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Preprint ARTICLE | doi:10.20944/preprints202304.0331.v1

The Effect of Circadian Photoreceptors Stimulation on the Stress Response of Subjects with High Anxiety

Mariya Stanislavovna Sergeeva, Oksana Viacheslavovna Borisova, Natalia Petrovna Romanchuk, Arseniy Andreevich Videnin, Vasiliy Fedorovich Pyatin, Natalia Nikolaevna Shusharina, Alexander Vladimirovich Zakharov, Alexander Vladimirovich Kolsanov

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: anxiety; circadian system; heart rate variability; melanopsin-containing retinal ganglion cells; stress

Online: 14 April 2023 (02:40:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0432.v1

Cardiac Myofibroblast and Fibrosis

Hitoshi Kurose

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: myofibroblasts; fibrosis; heart failure

Online: 19 May 2021 (07:55:59 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.1376.v1

Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds

IVAN VITO FERRARI

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart fatty acid-binding protein; Morusin; molecular docking; FABP3; Resistomycin; pkCSM

Online: 19 December 2023 (09:45:41 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1490.v1

Liver-Kidney-Heart Axis – A Clinical Challenge

Dina Fernandes Neto, Iago Blanco, María Melendo Viu, David Dobarro Perez, Andrés Iñiguez Romo

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type-5 cardio-renal syndrome; heart failure; cirrhosis; Liver-Kidney-Heart axis

Online: 19 January 2024 (13:11:37 CET)

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Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome. A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states. With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.

Preprint COMMUNICATION | doi:10.20944/preprints202309.1187.v1

Preliminary Study on the Immunohistochemical Expression of Galectin-3 in Hypertrophic Hearts

Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: galectin-3; cardiac hypertrophy; immunohistochemical expression; heart transplantation; heart disease; cardiorenal syndrome

Online: 19 September 2023 (03:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0131.v2

Use of Deep Learning to Detect the Maternal Heart Rate and False Signals on Fetal Heart Rate Recordings

Samuel Boudet, Agathe Houzé de l'Aulnoit, Laurent Peyrodie, Romain Demailly, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: fetal heart rate; maternal heart rate; cardiotocogram; gated recurrent unit; deep learning

Online: 22 July 2022 (03:08:59 CEST)

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We have developed deep learning models for automatic identification of the maternal heart rate (MHR) and, more generally, false signals (FSs) on fetal heart rate (FHR) recordings. The models can be used to preprocess FHR data prior to automated analysis or as a clinical alert system to assist the practitioner. Three models were developed and used to detect (i) FSs on the MHR channel (the FSMHR model), (ii) the MHR and FSs on the Doppler FHR sensor (the FSDop model), and (iii) FSs on the scalp ECG channel (the FSScalp model). The FSDop model was the most useful because FSs are far more frequent on the Doppler FHR channel. All three models were based on a multilayer, symmetric, GRU and were trained on data recorded during the first and second stages of delivery. The FSMHR and FSDop models were also trained on antepartum recordings. The training dataset contained 1030 expert-annotated periods (mean duration: 36 min) from 635 recordings. In an initial evaluation of routine clinical practice, 30 fully annotated recordings for each sensor type (mean duration: 5 h for MHR and Doppler sensors, and 3 h for the scalp ECG sensor) were analyzed. The sensitivity, positive predictive value (PPV) and accuracy were respectively 62.20%, 87.1% and 99.90% for the FSMHR model, 93.1%, 95.6% and 99.68% for the FSDop model, and 44.6%, 87.2% and 99.93% for the FSScalp model. We built a second test dataset with a more solid ground truth by selecting 45 periods (lasting 20 min, on average) on which the Doppler FHR and scalp ECG signals were recorded simultaneously. Using scalp ECG data, the experts estimated the true FHR value more reliably and thus annotated the Doppler FHR channel more precisely. The models achieved a sensitivity of 53.3%, a PPV of 62.4%, and an accuracy of 97.29%. In comparison, two experts (blinded to the scalp ECG data) respectively achieved a sensitivity of 15.7%, a PPV of 74.3%, and an accuracy of 96.91% and a sensitivity of 60.7%, a PPV of 83.5% and an accuracy of 98.24%. Hence, the models performed at expert level (better than one expert and worse than the other), although a well-trained expert with good knowledge of FSs could probably do better in some cases. The models and datasets have been included in the Fetal Heart Rate Morphological Analysis open-source MATLAB toolbox and can be used freely for research purposes.

Preprint ARTICLE | doi:10.20944/preprints202305.1335.v1

Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft

Filip Dulguerov, Tamila Abdurashidova, Emeline Christophel-Plathier¹, Barbara Pitta-Gros, Anna Nowacka, Ziyad Gunga, Raymond Pfister, Mario Verdugo-Marchese, Valentina Rancati, Lars Niclauss, Piergiorgio Tozzi, Albert Adelin, Zied Ltaief, Samuel Rotman, Philippe Meyer, Roger Hullin, Matthias Kirsch

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart Transplantation; Cardiac Preservation Solutions; Inotropic Score; Early Results; Mid-term Results

Online: 18 May 2023 (10:50:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2249.v1

Assessment and Therapeutic Modulation of Heart Rate Variability: Potential Implications in Patients with COVID-19

Luiz G. Schnekenberg, Annahita Sedghi, Daniela Schöne, Lars-Peder Pallesen, Jessica Barlinn, Felix Woitek, Axel Linke, Volker Puetz, Kristian Barlinn, Norman Mangner, Timo Siepmann

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SARS-CoV-2; COVID-19; heart rate variability; cardiac; cardiovascular; parasympathetic; sympathetic; autonomic

Online: 31 May 2023 (12:55:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1402.v1

Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy

Arsalan Farhangee, Marke J Davies, Ion Mindrila, Mihai Mesina

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Cardiac resynchronisation therapy; trans-septal LV lead; Heart Failure; Quality of life

Online: 21 July 2023 (05:19:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0031.v1

Effects of Cardiovagal Training on Autonomic Function, Inflammatory Markers and Insulin Levels in Adults with Obesity

Alexis Espinoza-Salinas, Luis Peiret-Villacura, Edgardo Molina-Sotomayor, Igor Cigarroa-Cuevas, Giovanny Arenas-Sánchez, Israel Podestá, José González-Jurado

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: obesity; high-intensity interval training; heart rate variability; inflammatory markers; insulin resistance; autonomic function

Online: 2 March 2022 (02:44:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1122.v1

Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation

Sarah Mende, Syed Ahmed, Lise DeShea, Edgardo Szyld, Birju A. Shah

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: electrocardiogram; heart rate; neonatal resuscitation

Online: 17 April 2024 (08:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1198.v1

Pirfenidone Prevents the Onset of Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy

Tatiana Araújo Silva, Diane Thomas, Jair Lage Siqueira-Neto, Claudia Magalhaes Calvet

Subject: Biology And Life Sciences, Parasitology Keywords: Heart fibrosis; Chagas disease; Pirfenidone

Online: 20 November 2023 (07:34:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0466.v1

