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Preprint ARTICLE | doi:10.20944/preprints202010.0641.v1

Aging-induced Changes in Sperm DNA Methylation are Modified by Low Dose of Perinatal Flame retardants

J.Richard Pilsner, Alex Shershebnev, Haotian Wu, Chelsea Marcho, Olga Dribnokhodova, Victoria Shtratnikova, Oleg Sergeyev, Alexander Suvorov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; paternal exposure; sperm; advanced paternal age; epigenetics; DNA methylation; RRBS, 2,2′,4,4′-tetrabromodiphenyl ether; PBDE; BDE-47; perinatal; environment

Online: 30 October 2020 (13:37:14 CET)

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Advanced paternal age at fertilization has been suggested to be a risk factor for neurodevelopmental, psychiatric and other disorders in offspring. One emerging hypothesis suggests that altered offspring phenotype is linked with age-related accumulation of epigenetic changes in the sperm of fathers. Given that paternal age is increasing in the developed world, understanding aging-related epigenetic changes in sperm is needed as well as environmental factors that modify such changes. In this study, we characterize age-dependent changes in sperm DNA methylation profiles between young pubertal (postnatal day (PNDs) 65) and mature (PND120) Wistar rats. We also analyze these changes in rats exposed perinatally to 0.2 mg/kg of ubiquitous environmental xenobiotic 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47). Reduced representation bisulfite sequencing (RRBS) libraries were prepared from caudal epididymal sperm DNA and differentially methylated regions (DMRs; ≥ 10x coverage depth, ≥ 3 CpGs per cluster, ≥ 5% methylation change, q < 0.05) were identified via MethPipe package. In control animals, 5,319 age-dependent DMRs were identified, with 99.3% DMRs hypermethylated in mature animals compared to young pubertal rats. These age-related DMRs were enriched for functional categories essential for embryonic development, such as pattern specification, forebrain and sensory organ development, Hippo and Wnt pathways. Age-related changes in sncRNA, reported in different study, target similar list of genes and biological categories.In BDE-47 exposed rats, sperm DNA methylation was higher in young pubertal and lower in mature animals when compared to controls, which resulted in a significant attenuation in the number of age-dependent DMRs (N = 189) identified in the exposed group. In conclusion, our results indicate that the natural aging process has profound effects on sperm methylation levels and this effect may be modified by environmental exposures. Moreover, our results further support the role of epigenetic mechanisms as a likely link betwen paternal age and offspring health and development.

Preprint REVIEW | doi:10.20944/preprints201808.0511.v1

Natural Background and Anthropogenic Arsenic Enrichment in Florida Soils, Surface Water, and Groundwater: A Review with a Discussion on Public Health Risk

Thomas M. Missimer, Christopher M. Teaf, William T. Beeson, Robert G. Maliva, John Woolschlager, Douglas J. Covert

Subject: Environmental And Earth Sciences, Environmental Science Keywords: arsenic; florida; soils; geologic units; groundwater; exposure; public health risk

Online: 30 August 2018 (05:13:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0505.v2

Non-coronavirus Genome Sequences Identified from Metagenomic Analysis of Clinical Samples from COVID-19 Infected Patients: An Evidence for Co-infection

Mohamed Abouelkhair

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Viral Co-infection; SARS-CoV-2; Influenza A virus; Human Immunodeficiency virus

Online: 18 June 2020 (04:57:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0101.v1

Nutrient Resources Recovery by a Creative Co-Composting Method of Municipal Solid Wastes and Wastewater Treatment Plant Sludge

Saeed Nemati, Bijan Samali, Farzaneh Tahmoorian, Nader Mokhtarani, Farshad Sanati

Subject: Engineering, Civil Engineering Keywords: nutrient resources recovery , chemical oxygen demand (COD), carbon to nitrogen ratio (C/N), co-composting, wastewater sludge, municipal solid wastes (MSW)

Online: 8 March 2019 (04:06:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0373.v1

Decoding the Relationship of Artificial Intelligence, Advertising, and Generative Models

Han Woo Park, Camille Velasco Lim, Yu Peng Zhu, Muhammad Omar

Subject: Business, Economics And Management, Marketing Keywords: generative AI advertising; artificial intelligence advertising; machine learning advertising; bibliometrics; full counting; co-occurrence network analysis; co-author network analysis

Online: 4 January 2024 (08:59:13 CET)

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Working Paper REVIEW

Law and Regulations to Control Pesticide Exposure Among the General Population: Comparing the Australian and the European Union Pesticide Regulatory System

Maisarah Nasution Waras, Kateryna Babina, Ismaniza Ismail, Claire E. Lenehan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: pesticide regulation; pesticide exposure; pesticide policy; non-occupational pesticide exposure; human health; pesticide pollution

Online: 4 December 2020 (15:09:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0001.v1

3D Printed Lab-on-a-Chip Diagnostic Systems - Developing a Safe-by-Design Manufacturing Approach

Panagiotis Karayannis, Fotini Petrakli, Anastasia Gkika, Elias Koumoulos

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: 3D printing; lab-on-a-chip; FFF; Safe-by-Design; exposure assessment

Online: 1 November 2019 (03:40:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0300.v1

Performance of Napier Hybrids Cultivars CO5 (Pennisetum glaucum × P. Purpureum schumach) and Sampoorna (Pennisetum pedicillatum × P. americanum) Harvested at Five Intervals

Dilini Weerathunga, Deepani Udagama, Shane Campbell, David Barber, Piyatilak Weerasinghe

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: dry matter yield; CO-5; harvesting interval; In-vitro gas fermentation; nutritional composition; pasture quality; Sampoorna

Online: 13 April 2023 (07:17:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0394.v1

Co-Operation among Irish Beef Farmers: Current Perspectives and Future Prospects in the Context of New Producer Organisation (PO) Legislation

Teresa Hooks, Aine Macken-Walsh, Olive McCarthy, Carol Power, Maeve Henchion

Subject: Social Sciences, Sociology Keywords: Ireland; beef farms; Producer Organisations (POs), product differentiation; co-operatives; values-based supply chain

Online: 20 September 2018 (04:16:57 CEST)

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Working Paper ARTICLE

A Study on the Co-Creation of Value in Service Ecosystem: An Appraisal of the Platform of My Health Bank of National Health Insurance

Yu-Hua Yan, Shih-Chieh Fang

Subject: Social Sciences, Law Keywords: value co-creation; National Health Insurance; My Health Bank; Service Ecosystem

Online: 22 January 2020 (02:55:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0253.v1

Calculating Point Cloud Object Volume Using Co-Opposite-Direction Slicing Method

Bin Li, Xiaowei Bi, Cheng Peng, Yong Chen, Xiaofa Zhao, Chengsheng Yang

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: point cloud objects (PCOs); volume calculation (VC); co-opposite-direction slicing method (CODSM); systematic directional errors; random errors

Online: 22 November 2019 (05:37:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0057.v1

Assessment of Microplastic Impacts in the Marine Environment: A Review

Tony Walker

Subject: Environmental And Earth Sciences, Environmental Science Keywords: impacts; microplastics; marine environment; single-use plastics; co-management initiatives

Online: 4 October 2021 (12:23:39 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201909.0081.v1

Prenatal Mercury Exposure and Postnatal Outcome: A Case Series in Bogotá, Colombia

