power methods, while the antidiabetic property was tested by α-amylase and α-glucosidase inhibition and in vitro on a murine insulinoma cell line (β-TC-6). M. sativa obtained by laser irradiation and concentrated by nanofiltration had the highest DPPH• scavenging (IC50 = 105.2±1.1 and reducing power activities (IC50 = 40.98±0.2 µg/mL). M. sativa extracts had higher inhibition on α-amylase (IC50 = 23.9±1.2, respectively 26.8±1.1), while S. virgaurea had the highest α-glucosidase inhibition (9.3±0.9 ?g/mL respectively 8.6±0.7 ?g/mL). The results obtained after evaluating the antidiabetic in vitro activity showed that the treatment with M. sativa and S. virgaurea flavonoid- and isoflavonoid-rich extracts stimulated the insulin secretion of β-TC-6 cells, both under normal conditions as well as in hyperglycemic conditions. This paper argued that M. sativa and S. virgaurea flavonoid-rich and isoflavonoid-rich extracts could be an excellent natural source with promising antidiabetic potential.

Superconductivity in highly-pressurized hydrides became primary direction for the exploration of fundamental upper limit for the superconducting transition temperature, Tc, after Drozdov et al (Nature 2015, 525, 73) discovered superconducting state with Tc=203 K in highly-compressed sulphur hydride. To date several dozens of high-temperature superconducting polyhydrides have been discovered. In addition, recently, it was reported that highly-compressed titanium and scandium exhibit record-high (up to 36 K), which is by manifold exceeded of niobium, which is the record high- ambient pressure metallic superconductor. Here we analysed experimental data on for recently discovered high-pressure superconductors (which exhibit high transition temperatures within their classes): elemental titanium (Zhang et al, Nature Communications 2022; Liu et al, Phys. Rev. B 2022), TaH3 (He et al, Chinese Phys. Lett. 2023), LaBeH8 (Song et al, Phys. Rev. Lett. 2023), and black (Li et al, Proc. Natl. Acad. Sci. 2018) and violet (Wu et al, arXiv 2023) phosphorous, to reveal the nonadiabaticity strength constant, TθTF (where Tθ is the Debye temperature, and TF the Fermi temperature) in these superconductors. The analysis showed that δ-phase of titanium and black phosphorous exhibit the Tθ/TF which are nearly identical to ones associated in A15 superconductors, while studied hydrides and violet phosphorous exhibit the constants in the same ballpark with H3S and LaH10.

Li-rich manganese-based cathode materials (LRMs) are considered one of the most promising cathode materials for the next generation lithium-ion batteries (LIBs) because of their high energy density. However, there are problems such as capacity decay, poor rate performance, and continuous voltage drop, which seriously limit their large-scale commercial applications. In this work, Li1.2Mn0.54Co0.13Ni0.13O2 coated with Li2MoO4 with unique spinel structure was prepared by wet chemistry method and the subsequent calcination process. The Li2MoO4 coating layer with spinel structure can provide a 3D Li+ transport channel, which is beneficial for improving rate performance, while protecting LRMs from electrolyte corrosion, suppressing interface side reactions, and improving cycling stability. The capacity retention rate of LRMs coated with 3wt% Li2MoO4 increased from 69.25% to 81.85% after 100 cycles at 1C, and the voltage attenuation decreased from 7.06 to 4.98 mV per cycle. The lower Rct also exhibits improved magnification performance. The results indicate that the Li2MoO4 coating effectively improves the cyclic stability and electrochemical performance of LRMs.