Prevalence and Intensity of Sarcocystis Infections in Alpine Chamois (Rupicapra r. rupicapra) in Germany

Steffen Rehbein, Martin Visser

Subject: Biology And Life Sciences, Parasitology Keywords: Sarcocystis; chamois; heart; diaphragm; Germany

Online: 9 October 2023 (07:36:37 CEST)

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Chamois are mountain ungulates (Subfamily Caprinae) which inhabit several medium and high altitude mountain ranges from southern Europe to the Near East. The first findings of Sarcocystis cysts in the musculature of chamois were reported in the 1970s. However, only limited work on the epidemiology of sarcocystosis and identification of the species of Sarcocystis in chamois has been done in the past. The present work was part of a comprehensive study on the parasites of chamois in Germany aiming to provide, for the first time, data on the prevalence and intensity of Sarcocystis infection in native Alpine chamois using histology examination of heart and/or diaphragm tissue samples collected from 216 chamois (40 kids and 176 chamois ranging of one up to 18 years of age). Sarcocysts were detected in either heart or diaphragm of 167/216 chamois (77.3%) with 131 of 183 heart samples and 127 of 215 diaphragm samples testing sarcocyst positive. Of the 181 chamois with both heart and diaphragm available (34 kids and animals up to 18 years of age), sarcocysts were detected in heart and/or diaphragm of 142 animals translating in an overall 78.5% prevalence of Sarcocystis infection (95%CI 72.5% - 84.4%). Sarcocysts were more frequently recorded in heart vs. diaphragm (72.4% vs. 56.4%; p=0.0021), and diaphragm positivity was associated with heart positivity (p=0.0001). Sarcocyst positivity (heart and/or diaphragm) was significantly (p<0.001) lower in kids than in the older chamois (27.1% vs. 88.6%, respectively) but prevalence did not differ between the sexes, regardless of the chamois’ age (p>0.3). Intensity of infection was generally low (<10 sarcocysts per cm² muscle cut) in both heart positive and diaphragm positive animals (94.7% and 93.7%, respectively) with heart yielding higher sarcocyst counts than diaphragm (p<0.001). Both heart and diaphragm sarcocyst counts were significantly (p<0.001) lower in kids than in the older chamois. Sarcocystis infection was demonstrated to be prevalent in chamois in Germany but intensity is apparently low. Further studies are desired to identify the species of Sarcocystis parasitizing the chamois using both phenotypic and molecular characteristics.

Preprint ARTICLE | doi:10.20944/preprints202212.0290.v2

A New Algorithm for Estimating Fast Variations in the Heart Rate

Enrico Maria Staderini, Harish Kambampati, Amith K. Ramakrishnaiah, Stefano Mugnaini, Andrea Magrini, Sandro Gentili

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability; signal analysis

Online: 6 February 2023 (04:45:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0040.v1

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Dae Yun Seo, Jeong Rim Ko, Jung Eun Jang, Tae Nyun Kim, Jae Boum Youm, Hyo-Bum Kwak, Jun Hyun Bae, Amy Hyein Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diabetes; exercise; cardiomyopathy; heart failure

Online: 3 October 2019 (13:59:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0235.v1

Bile Acid Signaling and Cardioprotection

Noorul Izzati Hanafi, Anis Syamimi Mohamed, Siti Hamimah Sheikh Abdul Kadir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heart; ursodeoxycholic acid; cardioprotection; signaling

Online: 11 October 2018 (08:35:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2112.v1

Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation, a 10-Year Single-Center Report

Antonio Amodeo, Milena Stojanovic, Tugba Erdil, Hitendu Dave, Robert A. Cesnjevar, Sebastian Paal, Oliver Kretschmar, Martin Schweiger

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ongenital heart disease; extracorporeal life support; ECMO; single ventricle; complications; risk factors; mortality

Online: 30 June 2023 (03:41:18 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0438.v1

Exercise-Induced Arrhythmia or Munchhausen Syndrome in a Marathon Runner?

Robert Gajda, Wojciech Drygas, Jacek Gajda, Pawel Kiper, Beat Knechtle, Magdalena Kwaśniewska, Maciej Sterliński, Elżbieta Katarzyna Biernacka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate monitor; endurance running; arrhythmia, tachycardia; artifacts; exertion rhythm disorders; Munchhausen syndrome; athlete's heart

Online: 7 July 2023 (07:41:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0017.v1

Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left-Heart Syndrome, Ciliopathies and Neurodevelopmental Delays

Kalyani B Karunakaran, George C Gabriel, N Balakrishnan, Cecilia W Lo, Madhavi K Ganapathiraju

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein-protein interactions; interactome; congenital heart disease; developmental disorder; hypoplastic left heart syndrome; web application

Online: 1 February 2022 (16:00:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1233.v1

Effect of Sleep Duration on Autonomic Nervous System Regulation in Patients with Plausible Alzheimer: A Cross-Sectional Pilot Study

Chuen-Ru Liu, Chih-Yuan Yang, Dipanshu Sharma, Tun-Hao Chen, Xian-Qing Huang, Tsui-Mei Hung, Terry B. J. Kuo, Jwo-Huei Jou

Subject: Public Health And Healthcare, Nursing Keywords: Alzheimer’ s disease; autonomic nervous system regulation; dementia severity; heart rate variability; sleep duration

Online: 20 March 2024 (14:30:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0086.v1

Information Needs and Communication Strategies for People with Coronary Heart Disease: A Scoping Review

Clara Zwack, Carlie Smith, Vanessa Poulsen, Natalie Raffoul, Julie Redfern

Subject: Social Sciences, Behavior Sciences Keywords: Information; resources; coronary heart disease; digital health; education; cardiac rehabilitation; secondary prevention; text message; sensors; cardiovascular risk

Online: 6 December 2022 (02:09:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1181.v1

Hemodialysis Efficiency Predictor in End Stage Kidney Disease Using Real-Time Heart Rate Variability

Sung Il Im, Ye Na Kim, Hyun Su Kim, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, YeonSoon Jung, Hark Rim, Sung Pil Cho, Jung Hwan Park, Ho Sik Shin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: predictors of hemodialysis; heart rate variability

Online: 16 January 2024 (13:55:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0027.v1

The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle

Igor Giarretta, Eleonora Gaetani, Paolo Tondi, Takayuki Asahara, Roberto Pola

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hedgehog; Ischemia; Heart; Brain; Skeletal muscle

Online: 1 August 2018 (16:31:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0788.v1

The Lipid-Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-fat and High Linoleic Acid Consumption

Academic Editor: Mary T Newport, Fabian M Dayrit

Subject: Public Health And Healthcare, Health Policy And Services Keywords: lipid-heart hypothesis; Ancel Keys; saturated fat; trans-fat; polyunsaturated fat; cholesterol; heart disease; dietary guidelines

Online: 11 April 2024 (10:20:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0867.v1

Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician

Ageliki A Karatza, Sotirios Fouzas, Despoina Gkentzi, Eirini Kostopoulou, Nikoleta Oikonomou, Gabriel Dimitriou, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; acquired heart disease; children; diagnostic errors; missed diagnosis; delayed diagnosis; primary care pediatrician

Online: 17 March 2024 (16:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.2138.v1

Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension

Edelvita Fernanda Duarte Cunha, Matheus Sobral Silveira, Juliana Cristina Milan-Mattos, Heitor Fernandes Silveira Cavalini, Ádrya Aryelle Ferreira, Joice de Souza Batista, Lara Cazé Uzumak, João Paulo Coelho Guimarães, Pedro Igor Lustosa Roriz, Fabianne Maisa de Novaes Assis Dantas, Arto J. Hautala, Raphael Martins De Abreu, Aparecida Maria Catai, Paulo Adriano Schwingel, Victor Ribeiro Neves

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: hypertension; SARS-CoV-2; post-COVID conditions; physical functional performance; autonomic nervous system diseases; heart rate control.

