Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration

Version 1 : Received: 5 May 2021 / Approved: 7 May 2021 / Online: 7 May 2021 (12:02:03 CEST)

How to cite: Bajinka, O.; Bradbury, R.; Qi, M.; Barrow, A.; Touray, A.O.; Tan, Y. Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration. Preprints 2021, 2021050143 (doi: 10.20944/preprints202105.0143.v1). Bajinka, O.; Bradbury, R.; Qi, M.; Barrow, A.; Touray, A.O.; Tan, Y. Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration. Preprints 2021, 2021050143 (doi: 10.20944/preprints202105.0143.v1).

Abstract

Antibiotic inefficacy in treating bacterial infections is largely studied in the context of developing resistance mechanisms. However, little attention has been paid to combined diseases mechanisms, interspecies pathogenesis and the resulting impact on antimicrobial treatment. This review will consider the co-infections of Salmonella and Schistosoma mansoni. It summarises the protective mechanisms that the pathophysiology of the two infections confer, which leads to an antibiotic protection phenomenon. This review will elucidate the functional characteristics of the gut microbiota in the context of these co-infections, the pathogenicity of these infections in infected mice, and the efficacy of the antibiotics used in treatment of these co-infections over time. Salmonella-Schistosoma interactions and the mechanism for antibiotic protection are not well established. However, antimicrobial drug inefficacy is an existing phenomenon in these co-infections. The treatment of schistosomiasis to ensure the efficacy of antibiotic therapy for bacterial infections should be considered in co-infected patients.

Subject Areas

Co-infection; Drug resistance; Gut microbiota; Salmonellosis; Schistosoma

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