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Preprint ARTICLE | doi:10.20944/preprints202308.1774.v1

Revitalizing English Language Teaching (ELT): Unveiling Evolving Pedagogies and AI-Driven Dynamics in the Post-Pandemic Era

Edgar R. Eslit

Subject: Social Sciences, Education Keywords: AI-Driven Dynamics; English Language Teaching; Evolving Pedagogies; Post-Pandemic Era

Online: 25 August 2023 (09:01:44 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202109.0505.v1

The SPHN Ecosystem Towards FAIR Data

Sabine Österle, Vasundra Touré, Katrin Crameri

Subject: Public Health And Healthcare, Other Keywords: Semantics; standards; clinical research infrastructure; terminology; graph data; data-driven medicine

Online: 29 September 2021 (17:32:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0171.v1

The Effects of Chronic Stress on Neuroanatomy and Cognitive Function

Niki Viradia, Jesica Godinez Paredes, Syed Hassan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s; aging; amygdala; brain plasticity; CA1; CA3; chronic stress; cognition; GABA; HIF-1; hippocampus; hypoxia; neurogenesis; Parkinson’s; prefrontal cortex; PSA-NCAM; ROS; spatial learning

Online: 12 July 2022 (04:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0733.v1

Integrative Analysis of Global Gene Expression Identifies Opposite Patterns of Reactive Astrogliosis in Aged Human Prefrontal Cortex

César Payán-Gómez, Diego Rodríguez, Diana Amador-Munoz, Sandra Ramirez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: prefrontal cortex aging; meta-analysis of transcriptomic; synapsis aging; reactive astrogliosis

Online: 31 October 2018 (05:02:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0192.v1

On the Generalization Ability of Data-Driven Models in the Problem of Total Cloud Cover Retrieval

Mikhail Krinitskiy, Marina Aleksandrova, Polina Verezemskaya, Sergey Gulev, Alexey Sinitsyn, Nadezhda Kovaleva, Alexander Gavrikov

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Total cloud cover; all-sky camera; algorithms assessment; neural networks; machine learning; data-driven approach

Online: 4 November 2020 (10:55:10 CET)

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Total cloud cover (TCC) retrieval from ground-based optical imagery is a problem being tackled by a few generations of researchers. The number of human-designed algorithms for the estimation of TCC grows every year. However, there is not very much progress in terms of quality, mostly due to the lack of systematic approach to the design of the algorithms, to the assessment of their generalization ability, and to the assessment of the TCC retrieval quality. In this study, we discuss the optimization nature of data-driven schemes for TCC retrieval. In order to compare the algorithms, we propose the framework for the assessment of the algorithms characteristics. We present several new algorithms that are based on deep learning techniques: a model for outliers filtering, and a few models for TCC retrieval from all-sky imagery. For training and assessment of data-driven algorithms of this study, we present the Dataset of All-Sky Imagery over the Ocean (DASIO) containing over one million of all-sky optical images of visible sky dome taken in various regions of the World Ocean. The research campaigns contributed to DASIO collection took place in the Atlantic ocean, the Indian ocean the Red and Mediterranean seas, and also in the Arctic ocean. Optical imagery collected during these missions are accompanied by standard meteorological observations of cloudiness characteristics made by experienced observers. We assess the generalization ability of the presented models in several scenarios that differ in terms of the regions selected for the train and validation subsets. As a result, we demonstrate that our models based on convolutional neural networks deliver superior quality compared to all previously published schemes. As a key result, we demonstrate considerable drop of the ability to generalize the training data in case of strong covariate shift between training and validation subsets of imagery which may take place in case of region-aware subsampling.

Preprint REVIEW | doi:10.20944/preprints201806.0163.v2

A Review of the Recent Advances Made with SIRT6 and Its Implications on Aging Related Processes, Major Human Diseases and Possible Therapeutic Targets

Rubayat Islam Khan, Saif Nirzhor, Raushanara Akter

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SIRT6, Diabetes, Gluconeogenesis, Cancer, Aging, Heart Disease, Pharmacological SIRT6 Inhibitor, Cardiac Hypertrophy, Tumorigenesis, Neurodegeneration, Neurodegenerative Diseases, AD

Online: 29 August 2018 (13:04:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0162.v1

Anxiety, Impaired Social and Aggressive Behaviour Correlates With Cognitive Decline Accompanied by Molecular Alterations in Older SAMP8 Males

Foteini Vasilopoulou, Júlia Companys-Alemany, Anna-Maria Canudas, Verónica Palomera-Ávalos, Daniel Ortuño-Sahagún, Mercè Pallàs, Christian Griñán-Ferré

Subject: Social Sciences, Psychology Keywords: behaviour; BPSD; cognitive decline; aging; SAMP8.

Online: 8 January 2021 (13:48:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0267.v1

Data–Driven Control Techniques for Renewable Energy Conversion Systems: Wind Turbine and Hydroelectric Plants

Silvio Simani, Stefano Alvisi, Mauro Venturini

Subject: Engineering, Control And Systems Engineering Keywords: wind turbine system; hydroelectric plant simulator; model--based control; data–driven approach; self–tuning control; robustness and reliability

Online: 26 January 2019 (10:08:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0189.v1

Epigenetic Clock, Circadian Rhythms and Cell Aging

Ekaterina Samoilova, Vladimir Belopasov, Evgenia Ekusheva, Chao Zhang, Alexander Troitskiy, Vladimir Baklaushev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: circadian clock; epigenetic clock; aging; senescence; reprogramming; methylome; DNA methylation; CpG-islands; induced pluripotent stem cells

Online: 10 September 2021 (15:13:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0362.v1

Alzheimer’s Disease as a Chronic Maladaptive Polyamine Stress Response

Baruh Polis, David Karasik, Abraham Samson

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: polyamines; arginase; senescence; aging; neurodegeneration

Online: 17 February 2021 (10:05:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0110.v1

Prediction Models to Control Aging Time in Red Wine

G Astray, JC Mejuto, V Martinez-Martinez, I Nevares, M Alamo-Sanza, Jesus Simal-Gandara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Food authenticity; Toro appellation of origin; Prediction Models; Wine; Aging.