Online: 31 August 2023 (09:55:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0339.v1

Identification of Key Proteins Associated with Myocardial Infarction using Bioinformatics and Systems Biology

Ishtiaque Ahammad

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: myocardial infarction; heart attack; gene set enrichment analysis; protein-protein interaction network; bioinformatics; systems biology; in silico study

Online: 26 April 2018 (10:22:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0240.v1

Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Clara Liu Chung Ming, Kimberly Sesperez, Eitan Ben-Sefer, David Arpon, Kristine McGrath, Lana McClements, Carmine Gentile

Subject: Engineering, Automotive Engineering Keywords: preeclampsia; cardiovascular disease; heart failure; ischemic/reperfusion injury; in vivo model system; in vitro model system; ex vivo model system

Online: 8 April 2021 (12:23:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0237.v1

In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease

Francesco Nappi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart disease; first heart field; second heart field; whole exome sequencing; whole genome sequencing; loss-of-function variant; copy number variants; gene variants; deletion; de novo mutations

Online: 3 January 2024 (11:57:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0531.v1

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-ischemic Hypertensive Heart Disease

Nikolaos PE Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael Myrianthefs

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertensive heart disease; echocardiography; prognosis; speckle tracking

Online: 8 March 2024 (16:49:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2153.v1

Different Mechanisms in Doxorubicin-induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

Hien C. Nguyen, Jefferson C. Frisbee, Krishna K. Singh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BRCA2; BRCA1; doxorubicin; breast cancer; heart failure

Online: 28 December 2023 (05:10:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1483.v1

Radiation Exposure Assessment in Coronary Angiography CT Scan: Establishing Diagnostic Reference Level for Northeast Assam Population

Arnabjyoti Deva Sarma, Jibon Sharma, Manash Pratim Sarma, Mrinal Kanti Singha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: radiology; computed tomography; coronary angiography; phantom; heart

Online: 22 September 2023 (05:16:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1473.v1

Characterization of a Decellularized Sheep Pulmonary Heart Valves and Analysis of their Capability as a Xenograft Initial Matrix Material in Heart Valve Tissue Engineering

Müslüm Süleyman İNAL, Cihan DARCAN, Ali AKPEK

Subject: Engineering, Bioengineering Keywords: Decellularization; heart valve; tissue engineering; xenograft; biomaterial

Online: 22 May 2023 (08:26:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0185.v1

Role of Chest Radiographs and Electrocardiograms in Predicting the Hemodynamics of Congenital Heart Disease

Romila Chimoriya, Gaurav Kumar, Kritika Rana, Ritesh Chimoriya, Reena Anand, Kulbhusan S. Dagar, Neeraj Awasthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; chest radiograph; electrocardiogram; echocardiography

Online: 14 September 2022 (02:55:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0258.v1

Comparison of the Use of Desflurane vs. Propofol in Aortic Valve Replacement Surgery: Differences in Nephroprotection

Jose Luis Guerrero Orriach, Alfredo Malo-Manso, Mercedes Nuñez Galo, Inmaculada Bellido Estevez, Amalio Ruiz Salas, Jose Cruz Mañas, Lourdes Garrido Sanchez, Laura Gonzalez-Alvarez

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: desflurane; cardiac surgery; halogenated; kidney; heart; preconditioning

Online: 20 June 2022 (04:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0116.v1

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and EPAC : A Role for the Mitochondrial Permeability Transition Pore

Martin John Lewis, Igor Khaliulin, Katie Hall, M.Saadeh Suleiman

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Ischaemia/reperfusion injury; Development; Mitochondria; Immature Heart

Online: 10 January 2022 (13:38:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0493.v1

Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications

Abdallah Fayssoil, Marie Charlotte De Carne De Carnavalet, Nicolas Mansencal, Frédéric Lofaso, Benjamin Davido

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Obesity; BMI; heart; lung; severity

Online: 23 October 2020 (13:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0034.v1

Acupuncture on Lactate, Perceived Exertion in Recreational Athletes Submitted to HIIT

Carlos Soares Pernambuco, Rodrigo Gomes de Souza Vale, João Rafael Valentim-Silva, Carlos Alberto de Souza Filho, Vinicius do Espirito Santo de Jesus, Eliane da Silva Borges, Leandra Silva Cardoso, Isabel Cristina Regazzi, Estelio Henrique Martin Dantas

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Acupuncture; lactate; heart rate; physical performance; sustainability

Online: 2 August 2020 (14:46:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0039.v1

Fetal Heart Rate Signal Dataset for Training Morphological Analysis Methods and Evaluating them Against an Expert Consensus

Samuel Boudet, Agathe Houze de l'Aulnoit, Romain Demailly, Aline Delgranche, Laurent Peyrodie, Régis Beuscart, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Other Keywords: fetal heart rate, baseline, acceleration, deceleration, dataset

Online: 2 July 2019 (11:17:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0139.v1

A Fetal Heart Rate Morphological Analysis Toolbox for MATLAB

Samuel Boudet, Agathe Houzé de l'Aulnoit, Romain Demailly, Aline Delgranche, Laurent Peyrodie, Régis Beuscart, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Other Keywords: fetal heart rate; baseline; acceleration; deceleration; MATLAB

Online: 15 June 2019 (03:39:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0325.v1

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability

Zdravko Taralov, Peter Dimov, Kiril Terziyski, Blagoi Marinov, Mariyan Topolov, Stefan Kostianev

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability, smoking, hypoxia, autonomic dysfunction

Online: 20 June 2018 (15:38:52 CEST)

