Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study

Version 1 : Received: 9 July 2020 / Approved: 12 July 2020 / Online: 12 July 2020 (16:57:10 CEST)

How to cite: Dal Lin, C.; Marinova, M.; Brugnolo, L.; Rubino, G.; Plebani, M.; Iliceto, S.; Tona, F. Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study. Preprints 2020, 2020070268 (doi: 10.20944/preprints202007.0268.v1). Dal Lin, C.; Marinova, M.; Brugnolo, L.; Rubino, G.; Plebani, M.; Iliceto, S.; Tona, F. Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study. Preprints 2020, 2020070268 (doi: 10.20944/preprints202007.0268.v1).

Abstract

Mental stress represents a pivotal factor in cardiovascular diseases. The mechanism by which stress produces its deleterious effects is still under study but one of the most explored pathway is cell senescence. In this scenario, circulating microRNAs appear to be mobile regulatory elements of the telomerase activity and alternative splicing within the ”senectome” network. Anti-stress techniques seem to be able to slow-down aging process. As we have recently verified how the practice of Relaxation Response (RR), counteracting psychological stress, determines favorable changes of some inflammatory genes expression, of some neurotransmitters, hormones, cytokines and inflammatory circulating microRNAs, we aimed to verify a possible change even in serum levels of 4 senectome micro-RNAs (SE-miRNAs -20, -30, -410, -515), testing the activity of telomerase in peripheral blood mononuclear cells-PBMCs. We analyzed also alternative splicing microRNAs 134 and 183. According to our data, miRNA-20 and -30 levels and PBMCs-telomerase activity increase during the RR while -410 and -515 levels decrease. Moreover, during the RR sessions both miRNA-134 and -183 decrease. The mediators considered in this work seem to vary rapidly according to a (stress)-relaxation condition showing that psychic activity should be part of the study of aging factors.

Subject Areas

cardiovascular disease; inflammation; aging; senectome, telomerase; alternative splicing; relaxation response; microRNA

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