Online: 11 January 2019 (10:50:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0556.v1

The Structure of Urban Flows

Pablo Torres, Soledad Le Clainche, Ricardo Vinuesa

Subject: Engineering, Mechanical Engineering Keywords: urban flows; coherent structures; experiments; simulations; data-driven methods

Online: 23 September 2020 (17:45:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0120.v1

The Validity of a Mixed Reality-Based Automated Functional Mobility Assessment

Ruopeng Sun, Roberto G. Aldunate, Jacob J Sosnoff

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: mixed reality headset; mobility assessment; wearable sensor; fall risk; aging

Online: 10 April 2019 (08:33:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0529.v1

Hemodialysis Impact on Motor Function Beyond Aging and Diabetes – Objectively Assessing Gait and Balance by Wearable Technology

He Zhou, Fadwa Al-Ali, Hadi Rahemi, Nishat Kulkarni, Abdullah Hamad, Rania Ibrahim, Talal Talal, Bijan Najafi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: hemodialysis; end stage renal disease; diabetes; motor performance; gait; balance; wearable; aging; frailty; diabetic peripheral neuropathy

Online: 27 September 2018 (04:19:43 CEST)

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Motor functions are deteriorated by aging. Some conditions may magnify this deterioration. To examine whether hemodialysis (HD) process would negatively impact gait and balance beyond diabetes condition among mid-age adults (48-64 years) and older adults (65+ years). One hundred and ninety-six subjects (age=66.2±9.1 years, body-mass-index=30.1±6.4 kg/m², female=56%) in 5 groups were recruited: mid-age adults with diabetes undergoing HD (Mid-age HD+, n=38) and without HD (Mid-age HD-, n=40); older adults with diabetes undergoing HD (Older HD+, n=36) and without HD (Older HD-, n=37); and non-diabetic older adults (Older DM-, n=45). Gait parameters (stride velocity, stride length, gait cycle time, and double support) and balance parameters (ankle, hip, and center of mass sways) were quantified using validated wearable platforms. Groups with diabetes had overall poorer gait and balance compared to the non-diabetic group (p<0.050). Among people with diabetes, the HD+ had significantly worsened gait and balance when comparing to the HD- (Cohen’s effect size d=0.63-2.32, p<0.050). Between-group difference was more pronounced among older adults with the largest effect size observed for stride length (d=2.32, p<0.001). Results suggested that deterioration in gait speed among the HD+ was correlated with age (r=-0.440, p<0.001), while this correlation was diminished among the HD-. Interestingly, results also suggested that poor gait in the Older HD- related to poor balance, while no correlation was observed between poor balance and poor gait among the Older HD+. Using objective assessments, results confirmed that the presence of diabetes can deteriorate gait and balance, and this deterioration can be magnified by HD process. Among non-HD people with diabetes, poor static balance described poor gait. However, among people with diabetes undergoing HD, age was a dominate factor describing poor gait irrespective of static balance. Results also suggested feasibility of using wearable platforms to quantify motor performance during routine dialysis clinic visits. These objective assessments may assist in identifying early deterioration in motor function, which in turn may promote timely intervention.

Preprint ARTICLE | doi:10.20944/preprints202011.0622.v1

The Data-Driven Pattern for Healthy Behaviors of Car Drivers Based on Daily Records of Traffic Count Data From 2018 To 2019 Near Airports. A Functional Data Analysis

Mohammad Fayaz, Alireza Abadi, Soheila Khodakarim, Mohammadreza Hoseini, Alireza Razzaghi

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Driving Offenses; Speed Zone; Airports; Functional Data Analysis; Data-Driven Policy;

Online: 24 November 2020 (16:12:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0252.v1

A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications

Samantha Drouet, Emilie Leclerc, Laurine Garros, Duangjai Tungmunnithum, Atul Kabra, Bilal Haider Abbasi, Eric Lainé, Christophe Hano

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Silybum marianum; silymarin; flavonolignans; ultrasound-assisted extraction; design of experiement; antioxidant; anti-aging

Online: 23 July 2019 (09:51:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0601.v1

Successful Aging and Chronic Osteoarthritis

Ray Marks

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: aging; disability; healthy aging; osteoarthritis; pain, rehabilitation, successful aging

Online: 30 July 2018 (22:20:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0268.v1

Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study

Carlo Dal Lin, Mariela Marinova, Laura Brugnolo, Giorgio Rubino, Mario Plebani, Sabino Iliceto, Francesco Tona

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cardiovascular disease; inflammation; aging; senectome, telomerase; alternative splicing; relaxation response; microRNA

Online: 12 July 2020 (16:57:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0338.v2

Effect of Artificial Aging Treatment and lubrication Modes on the Machinability of A356 Cast Alloys

Mohamed Amine Alliche, Abdelhakim Djebara, Yasser Zedan, Victor Songmene

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: aluminum alloys; artificial aging; drilling; surface quality; cutting fluid; burr formation

Online: 27 March 2020 (02:54:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0032.v1

Machine Learning for Intelligent Data Analysis and Automation in Cybersecurity: Current and Future Prospects

Iqbal H. Sarker

Subject: Computer Science And Mathematics, Security Systems Keywords: cybersecurity; machine learning; deep learning; artificial intelligence; data-driven decision making; automation; cyber analytics; intelligent systems;

Online: 2 September 2022 (03:32:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0061.v1

Sustainable Transformation of Digital Health Services- A Stakeholder Exploratory Case Study

Siyu Zhou, Ziling Ni, Atsushi Ogihara, Xiaohe Wang

Subject: Public Health And Healthcare, Health Policy And Services Keywords: sustainability; digital transformation; suitable for aging; service ecological theory; health service

Online: 6 May 2022 (07:45:20 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202012.0069.v1

Gross Ways to Live Long: Parasitic Worms as an Anti-Inflammaging Therapy?

Bruce Zhang, David Gems

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; anti-inflammaging helminth hypothesis; evolutionary medicine; helminth therapy; hygiene theory; inflammaging; old friends

Online: 2 December 2020 (15:25:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0412.v1

Synthesis of Hydronium-Potassium Jarosite; Effect of pH and Aging Time on their Structural, Morphological and Electrical Properties

Elías Hernández-Lazcano, E. Cerecedo-Sáenz, J. Hernández-Ávila, Norman Toro, T.V.K. Karthik, D. Mendoza-Anaya, M. E. Fernández-García, V. Rodríguez-Lugo, E. Salinas-Rodríguez

Subject: Chemistry And Materials Science, Biomaterials Keywords: Hydronium jarosite; potassium jarosite; micro particles; pH; aging time; energy storage; euhedral morphology

Online: 16 December 2020 (13:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0603.v1

Coexistence of Different Scaling Laws for the Entanglement Entropy in a Periodically Driven System

Tony J. G. Apollaro, Salvatore Lorenzo

Subject: Physical Sciences, Condensed Matter Physics Keywords: entanglement entropy; quantum phase transition; finite size scaling; periodically driven model; quantum Ising chain