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Background and objectives: Smoking leads to autonomic dysfunction. However, the clinical methods for diagnosing this dysfunction are not sufficient. Since exogenous hypoxia leads to changes in the autonomic cardiac control, the aim of our study was to compare the activity of the autonomic nervous system via heart rate variability (HRV) in young “healthy” smokers and non-smokers before, during and after a short-term exogenous hypoxic exposure. Methods: Twenty-one healthy non-smoking males aged 28.0±7.4 (mean±SD) and fourteen healthy smoking males aged 28.1±4.3 with 9.2±5.6 pack-years were subjected to one-hour hypoxic exposure (FiО2=12.3±1.5%) via hypoxicator (AltiPro 8850 Summit+, Altitude Tech, Canada) with simultaneous recording of electrocardiography and pulse oximetry. HRV data was derived via specific software (Kubios HRV, Finland) by analyzing the pre-hypoxic, hypoxic and post-hypoxic periods. Results: Standard deviation of the intervals between normal beats (SDNN) was higher in non-smokers in the pre-hypoxic period (62.0±32.1 vs 40.3±16.2, p=0.013) but not in hypoxia (75.7±34.8 vs 57.9±18.3, p=0.167). When comparing intragroup HRV changes of shifting from hypoxic to post-hypoxic (normoxic) conditions we found that there is a significant increase in the root mean square of successive RR interval differences (RMSSD) (65.9±40.2 vs 75.1±45.9, p=0.011) and in the high frequency (lnHF) (6.8±1.4 vs 7.2±1.3, p=0.014) and a decrease in LF/HF (3.0±2.3 vs 1.9±1.5, p<0.001), but these changes were observed only in the group of non-smokers. Conclusions: Smoking likely impairs autonomic regulation in young healthy males and may lead to a decreased HRV even before subjective clinical signs and symptoms. Hypoxic exposure test could be applied in clinical practice for early detection of autonomic dysfunction in smokers, because their parasympathetic reactivation is blunted when shifting from hypoxic to normoxic ambient conditions measured by HRV.

Preprint ARTICLE | doi:10.20944/preprints202212.0410.v1

Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization

Estelle A.M.C. Adang, Maud T. A. Strous, Joop van den Bergh, Debbie Gach, Vivian E.M. Van Kampen, Roel E.P. van Zeeland, Dennis G. Barten, Frits H. M van Osch

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Heart rate variability; COVID-19; post-COVID-19 condition; long COVID; autonomic dysfunction; vagal nerve activity; symptomatology; lung function

Online: 22 December 2022 (03:13:53 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0163.v2

A Review of the Recent Advances Made with SIRT6 and Its Implications on Aging Related Processes, Major Human Diseases and Possible Therapeutic Targets

Rubayat Islam Khan, Saif Nirzhor, Raushanara Akter

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SIRT6, Diabetes, Gluconeogenesis, Cancer, Aging, Heart Disease, Pharmacological SIRT6 Inhibitor, Cardiac Hypertrophy, Tumorigenesis, Neurodegeneration, Neurodegenerative Diseases, AD

Online: 29 August 2018 (13:04:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0249.v1

Ultra-High Resolution Electrocardiography Enables Earlier Detection of Transmural and Subendocardial Myocardial Ischemia Compared to Conventional Electrocardiography

Kirill V. Zaichenko, Anna A. Kordyukova, Dmitry L. Sonin, Michael M. Galagudza

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart; ischemia; reperfusion; electrocardiography; ultra-high resolution electrocardiography; power spectral density; ischemic heart disease; subclinical atherosclerosis; sensitivity; risk stratification

Online: 3 August 2023 (05:17:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0508.v1

Is Continuous ECG Recording on Heart Rate Monitors the Most Expected Function by Endurance Athletes, Coaches, and Doctors?

Robert Gajda

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: heart rate monitor; ECG; portable/wearable monitoring system; heart rate variability; long-term assessment; arrhythmia; QARDIO MD VSI system

Online: 24 August 2020 (07:45:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1054.v1

Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu, Octavian-Marius Cretu, Daniel Florin Lighezan, Minodora Andor, Ioana Citu, Dragoș Cozma, Brenda-Cristiana Bernad, Adrian-Pavel Trifa, Diana Lighezan, Elena-Silvia Bernad, Dragos Catalin Jianu, Cristian Oancea, Ioan-Radu Lala, Sergiu-Florin Arnautu, Mirela-Cleopatra Tomescu

Subject: Biology And Life Sciences, Life Sciences Keywords: dilated cardiomyopathy; genetics; heart failure; genotype - specific therapy

Online: 16 April 2024 (15:53:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0573.v1

Within-week variation of training load in Turkish elite soccer players by players positions (a GPS technology study)

Hakan BAYRAKTAR, Erkan GÜNAY, Erhan Çene, Egemen Mancı, Zeki Akyıldız

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Soccer; TRIMP; Workload; Players; Heart Rate; GPS; Microcycles.

Online: 8 April 2024 (15:01:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1313.v1

Hearables: In-ear Multimodal Data Fusion for Robust Heart Rate Estimation

Marek Zylinski, Amir Nassibi, Edoardo Occhipinti, Adil Malik, Matteo Bermond, Harry J. Davies, Danilo P. Mandic

Subject: Engineering, Bioengineering Keywords: Data fusion method; Heart rate tracing; Hearables; Wearables

Online: 22 February 2024 (12:21:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0619.v1

Embodimetrics: A Principal Component Analysis of the Combined Assessment of Cardiac, Cognitive and Mobility Parameters

Andrea Chellini, Katia Salmaso, Michele Di Domenico, Nicola Gerbi, Marco Donati, Marco Iosa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: embodiment; heart rate variability; stroop task; motor control

Online: 12 February 2024 (13:19:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1262.v1

Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation

Aurelio Quesada, Javier Quesada-Ocete, Blanca Quesada-Ocete, Victor Del Moral-Ronda, Javier Jiménez-Bello, Ricardo Rubini-Costa, Carl J. Lavie, Daniel P. Morin, Fernando De la Guía-Galipienso, Ricardo Rubini-Puig, Fabian Sanchis-Gomar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; gender; electrical cardioversion; heart failure; mortality

Online: 17 August 2023 (07:15:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1254.v1

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca, Valeria de Cassia Gonçalves, Mario Augusto Izidoro, Antônio-Carlos G. de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Online: 16 June 2023 (14:16:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0731.v1

The Effect of Drotaverine on Gastrointestinal Motility and Heart Rate Variability in Normal, Resting Horses

Alina Anton

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: antispasmodic; heart rate variability; intestinal function; parasympathetic activity

Online: 9 June 2023 (15:50:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0415.v1

Heart Rate Estimation by Video-Based Reflec-tance Photoplethysmography

Ozzy King

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: reflectance PPG; reflectance photoplethysmography; heart rate estimation; video

Online: 24 February 2023 (02:52:59 CET)

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Non-invasive heart rate (HR) monitoring is important in clinical settings as it plays a critical role in diagnosing a range of health conditions and assessing well-being. Presently, the gold standards for HR measurement are all based on sensors which require skin contact. Apart from inconvenience, contact sensors have proven problematic in certain scenarios – they cannot be used when mechanical isolation of the patient is imperative (burn victims, patients with shaky hands and feet), cause skin damage to premature babies in the ICU and increase the risk of spreading infections. Non-contact HR monitoring using a camera has been recently shown to be a viable alternative. It is now possible to record cardiac-synchronous blood volume variations from facial videos of human subjects under ambient lighting. These variations produce corresponding changes in skin reflectance which can be extracted as a raw reflectance photoplethysmography (rPPG) signal and processed to reveal HR. In this project, an algorithmic framework for webcam-based HR detection was successfully implemented in MATLAB. The investigation was based on 100 self-captured videos (dark-skinned subject) and 48 videos (from 12 subjects, all but one fair-skinned) obtained from COHFACE – an online database of facial videos and corresponding physiological signals. While the performance metrics (mean error, SNR) of the rPPG signals obtained from the self-captured videos were poor (best case mean error of 22%), they were good enough to demonstrate the success of the implementation. The poor results were primarily imputed to skin tone as rPPG SNR is known to be particularly low for dark tones. The results of the COHFACE videos were far superior, with mean error ranging from 3% to 15% (among 8 different rPPG signals) and 0% to 9% under ambient and dedicated lighting, respectively. This investigation sets the foundation for future research directed at optimizing rPPG performance metrics for dark-skinned subjects.