Co-free Li-rich oxide is a promising cathode for low cost high energy density Li-ion battery but presents poor cyclic stability. To address this issue, CeO2 is coated on Co-free Li-rich oxide through a low-temperature aged process, resulting in a novel CeO2-coated Li-rich oxide compo-site. Due to the low-temperature aged process, a uniform CeO2 coating layer of 6 nm in thickness is successfully coated on Co-free Li-rich oxide. With this uniform coating, the resulting CeO2-coated Li-rich oxide composite presents improved cyclic stability as well as rate capability as the cathode of Li-ion battery. The capacity retention of the resulting CeO2-coated Li-rich oxide is enhanced from 67% to 85% after 100 cycles and its capacity retention of 5C/0.05C is enhanced from 10% to 23%, compared with the uncoated sample. Such significant improvements enable this low-temperature aged process to be helpful for the practical application of Li-rich oxide materials, not limited to Co-free Li-rich oxide.

Lithium rich layered oxides (LRLO) are a wide class of innovative active materials for positive electrodes in lithium-ion (LIB) and lithium-metal secondary batteries (LMB). LRLOs are over-stoichiometric layered oxides rich in lithium and manganese, with general formula Li1+xTM1-xO2, where TM is a blend of transition metals comprising Mn (main constituent), Ni, Co, Fe and others. Due to the very variable composition and the extended defectivity their structural identity is still debated among researchers being likely an unresolved hybrid between a monoclinic (mC24) and a hexagonal lattice (hR12). Once casted in composite positive electrode films and assembled in LIBs or LMBs, LRLOs can delivery reversible specific capacities above 220-240 mAhg-1, thus beyond any other available intercalation cathode material for LIBs, with mean working potential above 3.3-3.4 V vs Li for hundreds of cycles in liquid aprotic commercial electrodes. In this review we critically outline the recent advancements in the fundamental understanding of the physico-chemical properties of LRLO as well as the most exciting innovations in their battery performance. We focus in particular on the elusive structural identity of these phases, on the complexity of the reaction mechanism in batteries as well as on practical strategies to minimize or remove cobalt from the lattice while preserving the outstanding performance upon cycling.

Water plays a crucial role in maintaining plant functionality and drives many ecophysiological processes. The distribution of water resources is in a continuous change due to global warming affecting the productivity of ecosystems around the globe, but there is a lack of non-destructive methods capable of continuous monitoring of plant and leaf water content that would help us in understanding the consequences of the redistribution of water. We studied the utilization of novel small hyperspectral sensors in the 1350-2450 nm spectral range in non-destructive estimation of leaf water content in laboratory and field conditions. We found that the sensors captured up to 96% of the variation in equivalent water thickness (EWT, g/m²) and up to 90% of the variation in relative water content (RWC). These laboratory findings were supported by field measurements, where repeated leaf spectra measurements were in good agreement (R²=0.79) with a time-lagged change of tree xylem diameter. Further tests were done with an indoor plant (Dracaena marginate Lem.) by continuously measuring leaf spectra while drought conditions developed, which revealed detailed diurnal dynamics of leaf water content. We conclude that close-range hyperspectral spectroscopy can provide a novel tool for continuous measurement of leaf water content at the single leaf level and help us to better understand plant responses to varying environmental conditions.

The issue of degradation of drinking water quality has become a problem of great concern in Pakistan, and especially availability of water treatment facilities in the Sindh province of Pakistan is almost negligible, particularly in rural areas. And, the public has been using traditional methods to reduce the concentration of physic-chemical parameters in drinking water. Therefore this study was carried out to analyze the impact of a Clay-water cooler on physic-chemical parameters of drinking water. Analysis revealed that samples remained colorless, with the passage of time odor of water changed to a clayey odor; Turbidity increased with the passage of time and temperature decreased; the pH value of water increased initially and crossed the allowable limit but with time it was observed that pH of water decreased came under the limit; the concentration of EC, Cl, Ca, Total Hardness and TDS decreased for first 12 hours, but increased with increase in storage time. The value of Magnesium increased as storage time increased. Overall, it was disclosed that a Clay-water cooler has a positive impact on the quality of drinking water particularly if water is stored in a clay-water cooler for a time not longer than 8 hours.

Our analysis of previous studies shows that solar energy and wind can consume negligible amount of water to generate one megawatt of electricity.

