Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Olajuwon Okubena
* ,
Adaeze Adebesin
,
Adrian Omogbiya
,
Oluwafemi Oluwole
,
Rita Asomadu
ORCID logo ,
Michael Afolabi
,
Samira Makanjuola
,
Louis Ajonuma
,
Adedoyin Dosunmu
,
Ololade Otitoloju
,
Solomon Umukoro
*
Version 1 : Received: 23 July 2022 / Approved: 1 August 2022 / Online: 1 August 2022 (08:06:10 CEST)

How to cite: Okubena, O.; Adebesin, A.; Omogbiya, A.; Oluwole, O.; Asomadu, R.; Afolabi, M.; Makanjuola, S.; Ajonuma, L.; Dosunmu, A.; Otitoloju, O.; Umukoro, S. Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects. Preprints 2022, 2022080011. https://doi.org/10.20944/preprints202208.0011.v1. Okubena, O.; Adebesin, A.; Omogbiya, A.; Oluwole, O.; Asomadu, R.; Afolabi, M.; Makanjuola, S.; Ajonuma, L.; Dosunmu, A.; Otitoloju, O.; Umukoro, S. Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects. Preprints 2022, 2022080011. https://doi.org/10.20944/preprints202208.0011.v1.

Abstract

Across different cultures around the globe, human beings have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants can be strongly attributed to the presence of secondary metabolites, particularly polyphenols. The health-promoting effects of Sorghum bicolor supplement Jobelyn® (SBSJ) —a unique supplement derived from the leaf sheaths of a West African variety of Sorghum bicolor (L.) Moench—have also been ascribed to its high levels of polyphenols. This review seeks to gather and synthesize findings from various experimental and clinical studies on the health benefits of SBSJ in arthritis, cancer, chronic viral infections, stroke, anaemia, and aging. SBSJ has been reported to contain potent bioactive polyphenolic compounds with polyvalent biological activities, including antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. Moreover, the probable benefits of SBSJ in chronic viral infections (e.g., HIV/AIDS and COVID-19) have been attributed to its potent anti-inflammatory and immunomodulatory activities. As this supplement is increasingly becoming one of the fastest-selling herbal medicines in Nigeria, there is a need for more robust studies (including clinical trials) in order to replicate and validate the prior insights gleaned from experimental studies.

Supplementary and Associated Material

http://www.healthforeverng.com: Website for nutritional supplement, sorghum bicolor supplement Jobelyn
http://www.jobelyn.us: US website for sorghum bicolor supplement Jobelyn
http://www.jobelyn.uk: United Kingdom website for sorghum bicolor supplement Jobelyn

Keywords

SBSJ; polyphenolic constituents; antioxidants; anti-inflammatory, chemoprevention; immunomodulation; anti-aging; adaptogen

Subject

MEDICINE & PHARMACOLOGY, Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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