Preprint ARTICLE | doi:10.20944/preprints202212.0376.v2

A Fresh View at Sports PSM-Systems

Vladimir Savostyanov, Alexander Kobelev

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Sport; Heart Rate; Breathe Rate; Monitoring; Functional Athlete Readiness; Impedance; Rheography

Online: 6 January 2023 (02:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0250.v1

Folic Acid Exerts Dose-Dependent Biphasic Effects on Cardiac Development of Zebrafish Embryos

Xuhui Han, Bingqi Wang, Hongjie Wang, Yao Zu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mthfr; folic acid; heart development; zebrafish; CRISPR/Cas9

Online: 15 September 2021 (09:16:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0655.v1

ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

Mario Pavez-Giani, Pablo Sanchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Paula Giraldo, Silke Oberdorf-Maass, Kirsten Nijholt, Salva Yurista, Hendrik Milting, Joan Heller Brown, Peter Van Der Meer, Rudolf A. de Boer, Herman H.W. Silljé, B. Daan Westenbrink

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondria; Ca2+ handling; heart failure; CaMKII; cardiomyocyte hypertrophy

Online: 26 March 2021 (10:41:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0291.v1

Heart Diseases Diagnose via Artificial Intelligence-Powered Mobile Application

Mesut Guven, Firat Hardalac, Kanat Ozisik, Funda Tuna

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Heart diseases; Auscultation; Machine learning; Telemedicine; Digital Stethoscope

Online: 15 January 2021 (12:45:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0278.v1

Perinatal Cardiovascular Evaluation in Dorper Sheep: Echocardiographic Description and Behavior of the Heart Rate Variability on the Field

Amanda Sarita Cruz Aleixo, Mayra de Castro Ferreira Lima, Ana Luisa Holanda de Albuquerque, Raphael Tortorelli Teixeira, Renata Alves de Paula, Marina Cecília Grandi, Danilo Otávio Laurenti Ferreira, Lukas Garrido Albertino, Miriam Harumi Tsunemi, Simone Biagio Chiacchio, Maria Lucia G. Lourenço

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: sheep; gestation; hemodinamycs; heart rate variability; cardiac output

Online: 13 October 2020 (12:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0174.v1

Strangers, Friends, and Lovers Show Specific Physiological Synchronies In Different Emotional Contexts

Andrea Bizzego, Atiqah Azhari, Nicola Campostrini, Anna Truzzi, Li Ying Ng, Giulio Gabrieli, Marc H. Bornstein, Peipei Setoh, Gianluca Esposito

Subject: Social Sciences, Behavior Sciences Keywords: heart rate variability; dyads; physiological synchrony; relationship; emotion

Online: 15 November 2019 (06:09:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0088.v1

Signal Quality Valuation with Optimal Power Consumption and High Compression Ratio Method for Estimate Heart Rate Applied to Real-time PPG Measurement

Ngoc-Thang Bui, Tri Ho Minh, Bang Le-Huy Nguyen, Trong Toai Truong, Dinh Luong Le

Subject: Engineering, Bioengineering Keywords: Lossy/ lossless compression; Huffman coding; real-time PPG measurement; heart rate estimate, Message Queueing Telemetry Transport (MQTT); healthcare system

Online: 11 April 2022 (04:21:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201901.0312.v1

Functional Morphology of the Cardiac Jelly in the Tubular Heart of Vertebrate Embryos

Jörg Männer, Talat Mesud Yelbuz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: embryonic heart tube; extracellular matrix; cardiac jelly; hydraulic skeleton; heart skeleton; valveless pumping; blood flow; non-circular cross sections; ballooning; trabeculation

Online: 30 January 2019 (11:16:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1922.v1

Statistical and Diagnostic Properties of pRR30, pRR3.25% and Asymmetrical Entropy Descriptors in Atrial Fibrillation Detection

Bartosz Biczuk, Szymon Buś, Sebastian Żurek, Jarosław Piskorski, Przemysław Guzik

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: atrial fibrillation; cardiac arrhythmia; electrocardiography; heart rate variability; entropy

Online: 26 January 2024 (13:50:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1359.v1

Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation

Székely Andrea MD PhD, Pállinger Éva MD PhD, Töreki Evelin MD, Ifju Mandula, Barta Bálint András MD, Szécsi Balázs MD, Losoncz Eszter MD, Dohy Zsófia MD, Barabás Imre János MD PhD, Kosztin Annamária MD PhD, Buzas I Edit MD PhD, Radovits Tamás MD PhD, Merkely Béla MD PhD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: organ recipient; heart transplantation; primary graft dysfunction; interleukin; apolipoprotein

Online: 20 October 2023 (13:40:14 CEST)

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End-stage heart failure (ESHF) leads to hypoperfusion and edema formation in the whole body and is accompanied by neurohormonal and immunological alterations. Orthotopic heart transplantation (HTX) has been used as a beneficial option for ESHF. Due to the shortage of donor hearts, the ideal matching and timing of donors and recipients has become more important. Our aim was to explore the relationship between the clinical outcome of HTX and the cytokine and apolipoprotein profiles of the recipient pericardial fluid obtained at transplantation after opening the pericardial sac. The clinical data and the interleukin, adipokine and lipoprotein levels in the pericardial fluid of twenty recipients were investigated. Outcome variables included primer graft dysfunction (PGD), need for posttransplantation mechanical cardiac support (MCS), International Society for Heart and Lung Transplantation grade ≥ 2R rejection and mortality. Recipient risk scores were also investigated. Leptin levels were significantly lower in patients with PGD than in those without PGD (median: 6.36 [IQR: 5.55-6.62]; versus 7.54 [IQR=6.71-10.44]; p = 0.029). Higher ApoCII levels (median: 14.91 [IQR: 11.55-21.30] versus 10.31 [IQR=10.02-13.07]; p = 0.042) and ApoCIII levels (median: 60.32 [IQR: 43.00-81.66] versus 22.84 [IQR=15.84-33.39]; p=0.005) were found in patients (n=5) who died in the first 5 years after HTX. In patients who had rejection (n=4) in the first month after transplantation, the levels of adiponectin (median: 74.48 [IQR: 35.51-131.70] versus 29.96 [IQR: 19.86-42.28]; p=0.039), ApoCII (median: 20.11 [IQR: 13.06-23.54] versus 10.32 [IQR: 10.02-12.84]; p=0.007) and ApoCIII (median: 70.97 [IQR: 34.72-82.22] versus 26.33 [IQR: 17.18-40.17; p=0.029) were higher than those in the nonrejection group. Moreover, the pericardial thyroxine (T4) levels (median: 3.96 [IQR: 3.49-4.46] versus 4.69 [IQR: 4.23-5.77]; p=0.022) were lower in patients with rejection than in patients who did not develop rejection. Our results indicate that apolipoproteins can facilitate the monitoring of rejection and could be a useful tool in the forecast of early and late complications.