Nelsy Niño-Rodríguez, María Margarita Manrique Andrade, Diana María Perez-Castiblanco, Cesar Alejandro Geney, Diana Patricia Castro Aguilar, Adriana Ruíz, Angélica María Téllez, Luis Jorge Hernández-Florez, Oscar Andrés Bociga, Helena Groot de Restrepo, Diana María Narváez

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: mercury; prenatal exposure; postnatal outcome; environmental health; epidemiological monitoring

Online: 7 September 2019 (01:06:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0484.v1

The Relationship between Nature Deprivation and Individual Wellbeing across Urban Gradients under COVID-19

Linda Powers Tomasso, Jie Yin, Jose Guillermo Cedeno Laurent, Jarvis T. Chen, Paul Catalano, John D. Spengler

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: nature exposure; nature deprivation; health disparities; wellbeing; built environment; urban health interventions

Online: 21 December 2020 (09:00:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0130.v1

Assessment and Calibration on Low-cost PM2.5 Sensor using Machin Learning (Hybrid-LSTM Neural Network): Feasibility Study to Build Air Quality Monitoring System

Donggeun Park, Geon-Woo Yoo, Seong-Ho Park, Jong-Hyeon Lee

Subject: Environmental And Earth Sciences, Environmental Science Keywords: machine learning; deep learning; calibration; air quality; low-cost sensors; exposure assessment

Online: 7 September 2021 (14:24:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0491.v1

On the nature of evidence and 'proving' causality: smoking and lung cancer vs. sun exposure, vitamin D and multiple sclerosis

Robyn Lucas, Rachael Rodney Harris

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: epidemiology, causality, association, smoking, lung cancer, vitamin D, sun exposure, multiple sclerosis

Online: 29 June 2018 (15:42:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0272.v1

Habitat Climate Change Vulnerability Index Applied to Major Vegetation Types of the Western Interior United States

Patrick J. Comer, Jon C. Hak, Marion S. Reid, Stephanie Auer, Keith Schulz, Healy Hamilton, Regan Smyth, Matthew Kling

Subject: Environmental And Earth Sciences, Environmental Science Keywords: adaptive capacity; climate change vulnerability; exposure; resilience; sensitivity; vegetation

Online: 22 May 2019 (09:55:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0238.v1

A radio-fluorogenic polymer-gel makes fixed fluorescent images of complex radiation fields

John Warman, Matthijs deHaas, Leonard Luthjens, Antonia Denkova, Tiantian Yao

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Keywords: 3D dose imaging; radio-fluorogenic gel; polymer gel dosimetry; radio-fluorogenic co-polymerization; tertiary-butyl acrylate gel; proton beam imaging

Online: 14 June 2018 (16:05:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0452.v1

Performance Analysis of an Intermediate Temperature SOE Test Bench Under CO₂-H₂O Feeding Stream

Petronilla Fragiacomo, Giuseppe De Lorenzo, Orlando Corigliano

Subject: Engineering, Energy And Fuel Technology Keywords: CO/H2 production; intermediate temperature SOEC; SOEC modeling; performance analysis

Online: 24 July 2018 (10:20:27 CEST)

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Working Paper ARTICLE

Design and Demonstration of Compact, High Bandwidth Optical Mode Selective Devices by Realizing ITO-Based Controllable Phase Shifters Integrated on Silicon-on-Insulator Waveguides

Cao Dung Truong, Hai Ta Duy, Duy Nguyen Thi Hang, Thuy Tran Thi Thanh, Duy Duong Quang, Hoang Chu Duc

Subject: Physical Sciences, Acoustics Keywords: co-design; ITO; thermo-optic phase shifter; mode selective converter; mode selective router; numerical simulation

Online: 14 April 2021 (10:13:38 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202009.0701.v1

Risks of Simultaneous Co-Infection of Dengue and COVID-19 in Bangladesh: Challenges and Recommendations

Md. Sahidur Rahman, Tazrina Rahman

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Challenges; coinfection; COVID-19; dengue fever; co-epidemic; health care facility

Online: 29 September 2020 (09:12:06 CEST)

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Working Paper ARTICLE

Investigation of the Health Effects of Workers Exposed to Respirable Crystalline Silica during Outdoor and Underground Construction Projects in Greece

Dimitrios Keramydas, Petros Bakakos, Manos Alchanatis, Ioannis Konstantakopoulos, Petros Papalexis, Kyriaki Tavernaraki, Vasileios Dracopoulos, Antonios Papadakis, Eugenia Pantazi, Nektaria Sidiropoulou, Georgios Chelidonis, Elias Chaidoutis, Theodoros C. Constantinidis, Dimosthenis Chochlakis, Nikolaos Kavantzas, Efstratios Patsouris, Andreas Ch. Lazaris

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: ilicosis; silicon powder; crystalline silica (SiO2); construction workers; occupational exposure; occupational exposure limit; occupational hygiene

Online: 8 April 2020 (04:22:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0211.v2

HIV-1: Tackling the Obstacles that Limit the Effectiveness of CRISPR-Cas9 Gene Editing of the T Cell Co-receptor CCR5

Tatiana Hillman

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HIV-1; CRISPR-Cas9; T-cells; lipid nanoparticles; gut-associated-lymphoid tissue; Co-receptors; Probiotics; GI Tract,; Gene Editing

Online: 13 April 2020 (10:57:52 CEST)

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HIV-1 is a complicated and perplexing virus. It infects T cells, reverse transcribes its RNA into DNA, utilizes its host DNA machinery to replicate its HIV-DNA, translates the HIV-DNA into proteins, assembles itself for a budding escape from the T cell, and rapidly mutates its conformation. Partially, due to its complexity, there remains no cure for HIV or AIDs. However, recently with the discovery of TALENs, the use of zinc fingers, and most of all the applications of CRISPR-Cas9 technology, has given researchers new hope in finding alternative gene therapies and treatments for diseases. With more focus on CRISPR-Cas9, this new and novel technology uses a guiding RNA, sgRNA, to lead a Cas9 nuclease to its target for deletion or to change that DNA site. CRISPR-Cas9 can delete point mutations and multiple DNA sites. Because CRISPR can alter DNA sequences, several scientists have conducted research into CRISPR, possibly treating more diseases such as cancer, diabetes, and even HIV. HIV-1 drew the focus of a researcher named Dr. Ebina in 2013 when he was the first to design and apply CRISPR-Cas9 to genes found in the binding sites of HIV-1, inhibiting HIV-1 gene expression. Since 2013, several other researchers have blocked HIV replication and infection through CRISPR-Cas9 targeting the receptors of T cells called the CC chemokine receptor 5 or CCR5. HIV-1 binds to the CD4 receptor of T cells, which consists of co-receptors CCR5 and CXCR4. If CCR5 expression can be removed, the HIV virus cannot bind to T-cells, blocking the initial attachment stage, and discontinuing the infection. However, there remain obstacles and issues for the CRISPR deletion of CCR5 for treating HIV-1. The issues include: 1) finding new and safe methods of CRISPR-Cas9 delivery, 2) clearing the latent HIV reservoirs, 3) improving the sgRNA design to avoid off-target mutations or deletions, and 4) effectively analyze the viral escape of HIV from CRISPR-Cas9 modifications. Therefore, the purpose of this review is to discuss possible techniques for removing the obstacles that can lessen the potential of CRISPR to delete CCR5, repressing HIV-1 into long-term remission or a functional cure.