Sachet water (SW) is a major source of drinking water in most Nigerian homes, thus making it a possible conveyance medium for health risks due to contamination rather than for replenishment of the body. This study collected SW from three busy neighborhoods and investigated for the presence of indicator bacteria – Escherichia coli (E. coli), Total Coliform (TC), Total Heterophilic Bacteria (THB), and Staphylococcus – and some physio-chemical parameters – total dissolved solids (TDS), pH, electrical conductivity (EC), and salinity. Multi-variable and exploratory statistical methods were applied to the results to determine correlations between bacterial contamination levels and perceived brand reputation. Bacteriological test with raw SW samples appeared too numerous to count (TNC) and thus required serial dilutions. After seven dilutions, results obtained revealed that SW brands with good reputation had no TC and E. coli and was statistically significant with groupings of other SW brands (χ2 = 12.28; p < 0.05 and χ2 = 37.96; p < 0.05) respectively. Additionally, SW brands with poor reputation had mean values of TC (19.7X10^8 cfu/ml;14X10^8 cfu/ml1.15X10^8 cfu/ml) and E.coli (18.2X10^8 cfu/ml;38.7X10^8 cfu/ml,32.4X10^8 cfu/ml) exceeding threshold value of zero set by the World Health Organization (WHO). Only one sample from poor reputation brand tested positive for Staphylococcus and was not statistically significant (χ2 =5.2191; p = 0.074). Principal Component Analysis (PCA)/ Factor Analysis (FA) revealed that most of the SW had fecal contamination in an alarming magnitude. Therefore, this study suggests that periodic cleaning of distribution lines, location specific treatment, QC and QA measures should be taken to reduce water security risk for SW consumption in the region.

Water pollution in Iraq has been extended disaster edge; this pollution is caused by wastes and sewages into soil and rivers, pollutant water sources influence the outbreak and serious epidemic status among the population.. The aim of this study is to determine the bacteriological quality of drinking water sources and characteristics of water-borne diseases especially diarrheal cases in Darbandikhan city. 166 water samples, collected from the different sources and areas, were tested for the presences of coliform bacteria as an indicator for pathogen contamination. Most probable number index was used for coliform enumeration. 161 diarrheal cases were taken as a sample from the patients were admitted to the general hospital in Darbandikhan district.. The questionnaire form was planned to view characteristics of diarrheal cases and patients were interviewed directly, the data was analyzed by STATA software application. 46% of the diarrheal cases used tap water for drinking. On the other hand, the reminder (54%) used other sources for the same purpose. All the risk factor such as type of water source, sufficiency of the water, duration of water storage and chlorination were associated with diarrhea. Almost half of the cases were children and three quarters were single. The data was analyzed by STATA version 13.1.This study indicated that the majority of drinking water sources in Darbandikhan city are not suitable for drinking, although net pipe system supplied chlorine significantly it has been proven that the tap water from the homes is not suitable for consumption.

Shanghai is experiencing water supply problems caused by heavy pollution of its raw water supply, deficiencies in its treatment processes and water quality deteoriation in the distribution system. However, little attention has been paid these problems of water quality in raw water, water treatment and household drinking water. Based on water quality data we show that the raw water sources of the Huangpu River and the Changjiang (Yangtze River) estuary are polluted by microbes (TBC), eutrophication (TP, TN and NH3-N), heavy metals (Fe, Mn and Hg) and organic contamination (chemical oxygen demand [COD], detergent and volatile phenols [VP]). The average concentrations of these contaminants in the Huangpu River are almost double that of the Changjiang estuary forcing a rapid shift to the Changjiang estuary for raw water. In spite of filtering and treatment, TN, NH3-N, Fe, COD and chlorine maxima of the treated water and drinking water still exceed the Chinese National Standard (GB5749). We determine that the relevant threats from water source to household water in Shanghai are: 1) eutrophication arising from highly concentrated TN, TP, COD and algal density in the raw water; 2) increasing salinity in the river estuary, especially at the Qingcaosha Reservoir (currently the major freshwater source for Shanghai); 3) more than 50% of organic constituents and by-products remain in treated water; 4) bacteria and turbidity increase in the course of water delivery to users. The analysis presents an holistic assessment of the water quality threats to metropolitan Shanghai in relation to the city’s rapid development.

