Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Anxiety, Impaired Social and Aggressive Behaviour Correlates With Cognitive Decline Accompanied by Molecular Alterations in Older SAMP8 Males

Foteini Vasilopoulou
,
Júlia Companys-Alemany
ORCID logo ,
Anna-Maria Canudas
,
Verónica Palomera-Ávalos
,
Daniel Ortuño-Sahagún
ORCID logo ,
Mercè Pallàs
* ORCID logo ,
Christian Griñán-Ferré
* ORCID logo
Version 1 : Received: 7 January 2021 / Approved: 8 January 2021 / Online: 8 January 2021 (13:48:22 CET)

How to cite: Vasilopoulou, F.; Companys-Alemany, J.; Canudas, A.; Palomera-Ávalos, V.; Ortuño-Sahagún, D.; Pallàs, M.; Griñán-Ferré, C. Anxiety, Impaired Social and Aggressive Behaviour Correlates With Cognitive Decline Accompanied by Molecular Alterations in Older SAMP8 Males. Preprints 2021, 2021010162. https://doi.org/10.20944/preprints202101.0162.v1 Vasilopoulou, F.; Companys-Alemany, J.; Canudas, A.; Palomera-Ávalos, V.; Ortuño-Sahagún, D.; Pallàs, M.; Griñán-Ferré, C. Anxiety, Impaired Social and Aggressive Behaviour Correlates With Cognitive Decline Accompanied by Molecular Alterations in Older SAMP8 Males. Preprints 2021, 2021010162. https://doi.org/10.20944/preprints202101.0162.v1

Abstract

Alzheimer’s disease (AD) is characterized by cognitive impairment and different non-cognitive deficits called “Behavioural and psychological symptoms of dementia” (BPSD) related to neurotrophin alterations, which differ from those presented in normal aging. Mouse models, both transgenics and inbreed mice models of AD, are a useful tool in understanding the underlying mechanisms of the disease. The SAMP8 (senescence-accelerated mouse prone 8) mice line was generated from AKR/J strain by Professor Toshio Takeda at the University of Kyoto. This strain exhibited a particular early-onset and accelerated aging phenotype. The present study characterizes and provides information regarding the non-cognitive and cognitive states as well as molecular alterations and their relationship, demonstrating the AD-like symptoms presented in older SAMP8 males. The cognitive impairment presented was accompanied by a reduction in sociability and an increase in aggressive as well as anxiety behaviours. Furthermore, changes in three of the most important neurotrophins, such as NT3, BDNF, and NGF as well as their receptors TrkA and TrkB, were found. Thus, the present results reveal new insights in this useful inbred mouse model of neurodegeneration and AD, demonstrating the potential relationship between neurotrophin alterations, cognitive impairment and neuropsychiatric disorders (ND).

Keywords

behaviour; BPSD; cognitive decline; aging; SAMP8.

Subject

Social Sciences, Psychology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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