Online: 30 September 2018 (08:00:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0224.v1

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Preliminary Results from the BIOSPHERE Study

Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Helio Coelho-Junior, Maurizio Bossola, Andrea Urbani, Francesco Landi, Roberto Bernabei, Emanuele Marzetti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; muscle; protein; metabolism; metabolomics; profiling; biomarkers; multi-marker; physical performance; multivariate

Online: 12 September 2018 (17:11:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0505.v1

Induced Short-term Hearing Loss due to Stimulation of Age-related Factors by Intermittent Hypoxia, High-Fat Diet, and Galactose Injection

Dong Jun Park, Sunmok Ha, Jin Sil Choi, Su Hoon Lee, Jeong-Eun Park, Young Joon Seo

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: mitochondria dysfunction; reactive oxygen species; hypoxic; D-galactose; high fat diet; aging; hearing loss; mechanisms of hearing loss

Online: 22 July 2020 (07:58:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0336.v1

Anxiety, Impaired Social and Aggressive Behaviour Correlates with Cognitive and Molecular Changes in Older SAMP8 Males

Foteini Vasilipoulou, Júlia Companys-Alemany, Anna-Maria Canudas, Verónica Palomera-Ávalos, Daniel Ortuño-Sahagún, Mercè Pallàs, Christian Griñán-Ferré

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: behaviour; BPSD; cognitive decline; aging; correlations; SAMP8

Online: 12 November 2020 (09:46:48 CET)

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Working Paper ARTICLE

Data-Driven Learning of Boolean Networks and Functions by Optimal Causation Entropy Principle (BoCSE)

Jie Sun, Abd AlRahman AlMomani, Erik Bollt

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Data Driven; causation entropy; Boolean networks; Boolean functions; causality inference

Online: 2 June 2020 (09:50:09 CEST)

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Boolean functions and networks are commonly used in the modeling and analysis of complex biological systems, and this paradigm is highly relevant in other important areas in data science and decision making, such as in the medical field and in the finance industry. In a Boolean model, the truth state of a variable is either 0 or 1 at a given time. Despite its apparent simplicity, Boolean networks are surprisingly relevant in many areas of application such as in bioinformatics to model gene expressions and interactions. In the latter case, a gene is either ``on" or ``off" depending on its expression level. Despite the promising utility of Boolean modeling, in most practical applications the Boolean network is not known. Automated learning of a Boolean network and Boolean functions, from data, is a challenging task due in part to the large number of unknowns (including both the structure of the network and the functions) to be estimated, for which a brute force approach would be exponentially complex. In this paper we develop a new information theoretic methodology that we show to be significantly more efficient than previous approaches. Building on the recently developed optimal causation entropy principle (oCSE), that we proved can correctly infer networks distinguishing between direct versus indirect connections, we develop here an efficient algorithm that furthermore infers a Boolean network (including both its structure and function) based on data observed from the evolving states at nodes. We call this new inference method, Boolean optimal causation entropy (BoCSE), which we will show that our method is both computationally efficient and also resilient to noise. Furthermore, it allows for selection of a set of features that best explains the process, a statement that can be described as a networked Boolean function reduced order model. We highlight our method to the feature selection in several real-world examples: (1) diagnosis of urinary diseases, (2) Cardiac SPECT diagnosis, (3) informative positions in the game Tic-Tac-Toe, and (4) risk causality analysis of loans in default status. Our proposed method is effective and efficient in all examples.

Preprint ARTICLE | doi:10.20944/preprints202304.0406.v1

Dietary Tyrosine Intake Is Associated with Locus Coeruleus Integrity, Attentive Cognitive Control and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II

Emanuele Raffaele Giuliano Plini, Michael Christopher Melnychuk, Andrew Harkin, Martin J Dahl, Matthew McAuslam, Simone Kühn, Rory Thomas Boyle, Robert Whelan, Ralph Andrews, Sandra Duzel, Johanna Drewelies, Gert G Wagner, Ulman Lindenberger, Kristina Norman, Ian Hamilton Robertson, Paul Michael Dockree

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: tyrosine; Locus Coeruleus; protein intake; attention; grey matter; neuroimaging; diet; healthy aging

Online: 17 April 2023 (05:00:06 CEST)

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Background & aims It is documented that low protein and amino-acid dietary intake is related to poorer cognitive health and increased risk of dementia. Degradation of the neuromodulatory pathways, (comprising the cholinergic, dopaminergic, serotoninergic and noradrenergic systems) is observed in neurodegenerative diseases and impairs the proper biosynthesis of key neuromodulators from micro-nutrients and amino acids. How these micro-nutrients are linked to neuromodulatory pathways in healthy adults is less studied. The Locus Coeruleus–Noradrenergic System (LC-NA) is the earliest subcortical structure affected in Alzheimer’s disease, showing marked neurodegeneration, but is also sensitive for age-related changes. The LC-NA system is critical for supporting attention and cognitive control, functions that are enhanced both by tyrosine administration and chronic tyrosine intake. The purpose of this study was to 1) investigate whether the dietary intake of tyrosine, the key precursor for noradrenaline (NA), is related to LC integrity 2) whether LC integrity mediates the reported association between tyrosine intake and higher cognitive performance (measured with Trail Making Test – TMT), and 3) whether LC integrity relates to an objective measure of brain maintenance (BrainPAD). Methods The analyses included 398 3T MRIs of healthy participants from the Berlin Aging Study II to investigate the relationship between LC integrity and habitual dietary tyrosine intake-daily average (HD-Tyr-IDA). As a control procedure, the same analyses were repeated on other main seeds of the neuromdulatory subcortical system (Dorsal and Medial Raphe, Ventral Tegmental Area and Nucleus Basalis of Meynert). In the same way, the relationships between the five nuclei and BrainPAD were tested. Results Results show that HD-Tyr-IDA is positively associated with LC integrity. Similarly, LC integrity disproportionally relates to better brain maintenance (BrainPAD). Mediation analyses reveal that only LC, relative to the other nuclei tested, mediates the relationship between HD-Tyr-IDA I and performance in the TMT and between HD-Tyr-IDA and BrainPAD. Conclusions These findings provide the first evidence linking tyrosine intake with LC-NA system integrity and its correlation with neuropsychological performance. This study strengthens the role of diet for maintaining brain and cognitive health and supports the noradrenergic theory of cognitive reserve. Within this framework, adequate tyrosine intake might increase the resilience of LC-NA system functioning, by preventing degeneration and supporting noradrenergic metabolism required for LC function and neuropsychological performance.