Preprint ARTICLE | doi:10.20944/preprints201807.0224.v2

Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha

Julia Sperlich, Nicole Teusch

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: pseudopterosin; triple negative breast cancer; glucocorticoid receptor alpha; dexamethasone; cell proliferation; 3D invasion; tumor spheroid; co-culture; interleukin 6; interleukin 8

Online: 2 August 2018 (06:08:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0163.v1

Sublethal Effects of Wild-Type and a vIF-2α-Knockout Frog virus 3 on Post-Metamorphic Wood Frogs (Rana sylvatica)

Joe-Felix Bienentreu, Leon Grayfer, Dannah M. Schock, Matthew Guerreiro, Stephanie J. DeWitt-Orr, Jacques Robert, Craig R. Brunetti, David Lesbarreres

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Ranavirus; FV3; vIF-2α knockout mutant; bath exposure; wood frog; sublethal effects; reservoir host

Online: 15 March 2019 (11:58:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0322.v1

Transporter Associated with Antigen Processing 1 (TAP1) as a Potential Biomarker for Breast, Lung, Liver and Ovarian Cancer using Health Informatics

Anika Tabassum, Md. Nazmus Samdani, Tarak Chandra Dhali, Rahat Alam, Foysal Ahammad, Abdus Samad, Tomasz M. Karpiński

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TAP1; transcriptional expression; methylation analysis; survival analysis; co-expression; pathway analysis; health informatics

Online: 14 August 2020 (11:17:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0397.v1

Numerical Simulation and Experimental Study of Capacitive Imaging Technique as a Non-Destructive Testing Method

Farima Abdollahi Mamoudan, Sebastien Savard, Tobin Filleter, Clemente Ibarra-Castanedo, Xavier Maldague

Subject: Engineering, Automotive Engineering Keywords: co-planar sensor; capacitive sensing; NDT techniques; FE modelling; defects

Online: 15 March 2021 (15:31:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0483.v1

Andrio Adwibowo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: city; CO; COVID 19; emission; social distancing

Online: 28 April 2020 (07:36:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0180.v1

Antagonistic Interactions between Benzo[a]pyrene and C₆₀ in Toxicological Response of Marine Mussels

Audrey Barranger, Laura M. Langan, Vikram Sharma, Graham A. Rance, Yann Aminot, Nicola J. Weston, Farida Akcha, Michael N. Moore, Volker M. Arlt, Andrei N. Khlobystov, James W. Readman, Awadhesh N. Jha

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Trojan Horse effect; B[a]P; nC60; co-exposure; Mussels; DNA damage; proteomics

Online: 15 May 2019 (09:57:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0503.v1

In-vitro Investigation of Polymeric Lipid Hybrid Nanoparticles (Plhns) Of a Chemotherapeutic Drug for the Treatment of Glioblastoma Multiforme

Sankha Bhattacharya

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cytotoxicity; Glioblastoma multiform; Lactate dehydrogenase (LDH); Poly D- L-lactic-co-glycolic acid (PLGA); U-87 MG glioma cell lines

Online: 21 July 2021 (16:37:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0587.v1

Magneto-Optic Surface Plasmon Resonance Ti/Au/Co/Au/Pc Configuration and Sensitivity

Conrad Rizal

Subject: Engineering, Bioengineering Keywords: Ti/Au/Co/Au; X-ray diffraction; MOSPR; sensitivity; polycarbonate plastics

Online: 30 July 2018 (11:55:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0471.v1

Bacterial Foraging Algorithm for Optimal Joint-Force Searching Strategy of Multi – SAR Vessels at Sea

Ngoc Ha Pham, Minh Duc Nguyen

Subject: Engineering, Marine Engineering Keywords: search and rescue; optimal search algorithm; BFOA; multi-direction search; co-ordinate SAR operations

Online: 31 March 2020 (23:26:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0288.v1

The Influence and Interaction of Tobacco-Related Information Exposure on Youth Smoking Behavior and Smoking Susceptibility: Sex and School Type Difference

Jingfen Zhu, Jiahui Li, Yaping He, Na Li, Gang Xu, Jinming Yu

Subject: Social Sciences, Behavior Sciences Keywords: adolescent; current smoking; smoking behavior; tobacco message exposure

Online: 24 May 2019 (08:34:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0128.v2

Conjunctivitis and Exposure to Ambient Ozone

Mieczyslaw Szyszkowicz, Ariela Gordon Shaag, Einat Shneor

Subject: Medicine And Pharmacology, Ophthalmology Keywords: air pollution; conjunctivitis; exposure; linear; model; case-crossover; poisson

Online: 17 April 2019 (11:58:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0450.v1

Replacement Strategies for Animal Studies in Inhalation Testing

Eleonore Fröhlich

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: 3Rs; replacement of animals; inhalation; in vitro; animal models; species differences; lung morphology; rodents; aerosol exposure

Online: 19 May 2021 (14:30:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0724.v1

Enhanced Anticancer Activity of Nanoformulation of Dasatinib against Triple-Negative Breast Cancer by Reduced Metabolic Degradation

Fatemah Bahman, Valeria Pittalà, Mohamed Haider, Khaled Greish

Subject: Chemistry And Materials Science, Biomaterials Keywords: TNBC; dasatinib; poly(styrene-co-maleic acid) micelles; nanoformulation; metabolism; EPR; nanomedicine; targeted therapy.

Online: 27 April 2021 (13:56:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0164.v1

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and Human Cells

Ines Reigada, Ramón Pérez-Tanoira, Jayendrakumar Patel, Kirsi Savijoki, Jari Yli-Kauhaluoma, Teemu J. Kinnari, Adyary Fallarero

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: biofilm; co-culture; Staphylococcus aureus; SaOS-2; biomaterials; implanted devices

Online: 12 December 2019 (05:24:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0501.v1

Elevated Urinary Arsenic Level among Residents of an Arsenic-Endemic Area of Southern Thailand and its Related Factors: Three Decades after Mitigation Attempts

Udomsak Saengow, Surasak Vijitpongjinda, Supabhorn Yimthiang, Apichai Wattanapisit, Sirilak Thaicharoen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: human arsenic exposure; water source; risk factors; Thailand

Online: 21 September 2020 (11:32:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0168.v2

Awareness of Adverse Health Effects of Silica Dust Exposure Among Stone Quarry Workers in Ghana

Dzifa Francis Ahadzi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: awareness, adverse health effects, exposure, stone quarry workers, silica dust

Online: 13 May 2021 (11:02:43 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202103.0152.v1

Translating Virtual Reality Cue Exposure Therapy for Binge Eating into a Real-World Setting: A Pilot Study

Katherine Nameth, Theresa Brown, Kim Bullock, Sarah Adler, Giuseppe Riva, Debra Safer, Cristin Runfola

Subject: Social Sciences, Psychology Keywords: eating disorder; binge-eating disorder; bulimia nervosa; binge eating, cue-exposure; therapy; treatment; virtual reality

Online: 4 March 2021 (10:08:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0323.v1

