Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Version 1 : Received: 7 April 2021 / Approved: 8 April 2021 / Online: 8 April 2021 (12:23:43 CEST)

A peer-reviewed article of this Preprint also exists.

Liu Chung Ming, C.; Sesperez, K.; Ben-Sefer, E.; Arpon, D.; McGrath, K.; McClements, L.; Gentile, C. Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells 2021, 10, 899. Liu Chung Ming, C.; Sesperez, K.; Ben-Sefer, E.; Arpon, D.; McGrath, K.; McClements, L.; Gentile, C. Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells 2021, 10, 899.

Journal reference: Cells 2021, 10, 899
DOI: 10.3390/cells10040899

Abstract

Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation that is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD) including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion, however, that therapeutic approach leads to ischemic/reperfusion injury (IRI) often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.

Subject Areas

preeclampsia; cardiovascular disease; heart failure; ischemic/reperfusion injury; in vivo model system; in vitro model system; ex vivo model system

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