Version 1
: Received: 12 February 2019 / Approved: 14 February 2019 / Online: 14 February 2019 (10:29:29 CET)
How to cite:
Sousa, F.; Machado, V.; Botelho, J.; Proença, L.; João Mendes, J.; Alves, R. Effect of A-PRF Application on Palatal Wound Healing after Free Gingival Graft Harvesting: A Prospective Randomized Study. Preprints2019, 2019020131. https://doi.org/10.20944/preprints201902.0131.v1
Sousa, F.; Machado, V.; Botelho, J.; Proença, L.; João Mendes, J.; Alves, R. Effect of A-PRF Application on Palatal Wound Healing after Free Gingival Graft Harvesting: A Prospective Randomized Study. Preprints 2019, 2019020131. https://doi.org/10.20944/preprints201902.0131.v1
Sousa, F.; Machado, V.; Botelho, J.; Proença, L.; João Mendes, J.; Alves, R. Effect of A-PRF Application on Palatal Wound Healing after Free Gingival Graft Harvesting: A Prospective Randomized Study. Preprints2019, 2019020131. https://doi.org/10.20944/preprints201902.0131.v1
APA Style
Sousa, F., Machado, V., Botelho, J., Proença, L., João Mendes, J., & Alves, R. (2019). Effect of A-PRF Application on Palatal Wound Healing after Free Gingival Graft Harvesting: A Prospective Randomized Study. Preprints. https://doi.org/10.20944/preprints201902.0131.v1
Chicago/Turabian Style
Sousa, F., José João Mendes and Ricardo Alves. 2019 "Effect of A-PRF Application on Palatal Wound Healing after Free Gingival Graft Harvesting: A Prospective Randomized Study" Preprints. https://doi.org/10.20944/preprints201902.0131.v1
Abstract
This study aimed to investigate the healing effect of advanced platelet-rich fibrin (A-PRF) clot membranes in the reduction of palatal wounds resulting from free gingival graft (FGG) harvesting, in the re-epithelization rate and in the pain experience after surgery. Twenty-five patients requiring soft tissue augmentation (gingival recession coverage or keratinized gingiva augmentation) participated in this prospective randomized clinical study. After FGG harvesting, the test group (n=14) received A-PRF clot membranes at the palatal wound and the control group (n=11) a gelatin sponge. Epithelialization rate of the palatal wound, wound healing area, correspondent percentage of reduction and post-surgical pain experience were assessed. The follow-up period was 90 days. There was a significantly higher reduction of the palatal wound area in the A-PRF group vs. the control group, at 7 (p<0.001), 14 (p=0.009) and 30 days (p<0.001) follow-up. The maximum difference between groups was attained at 30 days (91.5% for A-PRF vs. 59.0% for the control group). At 14 days a significant difference in the proportion of patients showing total epithelization was found: 64.3% for A-PRF vs. 9.1% for the control group (p=0.012). At 90 days, both groups showed total recovery. Overall, the control group experienced a higher level of pain and discomfort until the 14th day, being significantly higher on the second day (p=0.013). The results suggest that A-PRF membranes haste the healing process by promoting a greater reduction along the recovery period and an apparent less painful postoperative period.
Keywords
Platelet-rich fibrin, A-PRF, Gingival graft harvesting, Healing, Periodontal plastic surgery
Subject
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