Cross-Reactivity of Zika and Other Flaviviruses in Serological Diagnostics

Kelli L. Barr, Erika R. Schwarz, Dhani Prakoso, Kehkashan Imtiaz, Ruiyu Pu, J. Glenn Morris Jr., Erum Khan, Maureen T. Long

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Zika virus; flavivirus; cross-reactivity; neutralization; diagnostics; serology; plaque reduction neutralization test; flavivirus exposure

Online: 27 November 2019 (03:45:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0323.v1

Evaluation of Face Shields, Goggles and Safety Glasses as a Virus Transmission Control Measure to Protect the Wearer Against Cough Droplets

Samantha Hall, Paul Johnson, Claire Bailey, Zoe Gould, Robert White, Brian Crook

Subject: Physical Sciences, Applied Physics Keywords: face shield; goggles; safety glasses; cough; droplets; virus transmission; COVID 19; exposure

Online: 25 February 2022 (06:52:12 CET)

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Face shields (also referred to as visors), goggles and safety glasses have been worn during the COVID-19 pandemic as one measure to control transmission of the virus. However, their effectiveness in controlling facial exposure to cough droplets is not well established and standard tests for evaluating eye protection for this application are limited. A method was developed to evaluate face shields, goggles and safety glasses as a control measure to protect the wearer against cough droplets. The method uses a semi-quantitative assessment of facial droplet deposition. A cough simulator was developed to generate droplets comparable to those from a human cough. The droplets consisted of a UV fluorescent marker (fluorescein) in water. Fourteen face shields, four pairs of goggles and one pair of safety glasses were evaluated by mounting them on two different sizes of breathing manikin head and challenging them with the simulated cough. The manikin head was positioned in seven orientations relative to the cough simulator to represent various potential occupational exposure scenarios, for example, a nurse standing over a patient. Droplet deposition in the eyes, nose and mouth regions were visualised following three ‘coughs’. Face shields, goggles and safety glasses reduced, but did not eliminate exposure to the wearer from droplets such as those produced by a human cough. The level of protection differed based on the design of the personal protective equipment and the relative orientation of the wearer to the cough. For example, face shields and goggles offered the greatest protection when a cough challenge was face on or from above and the least protection when a cough challenge was from below. Face shields were also evaluated as source control to protect others from the wearer. Results suggested that if a coughing person wears a face shield, it can provide some protection from cough droplets to those standing directly in front of the wearer.

Preprint ARTICLE | doi:10.20944/preprints202201.0337.v1

Particle Size of Biochar as Co-composted Fertilizer: Influence on Growth Performance of Lettuce and Concentration of Bioavailable Soil Nutrients under Salinity Stress Conditions

Arifa Malik, Shamim Gul, Abdul Hanan Buriro, Hidayatullah Kakar, Tariq Ziad

Subject: Biology And Life Sciences, Plant Sciences Keywords: Co-composted biochar; drought; NUE; PUE; salinity

Online: 24 January 2022 (09:41:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0056.v1

Electrodeposition of Co-B/SiC Composite Coatings: Characterization and Evaluation of Wear Volume and Hardness

A. Villa-Mondragón, A. Martínez-Hernández, F. Manríquez, Y. Meas, J.J. Pérez-Bueno, Francisco J. Rodríguez-Valadez, J.C. Ballesteros, J. Morales-Hernández, Alia Méndez-Albores, G. Trejo

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Co-B/SiC composite coatings; electrodeposition; hard coatings; wear volume

Online: 4 April 2019 (12:52:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0566.v2

Self-Healing Biogeopolymers Using Biochar-Immobilized Spores of Pure- and Co-Cultures of Bacteria

Jadin Zam S. Doctolero, Arnel B. Beltran, Marigold O. Uba, April Anne S. Tigue, Michael Angelo B. Promentilla

Subject: Engineering, Architecture, Building And Construction Keywords: geopolymer; self-healing; crack repair; biomineralization; healing agent; ureolytic bacteria; non-ureolytic bacteria; co-cultured bacteria

Online: 30 November 2020 (11:03:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0088.v1

The Effects of Anthropogenic Sound and Artificial Light Exposure on Microbiomes: Ecological and Public Health Implications

Jake M Robinson, Ross Cameron, Brenda Parker

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Microbiome; sound exposure; noise pollution; microalgae; artificial light; bioacoustics; ecosystem health; light pollution; photo-sonic restoration hypothesis

Online: 2 February 2021 (13:12:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1160.v1

Drinking Water Systems as a Cocktail of Emerging Organic Contaminants: Occurrence, Public Health Risks, and Research Needs

Jerikias Marumure, Tinoziva T Simbanegavi, Zakio Makuvara, Rangarirayi Karidzagundi, Richwell Alufasi, Marvelous Goredema, Claudious Gufe, Nhamo Chaukura, Willis Gwenzi

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Human exposure; high-risk environments; human health hazards; personal care products; pharmaceuticals; per- and polyfluoroalkyl substances; risk factors

Online: 16 June 2023 (03:16:14 CEST)

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Emerging organic contaminants (EOCs) of anthropogenic origins are ubiquitous in environmental compartments, including aquatic systems. Thus, EOCs have attracted considerable research and public attention due to their potential human and ecological health risks. However, compared to other aquatic environments such as wastewater systems, comprehensive reviews focussing on the occurrence and human health risks of EOCs in drinking water systems are still lacking. Therefore, to address this knowledge gap, the current review posits that drinking water systems harbour a cocktail of toxic EOCs, which pose public health risks via multiple exposure routes. In the present review, global evidence is examined to track EOCs along the source-pathway-receptor-impact-mitigation (SPRIM) continuum. Evidence shows that, various groups of EOCs, including pharmaceuticals and personal care products, solvents, plasticizers, endocrine disrupting compounds, gasoline additives, per- and polyfluoroalkyl substances (PFAS), food colourants, artificial sweeteners, and musks and fragrances, have been detected in drinking water systems. The anthropogenic sources of EOCs detected in drinking water systems, including wastewater systems and industrial emissions, are summarized. Further, the behaviour and fate of EOCs in the drinking water systems, including removal processes are discussed. Once in drinking water systems, human exposure to EOCs may occur via ingestion of contaminated drinking water and cooked foods, and possibly dermal contact and inhalation. The high-risk environments, and risk factors and behaviours predisposing humans to EOC exposure are discussed. Evidence on the human health risks of the various EOCs and a critique of the data are presented. Notably, besides inferential data, quantitative epidemiological evidence directly relating the occurrence of EOCs in drinking water systems to specific adverse human health outcomes is still scarce. Lastly, future research directions, including the need for quantitative public health risk assessment, and the application of emerging detection tools are discussed.

