Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Inducing Angiogenesis, A Key Step in Cancer Vascularization, and Treatment Approaches

Version 1 : Received: 21 April 2020 / Approved: 23 April 2020 / Online: 23 April 2020 (04:09:02 CEST)

How to cite: Saman, H.; Raza, S.S.; Uddin, S.; Rasul, K. Inducing Angiogenesis, A Key Step in Cancer Vascularization, and Treatment Approaches. Preprints 2020, 2020040400 (doi: 10.20944/preprints202004.0400.v1). Saman, H.; Raza, S.S.; Uddin, S.; Rasul, K. Inducing Angiogenesis, A Key Step in Cancer Vascularization, and Treatment Approaches. Preprints 2020, 2020040400 (doi: 10.20944/preprints202004.0400.v1).

Abstract

Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of nutrients and oxygen and the ability to evacuate metabolic waste. As one of the hallmarks of cancer, angiogenesis has been studied extensively in animal and human models to enable better understanding of cancer biology and the development of new anti-cancer treatments. Angiogenesis plays a crucial role in the process of tumour genesis, because solid tumour need a blood supply if they are to grow beyond a few millimeters in size. On the other hand, there is growing evidence that some solid tumour exploit existing normal blood supply and do not require a new vessel formation to grow and to undergo metastasis. This review of the literature will present the current understanding of this intricate process and the latest advances in the use of angiogenesis-targeting therapies in the fight against cancer.

Subject Areas

angiogenesis; cancer; VEGF; anticancer; vessel co-option; resistance to anti-angiogenesis treatment; cancer hallmark

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