Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

How to Enhance the Effects of Platelet Rich Plasma on Tissue Regeneration: AMPLEX PLUS Technology, a New Strategy

Version 1 : Received: 18 July 2023 / Approved: 19 July 2023 / Online: 19 July 2023 (05:42:08 CEST)

How to cite: Ferruggia, G.; Contino, M.; Zimbone, M.; Brundo, M. V. How to Enhance the Effects of Platelet Rich Plasma on Tissue Regeneration: AMPLEX PLUS Technology, a New Strategy. Preprints 2023, 2023071291. https://doi.org/10.20944/preprints202307.1291.v1 Ferruggia, G.; Contino, M.; Zimbone, M.; Brundo, M. V. How to Enhance the Effects of Platelet Rich Plasma on Tissue Regeneration: AMPLEX PLUS Technology, a New Strategy. Preprints 2023, 2023071291. https://doi.org/10.20944/preprints202307.1291.v1

Abstract

The employment of PRP in regenerative medicine has not generated the promised grandiose outcomes. Nonetheless, it currently remains the gold standard strategy for tissue regeneration. Therefore, scientific research has focused on identifying other matrices rich in growth factors and cytokines to improve the efficacy of PRP. In the present study, a new technology called AMPLEX PLUS -compound derived from colostrum enriched with exosomes- was applied in combination with PRP to evaluate the concentration trend of 20 bioactive molecules. The results show that the concentration of all the compounds analyzed increased significantly in PRP samples with AMPLEX PLUS technology compared with samples containing only plasma or PRP, suggesting how this new strategy could improve the performance of PRP and make significant advances in regenerative medicine.

Keywords

Regenerative medicine; Platelet Rich Plasma; colostrum; growth factors; cytokines

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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