Preprint REVIEW | doi:10.20944/preprints202011.0728.v1

The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

Hagai Rottenberg, Joannes Hoek

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mitochondrial permeability transition; aging; longevity; aging-driven degenerative disease; Reactive Oxygen Species; mitophagy; autophagy; Parkinson’s disease

Online: 30 November 2020 (12:53:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0739.v1

An Efficient Isolated Speech Recognition Based on the Adaptive Rate Processing and Analysis

Saeed MIAN QAISAR

Subject: Engineering, Electrical And Electronic Engineering Keywords: Event-Driven Processing, Speech recognition, Adaptive Resolution Analysis, Features extraction, Dynamic Time Warping, Classification

Online: 31 October 2018 (08:14:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0004.v2

Battery Life Estimation of a Battery Under Different Stress Conditions

Natascia Andrenacci, Francesco Vellucci, Vincenzo Sglavo

Subject: Engineering, Energy And Fuel Technology Keywords: cycle aging; Lithium battery; stochastic algorithm

Online: 29 October 2021 (12:08:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0240.v1

Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Miji Kim, Chang Won Won

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: sarcopenia; slow gait speed; cognitive impairment; older adult; aging

Online: 22 April 2019 (11:28:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0478.v1

The Cytogenomic “Theory of Everything”: Chromohelkosis May Underlie Chromosomal Instability and Mosaicism in Disease and Aging

Ivan Y Iourov, Svetlana G Vorsanova, Yuri B. Yurov, Maria A Zelenova, Oxana S Kurinnaia, Kirill S Vasin, Sergei I Kutsev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chromosome; copy number variations; chromosome instability; chromosomal mosaicism; chromosomal imbalances; aneuploidy; disease; aging; pathways; cytogenomics

Online: 23 October 2020 (10:23:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0088.v1

IoT-based Technologies for Addressing the Unique Healthcare Needs of the Elderly Population

Syed Adnan Ali, Rehan Khan

Subject: Computer Science And Mathematics, Information Systems Keywords: IoT; geriatric healthcare; IoMT; biomedical devices; telemedicine; remote monitoring; aging population

Online: 6 March 2023 (04:20:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0388.v1

Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?

Kouminin Kanwore, Xiao-xiao Guo, Ayanlaja Abdulrahman Abiola, Piniel Alphayo Kambey, Adekunle Adebayo Oluwafemi, Dianshuai Gao

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GDNF; SOX1; CAFs; senescence; aging cell; methylation; tumour; glioma

Online: 24 May 2020 (16:53:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0539.v1

Energy Metabolism Decline in the Aging Brain; Pathogenesis of Neurodegenerative Disorders

Janusz Błaszczyk

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain aging; energy metabolism; neurodegeneration; neurodegenerative disorders

Online: 23 September 2020 (04:55:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0133.v2

Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster

Karis A. Ederer, Kelly Jin, Sarah Bouslog, Lu Wang, Greg S. Gorman, Glenn C. Rowe, Peter Abadir, Daniel Raftery, Douglas Moellering, Daniel Promislow, Patricia Jumbo-Lucioni, Maria De Luca

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress

Online: 29 October 2018 (10:33:59 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0190.v1

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli, Sandra Atlante, Tiziana Bacchetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

Online: 16 November 2019 (00:59:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0165.v1

Coherently Driven and Superdirective Antennas

Alex Krasnok

Subject: Physical Sciences, Applied Physics Keywords: antennas; coherently driven antennas; superdirective antennas

Online: 17 June 2019 (14:24:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0380.v1

Early Life Exercise Training and Inhibition of Apolipoprotein B Expression to Improve Age-Related Arrhythmias and Prolong the Average Lifespan in Drosophila

Meng Ding, Qiufang Li, Tianhang Peng, Tongquan Wang, Hanhui Yan, Chao Tang, Xiaoya Wang, Yin Guo, Lan Zheng

Subject: Biology And Life Sciences, Insect Science Keywords: Exercise training; arrhythmias; Drosophila; apolipoprotein B; aging

Online: 29 March 2022 (10:07:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0563.v1

Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from Drosophila melanogaster

Camille M. Champigny, Robert P.J. Cormier, Chloé J. Simard, Patrick-Denis St-Coeur, Samuel Fortin, Nicolas Pichaud

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondrial metabolism; aging; monoacylglyceride; polyunsaturated fatty acids; oxidative stress

Online: 24 October 2018 (09:40:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0018.v1

Life-Course Persistent Antisocial Behavior and Accelerated Biological Aging in a Longitudinal Birth Cohort

Stephanie Langevin, Ashalom Caspi, J. C. Barnes, Grace Brennan, Richie Poulton, Suzanne C. Purdy, Sandhya Ramrakha, Peter T. Tanksley, Peter R. Thorne, Graham Wilson, Terrie E. Moffitt

Subject: Social Sciences, Psychology Keywords: Antisocial Trajectories; Biological Aging; Crime; Accelerated aging

Online: 4 October 2022 (10:47:36 CEST)

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Prior research shows that individuals who have exhibited antisocial behavior are in poorer health than their same-aged peers. A major driver of poor health is aging itself, yet research has not investigated relationships between offending trajectories and biological aging. We tested the hypothesis that individuals following a life-course persistent (LCP) antisocial trajectory show accelerated aging in midlife. Trajectories of antisocial behavior from age 7 to 26 years were studied in the Dunedin Multidisciplinary Health and Development Study, a population-representative birth cohort (N=1037). Signs of aging were assessed at age 45 years using previously validated measures including biomarkers, clinical tests, and self-reports. First, we tested whether the association between antisocial behavior trajectories and midlife signs of faster aging represented a decline from initial childhood health. We then tested whether decline was attributable to tobacco smoking, antipsychotic medication use, debilitating illnesses in adulthood, adverse exposures in childhood (maltreatment, socioeconomic disadvantage) and adulthood (incarceration), and to childhood self-control difficulties. Study members with a history of antisocial behavior had a significantly faster pace of biological aging by midlife, and this was most evident among individuals following the LCP trajectory (β, .22, 95%CI, .14, .28, p.001). This amounted to 4.3 extra years of biological aging between ages 25-45 years for Study members following the LCP trajectory compared to low-antisocial trajectory individuals. LCP offenders also experienced more midlife difficulties with hearing (β, -.14, 95%CI, -.21, -.08, p.001), balance (β, -.13, 95%CI, -.18, -.06, p.001), gait speed (β, -.18, 95%CI, -.24, -.10, p.001), and cognitive functioning (β, -.25, 95%CI, -.31, -.18, p.001). Associations represented a decline from childhood health. Associations persisted after controlling individually for tobacco smoking, antipsychotic medication use, midlife illnesses, maltreatment, socioeconomic status, incarceration, and childhood self-control difficulties. However, the cumulative effect of these lifestyle characteristics together explained why LCP offenders have a faster Pace of Aging than their peers. While older adults typically age-out of crime, LCP offenders will likely age-into the healthcare system earlier than their chronologically same-aged peers. Preventing young people from offending is likely to have substantial benefits for health, and people engaging in a LCP trajectory of antisocial behaviors might be the most in need of health promotion programs. We offer prevention and intervention strategies to reduce the financial burden of offenders on health care systems and improve their wellbeing.