Preprint REVIEW | doi:10.20944/preprints202308.1645.v1

Dilated Cardiomyopathy: A New Era of Treatment

Vinicius Machado Correia, Lucas Lentini Herling de Oliveira, Vagner Madrini Junior, Ruiza Gonçalves Rocha, Juliana Alzira Gonzales O. Leguizamon, Leandro Menezes Alves da Costa, Fábio Fernandes, José Eduardo Krieger, Paulo Rogério Soares, Thiago Luis Scudeler

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: dilated cardiomyopathy; heart failure; cardiac device therapy; genetic analysis

Online: 23 August 2023 (09:20:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0732.v1

Heart Rate Variability Measurement through a Wearable Device: Another Breakthrough for Personal Health Monitoring?

Ke Li, Cristiano Cardoso, Angel Moctezuma-Ramirez, Abdelmotagaly Elgalad, Emerson Perin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart rate variability, wearable device, autonomic nervous system, stress

Online: 9 August 2023 (08:13:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1283.v2

The Future of Stress Management: Integration Smartwatches and HRV Technology

Ravinder Jerath, Mohammad Syam, Shajia Ahmed

Subject: Biology And Life Sciences, Life Sciences Keywords: smartwatch; stress; wearable device; heart rate variability; comparative analysis

Online: 25 July 2023 (09:28:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0511.v1

Ergonomic Workload Evaluation of Motor-Manual Tree Processing

Eva Abramuszkinová Pavlíková, Pavel Nevrkla, Martin Rohrich

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: tree processing; ergonomic evaluation; workload; heart rate; wearable technology

Online: 7 July 2023 (13:09:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2247.v1

Experimental One Side Choppers Relating Neuro-Muscular Human Abilities to Heart Rates and Technological Evolution

Igor Parra, Maria Luisa Morales, Francisco Javier Mar, Eudald Carbonell

Subject: Arts And Humanities, Archaeology Keywords: hominins; chopper; human evolution; heart rate; piano playing; technome

Online: 30 June 2023 (11:47:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0876.v1

Position of Transseptal Puncture for Left Atrial Access in Invasive Procedures – A Brief History, Potential Complications and Available Techniques

Piotr Denysiuk, Adrianna Denysiuk, Marcin Szczasny, Joanna Popiolek-Kalisz, Piotr Blaszczak, Andrzej Glowniak

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Transseptal puncture; TSP; left atrium catheterization; left heart catheterization

Online: 13 June 2023 (04:33:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0346.v1

The Effects of Low-Dose Empagliflozin on Cardiac Function and Β-Adrenoceptor Responses in a Rat Model of Streptozotocin-Induced Diabetes

Zeynep Elif Yesilyurt, Irem Karaomerlioglu, Betul Rabia Erdogan, Gaye Ozturk, Martin C. Michel, Ebru Arioglu-Inan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: β-adrenoceptor; diabetes; empagliflozin; heart; pressure-volume loop analysis

Online: 25 May 2022 (09:59:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0437.v1

Current Status of Glucocorticoid Usage in Solid Organ Transplantation

Simin Dashti-Khavidaki, Reza Saidi, Hong Lu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Corticosteroids; Glucocorticoids; Solid organ transplantation; Liver; Kidney; Heart; Lung

Online: 16 June 2021 (10:30:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0167.v1

Predictive Utility of Changes in Optic Nerve Sheath Diameter after Cardiac Arrest for Neurologic Outcomes

Heekyung Lee, Joonkee Lee, Hyungoo Shin, Changsun Kim, Hyuk Joong Choi, Bo Seung Kang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Heart arrest; optic nerve sheath diameter; Patient outcome assessment

Online: 10 May 2021 (10:51:42 CEST)

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Working Paper BRIEF REPORT

The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement

Peter Hotez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; SARS 2; coronavirus; Th17; eosinophils; heart disease

Online: 9 April 2020 (14:45:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0384.v1

Moderate Effect of Flavonoids on Vascular and Renal Function In Spontaneously Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemi Atucha, Francisco O’Valle, Julian Castillo, M. Clara Ortiz, Joaquin Garcia-Estañ

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Flavonoids, nitric oxide, heart, kidney, sodium balance, phenylephrine, acetylcholine

Online: 20 July 2018 (12:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0190.v1

NOX Inhibition Improves β Adrenergic-Stimulated Contractility and Intracellular Calcium Handling in the Aged Heart

Alvaro Valdés, Guillermo Barrios, Nikol Ponce, Raul A Dulce, Daniel R Gonzalez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: NADPH oxidases; apocynin; VAS2870; aged heart; cardiomyocytes; isoproterenol; TBARS

Online: 16 April 2018 (06:17:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0060.v1

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemí M. Atucha, Francisco O’Valle, Julián Castillo, M. Clara Ortiz, Joaquín García-Estañ

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine

Online: 8 March 2018 (03:31:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0248.v1

Gross Motor Development of Children with Congenital Heart Disease Receiving Early Systematic Surveillance and Individualized Intervention: Brief Report

Solène Fourdain, Marie-Noëlle Simard, Lynn Dagenais, Manuela Materassi, Amélie Doussau, Justine Goulet, Karine Gagnon, Joëlle Prud'homme, Marie-Claude Vinay, Mathieu Dehaes, Ala Birca, Nancy C. Poirier, Lionel Carmant, Anne Gallagher

Subject: Social Sciences, Behavior Sciences Keywords: congenital heart disease; gross motor development; early intervention; Alberta Infant Motor Scales (AIMS); Bayley Scales of Infant and Toddler Development; Third edition (Bayley-III)

Online: 23 August 2019 (11:51:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0842.v1

Prognostic Value and Limits of Heart Rate and QT-Corrected in A Large Population

Paolo Giovanardi, Cecilia Vernia, Sara Roversi, Enrico Tincani, Giuseppe Spadafora, Federico Silipo, Claudio Giberti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: electrocardiogram; QT corrected; Bazett; heart rate; all-cause death; mortality

Online: 12 April 2024 (09:54:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0277.v1

Compartmentalized Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve

Meghan Martin, Chih-Ying Chen, Timothy McCowan, Sarah Wells

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart valves; extracellular matrix; remodeling; elastin; cardiac development; collagen; valvulogenesis

Online: 5 March 2024 (15:05:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1697.v1

Interplay of Angiotensin Peptides, Vasopressin and Insulin in the Heart: Altered Interactions in Obesity and Diabetes Mellitus

Ewa Szczepańska-Sadowska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Angiotensin; diabetes mellitus; heart failure; hypertension; hypoxia; insulin; obesity; vasopressin

Online: 22 December 2023 (08:12:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1152.v1

