Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Effect of Circadian Photoreceptors Stimulation on the Stress Response of Subjects with High Anxiety

Mariya Stanislavovna Sergeeva
,
Oksana Viacheslavovna Borisova
,
Natalia Petrovna Romanchuk
ORCID logo ,
Arseniy Andreevich Videnin
,
Vasiliy Fedorovich Pyatin
,
Natalia Nikolaevna Shusharina
,
Alexander Vladimirovich Zakharov
* ,
Alexander Vladimirovich Kolsanov
Version 1 : Received: 13 April 2023 / Approved: 14 April 2023 / Online: 14 April 2023 (02:40:18 CEST)

A peer-reviewed article of this Preprint also exists.

Sergeeva, M.; Borisova, O.; Romanchuk, N.; Videnin, A.; Pyatin, V.; Shusharina, N.; Zakharov, A.V.; Kolsanov, A. The Effect of Circadian Photoreceptors Stimulation on the Stress Response of Subjects with High Anxiety: A Pilot Study. Appl. Sci. 2023, 13, 6679. Sergeeva, M.; Borisova, O.; Romanchuk, N.; Videnin, A.; Pyatin, V.; Shusharina, N.; Zakharov, A.V.; Kolsanov, A. The Effect of Circadian Photoreceptors Stimulation on the Stress Response of Subjects with High Anxiety: A Pilot Study. Appl. Sci. 2023, 13, 6679.

Abstract

The circadian and stress-realizing systems are interconnected, and the balance of their interaction determines the state of human health. The objective of this study was to investigate the modulating effect of activating the circadian system on heart rate variability in female medical students with high anxiety while performing a cognitive task. After 20 minutes of adequate stimulation of circadian photoreceptors with a monochromatic blue light, the cognitive task performance resulted in a decrease in sympathetic impact. During the session of using Blue Sky Pro glasses, a trend of increasing heart rate variability was observed in a state of relative rest (especially in the first 5 minutes). A comparative analysis of the parameters of the letter cancellation test before and after light exposure revealed a statistically significant increase in the indexes reflecting mental productivity, work accuracy, and concentration of attention. The results suggest an essential physiological role of the human circadian system in modulating the autonomic and psycho-emotional conditions, as well as cognitive functions of individuals with high anxiety. Our findings indicate the possibility of quickly correcting the balance in human systemic regulatory mechanisms using the activation of retinal circadian photoreceptors by blue light.

Keywords

anxiety; circadian system; heart rate variability; melanopsin-containing retinal ganglion cells; stress

Subject

Biology and Life Sciences, Behavioral Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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