Preprint ARTICLE | doi:10.20944/preprints202205.0169.v1

Improved Multifactor Portfolio Optimization Method through Empirical Research in South Korea

DongJun Lee

Subject: Business, Economics And Management, Finance Keywords: asset allocation; risk factor; risk exposure; macro-factor

Online: 12 May 2022 (10:44:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0143.v1

Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration

Ousman Bajinka, Richard Bradbury, Mingming Qi, Amadou Barrow, Abdoulie O Touray, Yurong Tan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Co-infection; Drug resistance; Gut microbiota; Salmonellosis; Schistosoma

Online: 7 May 2021 (12:02:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0608.v1

A Comparative Analysis of Co-Production in Public Services

Pwint Kay Khine, Jianing Mi, Raza Shahid

Subject: Business, Economics And Management, Accounting And Taxation Keywords: co-production; knowledge production; public services

Online: 22 April 2021 (13:23:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0616.v1

Adaptive Numerical Modelling of Tsunami Wave Generation and Propagation with FreeFem++

Georges Sadaka, Denys Dutykh

Subject: Computer Science And Mathematics, Mathematics Keywords: tsunami wave; finite elements; mesh adaptation; domain adaptation; co-seismic displacements; tsunami wave energy; FreeFem++; unstructured meshes

Online: 27 August 2020 (12:17:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0410.v1

Developing an Integrative Theoretical Framework for Climate Proofing Spatial Planning Across Sectors, Policy Levels and Planning Areas

Maria Juschten, Florian Reinwald, Roswitha Weichselbaumer, Alexandra Jiricka-Pürrer

Subject: Social Sciences, Geography, Planning And Development Keywords: climate proofing; spatial planning; climate change adaptation; framework; cross-regional; integral; co-benefits

Online: 18 May 2021 (10:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0406.v1

Effect of Precious Metals on NO Reduction by CO in Oxidative Conditions

Joudia Akil, Stephane Siffert, Pirault-Roy Laurence, Damien P. Debecker, François Devred, Renaud Cousin, Christophe Poupin

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Environmental chemistry; Oxyfuel Combustion; NO-CO reaction; Heterogeneous catalysis.

Online: 27 February 2020 (12:25:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0258.v1

Children's Health in the Digital Age

Birgitta Dresp-Langley

Subject: Public Health And Healthcare, Primary Health Care Keywords: digital environments; over exposure; children; vitamin D; melatonin; myopia; sleep loss; depression; obesity internet addiction; serotonin; dopamine; oxidative stress

Online: 16 March 2020 (04:22:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0121.v1

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Laure-Alix Clerbaux, Maria Cristina Albertini, Núria Amigó, Anna Beronius, Gillina F.G. Bezemer, Sandra Coecke, Evangelos P. Daskalopoulos, Giusy Del Giudice, Dario Greco, Lucia Grenga, Alberto Mantovani, Amalia Muñoz, Elma Omeragic, Nikolaos Parissis, Mauro Petrillo, Laura A. Saarimäki, Helena Soares, Kristie Sullivan, Brigitte Landesmann

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: SARS-CoV-2 infection; COVID-19; modulating factors; Adverse Outcome Pathway; sex; age; co-morbidities; lifestyle; environment; pre-existing conditions

Online: 8 June 2022 (09:47:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0076.v1

Analyzing the Co-Competition Mechanism of High-Tech Park from the Perspective of Complex Socioeconomic Network

Lizhi Xing, Jingying Xu

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Complex Network Theory; Social Network Analysis; High-Tech Enterprises; Co-Competition Relationship; Innovation Ecological Niche

Online: 5 July 2021 (08:00:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0188.v2

Co-application of Biochar-Compost and Inorganic Nitrogen Fertilizer Affects the Growth and Nitrogen Uptake by Lowland Rice in Northern Ghana

Daniel Asiamah Aboagye, Wilfred TJ Adjadeh, Stella Asuming-Brempong, Eric Kwesi Nartey

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Co-composted Biochar; Nitrogen Uptake; Nitrogen Use Efficiency; Eutric Gleysol; Northern Ghana

Online: 26 April 2022 (10:02:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0199.v1

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Montse Marquès, Jose L Domingo

Subject: Medicine And Pharmacology, Hematology Keywords: polychlorinated dibenzo-p-dioxins (PCDDs); polychlorinated dibenzo-p-furans (PCDFs); human exposure; blood samples; dietary intake; risks

Online: 20 August 2019 (04:20:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0331.v1

Geochemical Association Rules of Elements Mined using Clustered Events of Spatial Auto-correlation: A Case Study in the Chahanwusu River Area, Qinghai Province, China

Baoyi Zhang, Zhengwen Jiang, Yiru Chen, Nanwei Cheng, Umair Khan, Jiqiu Deng

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Concentration field; Spatial auto-correlation; Association rules; Apriori algorithm; Element co-occurrence

Online: 21 January 2022 (13:42:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0029.v1

Hetero - Atom Doped Metal-Free Carbon Nanomaterials as Potential Electrocatalyst

Jayeeta Chattopadhyay, Tara Sankar Pathak, Dae-Won Pak

Subject: Chemistry And Materials Science, Nanotechnology Keywords: carbon nanomaterials; nitrogen doping; sulphur doping; co-doping; electrocatalysts

Online: 2 December 2021 (10:18:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0416.v1

All Femtosecond Optical Pump and X-Ray Probe: Holey-Axicon for Free Electron Laser

Vijayakumar Anand, Jovan Maksimovic, Tomas Katkus, Soon Hock Ng, Orestas Ulcinas, Mindaugas Mikutis, Justas Baltrukonis, Antanas Urbas, Gintas Slekys, H. Ogura, Daisuke Sagae, Tatiana Pikuz, Toshihiro Somekawa, Norimasa Ozaki, Arturas Vailionis, Gediminas Seniutinas, Vygantas Mizeikis, Karl Glazebrook, Jean P. Brodie, Paul R. Stoddart, Ludovic Rapp, Andrei V. Rode, Eugene G. Gamaly, Saulius Juodkazis

Subject: Physical Sciences, Quantum Science And Technology Keywords: X-rays; free electron laser (FEL); ultra-short phenomena; pump-probe; warm-dense matter; astrophotonics; co-axial volumetric interaction diagnostics

Online: 26 May 2020 (03:53:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0105.v1

Combining Three Cohorts of WTC Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality

Robert Brackbill, Amy Kahn, Jiehui LI, Rachel Zeig-Owens, David Goldfarb, Molly Skerker, Mark Farfel, James Cone, Janette Yung, Deborah Walker, Adrienne Solomon, Baozhen Qiao, Maria Schymura, Christopher Dasaro, Dana Kristjansson, Mayris Webber, Roberto Lucchini, Andrew Todd, David Prezant, Paolo Boffetta, Charles Hall

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: World Trade Center; Exposure; Cancer; Rescue and recovery workers; Pooling cohorts

Online: 6 January 2021 (10:30:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1092.v1

Assessing Impact of Microplastics on Aquatic Food System and Human Health

Mahmudul Hasan Mithun, Auditi kar, Atiqur Rahman Sunny, Masum Billah, Sharif Ahmed Sazzad, Sadeques Salehin, Al Maksud Foysal, Nusrat Jahan, Koushikur Rahman, Abdulla Al Shiam, Redoyan Chowdhury, Jubayer Arafat, Abdul Baten

Subject: Biology And Life Sciences, Aquatic Science Keywords: Micro-plastics; routes of MPs; eco-toxicology; aquatic organisms; human exposure

Online: 17 November 2023 (02:27:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0349.v1

Effect of Prenatal Ketamine Exposure: A Focused Literature Review

Alexa Simonetti, Alicia Trimble, Hattie Shrock, Revathi Gudi, Varsha Murthy

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: N-methyl-D-aspartate (NMDA) receptors; prenatal exposure; neurotoxic