A Technical Comparative Heart Disease Prediction Framework Using Boosting Ensemble Techniques

Najmu Nissa, Sanjay Jamwal, Mehdi Neshat

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Heart Disease; Diagnosis, Machine Learning; Boosting; Ensemble learning; Comparative framework

Online: 18 December 2023 (02:45:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1332.v1

Hippo Signaling Mediates TGFβ-Dependent Transcriptional In-Puts in Cardiac Cushion Mesenchymal Cells to Regulate Extracel-Lular Matrix Remodeling

Mrinmay Chakrabarti, Ahad Chattha, Abhijith Nair, Kai Jiao, Jay D Potts, Lianming Wang, Scotty Branch, Shea Harrelson, Saeed Khan, Mohamad Azhar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Transforming growth factor beta; YAP; SMAD3; Heart Valve; Extracellular matrix

Online: 20 October 2023 (12:22:01 CEST)

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Abstract: The transforming growth factor beta (TGFβ) and Hippo signaling pathways are evolutionarily conserved pathways that play a critical role in cardiac fibroblasts during embryonic development, tissue repair, and fibrosis. TGFβ and Hippo signaling is also important for cardiac cushion remodeling and septation during embryonic development. Loss of TGFβ2 in mice causes cardiac cushion remodeling defects resulting in congenital heart disease. In this study, we used in vitro molecular and pharmacologic approaches in the cushion mesenchymal cell line (tsA58-AVM) and investigated if Hippo pathway acts as a mediator of TGFβ2 signaling. Immunofluorescence staining showed that TGFβ2 induced nuclear translocation of activated SMAD3 in the cushion mesenchymal cells. In addition, the results indicated increased nuclear localization of Yes associated protein 1 (YAP1) following a similar treatment of TGFβ2. In collagen lattice formation assays, TGFβ2 treatment of cushion cells resulted in an enhanced collagen contraction compared to the untreated cushion cells. Interestingly, verteporfin, a YAP1 inhibitor, significantly blocked the ability of cushion cells to contract collagen gel in absence or presence of by exogenously added TGFβ2. To confirm the molecular mechanisms of verteporfin induced inhibition of TGFβ2-dependent extra-cellular matrix (ECM) reorganization we performed gene expression analysis of key mesenchymal genes involved in ECM remodeling in heart development and disease. Our results confirmed that verteporfin significantly decreased the expression of α-smooth muscle actin (Acta2), collagen 1a1 (Col1a1), Ccn1 (i.e., Cyr61), and Ccn2 (i.e., Ctgf). Western blot analysis indicated that verteporfin treatment significantly blocked TGFβ2-induced activation of SMAD2/3 in cushion mesenchymal cells. Collectively, these results indicate that TGFβ2 regulation of cushion mesenchymal cell be-havior and ECM remodeling is mediated by YAP1. Thus, TGFβ2 and Hippo pathway integration represents an important step in understanding the etiology of congenital heart disease.

Preprint ARTICLE | doi:10.20944/preprints202310.0971.v1

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; electrocardiography (ECG); Chronic Chagas Cardiomyopathy; Chagas heart disease

Online: 16 October 2023 (12:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1743.v1

Aggravation of Health Problems Subsequent to COVID-19 Lockdown

Fatma Nese Efil, Sania Qureshi, Nezihal Gokbulut, Evren Hınçal, Amanullah Soomro

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Covid-19; mathematical modeling; cancer; diabetes; heart diseases; sensitivity analysis

Online: 26 September 2023 (10:40:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0500.v2

Cardiovascular Response to Exercise in Vertebrates: Update

Antonio López-Román, Raquel Gómez-Lucas, Elena Jiménez-Herranz, Francisco Javier Calderón-Montero, Juan José Ramos-Álvarez

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: ; vertebrates; arterial pressure; cardiac output; exercise; heart rate; stroke volume ;

Online: 17 January 2024 (13:19:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.2222.v1

Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

Martina Belli, Lucy Barone, Susanna Longo, Francesca Romana Prandi, Dalgisio Lecis, Rocco Mollace, Davide Margonato, Saverio Muscoli, Domenico Sergi, Massimo Federici, Francesco Barillà

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Gut microbiota; Cardiovascular diseases; Trimethylamine N-Oxide; Heart failure; Atherosclerosis

Online: 30 June 2023 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0362.v1

Cardioprotective Potential of the Ethanol and Water Extracts of Four Psilocybin Mushrooms on Angiotensin II-Induced Hypertrophy and Oxidative Stress on H9C2 Cardiomyocytes

Sanah Malomile Nkadimeng, Christiaan Martin Steinmann, Jakobus Nicolaas Eloff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: reactive oxygen species; angiotensin II; hypertrophy; psilocybin mushrooms; heart failure

Online: 6 June 2023 (03:07:37 CEST)

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Psilocybin-containing mushrooms, commonly known as magic mushrooms have antidepressant effect, however, their safety in cardiovascular diseases such as heart failure is not fully known and needs to be investigated. Cardiac hypertrophy is an independent risk factor for heart failure morbidity and mortality. Angiotensin II (Ang-II) plays a major role in the pathogenesis of cardiac hypertrophy. We investigated the cardiovascular safety of extracts of Panaeolus cyanescens, Psilocybe natalensis, Psilocybe cubensis, and Psilocybe cubensis leucistic A+ strain mushrooms, well-known psilocybin-containing mushrooms in the Panaeolus and Psilocybe genus on Ang II-induced hypertrophy oxidative stress. The four mushrooms were grown, dried and extracted with 70% ethanol, cold and hot water. Extracts were tested for cytotoxicity on H9C2 cardiomyoblast cells. The cardiomyocytes were induced with (10 µM) AngII and treated with the three extracts of the four mushrooms over 48 hours. Control cells were serum starved but neither AngII induced nor treated while AngII cells were serum starved and stimulated with AngII but not treated. Losartan, an inhibitor of AngII type 1 receptor was used as positive control. Effects of the extracts on actin-filament labelling and cell surface area, mitochondrial activity, reactive oxygen species (ROS) and atrial natriuretic peptide levels were determined. Stimulation with AngII lowered cell viability, increased the cell width measurements and intracellular ROS levels significantly compared to control cells. The results indicated that the ethanol and water extracts of the four psilocybin mushrooms did not exacerbate the angiotensin II-induced hypertrophy conditions, but the extracts had cardio-protective activity against angiotensin II-induced oxidative stress. The phytochemical analysis of the extracts confirmed detections of known compounds with antioxidant and anti-inflammatory effects in the water and ethanol extracts of these four psilocybin mushrooms.

Preprint ARTICLE | doi:10.20944/preprints202305.1899.v1

The Effect of Caffeine on the Heart Rate Variability in Newborns: A Pilot Study

Helena Lenasi, Eva Rihar, Jerneja Filipič, Matjaž Klemenc, Petja Fister

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; heart rate variability; caffeine; apnoea; apnea; autonomic nervous system

Online: 26 May 2023 (09:36:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0713.v1

ECG Recordings as Predictors of Very Early Autism Likelihood: A Machine Learning Approach

Deepa Tilwani, Jessica Bradshaw, Amit P. Sheth, Christian O'Reilly

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Autism Spectrum Disorder, Biomarker, Electrocardiograms, Machine Learning, Heart rate variability.