Wind energy powered pumps could be an alternative to conventional fuel powered pumps for water abstraction because they rely on a free energy and they are environmentally friendly. The objective of this study was to assess the potential of wind energy to operate water abstraction systems in Teso sub-region of Uganda for livestock watering Daily mean wind speeds recorded at a height of 10 m for a period of ten years (2005–2015) were collected from Amuria and Soroti Meteorological stations in the study area. Data were analyzed using Weibull distribution to evaluate the annual wind speed frequency distributions and consequently assess their potential for water abstraction. The results indicated that warmer months (January, February and March) have higher mean wind speeds than the cold months (August, September and October). High wind speeds in the dry seasons corresponded to the periods of high water demand. The highest shape parameter (k) of 3.07 was registered in 2009 and scale parameter (c) of 3.78 in 2012. The highest wind power density of 43 W/m² was obtained the year 2012 while the lowest wind power density of 15.47 W/m² was obtained for Soroti district in the year 2009. The maximum power extractable in Amuria in 2012 was 324 W/m² which is potentially enough for water abstraction. Maximum discharges of 1.86 m³/s and 1.52 m³/s were obtained for Amuria and Soroti districts respectively at mean wind speeds of 5 m/s. Therefore, Teso sub region winds have potential for water abstraction and Amuria district better sites for livestock watering using wind energy.

Cleaning wastewater and using it again for secondary purposes is a measure to address water scarcity in urban areas. However, upscaling of recycled water schemes is challenging due to the possible emergence of various barriers. Based on a review of the governance literature we suggest that a set of five governance conditions is necessary for a successful upscaling of recycled water schemes; (1) policy leadership, (2) policy coordination, (3) availability of financial resources, (4) awareness of a problem, and (5) the presence of a public forum. In order to elaborate on the practical relevance of these conditions we studied a recycled water scheme currently being upscaled in Sabadell, Spain. We reviewed policy documents, conducted a set of 21 semi-structured interviews, and attended two policy meetings about the subject. Our results suggest that Sabadell meets the required conditions for upscaling reused water to a certain extent. However, the presence of a public forum is lacking. We discuss the implications of the absence of the venue and procedures for public participation in Sabadell and how it could be strengthened. Following this discussion, we conclude with some lessons for other cities that plan to upscale their recycled water schemes.

Packaged water consumption has grown rapidly in urban areas of many low and middle income countries, but particularly in Ghana. However, the sources of water used by this growing packaged water industry and its implications for water resource management and transport-related environmental impacts have not been described. This study aimed to assess the spatial distribution of regulated packaged water production in Ghana, both in relation to demand and for natural mineral water, to hydrogeological characteristics. 764 addresses for premises licenced to produce packaged water from 2009-2015 were mapped and compared to regional sachet water consumption and beverage import/export data examined. We find evidence to suggest packaged water is transported shorter distances in Ghana than in developed countries. For natural mineral waters, producers should be able to address the most widespread water quality hazards (including high salinity, iron and nitrates) in aquifers used for production through reverse osmosis treatment. The study suggests there is scope to integrate beverage product and groundwater regulatory databases to support groundwater management.

Water is a fundamental resource for ecosystems, humans, and the development of all economic sectors; it is necessary to identify and evaluate its environmental pressures or impacts. The water footprint (WF) is an appropriate indicator for the consumption of water used to produce a product. The present study uses this tool to evaluate the green and blue water requirements and the sustainability of irrigation water use for agroindustrial avocado production in Ziracuaretiro, Michoacán (2012-2021). Our analysis was based on aggregating weather and soil data at the municipal level and official government databases of avocado cultivated surface, fruit production, and water rights concessions. The analysis considers the homogeneity of information throughout the study area. We estimated that rainfed plantations require 839.03 m³/ton and irrigated plantations require 2355.80 m³/ton, with an average of 1597.47 m³/ton. In addition, we determined that avocado cultivation can demand up to 124.3% of agricultural water concessions in this municipality. In addition to the WF estimates, the analysis indicates that such studies are fundamental for decision-makers to develop and implement water use-efficiency strategies and shows the need for further research related to water consumption of avocado as a crop at more detailed scales to reduce uncertainty.