Preprint ARTICLE | doi:10.20944/preprints202104.0532.v3

Examining the Role of the Noradrenergic Locus Coeruleus for 2 Predicting Attention and Brain Maintenance in Healthy Old Age 3 and Disease: An MRI Structural Study for the Alzheimer’s Disease 4 Neuroimaging Initiative

Emanuele Raffaele Giuliano Plini, Erik O'Hanlon, Rory Boyle, Francesca Sibilia, Gaia Rikhye, Joanne Kenney, Robert Whelan, Michael Christopher Melnychuk, Ian Hamilton Robertson, Paul Michael Dockree

Subject: Social Sciences, Psychology Keywords: Locus Coeruleus; Reserve; Brain Age; Visual Attention; Alzheimer’s Disease; Mild Cognitive Impairment; normal Aging; Neuroimaging; Voxel Based Morphometry

Online: 21 June 2021 (11:41:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0481.v1

Investigating the Converter-Driven Stability of an Offshore HVDC System

Matthias Quester, Fisnik Loku, Otmane El Azzati, Leonel Noris, Yongtao Yang, Albert Moser

Subject: Engineering, Electrical And Electronic Engineering Keywords: Converter-driven stability; HVDC; Offshore, MMC, Converter, Replica, impedance-based stability analysis, Interactions.

Online: 18 March 2021 (12:31:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202208.0011.v1

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Olajuwon Okubena, Adaeze Adebesin, Adrian Omogbiya, Oluwafemi Oluwole, Rita Asomadu, Michael Afolabi, Samira Makanjuola, Louis Ajonuma, Adedoyin Dosunmu, Ololade Otitoloju, Solomon Umukoro

Subject: Biology And Life Sciences, Food Science And Technology Keywords: SBSJ; polyphenolic constituents; antioxidants; anti-inflammatory, chemoprevention; immunomodulation; anti-aging; adaptogen

Online: 1 August 2022 (08:06:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0028.v1

A Conceptual Introduction to Model Driven Development: From Softness to Complexity

Mohammad Reza Besharati, Mohammad Izadi

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Software Engineering; Model; Model-Driven; Model Driven Development; MDD; MDA

Online: 1 April 2021 (14:47:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0135.v1

MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles

Susana Carregal-Romero, Sandra Plaza-Carcía, Rafael Piñol, Losé Luís Murillo, Jesús Ruiz-Cabello, Daniel Padro, Ángel Millán, Pedro Ramos-Cabrer

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: iron oxide nanoparticles; multimodal nanoparticles; biodistribution; magnetic resonance imaging; aging; coating degradation

Online: 6 November 2018 (10:37:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0305.v1

Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts

Joong Hyun Shim

Subject: Biology And Life Sciences, Aging Keywords: PGE2; EP1; skin-aging; ERK1/2; intracellular calcium

Online: 27 October 2019 (11:04:31 CET)

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Working Paper REVIEW

Eye Movements Actively Reinstate Spatiotemporal Mnemonic Content

Jordana Wynn, Kelly Shen, Jennifer Ryan

Subject: Social Sciences, Cognitive Science Keywords: eyetracking, eye movements, gaze, memory, retrieval, vision, aging

Online: 20 May 2019 (12:25:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0132.v1

Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retina

Kyung Woo Kim, Sentaro Kusuhara, Atsuko Katsuyama-Yoshikawa, Sho Nobuyoshi, Megumi Kitamura, Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Makoto Nakamura

Subject: Medicine And Pharmacology, Ophthalmology Keywords: multidrug resistance protein 4; ATP-binding cassette (ABC) transporters; aging; retina; mouse; electroretinogram

Online: 4 February 2021 (10:58:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0115.v1

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

Vanesa Izquierdo, Verónica Palomera-Ávalos, Mercè Pallàs, Christian Griñán-Ferré

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cognitive decline; epigenetics; HFD; aging; SAM0P8; m6A, multigenerational inheritance.

Online: 4 December 2020 (14:54:58 CET)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0301.v1

Effect of Thermomechanical Aging of Orthodontic Aligners on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Ludger Keilig, Christoph Bourauel

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dentistry; Orthodontics; Biomechanics; Torque; Force; Tooth Movement; Removable Thermoplastic Appliance; Thermoforming; Aging.

Online: 17 February 2023 (07:07:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0510.v1

Effect of the Application of an Innovative Program on Prevention of Falls in Seniors

Zbigniew Borysiuk, Paweł Pakosz, Mariusz Konieczny, Krzysztof Kręcisz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: limits of stability; coactivation; EMG signal; falls; aging

Online: 22 October 2018 (16:07:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0457.v1

Influence of Cross Section Thickness and Aspect Ratio on Deformation during Diffusion Bonding and Impact of Metal Diffusion and Evaporation on Temperature Measurement Accuracy

Thomas Gietzelt, Volker Toth, Manfred Kraut, Uta Gerhards, Robin Duerrschnabel

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: diffusion welding; diffusion bonding; cross section width; aspect ratio; material thickness; thermocouple aging

Online: 29 February 2020 (09:01:14 CET)

