Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study

Carlo Dal Lin
* ORCID logo ,
Mariela Marinova
,
Laura Brugnolo
,
Giorgio Rubino
,
Mario Plebani
,
Sabino Iliceto
,
Francesco Tona
ORCID logo
Version 1 : Received: 9 July 2020 / Approved: 12 July 2020 / Online: 12 July 2020 (16:57:10 CEST)

A peer-reviewed article of this Preprint also exists.

C. Dal Lin, M. Marinova, L. Brugnoloet al., Rapid changes of miRNAs-20, -30,410,515,134, and183 andtelomerase with psychological activity: A one year study on the relaxation response and epistemological considerations, Journal ofTraditional and Complementary Medicine, https://doi.org/10.1016/j.jtcme.2021.02.005 C. Dal Lin, M. Marinova, L. Brugnoloet al., Rapid changes of miRNAs-20, -30,410,515,134, and183 andtelomerase with psychological activity: A one year study on the relaxation response and epistemological considerations, Journal ofTraditional and Complementary Medicine, https://doi.org/10.1016/j.jtcme.2021.02.005

Abstract

Mental stress represents a pivotal factor in cardiovascular diseases. The mechanism by which stress produces its deleterious effects is still under study but one of the most explored pathway is cell senescence. In this scenario, circulating microRNAs appear to be mobile regulatory elements of the telomerase activity and alternative splicing within the ”senectome” network. Anti-stress techniques seem to be able to slow-down aging process. As we have recently verified how the practice of Relaxation Response (RR), counteracting psychological stress, determines favorable changes of some inflammatory genes expression, of some neurotransmitters, hormones, cytokines and inflammatory circulating microRNAs, we aimed to verify a possible change even in serum levels of 4 senectome micro-RNAs (SE-miRNAs -20, -30, -410, -515), testing the activity of telomerase in peripheral blood mononuclear cells-PBMCs. We analyzed also alternative splicing microRNAs 134 and 183. According to our data, miRNA-20 and -30 levels and PBMCs-telomerase activity increase during the RR while -410 and -515 levels decrease. Moreover, during the RR sessions both miRNA-134 and -183 decrease. The mediators considered in this work seem to vary rapidly according to a (stress)-relaxation condition showing that psychic activity should be part of the study of aging factors.

Keywords

cardiovascular disease; inflammation; aging; senectome, telomerase; alternative splicing; relaxation response; microRNA

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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