Various methods of water purification, the aim of which is to obtain such a purity class that makes it suitable for consumption are presented in the article. It is a review of solutions, ranging from methods known and used for over 100 years, through research and experiments underway, to those that are only a concept. Some of the solutions are so effective that they should also be combined with the possibility of safe storage of purified water. Flexible tanks are used for this, which significantly improve logistics and provide a supply of water in all places where it is needed.

The semantic segmentation of high-resolution remote sensing images (HR-RSI) is crucial for a wide range of applications, such as precision agriculture, urban planning, natural resource assessment, and ecological monitoring. However, accurately classifying pixels in HR-RSI faces challenges due to densely distributed small objects and scale variations. Existing techniques, including Convolutional Neural Networks (CNNs) and other methods for hierarchical feature extraction and fusion of remote sensing image, often do not achieve the desired accuracy. In this paper, we propose a novel approach called the Hierarchical Rich-scale Fusion Network (HRFNet) to address these challenges. HRFNet utilizes advanced information rating and image partition techniques to extract rich-scale features within image layers. This allows for the adaptive exploration of both local and global contextual information. Moreover, we introduce a structured intra-layer to inter-layer feature aggregation module, which enables the adaptive extraction of fine-grained details and high-level semantic information from multi-layer feature maps in a highly flexible manner. Extensive experimentation has been conducted to validate the effectiveness of our proposed method. Our results demonstrate that HRFNet outperforms existing techniques, achieving state-of-the-art (SOTA) results on benchmark datasets, specifically the ISPRS Potsdam and Vaihingen datasets.

In the crustacean immune system, leucine-rich repeat (LRR) is one of the major structures for recognizing pathogen-associated molecular patterns (PAMPs). LRR domain-containing proteins belong to the LRR family, which is a large group of proteins with more than 6000 genes in the database. They are involved in very diverse physiological functions mainly by interacting with other proteins. In a previous study, the LvLRRm, a transmembrane protein containing only LRR domain, was identified in the white leg shrimp, Litopenaeus vannamei. Its versatile role in performing multiple immunomodulation activities has been reported. However, there is still a lack of research on its efficient function at the protein level. To investigate its interactions with other proteins, we applied a convenient method called ‘Hybrid LRR technique’ to produce a recombinant LvLRRm. The LvLRRm and hagfish’s variable lymphocyte receptors (VLRs) fragments were fused to the conserved LxxLxLxxN motif while retaining the β-strand. In addition, we established interactions between hybrid-proteins and flagellin of Salmonella by performing surface plasmon resonance (SPR) analysis. The designed hybrid proteins showed potential for universal applications without losing protein functions.

Objective: To describe technique of platelet rich plasma injection into the olfactory cleft in patients with long-term COVID-19 olfactory dysfunction. Methods: The technique starts with the blood extraction and the isolation of PRP through a 10-min centrifugation (4,200 rpm). The supernatant was injected in nasal regions with a 27-G needle after a local anesthesia with Xylocain 10% spray. The injection was performed through a 0° rigid optic. Precisely, several points of 0.2–0.5 mL were performed in the nasal septum in regard of the head of the middle turbine, and in the head of the middle turbine in both sides. Clinical, psychophysical and pain outcomes were evaluated pre- to post-injection. Results: A 22-year-old female with 24-month post-COVID-19 anosmia was recruited for the injection of PRP. The olfactory cleft endoscopic scale score was 0 and the threshold, discrimination and identification scores were 1, 8 and 0, respectively. The Olfactory Disorder Questionnaire score was 51. The patient benefited from the injection of 2.2 mL of PRP in nasal regions, which was done without complication. The procedure pain level was 2/10, while the local anesthesia with xylocaine 10% was judged as the most annoyance step with a score of 3/10. At 2-month post-injection, the TDI scores reached 16, 16, and 16 (48), while the Olfactory Disorder Questionnaire was 73. The patient described its recovery as very rapid, lasting 3-4 days, and occurring 3-week post-injection. Conclusion: The injection of PRP into the olfactory cleft is a safe and easiness new approach that may improve the recovery of smell sense.

