Version 1
: Received: 5 May 2021 / Approved: 7 May 2021 / Online: 7 May 2021 (12:02:03 CEST)
How to cite:
Bajinka, O.; Bradbury, R.; Qi, M.; Barrow, A.; Touray, A.O.; Tan, Y. Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration. Preprints2021, 2021050143. https://doi.org/10.20944/preprints202105.0143.v1
Bajinka, O.; Bradbury, R.; Qi, M.; Barrow, A.; Touray, A.O.; Tan, Y. Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration. Preprints 2021, 2021050143. https://doi.org/10.20944/preprints202105.0143.v1
Bajinka, O.; Bradbury, R.; Qi, M.; Barrow, A.; Touray, A.O.; Tan, Y. Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration. Preprints2021, 2021050143. https://doi.org/10.20944/preprints202105.0143.v1
APA Style
Bajinka, O., Bradbury, R., Qi, M., Barrow, A., Touray, A.O., & Tan, Y. (2021). Treatment Inefficacy for <em>Salmonella</em> During <em>Schistosoma-Salmonella</em> Co-Infections Background, Mechanisms and Future Exploration. Preprints. https://doi.org/10.20944/preprints202105.0143.v1
Chicago/Turabian Style
Bajinka, O., Abdoulie O Touray and Yurong Tan. 2021 "Treatment Inefficacy for <em>Salmonella</em> During <em>Schistosoma-Salmonella</em> Co-Infections Background, Mechanisms and Future Exploration" Preprints. https://doi.org/10.20944/preprints202105.0143.v1
Abstract
Antibiotic inefficacy in treating bacterial infections is largely studied in the context of developing resistance mechanisms. However, little attention has been paid to combined diseases mechanisms, interspecies pathogenesis and the resulting impact on antimicrobial treatment. This review will consider the co-infections of Salmonella and Schistosoma mansoni. It summarises the protective mechanisms that the pathophysiology of the two infections confer, which leads to an antibiotic protection phenomenon. This review will elucidate the functional characteristics of the gut microbiota in the context of these co-infections, the pathogenicity of these infections in infected mice, and the efficacy of the antibiotics used in treatment of these co-infections over time. Salmonella-Schistosoma interactions and the mechanism for antibiotic protection are not well established. However, antimicrobial drug inefficacy is an existing phenomenon in these co-infections. The treatment of schistosomiasis to ensure the efficacy of antibiotic therapy for bacterial infections should be considered in co-infected patients.
Keywords
Co-infection; Drug resistance; Gut microbiota; Salmonellosis; Schistosoma
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
