Version 1
: Received: 13 April 2023 / Approved: 14 April 2023 / Online: 14 April 2023 (04:29:05 CEST)
How to cite:
Simonetti, A.; Trimble, A.; Shrock, H.; Gudi, R.; Murthy, V. Effect of Prenatal Ketamine Exposure: A Focused Literature Review. Preprints2023, 2023040349. https://doi.org/10.20944/preprints202304.0349.v1
Simonetti, A.; Trimble, A.; Shrock, H.; Gudi, R.; Murthy, V. Effect of Prenatal Ketamine Exposure: A Focused Literature Review. Preprints 2023, 2023040349. https://doi.org/10.20944/preprints202304.0349.v1
Simonetti, A.; Trimble, A.; Shrock, H.; Gudi, R.; Murthy, V. Effect of Prenatal Ketamine Exposure: A Focused Literature Review. Preprints2023, 2023040349. https://doi.org/10.20944/preprints202304.0349.v1
APA Style
Simonetti, A., Trimble, A., Shrock, H., Gudi, R., & Murthy, V. (2023). Effect of Prenatal Ketamine Exposure: A Focused Literature Review. Preprints. https://doi.org/10.20944/preprints202304.0349.v1
Chicago/Turabian Style
Simonetti, A., Revathi Gudi and Varsha Murthy. 2023 "Effect of Prenatal Ketamine Exposure: A Focused Literature Review" Preprints. https://doi.org/10.20944/preprints202304.0349.v1
Abstract
Ketamine is a dissociative anesthetic and antidepressant with several biological targets. Among the many targets, ketamine, notably, has an antagonistic effect on molecular N-methyl-D-aspartate (NMDA) receptors and has been identified as a non-competitive inhibitor of these receptors. Although ketamine has a wide range of therapeutic uses in the clinical setting, it is often used recreationally due to its psychoactive and analgesic effects. Regardless of the indication, prenatal exposure to ketamine has been widely investigated. The misuse of this drug, particularly in pregnant women, has been a point of concern. The neurotoxic potential of ketamine positions it as a danger to a developing fetus. Furthermore, the ability of ketamine to cross the blood-placental barrier poses a threat to the health and maturation processes of the neonate. This paper reviewed published work that explores the mechanisms through which prenatal ketamine exposure can cause altered neurodevelopment, neurobehavior, and the physiological consequences that follow. By exploring investigations using multiple different subjects such as: rodents, non-human primates, and human subjects, this paper develops a full picture of the existing data to generate a strong foundation for improved and informed public health policies.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