Online: 14 April 2023 (04:29:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0085.v1

Ligand Docking Methods to Recognize Allosteric Inhibitors for G-protein Coupled Receptors

K Harini, S Jayashree, Vikas Tiwari, Sneha Vishwanath, Ramanathan Sowdhamini

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: allosteric ligands; AutoDock; cognate ligands; Tanimoto co-efficient; GPCRs

Online: 3 December 2020 (13:08:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0298.v1

Effect of the Incorporation of Titanium on the Optical Properties of ZnO Thin Films: From Doping to Mixed Oxide Formation

Miriam Yuste, Ramon Escobar-Galindo, Noelia Benito, Carlos Palacio, Oscar Martinez, Jose Maria Albella, Olga Sánchez

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Ti doped ZnO, Thin film, Co-Sputtering, UV-Visible

Online: 25 December 2018 (08:40:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0260.v1

High-Frequency Heat Treatment of AISI 1045 Specimens and Current Calculations of the Induction Heating Coil Using Metal Phase Transformation Simulations

Jinkyu Choi, Seoksoon Lee

Subject: Engineering, Automotive Engineering Keywords: AISI 1045; Co-simulation; High-Frequency Induction Heat Treatment; Metal Phase Transformation; RLC Circuit

Online: 13 October 2020 (07:13:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0042.v1

Feasibility Evaluation of CFD Approach for Inhalation Exposure Assessment: Case Study for Biocide Spray

Donggeun Park, Jong-Hyeon Lee

Subject: Environmental And Earth Sciences, Environmental Science Keywords: inhalation exposure assessment; computational fluid dynamics (CFD); biocides; spray model; unsteady RANS

Online: 4 January 2021 (13:17:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0518.v1

Data Fusion and Visualization of a Multi-Sensor Personal Exposure Campaign

Rok Novak, Ioannis Petridis, David Kocman, Johanna Amalia Robinson, Tjaša Kanduč, Dimitris Chapizanis, Spyros Karakitsios, Benjamin Flückiger, Danielle Vienneau, Ondřej Mikeš, Celine Degrendele, Ondřej Sáňka, Saul García Dos Santos-Alves, Thomas Maggos, Dementra Pardali, Asimina Stamatelopoulou, Dikaia Saraga, Marco Giovanni Persico, Jaideep Visave, Alberto Gotti, Dimosthenis Sarigiannis

Subject: Environmental And Earth Sciences, Environmental Science Keywords: data fusion; multi-sensor; data visualization; data treatment; participant reports; air quality; exposure assessment

Online: 30 September 2021 (14:13:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0339.v1

Aging Induces Profound Changes in sncRNA in Rat Sperm and these Changes are Modified by Perinatal Exposure to Environmental Flame Retardant

Alexander Suvorov, Vladimir Naumov, Victoria Shtratnikova, J.Richard Pilsner, Anna Zheludkevich, Evgeny Gerasimov, Maria Logacheva, Oleg Sergeyev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; paternal exposure; sperm; semen; epigenetics; sncRNA; piRNA; miRNA; 2,2′,4,4′-tetrabromodiphenyl ether; PBDE; BDE-47; perinatal; environment.

Online: 16 October 2020 (08:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0550.v1

Interdisciplinary Co-design Framework in Healthcare Design for Older Adult Patients with Chronic Low-back Pain

Muhammad Tufail, HaeBin Lee, Hwang Kim, KwanMyung Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Interdisciplinary co-design; healthcare design; exercise; low-back pain; older adult patients; rehabilitation

Online: 30 August 2021 (15:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0571.v1

Full Length Transcriptome Highlights the Coordination of Plastid Transcript Processing

Marine Guilcher, Arnaud Liehrmann, Chloé Seyman, Thomas Blein, Guillem Rigaill, Benoit Castandet, Etienne Delannoy

Subject: Biology And Life Sciences, Plant Sciences Keywords: Arabidopsis thaliana; plastid; co-maturation; post-transcriptional; Nanopore

Online: 31 August 2021 (11:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0157.v1

High Performance Lithium-Rich Layered Oxide Material: Effects of Preparation Methods on Microstructure and Electrochemical Properties

Qiming Liu, Huali Zhu, Jun Liu, Xiongwei Liao, Zhuolin Tang, Cankai Zhou, Mengming Yuan, Junfei Duan, Lingjun Li, Zhaoyong Chen

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: lithium-rich layered oxide; cathode material; 0.5Li2MnO3·0.5LiMn0.8Ni0.1Co0.1O2; voltage decay; co-precipitation method; sol–gel method

Online: 12 December 2019 (02:05:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0725.v1

Maize (Zea Mays L) Production in a Semiarid Area of South Africa from Co-Application of Biogas Slurry with Chemical Fertilizer and Effects on Soil Quality

Thandile Mdlambuzi, Mitsuru Tsubo, Pardon Muchaonyerwa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: dry matter yield; nutrient uptake; soil nutrient reserves; co-application; grain yield; dryland

Online: 30 March 2021 (10:18:06 CEST)

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Most smallscale farmers still use the traditional way of agricultural crop farming, and relay mostly use of chemical fertilizers (CF). Recently CF have become expensive and could in some way have a negative impact on soil quality after long term application. However, co-application of biogas slurry (BGS) with CF could help reduce farming costs while improving dry matter yields, grain yields, primary macronutrient uptake of (Nitrogen) N, (Phosphorus) P, (Potasium) K, (Calcium) Ca and (Magnesium) Mg and soil concentration of pH, (organic carbon) OC, N, P, K, Ca and Mg after crop harvest. The study was a field experiment conducted in 2016-2017 and 2017-2018 growing seasons. The field experiment was arranged in a randomized complete block design with four replicates. The treatments were based on percentages of recommended N rates of 120 kg N ha-1 for maize production. The BGS/CF treatments were (i) 0/0, (ii) 0/120, (iii) 24/96, (iv) 48/72, (v) 72/48, (vi) 96/24, (vii) 120/0 kg N ha-1. The spreading of the combination of BGS/CF treatments was performed by hand and incorporated into the top soil (0-10 cm) in each experimental plots. BGS/CF (48/72) treatment resulted into higher dry matter yield in 2016-2017, which was higher than all other treatment combinations, while in the 2017-2018 season, treatment of (0/120) resulted into higher dry matter than all other treatment combinations. The 48/72 and 0/120 treatments resulted into similar grain yield in 2016-2017 season which were higher than all other treatments. Treatments of 48/72, 72/48 and 120/0 had higher N, P, K, Ca and Mg uptake than 0/0, 0/120, 24/96 and 96/24 treatments in both seasons. Soil pH, total N, K, and Mg were high from the treatment of (120/0) than all other treatments in 2016-2017 while in the 2017-2018 season, treatment of (48/72) had higher OC, P and K after maize harvest. The findings of his study show that co-application of BGS/CF at 48/72 and 72/48 have maize yield benefits compared to the two resources, BGS/CF (120/0) and BGS/CF (0/120), applied separately in soil especially in the arid and semi-arid regions.