Online: 10 May 2023 (08:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0097.v1

Prognostic Implications of Physical Activity on Mortality from Ischaemic Heart Disease: Longitudinal Cohort Study Data

Dalia Luksiene, Vilma Jasiukaitiene, Ricardas Radisauskas, Abdonas Tamosiunas, Martin Bobak

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: physical activity; mortality risk; ischaemic heart disease; longitudinal cohort study

Online: 3 May 2023 (04:52:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0479.v2

Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects

Zubin Mehta, Marlin Touma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Posttranscriptional Modification; Alternative Splicing; Congenital Heart Defects; Transcriptome; Splicing Variants

Online: 27 December 2022 (10:54:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0706.v1

Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers

Hope Peterson, Rhiannon E Mayhugh, Mohsen Bahrami, W Jack Rejeski, Sean L Simpson, Keri Heilman, Steven W Porges, Paul J Laurienti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alcohol; brain networks; heart rate variability; abstinence; respiratory sinus arrhythmia

Online: 28 May 2021 (13:45:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0440.v1

Conversational Task Increases Heart Rate Variability on Individuals Susceptible to Perceived Social Isolation

Ying Xing Feng, Nur Syahirah Roslan, Lila Iznita Izhar, Muhammad Abdul Rahman, Ibrahima Faye, Eric, Tatt Wei Ho

Subject: Social Sciences, Psychology Keywords: Heart rate variability (HRV); Conversation; Extraversion personality; Perceived social isolation

Online: 19 May 2021 (12:42:21 CEST)

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Studies showed that introversion is the strongest personality trait related to perceived social isolation (loneliness), which can predict various complications beyond objective isolation such as living alone. Lonely individuals are more likely resort to social media for instantaneous comfort, but it is not a perpetual solution. Largely negative implications including poorer interpersonal relationship and depression were reported due to excessive social media usage. Conversational task is an established intervention to improve verbal communication, cognitive and behavioral adaptation among lonely individuals. Despite that behavioral benefits have been reported, it is unclear if they are accompanied by objective benefits underlying physiological changes. Here, we investigate the physiological signals from 28 healthy individuals during a conversational task. Participants were ranked by trait extraversion, where greater introversion is associated with increased susceptibility to perceived social isolation as compared to participants with greater extraversion as controls. We found that introverts had a greater tendency to be neurotic, and these participants also exhibited significant differences in task-related electrodermal activity (EDA), heart rate (HR) and HR variability (HRV) as compared to controls. Notably, resting state HRV among individuals susceptible to perceived loneliness was below the healthy thresholds established in literature. Conversational task with a stranger significantly increased HRV among individuals susceptible to isolation up to levels as seen in controls. Since HRV is also elevated by physical exercise and administration of oxytocin hormone (one form of therapy for behavioral isolation), conversational therapy among introverts could potentially confer physiological benefits to ameliorate social isolation and loneliness. Our findings also suggest that although the recent pandemic have changed how people are interacting typically, we should maintain a healthy dose of social interaction innovatively.

Preprint ARTICLE | doi:10.20944/preprints202010.0345.v1

Possible Early Generation of Physiological Helical Flow Could Benefit the Triflo Trileaflet Heart Valve Prosthesis Compared to Bileaflet Valves

Ch. Bruecker, Qianhui Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: physiological helical flow; mechanical heart valve prostheses; aorta; PIV; trileaflet

Online: 16 October 2020 (11:54:53 CEST)

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Background - Physiological helical flow in the ascending aorta has been well documented in the last two decades, accompanied by discussions on possible physiological benefits of such axial swirl. Recent 4D-MRI studies on healthy volunteers have shown indication of early generation of helical flow, early in the systole and already close to the valve plane. Objectives - Firstly, the aim of the study is to investigate the hypothesis of premature swirl existence in the ventricular outflow tract leading to already helical flow in the valve plane, and second to investigate the possible impact of two different mechanical valves design on the preservation of this early helical flow and its subsequent hemodynamic consequences. Methods - We use a pulse duplicator with an aortic arch and High Speed Particle Image Velocimetry to document the flow evolution in the systolic cycle. The pulse-duplicator is modified with a swirl-generating insert to generate early helical flow in the valve plane. Special focus is laid on the interaction of such helical flow with different designs of mechanical prosthetic heart valves, comparing a classical bileaflet mechanical heart valve, the St Jude Medical Regent valve (SJM Regent BMHV) with the Triflo trileaflet mechanical heart valve T2B version (Triflo TMHV). Results – When the swirl-generator is inserted, a vortex is generated in the core flow demonstrating early helical flow in the valve plane, similar as observed in the recent 4-D-MRI study taken for comparison. For the Triflo trileaflet valve, the early helical flow is not obstructed in the central orifice, similar as in the case of the natural valve. Conservation of angular momentum leads to radial expansion of the core flow and flattening of the axial flow profile downstream in the arch. Furthermore, the early helical flow helps to overcome separation at the outer and inner curvature. In contrast, the two parallel leaflets for the bileaflet valve impose a flow straightener effect, annihilating the angular momentum with negative impact on kinetic energy of the flow. Conclusion - The results imply better hemodynamics for the Triflo trileaflet valve based on hydrodynamic arguments under the discussed hypothesis. In addition, it makes the Triflo valve a better candidate for replacements in patients with pathological generation of nonaxial velocity in ventricle outflow tract.

Preprint ARTICLE | doi:10.20944/preprints202003.0229.v1

Evaluation of Left Ventricular Assist Device Electrical Current as a Predictor of Left Ventricular Recovery

Dmitry Telyshev, Alexander Pugovkin, Ivan Ephimov, Aleksandr Markov, Steffen Leonhardt, Marian Walter, Jamshid Karimov, Sergey Selishchev

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; left ventricular assist device; cardiac recovery; mechanical circulation

Online: 13 March 2020 (10:11:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0103.v1

Central and Peripheral Fatigue Related to the Type of Exercise

José Trinidad Quezada Chacón, Edson Francisco Estrada Meneses, Gustavo Sierra Muñiz, Arnulfo Ramos-Jimenez, Felipe Reynoso Sánchez, Janeth Miranda Mendoza, German Hernánez Cruz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: acute physical stress; sports performance; heart rate variability; physical exhaustion

Online: 5 November 2018 (10:35:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0093.v1

Developing Sensitive Golden Plate Biosensor for Early Detection of Serum Cardiac Troponin I as Diagnostic Biomarkers

Said Moselhy, Ehab Mostafa, Abdulrahman Almalki, Taha Kumosani, Youssri Soliman, Ibrahim Aboseda, Wesam Abduaal, Rwaa Abdulaal, Numan Salah, Walid Alshawafi, Afnan Kunosani

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Troponin I- Myocardial infarction- Ischemic heart diseases- Biosensors- golden plate.

Online: 5 September 2018 (10:09:33 CEST)

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