Version 1
: Received: 19 October 2023 / Approved: 20 October 2023 / Online: 20 October 2023 (08:29:54 CEST)
How to cite:
Paun, G.; Neagu, E.; Albu, C.; Alecu, A.; Seciu-Grama, A.; Radu, G. Evaluation of the Antioxidant, and Antidiabetic Properties of Flavonoids and Isoflavonoids-Rich Extracts of Medicago sativa and Solidago virgaurea. Preprints2023, 2023101307. https://doi.org/10.20944/preprints202310.1307.v1
Paun, G.; Neagu, E.; Albu, C.; Alecu, A.; Seciu-Grama, A.; Radu, G. Evaluation of the Antioxidant, and Antidiabetic Properties of Flavonoids and Isoflavonoids-Rich Extracts of Medicago sativa and Solidago virgaurea. Preprints 2023, 2023101307. https://doi.org/10.20944/preprints202310.1307.v1
Paun, G.; Neagu, E.; Albu, C.; Alecu, A.; Seciu-Grama, A.; Radu, G. Evaluation of the Antioxidant, and Antidiabetic Properties of Flavonoids and Isoflavonoids-Rich Extracts of Medicago sativa and Solidago virgaurea. Preprints2023, 2023101307. https://doi.org/10.20944/preprints202310.1307.v1
APA Style
Paun, G., Neagu, E., Albu, C., Alecu, A., Seciu-Grama, A., & Radu, G. (2023). Evaluation of the Antioxidant, and Antidiabetic Properties of Flavonoids and Isoflavonoids-Rich Extracts of <em>Medicago sativa</em> and <em>Solidago virgaurea</em>. Preprints. https://doi.org/10.20944/preprints202310.1307.v1
Chicago/Turabian Style
Paun, G., Ana-Maria Seciu-Grama and Gabriel-Lucian Radu. 2023 "Evaluation of the Antioxidant, and Antidiabetic Properties of Flavonoids and Isoflavonoids-Rich Extracts of <em>Medicago sativa</em> and <em>Solidago virgaurea</em>" Preprints. https://doi.org/10.20944/preprints202310.1307.v1
Abstract
The present study evaluated the antioxidant, antidiabetic properties, and biocompatibility of Medicago sativa and Solidago virgaurea extracts enriched in flavonoid and isoflavonoid compounds. The extracts were obtained by accelerated solvent extraction and laser irradiation. Then, nanofiltration was used for the concentration of flavonoid and isoflavonoid compounds from extracts. The extracts were analyzed for antioxidant capacity using DPPH radical scavenging and reducing power methods, while the antidiabetic property was tested by α-amylase and α-glucosidase inhibition and in vitro on a murine insulinoma cell line (β-TC-6). M. sativa obtained by laser irradiation and concentrated by nanofiltration had the highest DPPH• scavenging (IC50 = 105.2±1.1 and reducing power activities (IC50 = 40.98±0.2 µg/mL). M. sativa extracts had higher inhibition on α-amylase (IC50 = 23.9±1.2, respectively 26.8±1.1), while S. virgaurea had the highest α-glucosidase inhibition (9.3±0.9 ?g/mL respectively 8.6±0.7 ?g/mL). The results obtained after evaluating the antidiabetic in vitro activity showed that the treatment with M. sativa and S. virgaurea flavonoid- and isoflavonoid-rich extracts stimulated the insulin secretion of β-TC-6 cells, both under normal conditions as well as in hyperglycemic conditions. This paper argued that M. sativa and S. virgaurea flavonoid-rich and isoflavonoid-rich extracts could be an excellent natural source with promising antidiabetic potential.
Medicine and Pharmacology, Complementary and Alternative Medicine
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