Satterthwaite and Toepke (1970 Phys. Rev. Lett. 25 741) discovered that Th₄H₁₅-Th₄D₁₅ superhydrides exhibit superconductivity and have no isotope effect. The latter is fundamental contradiction with the concept of electron-phonon mediated superconductivity of Bardeen-Cooper-Schrieffer (BCS) theory. Soon after this work, Stritzker and Buckel (1972 Zeitschrift für Physik A Hadrons and nuclei 257 1-8) reported that superconductors in PdH_x-PdD_x system exhibit reverse isotope effect. Yussouff et al (1995 Solid State Communications 94 549) extended this finding on PdH_x-PdD_x-PdT_x system. Recent interest to hydrogen- and deuterium-rich superconductors is based on the discovery of near-room-temperature superconductivity in highly-compressed H₃S (Drozdov et al. 2015 Nature 525 73) and LaH₁₀ (Somayazulu et al 2019 Phys. Rev. Lett. 122 027001). To date, there is no clarity about isotope effect in H₃S-D₃S system, because thorough examination of available experimental data reported by Drozdov et al (2015 Nature 525 73) shows that H₃S-D₃S system perhaps has reverse isotope effect. In attempt to reaffirm/disprove our primary idea that the mechanism for near-room-temperature superconductivity in hydrogen-rich superconductors is not BCS electron-phonon interaction, we analyse the upper critical field data, B_c2(T), in Th₄H₁₅-Th₄D₁₅ phases (Satterthwaite and Toepke 1970 Phys. Rev. Lett. 25 741) and two recently discovered high-pressure hydrogen-rich phases of ThH₉ and ThH₁₀ (Semenok et al 2019 arXiv:1902.10206). As the result, it is found that all known to date thorium super-hydrides/deuterides are unconventional superconductors which have T_c/T_F ratios within a range of 0.008 < T_c/T_F < 0.120, where T_c is the superconducting transition temperature and T_F is the Fermi temperature.

Aedes aegypti (L.) is the primary vector of chikungunya, dengue, yellow fever and Zika viruses. The leucine-rich repeats (LRR)-containing domain is evolutionarily conserved in many proteins associated with innate immunity in invertebrates and vertebrates, as well as plants. We focused on the AaeLRIM1 and AaeAPL1 gene expressions in response to Zika virus (ZIKV) and Chikungunya virus (CHIKV) infection using a time course study, as well as the developmental expressions in the eggs, larvae, pupae, and adults. RNA-seq analysis data provided 60 leucine-rich repeat related transcriptions in Ae. aegypti in response to Zika virus (Accession number: GSE118858, https://www.ncbi.nlm.nih.gov/gds/?term=GSE118858). RNA-seq analysis data showed that AaeLRIM1 (AAEL012086-RA) and AaeAPL1 (AAEL009520-RA) were significantly upregulated 2.5 and 3-fold during infection by ZIKV 7-days post infection (dpi) of an Ae. aegypti Key West strain compared to an Orlando strain. The qPCR data showed that LRR-containing proteins AaeLRIM1, AaeAPL1 and five paralogues were expressed 100-fold lower than other nuclear genes, such as defensin, during all developmental stages examined. Together, these data provide insights into transcription profiles of LRR proteins of Ae. aegypti during its development and in response to infection with emergent arboviruses.