Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of Left Ventricular Assist Device Electrical Current as a Predictor of Left Ventricular Recovery

Version 1 : Received: 12 March 2020 / Approved: 13 March 2020 / Online: 13 March 2020 (10:11:43 CET)

How to cite: Telyshev, D.; Pugovkin, A.; Ephimov, I.; Markov, A.; Leonhardt, S.; Walter, M.; Karimov, J.; Selishchev, S. Evaluation of Left Ventricular Assist Device Electrical Current as a Predictor of Left Ventricular Recovery. Preprints 2020, 2020030229 (doi: 10.20944/preprints202003.0229.v1). Telyshev, D.; Pugovkin, A.; Ephimov, I.; Markov, A.; Leonhardt, S.; Walter, M.; Karimov, J.; Selishchev, S. Evaluation of Left Ventricular Assist Device Electrical Current as a Predictor of Left Ventricular Recovery. Preprints 2020, 2020030229 (doi: 10.20944/preprints202003.0229.v1).

Abstract

In this paper, we aim to assess the electric current parameters and report the analysis of the associated degree of ventricular recovery during left ventricular assist device (LVAD) support. An assumption was made there is a linear relationship between ventricular recovery degree and the pump electric current pulsatility index (PI). The experimental study was carried out using the ViVitro Pulse Duplicator System with Sputnik 1 LVAD connected. Cardiac output (CO) and cardiac power output (CPO) were used as a measure of ventricular recovery degree. Different heart rates (HR) (59, 73, 86 bpm) and pump speeds (7600–8400 rpm in 200 rpm steps) were investigated. Ventricular stroke volumes in the range of 30–80 ml for each heart rate at certain pump speed were used. The obtained relationships of CO and CPO vs. PI was linear as the coefficients of determination for each regression curve were more than 0.8. CO vs. PI: R2=0.9218; 0.9271; 0.9172 and CPO vs. PI: R2=0.8517; 0.841; 0.8244 for HR=59 bpm; 73 bpm; 86 bpm, respectively. Study findings suggest that adequate interpretation of parameters could potentially serve as a valuable clinical tool to assess ventricular recovery based on LVAD infrastructure without requiring any special hemodynamic assessment.

Subject Areas

heart failure; left ventricular assist device; cardiac recovery; mechanical circulation

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