Preprint ARTICLE | doi:10.20944/preprints202306.1205.v1

Microplastics, Additives, and Plasticizers in Freshwater Bivalves: Preliminary Research of Biomonitoring

Giulia Cesarini, Fabiana Corami, Beatrice Rosso, Massimiliano Scalici

Subject: Biology And Life Sciences, Aquatic Science Keywords: freshwaters; environmental exposure; gills; gastrointestinal tracts; biological uptake; nylon; rayon

Online: 19 June 2023 (09:47:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0234.v1

Physical Analysis of SARS-CoV-2 Routes: from Primary Production and Emissions to Exposures and COVID-19 Infection

Gjalt Huppes, Ruben Huele

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID-19; virions mass balance; spatial modelling of toxics concentrations; human exposure to airborne substances; Substance Flow Analysis (SFA); environmental routes of toxic viruses; primary production of SARS-2 virions

Online: 17 May 2022 (14:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0107.v1

On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Francesca Costabile, Stefano Decesari, Roberta Vecchi, Franco Lucarelli, Gabriele Curci, Dario Massabò, Matteo Rinaldi, Maurizio Gualtieri, Emanuela Corsini, Elena Menegola, Silvia Canepari, Lorenzo Massimi, Stefania Argentini, Maurizio Busetto, Gianluca Di Iulio, Luca Di Liberto, Marco Paglione, Igor Petenko, Mara Russo, Angela Marinoni, Gianpietro Casasanta, Sara Valentini, Vera Bernardoni, Federica Crova, Gianluigi Valli, Alice Corina Forello, Fabio Giardi, Silvia Nava, Giulia Pazzi, Paolo Prati, Virginia Vernocchi, Teresa La Torretta, Ettore Petralia, Milena Stracquadanio, Gabriele Zanini, Gloria Melzi, Emma Nozza, Martina Iulini, Donatella Caruso, Lucia Cioffi, Gabriele Imperato, Flavio Giavarini, Maria Battistoni, Francesca Di Renzo, Maria Agostina Frezzini, Cinzia Perrino, Maria Cristina Facchini

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric aerosol; chemical composition; secondary aerosol; source apportionment; ultrafine particles; oxidative potential; exposure; toxicology; forecasting; micrometeorology

Online: 12 April 2022 (09:54:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0284.v1

Production of Various Monomer-Ratio Biodegradable Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Films for Wide Range of Applications

Aneta Pospíšilová, Juraj Vodicka, Monika Trudicova, Zuzana Juglova, Jiri Smilek, Přemysl Menčík, Jiří Másilko, Eva Slaninova, Veronika Melčová, Michal Kalina, Stanislav Obruča, Petr Sedlacek

Subject: Chemistry And Materials Science, Biomaterials Keywords: Polyhydroxyalkanoates (PHA); P(3HB-co-4HB); Aneurinibacillus sp. H1; mechanical properties; surface morphology; crystallinity; active ingredients release

Online: 28 April 2022 (10:56:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0038.v1

Progeria and Aging - Omics Based Comparative Analysis

Aylin Caliskan, Samantha Agnetz Wilhelmine Crouch, Sara Giddins, Thomas Dandekar, Seema Dangwal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: progeria; aging; omics; RNA Sequencing; bioinformatics; sun exposure; HGPS; IGFBP2; ACKR4; WNT

Online: 4 July 2022 (08:10:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0586.v1

Co-digestion of Extended Aeration Sewage Sludge With Whey, Grease and Septage: Experimental and Modelling Determination

Gérard Merlin, Jonathan Outin, Hervé Boileau

Subject: Engineering, Automotive Engineering Keywords: Anaerobic co-digestion; ADM1; BMP; biogas

Online: 26 July 2021 (14:49:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0245.v1

Selection of Co-Belonging Ceramic Fragments from Archaeological Excavations and Their Location in Vase Bodies from Theroremanent Magnetization

Markos Ntoukakis, Apostolos Pantinakis, Antonios Vafidis, Theodoros Markopoulos

Subject: Physical Sciences, Applied Physics Keywords: thermoremanent magnetization; fluxgate-sensor; selection of co-belonging ceramic fragments; vase reconstruction; vase surface grooves; vases with arbitrary rotational symmetry; archaeometry.

Online: 20 May 2019 (11:58:34 CEST)

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Selection of co-belonging fragments from the numerous ceramic findings of an archaeological excavation remains a difficult process of questionable effectiveness, based exclusively on the experience and patience of the conservators. While the screening of the fragments is a central prerequisite and the most important stage of the process of vase reconstruction, established methods based on scientific criteria and guaranteed efficiency for the detection of co-belonging ceramic fragments suggested in the bibliography, do not exist. On the contrary, for methods dealing with the assembly of vases from co-belonging fragments, which is a secondary process that can be done more easily and effectively in an empirical way, there exist numerous studies based on fragment morphology. However, even these are also not implemented because of the time requirements, sheer volume and complexity of the proposed methods, in order for them to be applicable in practice. The proposed methods in this paper are based on thermoremanent magnetization (A/m), which is calculated from the weak magnetic field measurements by a fluxgate-sensor/magnet apparatus forming a three-dimensional orthogonal system. Experimental measurements from fragments of 6 vases show that the magnetization magnitude of co-belonging fragments display similar values, despite the magnetic anisotropy of the ceramic material, since these belong to vases that are made of the same clay and fired under the same conditions. This is the criterion for finding ceramic fragments of the same vase from archaeological excavations. The thermoremanent magnetism directionality of fragments, which is aligned along the geomagnetic field at the same place and time during the vase firing process, as it is configured by their rotational symmetry, defines the position of the fragments on the body of the 6 vases. The shape of the original vase can be reconstructed when only a few non adjacent fragments are available. The proposed measurement apparatus can be used for the construction of a useable portable magnetometer specialized for ceramic surface measurements to achieve the above objectives.

Preprint REVIEW | doi:10.20944/preprints202004.0400.v1

Inducing Angiogenesis, A Key Step in Cancer Vascularization, and Treatment Approaches

Harman Saman, Syed Shadab Raza, Shahab Uddin, Kakil Rasul

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: angiogenesis; cancer; VEGF; anticancer; vessel co-option; resistance to anti-angiogenesis treatment; cancer hallmark

Online: 23 April 2020 (04:09:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0535.v1

Explosives Use in Decommissioning – Guide for Assessment of Risk (EDGAR): II Determination of Sound Exposure Levels for Open Water Blasts and Severance of Conductors and Piles from Below the Seabed

Alison Brand

Subject: Physical Sciences, Acoustics Keywords: Underwater noise modelling; decommissioning; explosives; sound exposure level; marine mammals; fish

Online: 23 July 2021 (10:41:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0319.v1

Adsorption of Acid Red 52 Contained in Waste Water by Co-products of the Phosphate Industry: Kinetics and Thermodynamic

Samia Nasr, samira jeahi, Mustapha Hidouri, Khaled BOUGHZALA

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Waste water; Phosphate co-product; Adsorption; Red Acid 52

Online: 21 December 2021 (09:15:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0646.v2

A Diverse Virome of Leafroll-Infected Grapevine Unveil by dsRNA Sequencing

Mamadou L. Fall, Dong Xu, Pierre Lemoyne, Issam E. Ben Moussa, Carole Beaulieu, Odile Carisse

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Grapevine leafroll disease; viromics; dsRNA extraction; virus epidemiology; virus co-occurrence; Vitis vinifera; interspecific hybrid