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Diffusion bonding is often used on pre-machined parts to generate internal cavities, e.g. for cooling injection molding tools close to the mold cavity. Only then, the workpieces are finished to their final dimensions. In the case of micro-process devices, however, it is essential to precisely control the deformation, as otherwise uncontrollable pressure losses will occur with channel cross-sections in the sub-millimeter range. Post-processing is not possible. The most important process parameters for diffusion bonding are temperature, dwell time and contact pressure, with the bonding temperature and contact pressure acting in opposite directions and showing a strong non-linear dependence on deformation. In addition, the deformation is influenced by a number of other factors such as the absolute size of the cross-section and the aspect ratio of the parts, the dimensions and distribution of the internal cross sections and the overall percentage of the cross-section to be bonded. In micro process engineering, small material cross-sections in the range of the materials microstructure can facilitate additional deformation mechanisms such as grain boundary sliding, which are not relevant at all for larger structures. For parts consisting of multiple layers, tolerances in thickness and roughness of multiple surfaces must be levelled, contributing to the percentaged deformation. This makes it difficult, especially in micro process engineering and in single or small series production, to determine suitable joining parameters in advance, which on the one hand do not cause unforeseen large deformations, but on the other hand reliably produce highly vacuum-tight components. Hence, a definition of a fixed percentaged deformation does not work for all kinds of components. This makes it difficult to specify parameters for surely obtain high-vacuum tight parts. For successful diffusion bonding, atoms must diffuse over the bonding planes, forming a monolithic part in which the original layers are no longer visible. Only then, mechanical properties identical to those of the base material, which has been subjected to identical heat treatment, can be achieved. In this paper, the impacts of different material cross section widths as well as of the aspect ratio on deformation were investigated. By accident, it was found that also accuracy of the temperature measurement may have a serious impact in terms of deformation.

Preprint ARTICLE | doi:10.20944/preprints202010.0339.v1

Aging Induces Profound Changes in sncRNA in Rat Sperm and these Changes are Modified by Perinatal Exposure to Environmental Flame Retardant

Alexander Suvorov, Vladimir Naumov, Victoria Shtratnikova, J.Richard Pilsner, Anna Zheludkevich, Evgeny Gerasimov, Maria Logacheva, Oleg Sergeyev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; paternal exposure; sperm; semen; epigenetics; sncRNA; piRNA; miRNA; 2,2′,4,4′-tetrabromodiphenyl ether; PBDE; BDE-47; perinatal; environment.

Online: 16 October 2020 (08:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0473.v1

Temporal Dynamics of Event-Related Potentials During Inhibitory Control Characterize Age-Related Neural Compensation

Elizabeth R Paitel, Kristy A Nielson

Subject: Social Sciences, Behavior Sciences Keywords: inhibitory control; executive function; event-related potentials; electroencephalography; N200; P300; cognitive aging; neural recruitment

Online: 20 May 2021 (10:18:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1378.v1

Recent Advance Bakuchiol Application as a Potential Alternative to Retinol in Skincare and Cosmetics

Norisca Aliza Putriana, Patihul Husni, Soraya Ratnawulan Mita

Subject: Medicine And Pharmacology, Pharmacy Keywords: Bakuchiol; anti-aging; anti-hyperpigmentation; anti-oxidant; anti-inflammatory; anti-acne; and anti-melanogenesis

Online: 18 January 2024 (07:23:52 CET)

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Working Paper ARTICLE

Evaluation of Punicalagin Niosomes for Skin Aging

Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona I. Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: skin aging; punicalagin; niosomes; UV radiation; collagen

Online: 24 March 2021 (17:35:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0038.v1

Progeria and Aging - Omics Based Comparative Analysis

Aylin Caliskan, Samantha Agnetz Wilhelmine Crouch, Sara Giddins, Thomas Dandekar, Seema Dangwal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: progeria; aging; omics; RNA Sequencing; bioinformatics; sun exposure; HGPS; IGFBP2; ACKR4; WNT

Online: 4 July 2022 (08:10:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0079.v1

Mitophagy and the Brain

Natalie Swerdlow, Heather Wilkins

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Mitochondria; Alzheimer’s Disease; mitophagy; neurodegeneration; aging

Online: 3 December 2020 (10:36:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0207.v1

The Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review

Luiz José Valotto Neto, Matheus Reverete, Renato Cesar Moretti Junior, Nathalia Mendes Machado, Rakesh Kumar Joshi, Daiane dos Santos Buglio, Caroline Barbalho Lamas, Rosa Direito, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Bacopa monnieri; phytotherapy (plants, medicinal, herbal medicine); neurodegenerative diseases; Alzheimer´; s disease; memory; cognitive functions; aging; neuroprotection; oxidative stress; antioxidants; neuropharmacology

Online: 5 February 2024 (04:02:47 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202002.0280.v1

Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report

Yinhua Li, Yunge Jia, Wei Hou, Huibing Tan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: spinal disc herniation, dog, NADPH diaphorase, the aging-related NADPH diaphorase body, megaloneurite, homogeneous formazan globule, intermedial collateral pathway

Online: 19 February 2020 (11:47:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0091.v1

Frailty as a Moderator of the Relationship Between Social Isolation and Health Outcomes in Community-Dwelling Older Adults

Fereshteh Mehrabi, François Béland

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Frailty; Social Isolation; Social Networks; Social Support; Social Participation; Aging

Online: 2 February 2021 (14:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0429.v1

Almond Skin Extracts and Chlorogenic Acid Delay Replicative Aging by Enhanced Oxidative Stress Response Involving SIR2 and SOD2 in Yeast

Duangjai Tungmunnithum, Malika Abid, Ahmed Elamrani, Samantha Drouet, Mohamed Addi, Christophe Hano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Aging; Almond; Chlorogenic acid; Lipid peroxidation; Mitochondria; 8-Oxo-guanine; Oxidative stress; Protein carbonylation; Sirtuin; Superoxide dismutase; Yeast

Online: 24 April 2020 (08:54:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0130.v1

The Real Cause of Differential Aging in the Twin “paradox”

Gordon Liu

Subject: Physical Sciences, Theoretical Physics Keywords: Twin paradox; Relativity; Space-time; Time dilation; Differential aging

Online: 9 February 2022 (10:20:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0432.v1

Once/Day Provision of Essential Amino Acid Enriched Meal Replacement Improves Body Composition and Physical Function in Obese Elderly

Melynda Coker, Kaylee Ladd, Zeinab Barati, Carl Murphy, Terry Bateman, Bradley Newcomer, Robert Wolfe, Robert Coker

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: skeletal muscle; adipose tissue; aging

Online: 22 January 2021 (08:40:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0522.v1

Towards Modeling and Predicting the Yield of Oilseed Crops: Multi-Machine Learning Techniques Approach

Mahdieh Parsaeian, Mohammad Rahimi, Abbas Rohani, Shaneka S. Lawson

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Agro-morphological; Data-driven; Machine Learning; Seed yield; Sensitivity Analysis

Online: 30 August 2022 (11:21:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0146.v1

Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Devesh Tewari, Artur Jóźwik, Małgorzata Łysek-Gładysińska, Weronika Grzybek, Wioletta Adamus-Białek, Jacek Bicki, Nina Strzałkowska, Agnieszka Kamińska, Olaf K. Horbańczuk, Atanas G. Atanasov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: fenugreek; aging; liver; antioxidants; mice

Online: 8 July 2020 (11:03:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0394.v1

Free Convection Heat Transfer from Two Equal Triangular Cylinders Confined in Triangular Enclosure

Houssem Laidoudi

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Triangular cylinders; buoyancy-driven flow; annulus; ANSYS-CFX; cold enclosure

Online: 20 January 2021 (09:50:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2032.v1

Integrating Artificial Intelligence in Dairy Farm Management - Biometric Facial Recognition for Cows

Shubhangi Mahato, Suresh Neethirajan

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Dairy Welfare; Digital Livestock Farming; Dairy Cow Biometrics; Facial Recognition Technology; Artificial Intelligence in Agriculture; Digital Agriculture Innovation; Precision Dairy Farming; AI-Driven Livestock Management; Animal Identification Technology; Sustainable Dairy Practices

Online: 29 January 2024 (13:05:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202204.0055.v1

Activity-Dependent Induction of Younger Molecular, Cellular and Organism Phenotypes

Thomas Lissek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell; biology; aging; medicine; transcription; activity; neurons; brain; immune system; muscle

Online: 7 April 2022 (04:24:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0529.v1

A Unifying Perspective on Transfer Function Solutions to the Unsteady Ekman Problem

Jonathan M. Lilly, Shane Elipot

Subject: Environmental And Earth Sciences, Oceanography Keywords: Ekman currents; ocean surface currents; wind stress forcing; transfer function; wind-driven response

Online: 20 November 2020 (09:32:45 CET)

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Working Paper ARTICLE

Circulating MicroRNA-486 and MicroRNA-146a Serve as Potential Biomarkers of Sarcopenia in the Elderly

Huang-Chun Liu, Der-Sheng Han, Chih-Chin Hsu, Jong-Shyan Wang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: aging; microRNA; sarcopenia; cytokine

Online: 20 August 2020 (07:39:53 CEST)

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Age-related sarcopenia meaningfully increases the risks of functional limitations and mortality in the elderly. Although circulating microRNAs (c-miRNAs) are associated with aging-related cellular senescence and inflammation, the relationships between c-miRNAs and sarcopenia in the elderly remain unclear. This study investigates whether circulating myo-miRNAs and inflammation-related miRNAs are associated with sarcopenia in the elderly. This study recruited 77 eligible subjects (41 males and 36 females) from 597 community-dwelling older adults, and then divided into normal (n=24), dynapenic (loss of muscular function without mass, n=35), and sarcopenic groups (loss of muscular function with mass, n=18). Moreover, myo-miRNAs (c-miRNA-133a and c-miRNA-486), inflammation-related miRNAs (c-miRNA-21 and c-miRNA-146a), and inflammatory-related cytokine levels in plasma were determined using quantitative polymerase chain reaction and ELISA, respectively. The results demonstrated that sarcopenic group exhibited lesser skeletal muscle mass index (SMI), handgrip strength, and gait speed, as well as, lower c-miR-486 and c-miR-146a levels, compared to those of normal and dynapenic groups. Moreover, c-miR-486 level was positively related to SMI (r=0.334, P=0.003), whereas c-miR-146a level was positively associated with SMI (r=0.240, P=0.035) and handgrip strength (r=0.253, P=0.027). In the receiver operating characteristic analysis for predicting sarcopenia, the area under the curve in c-miR-486 was 0.708 (95% confidence interval: 0.561-0.855, P=0.008) and c-miR-146a was 0.676 (95% CI: 0.551-0.801, P=0.024). However, no significant relationships were observed between SMI/ handgrip strength/gait speed and plasma myeloperoxidase/interleukin-1?/interleukin-6 levels. In conclusion, myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) are superior to inflammatory peroxide/cytokines in plasma for serving as critical biomarkers of age-related sarcopenia.

Preprint ARTICLE | doi:10.20944/preprints202304.0429.v1

Call for Urgent Regulations on Artificial Intelligence

Pavlo O. Dral, Arif Ullah

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial intelligence; Super Artificial intelligence; ChatGPT; ChatGPT-4; AI harm; Negative impacts of AI; AI use in Weapons; AI-driven unemployment; AI use in research

Online: 17 April 2023 (09:06:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0394.v1

Performance of Thermal-Oxidative Aging on the Structure and Properties of Ethylene Propylene Diene Monomer (EPDM) Vulcanizates

Hu Quanchao, Chen Qiang, Song Peiru, Gong Xingyu, Chen Junyi, Zhao Yongxian

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: EPDM vulcanizates; thermal-oxidative aging; thermal decomposition kinetics; antioxidant

Online: 17 April 2023 (04:07:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0002.v1

Waste Heat Recovery Systems with Isobaric Expansion Technology Using Pure and Mixed Working Fluids

Sander Roosjen, Maxim Glushenkov, Alexander Kronberg, Sascha Kersten

Subject: Engineering, Energy And Fuel Technology Keywords: Isobaric expansion engines; heat driven pump; compressors; low-grade heat; mixed working fluids

Online: 1 July 2022 (03:59:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0572.v1

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

Young Eun Choi, Min Ji Song, Mari Hara, Kyoko Imanaka-Yoshida, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; collagen; extracellular matrix; fibroblast; skin; tenascin C; TGF-β

Online: 28 October 2020 (08:49:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0741.v1

Habitual Exercise Attenuates the Aging Associated Muscle Atrophy and Muscle Strength Decline in SAMP8

Kai Aoki, Masaki Konno, Katsunari Honda, Takuya Abe, Takeshi Nagata, Masaaki Takehara, Takehito Sugasawa, Kazuhiro Takekoshi, Hajime Ohmori

Subject: Biology And Life Sciences, Aging Keywords: Aging; Habitual exercise; SAMP8; Sarcopenia

Online: 31 July 2020 (09:55:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0026.v1

SATLabel: A Framework for Sentiment and Aspect Terms Based Automatic Topic Labeling

Khandaker Tayef Shahriar, Mohammad Ali Moni, Mohammed Moshiul Hoque, Muhammad Nazrul Islam, Iqbal H. Sarker

Subject: Computer Science And Mathematics, Computer Science Keywords: Data-driven Framework; LDA; Sentiment Terms; Aspect Terms; Unigrams; Soft Cosine Similarity; Topic; Automatic labeling

Online: 5 April 2022 (11:58:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0701.v1

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Darya Telegina, Oyuna Kozhevnikova, Anna Antonenko, Nataliya Kolosova

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: retina; neurodegeneration; AMD; aging; neurogenesis; development; transcription factor

Online: 29 June 2021 (12:41:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0220.v1

Smartphone-Based Facial Scanning as a Viable Tool for Facially Driven Orthodontics?