Online: 29 September 2020 (08:49:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0009.v1

Network Biology Analyses and Dynamic Modeling of Gene Regulatory Networks Under Drought Stress Reveal Major Transcriptional Regulators in Arabidopsis

Nilesh Kumar, Bharat Kumar Mishra, Jinbao Liu, Binoop Mohan, Karolina Marta Pajerowska-Mukhtar, M. Shahid Mukhtar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: co-expression network, water deprivation, drought, systems biology, network centrality, computational simulation, Arabidopsis, transcriptional regulation

Online: 1 July 2022 (08:15:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0267.v1

Poly(Vinyl Butyral-co-Vinyl Alcohol-co-Vinyl Acetate) Coating Performance on Copper Corrosion in Saline Environment

Adriana Samide, Claudia Merisanu, Bogdan Tutunaru, Gabriela Eugenia Iacobescu

Subject: Chemistry And Materials Science, Electrochemistry Keywords: adsorption; coatings; poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate); corrosion tests; atomic force microscopy

Online: 20 December 2019 (07:00:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0258.v1

Prevalence of Co-Infections With Respiratory Viruses in Individuals Investigated for Sars-Cov-2 in Ontario, Canada

Adriana Peci, Vanessa Tran, Jennifer L Gurtherie, Ye Li, Paul Nelson, Kevin L Schwartz, Sara A Buchan, Jonathan B Gubbay

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: co-infection; SARS-CoV-2; Covid-19; seasonal respiratory viruses

Online: 10 December 2020 (12:53:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0165.v1

Prevalence, Risk Factors and Residential Variation among HIV/TB co-infected Mortality in Amhara Region, Fenote Selam Hospital: Application of Multilevel Logistic Regression

Berhanu Bekele Debelu

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: HIV/TB co-infected Mortality; Residential Variations; Multilevel Logistic Regression

Online: 12 January 2022 (13:34:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202208.0530.v1

Potential Co-Disposal of Food Waste and Sewage Sludge in South Africa: A Review

Shalongo Angula, Teboho Mofokeng, David Ikumi, Moses Basitere

Subject: Engineering, Civil Engineering Keywords: Resource recovery; circular economy; food waste; anaerobic co-digestion

Online: 31 August 2022 (03:10:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0143.v1

Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella typhimurium

Logan Gildea, Joseph Ayariga, Junhuan Xu, Robert Villafane, Robertson Boakai, Michelle Samuel-Foo, Olufemi Ajayi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella; novel antibacterial agents; cannabidiol; co-therapy; bacterial genetics

Online: 12 September 2022 (09:55:22 CEST)

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Working Paper ARTICLE

Collaborative Learning Experiences in a Changing Environment. Innovative Educational Approaches in Architecture

Ernesto Antonini, Jacopo Gaspari, Cristina Visconti

Subject: Social Sciences, Anthropology Keywords: critical pedagogy; experiential learning; co-production

Online: 5 July 2021 (10:35:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0550.v1

Assessing Completeness of OpenStreetMap Building Footprints Using a Gamification Approach in MapSwipe

Tahira Ullah, Sven Lautenbach, Benjamin Herfort, Danijel Schorlemmer

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: OpenStreetMap; MapSwipe; data completeness; disaster management; exposure, Volunteered Geographic Information; data quality

Online: 30 January 2023 (09:29:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0013.v1

A Survey of Techniques Leveraging miRNA as Biomarkers for Generalized and Type Specific Cancer Diagnosis.

Abhik Banerjee, Shilpi Bose, Chandra Das

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA Expression; Feature Selection; Cancer Diagnosis; Fuzzy Logic; Co-Learning

Online: 1 September 2020 (11:42:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0005.v1

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Rajan Singh, Albert Barrios, Golnaz Dirakvand, Shehla Pervin

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Brown adipose tissue; beige adipose tissue; obesity; cold exposure; uncoupling protein-1, beta-adrenergic receptor; energy expenditure; adipose browning; micro-RNA

Online: 1 October 2021 (11:30:39 CEST)

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Obesity-associated metabolic abnormalities comprise of a cluster of conditions including dyslipidemia, insulin resistance, diabetes, and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. Variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. Substantially decreased BAT activity in individuals with obesity indicates a role for BAT in setting of human obesity. On the other hand, BAT mass and its prevalence has been reported to correlate with lower body mass index (BMI), decreased age and glucose levels, leading to lower incidence of cardio metabolic diseases. Increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. Deeper understanding of the role of BAT in human metabolic health and its inter-relationship with body fat distribution and deciphering proper strategies to increase energy expenditure by either increasing functional BAT mass, or inducing white adipose browning holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.

Preprint REVIEW | doi:10.20944/preprints202307.2138.v1

Scrub Typhus: Epidemiology, Clinical Presentations, and Diagnostic Approaches

Ramendra Pati Pandey, M Beyau Konyak, Monika Soni, Shyamalima Saikia, Tochi Chang, Indrani Gogoi, Ibakmensi Khongstid, Mohan Sharma

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Northeast India; scrub typhus; Orientia tsutsugamushi; clinical presentations; co-infections; diagnosis; genetic diversity; entomology

Online: 31 July 2023 (15:59:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0168.v1

With or Without You: Co-chaperones Mediate Health and Disease by Modifying Chaperone Function and Protein Triage

Selin Altinok, Rebekah Sanchez-Hodge, Mariah Stewart, Kaitlan Smith, Jonathan C. Schisler

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: heat shock proteins; co-chaperones; protein quality control; protein folding; protein degradation; cardioprotection; neuroprotection; cancer

Online: 11 October 2021 (14:38:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0144.v1

Co-Expression Networks for Causal Gene Identification Based on RNA-seq Data of Corynebacterium Pseudotuberculosis

Edian F. Franco, Pratip Rana, Ana Lidia Queiroz Cavalcante, Artur Luiz da Silva, Adriana R Carneiro Folador, Vasco Azevedo, Preetam Ghosh, Rommel T. J. Ramos

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Corynebacterium pseudotuberculosis; RNA-Seq; co-expression networks; influence genes; stress condition; causal genes

Online: 12 June 2020 (08:46:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0216.v1

Temporal Dominance of B.1.1.7 over B.1.354 SARS-CoV-2 Variant: A Hypothesis Based on Areas of Variant Co-Circulation

Evangelia Georgia Kostaki, Ioulia Tseti, Sotirios Tsiodras, George N. Pavlakis, Petros P. Sfikakis, Dimitrios Paraskevis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; variants; co-circulation; dominance; vaccines

Online: 7 April 2021 (17:24:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0033.v1

Whether Supercritical Extracts from the Aerial Parts of Helianthus salicifolius and Helianthus tuberosus May be Regarded as a Potential Raw Materials for Non-bioenergy Purposes?

Anna Malm, Agnieszka Grzegorczyk, Anna Biernasiuk, Tomasz Baj, Edward Rój, Katarzyna Tyśkiewicz, Agnieszka Dębczak, Mariusz Jerzy Stolarski, Michał Krzyżaniak, Ewelina Olba-Zięty

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: willow-leaf sunflower; Jerusalem artichoke; supercritical extraction; water as co-solvent; antimicrobial activity; biocidal effect

Online: 2 November 2020 (11:47:35 CET)

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