Andrej Thurzo, Martin Strunga, Romana Havlínová, Katarína Reháková, Renata Urban, Jana Surovková, Veronika Kurilová

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: TrueDepth; CBCT; Orthodontics; Face scan; Smartphone; Facial diagnostics; Smartphone-based sensors; Facially driven orthodontics

Online: 15 September 2022 (05:45:29 CEST)

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Working Paper ARTICLE

Chronic Effectiveness of Walking With Blood Flow Restriction on the Activation and Strength in Osteoporotic Older Women: A Randomized Clinical Trial

Simoni Teixeira Bittar, Heleodório Honorato Santos, Leonardo Silva Leandro, Leonardo Santos Oliveira, Maria Socorro Cirilo-Sousa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: aging; aerobic exercise; vascular occlusion; electromyography

Online: 19 March 2021 (11:11:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0879.v1

Neurodegeneration in Cognitive Impairment and Mood Dis-orders for Experimental, Clinical and Translational Neuropsy-chiatry

Simone Battaglia, Alessio Avenanti, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’ s disease;
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity

Online: 16 February 2024 (05:40:14 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202107.0075.v1

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A Zoller, Steve Horvath, Lori H Schwacke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Online: 5 July 2021 (07:59:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0043.v1

Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

Jan Wadstein, Israel Sánchez Alvarez, Erling Thom, Lidia Bernal López

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin Aging; Rejuvenation; Skin Cream; Retinoid formulation; RetileX-A; Vercilex

Online: 2 November 2021 (10:55:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0138.v1

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive, and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Victor Vasilyevich Dyakin, Nika Victorovna Dyakina-Fagnano, Laura Beth McIntire, Vladimir Nikolaevich Uversky

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: spontaneous; non-enzymatic; post translational modifications; racemization; biological clock; natural selection; allostatic load; psychological aging; psychological stress; stress response sys-tem; phase transitions.

Online: 8 November 2021 (13:08:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0255.v3

How Much of Aging Is Simply a Trash Collection Problem?

Michael Renteln

Subject: Biology And Life Sciences, Aging Keywords: Anti-aging therapy; lipofuscin; SENS; oncolytic vector; telomerase; TFEB; intracellular microbe

Online: 22 February 2023 (15:24:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0683.v1

Effectiveness of tDCS to Improve Recognition and Reduce False Memories in Older Adults

Juan C Melendez, Encarnación Satorres, Alfonso Pitarque, Iraida Delhom, Elena Real, Joaquin Escudero

Subject: Social Sciences, Psychology Keywords: transcranial direct current stimulation; true recognition; false recognition; aging; experiment.

Online: 28 December 2020 (11:15:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0217.v1

Longevity, Aging and Cancer: Thermodynamics and Complexity

J.M. Nieto-Villar, R. Mansilla

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: longevity; aging; cancer; complex systems; non-equilibrium thermodynamics; biological phase transition; ferroptosis

Online: 17 May 2022 (03:16:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0688.v1

Colour Fixation Strategies on Sustainable Polybutylene Succinate Using Biobased Itaconic Acid

Lidia García-Quiles, Julio Vidal, Debora Puglia, Franco Dominici, Ángel Fernández, Pere Castell

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biopolymers; Biocomposites; Polybutylene succinate; Itaconic Acid; Zirconium oxide; Colourant; Diazo pigment; Extrusion-compounding; Mechanical properties; Hardness; Colour fixing; Gloss; Aging effect; SEM (Scanning Electron Microscopy); Wettability

Online: 27 November 2020 (12:50:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0074.v1

The Effects of Age, Gender, and Control Device in a Virtual-Reality Driving Simulation

Wen-Te Chang

Subject: Arts And Humanities, Philosophy Keywords: VR; aging effect; gender difference; control device; wayfinding strategy

Online: 5 May 2020 (11:32:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1128.v1

Mitochondrial Function-Associated APOE Locus and its Implication in Alzheimer’s Disease and Aging

Eun-Gyung Lee, Lesley Leong, Sunny Chen, Jessica Tulloch, Chang-En Yu

Subject: Biology And Life Sciences, Aging Keywords: APOE locus; TOMM40; APOE; oxidative stress; mitochondrial dysfunction; mitochondrial DNA copy number; gene expression; Alzheimer’s disease; aging

Online: 28 April 2023 (07:08:33 CEST)

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Working Paper REVIEW

Updates on the Role of Molecular Alterations and NOTCH Signaling in the Development of Neuroendocrine Neoplasms

Claudia von Arx, Monica Capozzi, Elena López-Jiménez, Alessandro Ottaiano, Fabiana Tatangelo, Annabella Di Mauro, Guglielmo Nasti, Maria Lina Tornesello, Salvatore Tafuto

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Neuroendocrine Neoplasms; NOTCH; cancer driven genes; mutational mechanism; germline mutations.; small cell lung carcinoma; pancreatic NET; small bowel NET; medullary thyroid carcinoma; malignant castration-resistant prostatic cells

Online: 23 July 2019 (10:34:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0468.v1

Opioids in the Elderly Patients with Cognitive Impairment: A Narrative Review

Martina Rekatsina, Antonella Paladini, Dariusz Myrcik, Omar Viswanath, Ivan Urits, Joseph Pergolizzi, Frank Breve, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: aging; elderly; pain; opioids; dementia; cognitive impairment

Online: 29 December 2021 (13:42:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0662.v1

The Framework of Modeling and Simulation based-on Swarm Ontology for Autonomous Unmanned Systems

Xinghai Gao, Gang Xiao, Kai Xie, Weijia Wang, Yuhua Fu, Chuangye Chang, Zhouqi Wang

Subject: Computer Science And Mathematics, Robotics Keywords: swarm ontology; autonomous system; model-driven; multi-paradigm modeling; model-base systems engineering

Online: 21 April 2023 (03:09:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0059.v1

Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors

Helen Knaggs, Edwin D Lephart

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin; Anti-aging; Health, Lifestyle Factors, Diet, Sleep, Exercise, Social interactions, Polyphenols, Vitamins

Online: 1 September 2023 (10:30:06 CEST)

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